The city of Pittsburgh, Pennsylvania, currently has 14 active clinical trials seeking participants for Depression research studies.
RXWell to Decrease Post-Operative Opioid Use in Total Knee or Hip Arthroplasty
Recruiting
It is envisioned that multipronged benefits from this pilot work for the UPMC ISD and its members. It is expected the RxWell platform to provide the following benefits: expansion of the use of RxWell to all UPMC ISD members providing peri-operative mood management with advantage of improved peri-operative outcomes, improving saving for the UPMC ISD by hastening the recovery and decreased resource utilization, and addition to the high-value care of UPMC with this holistic approach to patient peri... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/05/2025
Locations: UPMC Shadyside, Pittsburgh, Pennsylvania +1 locations
Conditions: Mood Disorders, Anxiety, Depressive Symptoms, Depression, Anxiety Disorders, Anxiety Depression
Teen Brain Online II: Understanding How Social Media Affects the Teen Brain
Recruiting
There has been much interest in the potential role of social media (SM) use in driving a current mental health crisis among teens, with a dire need for evidence that goes beyond self-report. One important avenue is to understand the role of the brain in driving the effects of SM use on emotional health and vice versa. However, there is almost no research addressing these questions, largely due to a lack of tasks that can probe the neural correlates of modern SM use. The goal of this clinical tri... Read More
Gender:
ALL
Ages:
Between 13 years and 17 years
Trial Updated:
05/01/2025
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Depression
Ketamine Pharmacokinetics and Pharmacodynamics for Postpartum Depression and Pain After Cesarean Delivery
Recruiting
The purpose of this study is to identify pharmacokinetics of postpartum ketamine infusion. This study will assess ketamine kinetics and metabolism in this setting. Ketamine is expected to exert different kinetics during the physiologic state of post-pregnancy. The goal in conducting this study is to better understand the pharmacokinetics and pharmacodynamics of postpartum ketamine infusion. A secondary goal is to compare these kinetics to reproductive age matched controls and to assess sex diffe... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/14/2025
Locations: Magee Womens Hospital of UPMC, Pittsburgh, Pennsylvania +1 locations
Conditions: Pain, Postpartum Depression
Get ActivE Study for At-risk Youth
Recruiting
The study will adapt and deploy a digital Behavioral Activation app with mobile sensing, supported by health coaches, that encourages youth to engage in positive activities. The study has the potential to offer a low-cost and scalable behavioral intervention that may decrease risk of suicide among at-risk youth. This research will examine specifically whether an intervention involving an app called Vira, combined with health coaching (GET ActivE) can improve enjoyment for teens coping with depre... Read More
Gender:
ALL
Ages:
Between 12 years and 18 years
Trial Updated:
04/02/2025
Locations: University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
Conditions: Anhedonia, Depression and Suicide Ideation
Neurofeedback for Treatment Resistant Depression
Recruiting
The purpose of this study is to determine the clinical efficacy of real-time functional magnetic resonance imaging neurofeedback (rtfMRI-nf) training to increase the amygdala's response to positive autobiographical memories in patients with depression who are considered treatment-resistant
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
03/04/2025
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Treatment Resistant Depression
Life Experiences in Adolescents and the Development of Skills
Recruiting
The primary objective of this study is to assess acquisition and retention of a Cognitive Behavioral Therapy (CBT)-based "cognitive restructuring" skill, among young adolescents (12-15 years of age) with elevated depression symptoms and with population-level variability in lifetime exposure to adverse childhood experiences. This study uses a repeated-measures, longitudinal design to investigate associations between adversity exposure and learning-related cognitive control processes in the contex... Read More
Gender:
ALL
Ages:
Between 12 years and 15 years
Trial Updated:
02/03/2025
Locations: Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania
Conditions: Depression in Adolescence, Adverse Childhood Experiences
Apimostinel + Automated Neurocognitive Training for Depression
Recruiting
Apimostinel shows initial promise as a novel rapid-acting antidepressant medication with minimal side effects or safety concerns. Cognitive Training (CT) is a digital intervention that has shown promise in extending the durability of another similar drug (ketamine). This randomized controlled trial will test the efficacy and safety of apimostinel (vs. placebo) for the acute treatment of depression, and will test the potential of CT to enhance and/or extend the durability of apimostinel's antidep... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
02/03/2025
Locations: Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania
Conditions: Depression
Fitness for Brain Optimization for Late-Life Depression
Recruiting
Cognitive impairment and brain abnormalities are common and persist after depression remission in those with Late Life Depression (LLD), compounding dementia risk in both individuals with acute and remitted LLD (rLLD). In this study, investigators will examine systemic neural and cognitive benefits of aerobic exercise training in older adults with remitted LLD. This will generate preliminary data regarding neural targets of aerobic exercise training that may translate to cognitive benefits in th... Read More
Gender:
ALL
Ages:
60 years and above
Trial Updated:
10/19/2024
Locations: UPMC Western Psychiatric Hospital, Pittsburgh, Pennsylvania
Conditions: Depression in Old Age
Characterizing Cognitive Decline in Late Life Depression: The ADNI Depression Project
Recruiting
The purpose of this research study is to characterize the mechanisms contributing to cognitive impairment and accelerated cognitive decline in Late Life Depression (LLD). This is a non-randomized, observational, non-treatment study that originally launched in 2015, enrolling 133 participants. From the originally enrolled participants, the continuation of the ADNI-D study will enroll 120 participants which will include following participants from the original (parent) protocol and enrollment of... Read More
Gender:
ALL
Ages:
65 years and above
Trial Updated:
10/03/2024
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Major Depression, Late Life Depression (LLD)
Neuro-affective Response to Light in Depressed Adolescents and Young Adults
Recruiting
The goal of this neuroimaging pilot study is to understand developmental differences in the impact of therapeutic wavelength light (blue light) versus a non-therapeutic wavelength (red light) on emotional brain function in depression. The main questions this study aims to answer are: * Does acute exposure to blue light (vs red light) stabilize emotional brain function in depressed individuals? * Are stabilizing effects of blue light (vs red light) stronger for blue light in adolescents than you... Read More
Gender:
ALL
Ages:
Between 12 years and 30 years
Trial Updated:
09/22/2024
Locations: Western Psychiatric Hospital, Pittsburgh, Pennsylvania
Conditions: Depression in Adolescence, Depression in Adults
Dopaminergic Dysfunction in Late-Life Depression
Recruiting
Late-Life Depression (LLD), or depression in older adults, often presents with motivational deficits, deficits in performance in cognitive domains including processing speed and executive dysfunction, and mobility impairments. This triad of findings implicate dopaminergic dysfunction as a core pathophysiologic feature in depression, and may contribute to cognitive decline and motor disability. Normal aging results in brain-wide dopamine declines, decreased D1/D2 receptor density, and loss of dop... Read More
Gender:
ALL
Ages:
60 years and above
Trial Updated:
07/24/2024
Locations: University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
Conditions: Late Life Depression, Cognitive Decline, Depressive Disorder, Treatment-Resistant, Levodopa, Gait Impairment
Treatment, Emotion, and Neuromodulation of Depression (TREND) Study
Recruiting
The investigators will administer theta burst stimulation (TBS) in efforts to observe a decrease in severity of reported depression symptoms. A subset of participants will receive positive affect training during this intervention.
Gender:
ALL
Ages:
Between 18 years and 26 years
Trial Updated:
07/17/2024
Locations: The University of Pittsburgh, Department of Psychiatry, Pittsburgh, Pennsylvania
Conditions: Depression