The state of Pennsylvania currently has 47 active clinical trials seeking participants for Arthritis research studies. These trials are conducted in various cities, including Philadelphia, Pittsburgh, Hershey and Allentown.
ConsideRAte Study - Splenic Stimulation for RA
Recruiting
This study will evaluate the safety, tolerability, and effects of stimulating the splenic neurovascular bundle (NVB) with the Galvani System, which consists of a lead, implantable pulse generator, external components and accessories. The study will consist of 4 study periods, including a Randomized Control Trial period (Period 1), an Open Label period (Period 2), a Treat-to-target period (Period 3), and a Long-term Follow-up period (Period 4). Participants eligible for implant will have active r... Read More
Gender:
All
Ages:
Between 22 years and 75 years
Trial Updated:
05/20/2024
Locations: Altoona Center for Clinical Research, Altoona, Pennsylvania
Conditions: Rheumatoid Arthritis
AETOS Shoulder System
Recruiting
The goal of this study is to confirm the safety and performance of the AETOS Shoulder System for USA adoption. This is a prospective, open, adaptive, non-comparative, multi-centre investigation enrolling a maximum of 220 subjects in 2 cohorts (anatomic and reverse) at up to 15 sites. No intra-study comparator group will be included, and there will be no randomization
Gender:
All
Ages:
18 years and above
Trial Updated:
05/06/2024
Locations: Rothman Institute, Philadelphia, Pennsylvania
Conditions: Shoulder Osteoarthritis, Shoulder Arthritis
Biomechanical Footwear as a Non-invasive Alternative and Supplement to Total Knee Replacement
Recruiting
Osteoarthritis (OA), the most common type of arthritis, affects more than 32.5 million adults in the United States. It is also among the most expensive condition to treat when joint replacement surgery is required. Although biomechanics plays an important role in OA disease, the non-surgical treatment options addressing biomechanics are scarce with limited effect. AposHealth is the fist biomechanical treatment that was shown to have a significant short-term effect on patients with knee OA. The... Read More
Gender:
All
Ages:
Between 45 years and 80 years
Trial Updated:
03/26/2024
Locations: Geisinger Medical Center, Danville, Pennsylvania +1 locations
Conditions: Osteoarthritis, Knee
Psoriatic Arthritis D2P Screening
Recruiting
The overarching goal of this study is to develop a direct-to-patient screening approach that will improve early Psoriatic Arthritis (PsA) detection in patients with psoriasis. Previously developed screening questionnaires were intended for use in the setting of a doctor's office to assist providers with referral decisions. However, these screening questionnaires are infrequently used in routine practice because of limitations with time and resources. The study will aim to develop a practical scr... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/05/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Psoriatic Arthritis
A Study to Evaluate the Efficacy of Amniotic Suspension Allograft in Patients With Osteoarthritis of the Knee
Recruiting
This study is being conducted to evaluate the efficacy and safety of ASA compared to placebo in the management of osteoarthritis (OA) symptoms of the knee.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/01/2024
Locations: Lehigh Center for Clinical Research, Allentown, Pennsylvania
Conditions: Knee Osteoarthritis
COVID-19 VaccinE Response in Rheumatology Patients
Recruiting
The COVID-19 VaccinE Response in Rheumatology patients (COVER) study is a multicenter randomized controlled trial designed to evaluate the efficacy and safety of a mRNA COVID-19 vaccine supplemental dose (booster) in patients with autoimmune conditions and to evaluate the impact of different immunomodulatory therapies on vaccine response. The investigators propose to recruit up to 1000- patients with autoimmune conditions who have a completed 2-dose regime of mRNA COVID-19 vaccine (>28 days prio... Read More
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
11/06/2023
Locations: University of Pennsylvania Medical Center, Philadelphia, Pennsylvania
Conditions: Rheumatoid Arthritis, Psoriatic Arthritis, Spondylarthritis
Autologous Adipose-derived Stromal Vascular Fraction for Treatment of Knee Osteoarthritis
Recruiting
This study is a pivotal study to evaluate the efficacy and safety of a single injection of autologous adipose-derived SVF produced using the GID SVF-2 device system for treatment of pain with concomitant improvement in function associated with osteoarthritis of the knee joint.
Gender:
All
Ages:
Between 35 years and 85 years
Trial Updated:
09/07/2023
Locations: University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
Conditions: Osteoarthritis, Knee
The Effect of Guided Care With Vectra Compared to Treatment as Usual in Patients With Rheumatoid Arthritis
Recruiting
The goal of treating patients diagnosed with rheumatoid arthritis (RA) is to achieve remission or low disease activity and thereby prevent joint damage, loss of physical function, and disability. Optimal management requires regular assessment of disease activity, with treatment changes made as needed for optimal efficacy. Vectra is a blood serum test that looks at 12 biomarkers and produces a score on a scale of 1 to 100. The Vectra score has been shown to be the strongest predictor of risk for... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
08/07/2023
Locations: East Penn Rheumatology Associates, P.C., Bethlehem, Pennsylvania +3 locations
Conditions: Rheumatoid Arthritis (RA)
Safety & Effectiveness of Autologous Regenerative Cell Therapy on Pain & Inflammation of Osteoarthritis of the Shoulder
Recruiting
This is a prospective open-label clinical study of 50 patients to determine safety and treatment potential of autologous cell therapy for pain and inflammation associated with Osteoarthritis of the shoulder. Follow-up will consist of a larger sample including 4,000 patients.
Gender:
All
Ages:
Between 18 years and 90 years
Trial Updated:
08/04/2023
Locations: VivaTech International, Inc., Grove City, Pennsylvania
Conditions: Osteoarthritis
Safety & Effectiveness of Autologous Regenerative Cell Therapy on Pain & Inflammation of Osteoarthritis of the Knee
Recruiting
This is a prospective open-label clinical study of 50 patients to determine safety and treatment potential of autologous cell therapy for pain and inflammation associated with Osteoarthritis of the knee. Follow-up will consist of a larger sample including 4,000 patients.
Gender:
All
Ages:
Between 18 years and 90 years
Trial Updated:
08/04/2023
Locations: VivaTech International, Inc., Grove City, Pennsylvania
Conditions: Osteoarthritis
Safety & Effectiveness of Autologous Regenerative Cell Therapy on Pain & Inflammation of Osteoarthritis of the Hip
Recruiting
This is a prospective open-label clinical study of 50 patients to determine safety and treatment potential of autologous cell therapy for pain and inflammation associated with Osteoarthritis of the hip. Follow-up will consist of a larger sample including 4,000 patients.
Gender:
All
Ages:
Between 18 years and 90 years
Trial Updated:
08/04/2023
Locations: VivaTech International, Inc., Grove City, Pennsylvania
Conditions: Osteoarthritis