The state of Pennsylvania currently has 48 active clinical trials seeking participants for Arthritis research studies. These trials are conducted in various cities, including Philadelphia, Pittsburgh, Hershey and Allentown.
Rheumatoid Arthritis Shared Decision Making
Recruiting
Shared decision making is the first overarching principle for the treat to target guidelines for rheumatoid arthritis (RA) and has been proposed as a potential mechanism to reduce health disparities, however there is little evidence to inform effective ways to implement this practice in the care of Veterans with RA. The purpose of this project is to evaluate the effectiveness of a multi-component shared decision making intervention on RA disease activity, adherence to RA medications and patient... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
10/02/2023
Locations: Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, Philadelphia, Pennsylvania
Conditions: Rheumatoid Arthritis
RISC Panel Remnant Sample Collection
Recruiting
The primary objective of this study is to evaluate the usability and clinical utility of the Synovasure® RISC™ Panel. The secondary objective of this study is to create a repository of well-characterized synovial fluid samples from patients with knee pain and/or inflammation to be used for future research.
Gender:
All
Ages:
Between 18 years and 89 years
Trial Updated:
09/20/2023
Locations: Rothman Orthopaedic Institute, Philadelphia, Pennsylvania
Conditions: Arthritis, Inflammatory
Autologous Adipose-derived Stromal Vascular Fraction for Treatment of Knee Osteoarthritis
Recruiting
This study is a pivotal study to evaluate the efficacy and safety of a single injection of autologous adipose-derived SVF produced using the GID SVF-2 device system for treatment of pain with concomitant improvement in function associated with osteoarthritis of the knee joint.
Gender:
All
Ages:
Between 35 years and 85 years
Trial Updated:
09/07/2023
Locations: University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
Conditions: Osteoarthritis, Knee
Guselkumab vs Golimumab in PsA TNF Inadequate Responder Patients
Recruiting
The trial is a double-blinded randomized study that will examine whether switching to a selective IL23 inhibitor (guselkumab) is more effective than switching to a second TNFi (golimumab) among patients with PsA who have an inadequate response to a TNFi.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
08/31/2023
Locations: Hospital at the University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Psoriatic Arthritis
Rural Access to Physical Therapy for Osteoarthritis Rehabilitation - Pilot
Recruiting
This is a pilot study involving a hybrid in-person + telerehabilitation intervention for rural adults with knee osteoarthritis. The primary purpose is to demonstrate feasibility and safety of the RAPTOR program, and the secondary purpose is to estimate clinical effectiveness of the RAPTOR program on participants' pain, function, and quality of life.
Gender:
All
Ages:
40 years and above
Trial Updated:
08/09/2023
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Osteoarthritis, Knee
The Effect of Guided Care With Vectra Compared to Treatment as Usual in Patients With Rheumatoid Arthritis
Recruiting
The goal of treating patients diagnosed with rheumatoid arthritis (RA) is to achieve remission or low disease activity and thereby prevent joint damage, loss of physical function, and disability. Optimal management requires regular assessment of disease activity, with treatment changes made as needed for optimal efficacy. Vectra is a blood serum test that looks at 12 biomarkers and produces a score on a scale of 1 to 100. The Vectra score has been shown to be the strongest predictor of risk for... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
08/07/2023
Locations: East Penn Rheumatology Associates, P.C., Bethlehem, Pennsylvania +3 locations
Conditions: Rheumatoid Arthritis (RA)
Safety & Effectiveness of Autologous Regenerative Cell Therapy on Pain & Inflammation of Osteoarthritis of the Shoulder
Recruiting
This is a prospective open-label clinical study of 50 patients to determine safety and treatment potential of autologous cell therapy for pain and inflammation associated with Osteoarthritis of the shoulder. Follow-up will consist of a larger sample including 4,000 patients.
Gender:
All
Ages:
Between 18 years and 90 years
Trial Updated:
08/04/2023
Locations: VivaTech International, Inc., Grove City, Pennsylvania
Conditions: Osteoarthritis
Safety & Effectiveness of Autologous Regenerative Cell Therapy on Pain & Inflammation of Osteoarthritis of the Knee
Recruiting
This is a prospective open-label clinical study of 50 patients to determine safety and treatment potential of autologous cell therapy for pain and inflammation associated with Osteoarthritis of the knee. Follow-up will consist of a larger sample including 4,000 patients.
Gender:
All
Ages:
Between 18 years and 90 years
Trial Updated:
08/04/2023
Locations: VivaTech International, Inc., Grove City, Pennsylvania
Conditions: Osteoarthritis
Safety & Effectiveness of Autologous Regenerative Cell Therapy on Pain & Inflammation of Osteoarthritis of the Hip
Recruiting
This is a prospective open-label clinical study of 50 patients to determine safety and treatment potential of autologous cell therapy for pain and inflammation associated with Osteoarthritis of the hip. Follow-up will consist of a larger sample including 4,000 patients.
Gender:
All
Ages:
Between 18 years and 90 years
Trial Updated:
08/04/2023
Locations: VivaTech International, Inc., Grove City, Pennsylvania
Conditions: Osteoarthritis
Prevention of Cardiovascular Disease and Mortality in Patients With Psoriasis or Psoriatic Arthritis
Recruiting
The goal of this research is to test a novel centralized care coordinator program to assist patients with psoriatic disease in lowering their risk of cardiovascular disease through the application of standard of care approaches to improving modifiable cardiovascular risk factors.
Gender:
All
Ages:
Between 40 years and 75 years
Trial Updated:
07/10/2023
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Psoriasis, Psoriatic Arthritis, Psoriatic Conditions, Cardiovascular Diseases
Clinical Outcomes Study of the Nexel Total Elbow
Recruiting
The objectives of the study are to confirm safety and performance of the Zimmer Nexel Total Elbow when used in primary or revision total elbow replacement.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/18/2023
Locations: Rothman Institute, Philadelphia, Pennsylvania
Conditions: Elbow Joint Destruction, Post-traumatic Lesions, Ankylosed Joints, Advanced Rheumatoid Arthritis, Joint Instability or Loss of Motion, Acute Comminuted Articular Fracture of Elbow Joint Surfaces, Bone Loss Contributing to Elbow Instability, Bilateral Ankylosis From Causes Other Than Active Sepsis, Post-traumatic Arthritis, Degenerative Arthritis
Comparing Different Types of Physical Therapy for Treating People With a Meniscal Tear and Osteoarthritis
Recruiting
Knee osteoarthritis is a disabling problem affecting over 15 million adults in the United States. Many people who have knee arthritis also experience painful meniscal tears. There are a number of different treatments that can be used to manage meniscal tears in the presence of knee arthritis. Treatments include surgically removing the damaged part of the meniscus; strengthening exercises to improve pain and function; manual therapy including massage and mobilization; acupuncture; and others. The... Read More
Gender:
All
Ages:
Between 45 years and 85 years
Trial Updated:
09/13/2022
Locations: University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
Conditions: Meniscal Degeneration, Osteoarthritis, Knee