The state of Pennsylvania currently has 32 active clinical trials seeking participants for Depression research studies. These trials are conducted in various cities, including Philadelphia, Pittsburgh, Hershey and Allentown.
A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression
Recruiting
Objectives of this study are to determine whether active VNS Therapy treatment is superior to a no stimulation control in producing a reduction in baseline depressive symptom severity, based on multiple depression scale assessment tools at 12 months from randomization.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/24/2025
Locations: Scranton Medical Institutes, Moosic, Pennsylvania +1 locations
Conditions: Treatment Resistant Depression
Efficacy, Safety, and Tolerability of Two Administrations of COMP360 in Participants With TRD
Recruiting
Efficacy, Safety, and Tolerability of two administrations of COMP360 in participants with treatment-resistant depression (TRD)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/24/2025
Locations: Suburban Research Associates, Media, Pennsylvania
Conditions: Treatment Resistant Depression
Individualized (fMRI-guided) TMS Treatment for Depression
Recruiting
The purpose of this study is to investigate the responses of the brain region known as the subgenual anterior cingulate cortex (sgACC) during transcranial magnetic stimulation (TMS) in individuals with depression. Specifically, investigators aim to determine whether the sgACC is engaged when TMS is delivered to specific targets and if the engagement of sgACC changes throughout a full TMS treatment intervention. To achieve this goal, the investigators will employ a combination of TMS and Magnetic... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
07/21/2025
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Depression, Major Depressive Disorder, Persistent Depressive Disorder
Clinical Trial for Integrated Care to Help At Risk Teen (iCHART) Intervention
Recruiting
This protocol will test the effectiveness of an intervention, iCHART (integrated Care to Help At-Risk Teens) and facilitate recruitment for other studies in the larger ETUDES Center grant, which are focused on treatment development for target risk factors for suicidal behavior, specifically, sleep, anhedonia, and stress related to cybervictimization. This study will recruit 900 adolescents which will be enrolled in a randomized controlled trial to test iCHART and will be randomized to iCHART or... Read More
Gender:
ALL
Ages:
Between 12 years and 18 years
Trial Updated:
07/17/2025
Locations: Conemaugh Memorial Medical Center-Family Medicine, Johnstown, Pennsylvania +11 locations
Conditions: Suicide and Depression, Adolescent Behavior
Dopaminergic Dysfunction in Late-Life Depression
Recruiting
Late-Life Depression (LLD), or depression in older adults, often presents with motivational deficits, deficits in performance in cognitive domains including processing speed and executive dysfunction, and mobility impairments. This triad of findings implicate dopaminergic dysfunction as a core pathophysiologic feature in depression, and may contribute to cognitive decline and motor disability. Normal aging results in brain-wide dopamine declines, decreased D1/D2 receptor density, and loss of dop... Read More
Gender:
ALL
Ages:
60 years and above
Trial Updated:
07/11/2025
Locations: University of Pittsburgh Medical Center, Pittsburg, Pennsylvania
Conditions: Late Life Depression, Cognitive Decline, Depressive Disorder, Treatment-Resistant, Levodopa, Gait Impairment
Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)
Recruiting
The goal of this clinical trial is to evaluate the effectiveness and safety of bilateral stimulation of the subcallosal cingulate white matter (SCCwm) using Deep Brain Stimulation (DBS) as an adjunctive treatment of non-psychotic unipolar Major Depressive Disorder (MDD) in adults.
Gender:
ALL
Ages:
Between 22 years and 70 years
Trial Updated:
07/07/2025
Locations: Pennsylvania Hospital, Philadelphia, Pennsylvania
Conditions: Treatment Resistant Depression
Transdiagnostic Sleep and Circadian Intervention + Bright Light in Adolescents With Elevated Depression (TranS-C+BL)
Recruiting
The goal of this clinical trial is to adapt a sleep intervention for individuals representative of all demographic groups, including those who are at the highest risk for suicidal behavior. Sleep difficulties are a promising target for youth with suicidal thoughts and behavior to focus on as a prevention measure. We aim to increase intervention acceptability and impact by adapting it for the adolescent populations at highest risk for suicidal thoughts and behavior. The research project will comp... Read More
Gender:
ALL
Ages:
Between 12 years and 18 years
Trial Updated:
07/02/2025
Locations: Childrens Hospital of Philadelphia, Philadelphia, Pennsylvania +1 locations
Conditions: Sleep Disturbance, Sleep, Depression, Suicide
E-Mindfulness Approaches for Living After Breast Cancer
Recruiting
NRG-CC015 is a prospective, randomized phase III clinical trial to evaluate the efficacy of two distinct digital approaches for delivering a mindfulness-based intervention: a live, instructor-led version delivered over Zoom (MAPs LO), and an app-based, self-paced version (MAPs App). Participants will include younger breast cancer survivors (BCS) who were diagnosed with breast cancer at or before age 50 years, have completed their primary cancer treatment (i.e., surgery, radiation, and/or chemoth... Read More
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
07/01/2025
Locations: NRG Oncology, Pittsburgh, Pennsylvania
Conditions: Breast Cancer, Depression
Treatment, Emotion, and Neuromodulation of Depression (TREND) Study
Recruiting
The investigators will administer theta burst stimulation (TBS) in efforts to observe a decrease in severity of reported depression symptoms. A subset of participants will receive positive affect training during this intervention.
Gender:
ALL
Ages:
Between 18 years and 26 years
Trial Updated:
06/17/2025
Locations: The University of Pittsburgh, Department of Psychiatry, Pittsburgh, Pennsylvania
Conditions: Depression
Rapid Antidepressant Improvement Secondary to Excitatory Brain Responses
Recruiting
The central goal of this application is to demonstrate the causal contribution of reward learning signals (expected values and reward prediction errors \[RPE\]) to antidepressant responses (Aim1) by experimentally manipulating expected values using transcranial magnetic stimulation (TMS) targeting the vmPFC (Aim 2) and μ-opioid striatal RPE signal using pharmacological approaches (Aim 3).
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
06/03/2025
Locations: Bellefield Tower, Pittsburgh, Pennsylvania
Conditions: Major Depressive Disorder, Depression
Assessing Improvements in Mood and Sleep Trial
Recruiting
This is a multi-site randomized control trial involving people age 55+ years who have current depression symptoms plus another suicide risk indicator (either current suicidal ideation or a past history of attempt). Our goal is evaluate which of two different approaches works best to improve things like trouble sleeping, bad moods, and any suicidality. Participants will complete diagnostic interviews, self-report scales, and wear an actigraphy device for the 8 weeks starting at the baseline visi... Read More
Gender:
ALL
Ages:
55 years and above
Trial Updated:
06/02/2025
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Depression, Suicidality, Sleep
Sequential Multiple Assignment Randomized Trial for Bipolar Depression
Recruiting
This is a sequential multiple assignment randomized trial for adults (ages \> 18) with a bipolar disorder type 1 diagnosis currently experiencing a depressive episode. It is a randomized pragmatic trial that will compare four commonly prescribed treatments for bipolar depression, which includes three FDA-approved medications (Cariprazine, Quetiapine and Lurasidone) and one antipsychotic/antidepressant combination (Aripiprazole/Escitalopram).
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
05/21/2025
Locations: University of Pennsylvania, Philadelphia, Pennsylvania +1 locations
Conditions: Bipolar I Disorder, Depression