The state of Pennsylvania currently has 15 active clinical trials seeking participants for Autism research studies. These trials are conducted in various cities, including Philadelphia, Pittsburgh, Hershey and Allentown.
Effectiveness Trial of Mobile ESI for Toddlers With Autism Identified by Early Screening in Primary Care
Recruiting
The goal of this collaborative R01 is to demonstrate the therapeutic value and community-wide implementability of an early intervention (EI) platform for toddlers with autism spectrum disorder (ASD) that is completely virtual, from recruitment through intervention. This platform-Early Social Interaction Mobile Coaching (ESI-MC) deploys individual telehealth sessions with coaching and feedback to help families embed intervention in everyday activities. Specifically, the investigators will conduct... Read More
Gender:
All
Ages:
Between 15 months and 20 months
Trial Updated:
05/15/2024
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Autism Spectrum Disorder
Pimavanserin for the Treatment of Irritability Associated With Autism Spectrum Disorder
Recruiting
6-week, randomized, double-blind, fixed-dose, placebo-controlled, parallel group study in children and adolescents (aged 5 to17 years) with autism spectrum disorder (ASD) with irritability, agitation, or self-injurious behaviors to study the efficacy and safety of pimavanserin
Gender:
All
Ages:
Between 5 years and 17 years
Trial Updated:
05/08/2024
Locations: The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Irritability Associated With Autism Spectrum Disorder
Extension Study of Pimavanserin in Irritability Associated With Autism Spectrum Disorder
Recruiting
52-week, open-label extension study of double-blind study ACP-103-069 to determine the long-term safety and tolerability of pimavanserin for the treatment of irritability associated with ASD in children and adolescents (aged 5 to 17 years). ACP-103-069 is a 6-week, randomized, double-blind, fixed-dose, placebo controlled, parallel group study of pimavanserin in children and adolescents with irritability associated with autism spectrum disorder (ASD).
Gender:
All
Ages:
Between 5 years and 18 years
Trial Updated:
05/02/2024
Locations: The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Irritability Associated With Autism Spectrum Disorder
AIR-B4: Mind the Gap
Recruiting
The AIRB research team will compare the use and effectiveness of each intervention (Mind the Gap, Remaking Recess and Self Determination Learning Model of Instruction) with and without the addition of an implementation strategy, UNITED. In all groups, the research team will train community practitioners using remote delivery of professional development modules specific to the intervention, and active coaching for up to 12 sessions as dictated by the intervention procedures during a time span of... Read More
Gender:
All
Ages:
2 years and above
Trial Updated:
04/30/2024
Locations: UPENN, Philadelphia, Pennsylvania
Conditions: Autism Spectrum Disorder, Neurodevelopmental Disorders
AIR-B4: Remaking Recess (RR)
Recruiting
The AIRB research team will compare the use and effectiveness of each intervention (Mind the Gap, Remaking Recess and Self Determination Learning Model of Instruction) with and without the addition of our implementation strategy, UNITED. In all groups, the research team will train community practitioners using remote delivery of professional development modules specific to the intervention, and active coaching for up to 12 sessions as dictated by the intervention procedures. The research team w... Read More
Gender:
All
Ages:
Between 5 years and 12 years
Trial Updated:
04/30/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Autism Spectrum Disorder, Neurodevelopmental Disorders
ML-004 in Adolescents and Adults With Autism Spectrum Disorders (ASD)
Recruiting
ML-004-002 is a multi-center, randomized, double-blind, parallel-group, placebo-controlled study that will enroll approximately 150 adolescent and adult subjects with ASD. The primary objective is to evaluate the efficacy of ML-004 compared with placebo in the improvement of social communication deficits in subjects with ASD.
Gender:
All
Ages:
Between 12 years and 45 years
Trial Updated:
04/30/2024
Locations: Suburban Research Associates, Media, Pennsylvania +1 locations
Conditions: Autism Spectrum Disorder
Comparing Two Different Emotion Therapies for Autistic Youth and Young Adults
Recruiting
Too few clinicians are able and willing to help autistic patients. A recent review identified challenges to mental health service delivery in autism, including a lack of interventions designed for community implementation and limited workforce capacity. It has been argued that improving impairment in emotion regulation has the potential to improve a range of mental health difficulties in autistic people. In this clinical trial, the investigators are comparing two evidence-based interventions for... Read More
Gender:
All
Ages:
Between 12 years and 25 years
Trial Updated:
04/02/2024
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Autism Spectrum Disorder
Treatment to Improve Sleep in Caregivers With Insomnia and a Child With Autism
Recruiting
Autism Spectrum Disorder (ASD) represents one of the most perplexing neurobiological disorders with a prevalence of 1 in 54 children. The lifelong challenging and disruptive behaviors often associated with ASD requires caregivers to change their behavior and modify their environments to provide an ecosystem for optimal outcomes for their child, family and themselves. ASD behaviors can have significant impact on caregivers mental health and family functioning, including the ability to develop and... Read More
Gender:
All
Ages:
Between 3 years and 100 years
Trial Updated:
02/13/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania +1 locations
Conditions: Autism Spectrum Disorder, Insomnia Chronic, Caregiver Burden
Adaptation and Feasibility of the Community-Based Anxiety Program Tailored for Autism (CAPTA)
Recruiting
Anxiety is very common in autistic youth. Recently, an intervention has been created by the investigators to target these symptoms in autistic youth in a community setting. The purpose of this study is to determine the feasibility of implementing this treatment in community care centers.
Gender:
All
Ages:
Between 7 years and 17 years
Trial Updated:
02/13/2024
Locations: Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Anxiety, Autism Spectrum Disorder, Separation Anxiety, Generalized Anxiety Disorder, Social Anxiety Disorder of Childhood
Management of ADHD in Autism Spectrum Disorder
Recruiting
This study is a pragmatic clinical trial examining the comparative effectiveness of two stimulant medications (methylphenidate and amphetamine) in the treatment of ADHD in children and adolescents with autism. Using a sequential, multiple assignment randomization trial (SMART) design the study will not only assess these two medications but also the role of an increasingly popular class of ADHD medication, the alpha-2 agonists. Findings from this study will help improve clinicians' approach to me... Read More
Gender:
All
Ages:
Between 4 years and 17 years
Trial Updated:
02/06/2024
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania +1 locations
Conditions: ADHD, Autism Spectrum Disorder
Treatment Monitoring in Autism Spectrum Disorder (ASD) in Children
Recruiting
The goal of this clinical study is to learn about the utility and performance of the EarliPoint(™) System: Evaluation for Autism Spectrum Disorder to monitor changes in a child's verbal ability, non-verbal learning, and social disability over time in children ages 15-84 months with autism spectrum disorder or related developmental delays (DD) and in those who are typically developing. The main questions it aims to answer are: To estimate the change in each of the EarliPoint index scores in typ... Read More
Gender:
All
Ages:
Between 15 months and 84 months
Trial Updated:
02/02/2024
Locations: AJ Drexel Autism Institute, Drexel University, Philadelphia, Pennsylvania
Conditions: Autism Spectrum Disorder, Autism, Developmental Delay, Autism, Early Infantile, Autism, Infantile
A Comparison of Two Brief Suicide Prevention Interventions Tailored for Youth on the Autism Spectrum
Recruiting
Rates of suicide have increased significantly over the past two decades, particularly among youth. Compared to the general population, autistic people are significantly more likely to think about suicide, attempt suicide, and die by suicide. Autistic individuals have identified suicide prevention as a top research priority; however, little is known about how to best help autistic youth at risk for suicide. The purpose of this study is to compare the effectiveness, feasibility, and acceptability... Read More
Gender:
All
Ages:
Between 12 years and 99 years
Trial Updated:
12/13/2023
Locations: Children's Hospital of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Suicidal Ideation, Suicidal and Self-injurious Behavior, Suicide, Autism Spectrum Disorder