There are currently 1858 clinical trials in Philadelphia, Pennsylvania looking for participants to engage in research studies. Trials are conducted at various facilities, including University of Pennsylvania, Children's Hospital of Philadelphia, Fox Chase Cancer Center and Thomas Jefferson University. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Enroll -HD: A Prospective Registry Study in a Global Huntington's Disease Cohort
NCT01574053
Recruiting
Enroll-HD is a longitudinal, observational, multinational study that integrates two former Huntington's disease (HD) registries-REGISTRY in Europe, and COHORT in North America and Australasia-while also expanding to include sites in Latin America. More than 30,000 participants have now enrolled into the study. With annual assessments and no end date, Enroll-HD has built a large and rich database of longitudinal clinical data and biospecimens that form the basis for studies developing tools and b... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/26/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Huntington's Disease
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10 Year Registry of Children (Ages 2-17 Years) With Eczema That Have Used Pimecrolimus
NCT00568997
Recruiting
This study will examine the risk of systemic malignancies in pediatric patients with atopic dermatitis exposed to Elidel 1% cream.
Gender:
ALL
Ages:
Between 2 years and 17 years
Trial Updated:
02/22/2024
Locations: Registry, Philadelphia, Pennsylvania
Conditions: Atopic Dermatitis
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Development and Testing of a Pediatric Cervical Spine Injury Risk Assessment Tool
NCT05049330
Recruiting
Cervical spine injuries (CSI) are serious, but rare events in children. Spinal precautions (rigid cervical collar and immobilization on a longboard) in the prehospital setting may be beneficial for children with CSI, but are poorly studied. In contrast, spinal precautions for pediatric trauma patients without CSI are common and may be associated with harm. Spinal precautions result in well-documented adverse physical and physiological sequelae. Of substantial concern is that the mere presence of... Read More
Gender:
ALL
Ages:
18 years and below
Trial Updated:
02/21/2024
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Cervical Spine Injury
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Comparing Hypothermic Temperatures During Hemiarch Surgery
NCT02860364
Recruiting
Hypothermic circulatory arrest is an important surgical technique, allowing complex aortic surgeries to be performed safely. Hypothermic circulatory arrest provides protection to cerebral and visceral organs, but may result in longer cardiopulmonary bypass times during surgery, increased risks of bleeding, inflammation, and neuronal injury. To manage these consequences, a trend towards warmer core body temperatures during circulatory arrest has emerged. This trial will randomize patients to eith... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/21/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Thoracic Aortic Disease
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The Tether™ - Vertebral Body Tethering System Post Approval Study
NCT04505579
Recruiting
This study is an opportunity to provide continued reasonable assurance of the safety and probable benefit of The Tether HUD. The study will collect long term safety and efficacy information from patients who have had their idiopathic scoliosis treated via anterior vertebral body tethering (AVBT) with The Tether.
Gender:
ALL
Ages:
All
Trial Updated:
02/21/2024
Locations: Shriners Children's Hopital, Philadelphia, Pennsylvania
Conditions: Scoliosis Idiopathic
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Endotypic Stability in CRS
NCT06272123
Recruiting
A Case control study with 150 cases and 50 controls will be conducted. Immunologic (cytokines measurements in nasal secretions and sinonasal tissues), histopathologic (tissue eosinophilia) and clinical parameters (Lund-Mackay and Lund-Kennedy score, lung function tests), surveys (SNOT- 22, SF-36 quality of life survey) will be compared between different groups of patients
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
02/20/2024
Locations: Thomas Jefferson University Department of Otolaryngology, Philadelphia, Pennsylvania
Conditions: Chronic Sinusitis
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Erbium, Chromium: Yttrium, Scandium, Gallium, Garnet (Er,Cr:YSGG) Laser in Root Canal Disinfection
NCT05959629
Recruiting
The purpose of this study is to develop a protocol for biofilms disinfection with a FDA cleared, clinically approved and commercially available Er,Cr:YSGG laser treatments. This protocol will be testing local single topical application of Lasers within the canal system in patients going through routine endodontic treatment, evaluate its potential as anti-biofilm treatment and compare it to other currently used antibacterial protocols.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/15/2024
Locations: University of Pennsylvania, School of Dental Medicine, Philadelphia, Pennsylvania
Conditions: Endodontic Disease, Root Canal Infection
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A 52-Week Study of the Efficacy and Safety of BLU-5937 in Adults With Refractory Chronic Cough
NCT05599191
Recruiting
This is a randomized, double-blind, placebo-controlled, parallel-arm, Phase 3 study of BLU-5937 in participants with Refractory Chronic Cough (RCC).
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
02/14/2024
Locations: Temple Lung Center, Philadelphia, Pennsylvania
Conditions: Refractory Chronic Cough
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Contrast-Enhanced Ultrasound Scan for the Estimation of Tissue Pressure in Patients With Breast Cancer
NCT04721886
Recruiting
This clinical trial studies the use of contrast-enhanced ultrasound (CEUS) in estimating tissue pressure in patients with breast cancer. Diagnostic procedures, such as CEUS, may help estimate tissue pressure noninvasively.
Gender:
FEMALE
Ages:
21 years and above
Trial Updated:
02/14/2024
Locations: Thomas Jefferson University Hospital, Philadelphia, Pennsylvania
Conditions: Breast Carcinoma
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InformationSeekingMesolimbicEngagementStudy2
NCT06257433
Recruiting
Participants will complete a treasure task during neuroimaging where they have to learn which keys open a treasure chest, and then they are tested on the contents of the treasure chest.
Gender:
ALL
Ages:
Between 18 years and 45 years
Trial Updated:
02/12/2024
Locations: Temple University, Philadelphia, Pennsylvania
Conditions: Motivation
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InformationSeekingMesolimbicEngagementStudy1
NCT06257446
Recruiting
Study 1 will use a novel Game Show task, in which the investigators manipulate participant's agency to control their learning environment to specify unguided exploration.
Gender:
ALL
Ages:
Between 18 years and 45 years
Trial Updated:
02/12/2024
Locations: Temple University, Philadelphia, Pennsylvania
Conditions: Motivation
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Longitudinal Study of Urea Cycle Disorders
NCT00237315
Recruiting
Urea cycle disorders (UCD) are a group of rare inherited metabolism disorders. Infants and children with UCD commonly experience episodes of vomiting, lethargy, and coma. The purpose of this study is to perform a long-term analysis of a large group of individuals with various UCDs. The study will focus on the natural history, disease progression, treatment, and outcome of individuals with UCD.
Gender:
ALL
Ages:
All
Trial Updated:
02/10/2024
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Brain Diseases, Metabolic, Inborn, Amino Acid Metabolism, Inborn Errors, Urea Cycle Disorders
Register for Updates