There are currently 1947 clinical trials in Philadelphia, Pennsylvania looking for participants to engage in research studies. Trials are conducted at various facilities, including University of Pennsylvania, Children's Hospital of Philadelphia, Fox Chase Cancer Center and Thomas Jefferson University. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Positive Parenting Program in Foster Care
NCT03910491
Recruiting
The purpose of the study is to evaluate early implementation outcomes of a positive parenting program, Child Adult Relationship Enhancement in Primary Care (PriCARE), in the foster care setting and to assess the efficacy of PriCARE in promoting positive parenting and increasing empathy among foster caregivers.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/29/2024
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Child Behavior Problem, Child Behavior Disorders, Parenting
Register for Updates
The Impact of Oral Health in HIV Patients on Antiretroviral Therapy
NCT04645693
Recruiting
This is a prospective cohort study designed to investigate the range of metabolic abnormalities observed in patients living with HIV on antiretroviral therapy. This study will also explore the concurrent role of poor oral health in supporting and driving chronic immune activation and inflammation in HIV infection.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/29/2024
Locations: University of Pennsylvania School of Dental Medicine, Philadelphia, Pennsylvania
Conditions: HIV, Periodontal Diseases, Caries, Non-communicable Disease, Xerostomia
Register for Updates
Brightline-4: A Study to Test How Well Brigimadlin is Tolerated by People With a Type of Cancer Called Dedifferentiated Liposarcoma
NCT06058793
Recruiting
This study is open to adults with a type of cancer called dedifferentiated liposarcoma (DDLPS). They can join the study if their tumours are positive for MDM2. The purpose of this study is to find out whether a medicine called brigimadlin (BI 907828) is tolerated by and helps people with DDLPS. Brigimadlin is a so-called MDM2 inhibitor that is being developed to treat cancer. Participants take brigimadlin as a tablet once every 3 weeks. Participants may continue to take brigimadlin as long as t... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/29/2024
Locations: Abramson Cancer Center at Pennsylvania Hospital, Philadelphia, Pennsylvania
Conditions: Liposarcoma, Dedifferentiated
Register for Updates
AZD0305 as Monotherapy or in Combination With Anticancer Agents in Participants With Relapsed/Refractory Multiple Myeloma
NCT06106945
Recruiting
This is a Phase I/II, modular, open-label, multicenter, dose escalation, and dose expansion/optimization study to evaluate the safety, tolerability, PK, immunogenicity, pharmacodynamics, and preliminary efficacy of AZD0305 in participants with RRMM.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/29/2024
Locations: Research Site, Philadelphia, Pennsylvania
Conditions: Multiple Myeloma
Register for Updates
Study of Oral Atogepant When Added to OnabotulinumtoxinA (BOTOX) to Assess Adverse Events and Change in Disease Activity in Adult Participants With Chronic Migraine
NCT05216263
Recruiting
Migraine is characterized by attacks of throbbing, moderate or severe headache, often associated with nausea, vomiting, and/or sensitivity to light and/or sound. The study will assess safety and tolerability of atogepant when added to BOTOX, as well as prospectively evaluate the efficacy of add-on atogepant for migraine prevention. Adverse events and change in disease activity will be monitored. Atogepant is an investigational drug being developed to prevent chronic migraine. Approximately 75 a... Read More
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
04/29/2024
Locations: Jefferson Hospital for Neuroscience /ID# 243712, Philadelphia, Pennsylvania
Conditions: Chronic Migraine
Register for Updates
A Phase 2a Study of IV BCV in Subjects With Adenovirus Infection (ATHENA)
NCT04706923
Recruiting
The purpose of this study is to determine the Dose from the safety and tolerability of intravenous Brincidofovir (BCV, SyB V-1901) using multiple ascending doses in subjects with Adenovirus infection.
Gender:
All
Ages:
2 months and above
Trial Updated:
04/29/2024
Locations: Research Site, Philadelphia, Pennsylvania
Conditions: Adenovirus Infection
Register for Updates
Nerve Transfer to Improve Function in High Level Tetraplegia
NCT06288763
Recruiting
The goal of this observational study is to determine if nerve transfer surgeries improve upper extremity function and quality of life in patients with a high level cervical spinal cord injury. Participants will: undergo standard of care pre- and post-op testing and study exams complete pre- and post-questionnaires undergo standard of care nerve transfer surgeries follow-up with surgeon at 6/12/18/24/36 and potentially at 48 months attend therapy at local therapist for up to 2 years postop.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
04/29/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Cervical Spinal Cord Injury, Tetraplegia
Register for Updates
Study of Cretostimogene Given in Patients With Non-Muscle Invasive Bladder Cancer ,Unresponsive to Bacillus-Calmette-Guerin
NCT04452591
Recruiting
This is a Phase 3, open-label, single arm trial designed to evaluate Cretostimogene patients with NMIBC who have failed prior BCG therapy. Up to approximately 115 CIS bladder cancer patients with or without HG Ta or HG T1 papillary disease will be enrolled under the original protocol through Amendment 4, which will comprise Cohort C. Cohort C is closed to enrollment. Under Amendment 5-1, Cohort P was added to enroll up to 70 patients with HG Ta/T1 papillary bladder cancer. Under Amendment 6, t... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/29/2024
Locations: University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania
Conditions: Non Muscle Invasive Bladder Cancer, High-grade Ta/ T1 Papillary Disease Bladder Cancer
Register for Updates
Randomized Study in Children and Adolescents With Migraine: Acute Treatment
NCT04649242
Recruiting
The purpose of this study is to test the safety and efficacy of BHV-3000 versus placebo in the acute treatment of moderate or severe migraine in children and adolescents.
Gender:
All
Ages:
Between 6 years and 17 years
Trial Updated:
04/29/2024
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Pediatric Migraine
Register for Updates
Alzheimer's Disease Neuroimaging Initiative 4
NCT05617014
Recruiting
Since its launch in 2004, the overarching aim of the Alzheimer's Disease Neuroimaging Initiative (ADNI) Study has been to validate biomarkers for Alzheimer's disease (AD) clinical trials. ADNI4 continues the previously funded ADNI1, ADNI-GO, ADNI2, and ADNI3 studies that have combined public/private collaborations between academia and industry to determine the relationships between the clinical, cognitive, imaging, genetic and biochemical biomarker characteristics of the entire spectrum of AD.
Gender:
All
Ages:
Between 55 years and 90 years
Trial Updated:
04/29/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Mild Cognitive Impairment, Alzheimer Disease, Dementia
Register for Updates
EvaLuate EndoVascular Treatment of Acutely Ruptured Shallow Intradural Aneurysms With the Pipeline™ Flex Embolization Device With Shield TEchnology™ (ELEVATE)
NCT04391803
Recruiting
The purpose of the study is to assess the safety and effectiveness of the Pipeline™ Flex Embolization Device with Shield Technology™ in the treatment with acutely ruptured intracranial aneurysms.
Gender:
All
Ages:
Between 22 years and 80 years
Trial Updated:
04/29/2024
Locations: Thomas Jefferson University Hospital, Philadelphia, Pennsylvania
Conditions: Intracranial Aneurysm, Ruptured Aneurysm
Register for Updates
Neuroinflammation Imaging in AD
NCT04274998
Recruiting
This research study is being done to learn more about inflammation in the brain using Positron Emission Tomography/Computed Tomography (PET/CT) imaging in people with Alzheimer's Disease/Mild Cognitive Impairment or healthy controls. If the subject agrees to be in this study, she/ he will have a PET/CT scan using the investigational radiotracer [18F]NOS. A subject with a specific genetic polymorphism may also agree to be in the sub-study in which she/he will have another PET/CT scan using the i... Read More
Gender:
All
Ages:
55 years and above
Trial Updated:
04/29/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Alzheimer Disease, Healthy Volunteer
Register for Updates