There are currently 1875 clinical trials in Philadelphia, Pennsylvania looking for participants to engage in research studies. Trials are conducted at various facilities, including University of Pennsylvania, Children's Hospital of Philadelphia, Fox Chase Cancer Center and Thomas Jefferson University. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
A Study to Compare the Efficacy and Safety of Idecabtagene Vicleucel With Lenalidomide Maintenance Therapy Versus Lenalidomide Maintenance Therapy Alone in Adult Participants With Newly Diagnosed Multiple Myeloma Who Have Suboptimal Response After Autologous Stem Cell Transplantation
NCT06399393
Recruiting
The purpose of this study is to compare the efficacy, safety, and tolerability of ide-cel with lenalidomide (LEN) maintenance to that of LEN maintenance alone in adult participants with Newly Diagnosed Multiple Myeloma (NDMM) who have achieved a suboptimal response post autologous stem cell transplantation (ASCT).
Gender:
All
Ages:
18 years and above
Trial Updated:
05/01/2024
Locations: Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Multiple Myeloma
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Plantar Fasciitis Randomized Clinical Control Trial
NCT03231150
Recruiting
The primary aim of this clinical experiment is to compare, in terms of pain relief measured using the 10-cm visual analog scale (VAS) pain score (5-7), the clinical results of ultrasound-guided injection (USGI) versus anatomic topography-guided injection (ATGI) of corticosteroid for the treatment of proximal PF. Secondary aims will be to compare foot-related quality of life, as measured using the Foot Function Index (FFI)and the Bristol Foot Score (BFS), between the injection groups, and also to... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/30/2024
Locations: Penn Presbyterian Medical Center, Philadelphia, Pennsylvania
Conditions: Plantar Fascitis
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Neuroinflammation Imaging in AD
NCT04274998
Recruiting
This research study is being done to learn more about inflammation in the brain using Positron Emission Tomography/Computed Tomography (PET/CT) imaging in people with Alzheimer's Disease/Mild Cognitive Impairment or healthy controls. If the subject agrees to be in this study, she/ he will have a PET/CT scan using the investigational radiotracer \[18F\]NOS. A subject with a specific genetic polymorphism may also agree to be in the sub-study in which she/he will have another PET/CT scan using the... Read More
Gender:
ALL
Ages:
55 years and above
Trial Updated:
04/29/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Alzheimer Disease, Healthy Volunteer
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Performance of SGM-101 for the Delineation of Primary and Recurrent Tumor and Metastases in Patients Undergoing Surgery for Colorectal Cancer
NCT03659448
Recruiting
The performance of SGM-101, an intraoperative imaging agent, will be compared to that of standard "white light" visualization during surgical resections of colorectal cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/23/2024
Locations: Perelman Center for Advanced Medicine, Philadelphia, Pennsylvania
Conditions: Colorectal Neoplasms
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Head to Head Comparison of Upper Airway Stimulation and Continuous Positive Airway Pressure; a Pilot Study.
NCT04191512
Recruiting
To date, there has been no head to head comparison of Upper Airway Stimulation (UAS) and Continuous Positive Airway Pressure (CPAP) utilizing a full night polysomnographic evaluation. With this study we aim to evaluate a pilot cohort of patients with OSA treated with CPAP or UAS using the WatchPAT polysomnography system.
Gender:
ALL
Ages:
22 years and above
Trial Updated:
04/19/2024
Locations: Thomas Jefferson University Department of Otolaryngology, Philadelphia, Pennsylvania
Conditions: Obstructive Sleep Apnea
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Safety Study of Unlicensed IND Cord Blood Units Manufactured by the National Cord Blood Program for Unrelated Transplantation
NCT01656603
Recruiting
This study will evaluate the safety of infusion of the investigational cord blood units by carefully documenting all infusion-related problems.
Gender:
ALL
Ages:
All
Trial Updated:
04/17/2024
Locations: Abramson Cancer Center of the University of Pennsylvania Medical Center, Philadelphia, Pennsylvania +1 locations
Conditions: Infusion Reactions
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Early Antenatal Support for Iron Deficiency Anemia
NCT04278651
Recruiting
This is a randomized, controlled multi-site trial of iron therapy in pregnancy. The purpose of this research is to see if second trimester initiation of intravenous (IV) iron therapy is better than oral iron therapy for treatment of anemia in pregnancy by improving blood count, quality of life and reducing side effects.
Gender:
FEMALE
Ages:
Between 18 years and 65 years
Trial Updated:
04/17/2024
Locations: Thomas Jefferson University Hospital, Philadelphia, Pennsylvania
Conditions: Pregnancy Related, Anemia, Iron Deficiency, Anemia of Pregnancy
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Phase 0 Master Protocol for CIVO Intratumoral Microdosing of Anti-Cancer Therapies
NCT04541108
Recruiting
This is a multi-center, open-label Phase 0 Master Protocol designed to study the localized pharmacodynamics (PD) of anti-cancer therapies within the tumor microenvironment (TME) when administered intratumorally in microdose quantities via the CIVO device in patients with surface accessible solid tumors for which there is a scheduled surgical intervention. CIVO stands for Comparative In Vivo Oncology. Multiple substudies will include specified investigational agents and combinations to be evaluat... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/15/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Solid Tumor
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Effectiveness of Virtual Reality Vision Therapy - VERVE
NCT04691427
Recruiting
The purpose of this research study is to see how well the treatment of a participant's eye coordination and/or focusing problems improves eye muscle responses and symptoms of eyestrain. We will use an entertainment device called a virtual reality headset to play a custom-designed video game to find out how well the treatment of binocular vision improves a participant's coordination and/or focusing problem. The virtual reality headset uses eye-trackers to monitor progress in a totally objective m... Read More
Gender:
ALL
Ages:
Between 9 years and 35 years
Trial Updated:
04/15/2024
Locations: The Eye Institute at Salus University, Philadelphia, Pennsylvania
Conditions: Convergence Insufficiency
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COVID Booster in Pregnancy and Lactation
NCT05543993
Recruiting
This is a prospective longitudinal cohort study to evaluate the impact of COVID-19 vaccination and booster on maternal and infant immunity against COVID-19 variants over time.
Gender:
FEMALE
Ages:
Between 13 years and 55 years
Trial Updated:
04/15/2024
Locations: Thomas Jefferson University Hospital, Philadelphia, Pennsylvania
Conditions: COVID-19
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Quality of Pediatric Resuscitation in a Multicenter Collaborative
NCT02708134
Recruiting
This is a prospective, observational, multi-center cohort study of pediatric cardiac arrests. The purpose of the study is to determine the association between chest compression mechanics (rate, depth, flow fraction, compression release) and patient outcomes. In addition, the investigators will determine the association of post cardiac arrest care with patient outcomes.
Gender:
ALL
Ages:
Between 0 years and 17 years
Trial Updated:
04/12/2024
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Cardiac Arrest, Cardiopulmonary Arrest
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An Acceptance-Based Healthy Lifestyle Intervention for Diverse Adolescents
NCT06147973
Recruiting
The goal of this clinical trial is to learn about cardiovascular disease risk among adolescent girls with overweight/obesity. The main questions this trial aims to answer are: 1. Does an acceptance-based healthy lifestyle intervention demonstrate more weight loss than a health education intervention? 2. Does an acceptance-based healthy lifestyle intervention show more improvements in participants' physiological, health-related, and psychological factors compared to a health education interventi... Read More
Gender:
FEMALE
Ages:
Between 14 years and 19 years
Trial Updated:
04/09/2024
Locations: Drexel University, Philadelphia, Pennsylvania
Conditions: Overweight and Obesity
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