There are currently 1875 clinical trials in Philadelphia, Pennsylvania looking for participants to engage in research studies. Trials are conducted at various facilities, including University of Pennsylvania, Children's Hospital of Philadelphia, Fox Chase Cancer Center and Thomas Jefferson University. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Daily Aspirin vs Split Dosing in High-risk Pregnancies (DASH)
NCT06826859
Recruiting
Aspirin is recommended in high risk patients to reduce the risk of preeclampsia and preterm birth, which are leading causes of both maternal and neonatal morbidity and mortality, but up to 20% will have these adverse outcomes despite therapy. Gaps in knowledge regarding pregnancy specific aspirin pharmacology and the relationship of aspirin response and pregnancy outcome, along with a lack of consensus on aspirin dosing has limited the effective use of this intervention. The investigators aim to... Read More
Gender:
FEMALE
Ages:
Between 16 years and 55 years
Trial Updated:
07/14/2025
Locations: Thomas Jefferson University, Philadelphia, Pennsylvania
Conditions: Preterm Birth, Preeclampsia
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Excretion of Rivaroxaban in Human Breast Milk
NCT06831474
Recruiting
The purpose of this study is to investigate the distribution of rivaroxaban into human milk at both therapeutic and prophylactic doses, and over time with repeated dosing.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
07/14/2025
Locations: Thomas Jefferson University Hospital, Philadelphia, Pennsylvania
Conditions: Postpartum, VTE Prophylaxis, VTE (Venous Thromboembolism), Rivaroxaban, Breastfeeding, Breast Milk Collection
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TRANSPIRE: Lung Injury in a Longitudinal Cohort of Pediatric HSCT Patients
NCT04098445
Recruiting
Hematopoietic stem cell transplant (HSCT) is an effective but toxic therapy and pulmonary morbidity affects as many as 25% of children receiving transplant. Early pulmonary injury includes diffuse alveolar hemorrhage (DAH), thrombotic microangiopathy (TMA) interstitial pneumonitis (IPS) and infection, while later, bronchiolitis obliterans is a complication of chronic GVHD associated with severe morbidity and mortality. Improved diagnosis and treatment of pulmonary complications are urgently need... Read More
Gender:
ALL
Ages:
24 years and below
Trial Updated:
07/13/2025
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Hematopoietic Stem Cell Transplant (HSCT), Diffuse Alveolar Hemorrhage, Thrombotic Microangiopathies, Interstitial Pneumonitis, Bronchiolitis Obliterans
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ATEMPT 2.0: Adjuvant T-DM1 vs TH
NCT04893109
Recruiting
This research study is studying how well newly diagnosed breast cancer that has tested positive for a protein called HER2 responds using one of two different combination of HER2-directed therapies as a treatment after surgery. The name of the study drugs involved are: * Trastuzumab-emtansine (T-DM1, Kadcyla) * Trastuzumab SC (Herceptin Hylecta) * Paclitaxel
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/13/2025
Locations: University of Pennsylvania, Abramson Cancer Center, Philadelphia, Pennsylvania
Conditions: Breast Cancer, HER2-positive Breast Cancer
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Ruxolitinib for Early Lung Dysfunction After Hematopoietic Stem Cell Transplant
NCT04908735
Recruiting
Hematopoietic stem cell transplant (HSCT) is an effective but toxic therapy, and lung injury affects as many as 25% of children receiving HSCT. Improved transplant techniques and major improvements in survival mean that HSCT is being more widely used, and more mismatched grafts are being used. Bronchiolitis obliterans (BO) is a major limitation of pediatric HSCT success as BO is commonly diagnosed late in children, when lung injury is irreversible, leading to long term morbidity or even death. C... Read More
Gender:
ALL
Ages:
Between 5 years and 60 years
Trial Updated:
07/13/2025
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Hematopoietic Stem Cell Transplant (HSCT), Bronchiolitis Obliterans (BO)
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Identifying Genetic Characteristics That Increase Risk of Primary Graft Dysfunction Following Lung Transplantation
NCT00457847
Recruiting
Primary graft dysfunction (PGD) is a severe lung injury that can occur in the days following lung transplant surgery. The purpose of this study is to identify genetic factors that may put someone at risk for developing PGD.
Gender:
ALL
Ages:
Between 15 years and 65 years
Trial Updated:
07/11/2025
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Primary Graft Dysfunction, Lung Transplantation
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Valved Graft PMCF Study
NCT04754217
Recruiting
Multicenter, global, prospective, non-randomized, interventional, post-market trial. All subjects enrolled will receive an Abbott Valved Graft device.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/11/2025
Locations: Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Aortic Valve Disease, Ascending Aorta Abnormality, Aortic Dissection
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Phase 3 Study to Evaluate the Efficacy and Safety of HER2/Neu Peptide GLSI-100 (GP2 + GM-CSF) in HER2/Neu Positive Subjects
NCT05232916
Recruiting
This is a prospective, randomized, double-blinded, placebo-controlled, multi-center, Phase 3 study of GLSI-100 immunotherapy in HLA-A\*02 positive and HER2/neu positive subjects who are at high risk for disease recurrence and have completed both neoadjuvant and postoperative adjuvant standard of care therapy. Treatment consists of 6 intradermal injections, Primary Immunization Series (PIS), over the first 6 months of treatment and 5 booster intradermal injections spaced 6 months apart. A third o... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
07/11/2025
Locations: Sidney Kimmel Comprehensive Cancer Center - Thomas Jefferson University Hospital, Philadelphia, Pennsylvania
Conditions: Breast Cancer
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A Multicenter Trial Assessing the Impact of Lipoprotein(a) Lowering With Pelacarsen (TQJ230) on the Progression of Calcific Aortic Valve Stenosis
NCT05646381
Recruiting
The purpose of this study is to evaluate the efficacy, safety and tolerability of pelacarsen (TQJ230) administered subcutaneously once monthly compared to placebo in slowing the progression of calcific aortic valve stenosis.
Gender:
ALL
Ages:
Between 50 years and 80 years
Trial Updated:
07/11/2025
Locations: Perelman School of Medicine, Philadelphia, Pennsylvania
Conditions: Aortic Stenosis
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Oropharyngeal Candidiasis (OPC) and S-ECC
NCT05761197
Recruiting
The overall objective of this study is to investigate the association of early Candida infection (known as oral thrush or oropharyngeal candidiasis, OPC) in children during the first year of life with the onset and severity of severe early childhood caries (S-ECC).
Gender:
ALL
Ages:
Between 9 months and 24 months
Trial Updated:
07/11/2025
Locations: Temple University, Philadelphia, Pennsylvania
Conditions: Candida Infection, Oral Thrush, Early Childhood Caries
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Disentangling the Role of Depression in Hypersomnia
NCT05850676
Recruiting
Individuals who have disorders of hypersomnolence (excessive sleepiness) often report symptoms of depression. The goal of this study is to further understand of the relationship between depression and hypersomnia by examining mood-relevant domains of slow wave sleep and reward function.
Gender:
ALL
Ages:
Between 21 years and 55 years
Trial Updated:
07/11/2025
Locations: The University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Hypersomnia
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Development of a Database to Investigate Digital and Blood-Based Biomarkers and Their Relationship to Tau and Amyloid PET Imaging in Older Participants Who Are Cognitively Normal (CN), Have Mild Cognitive Impairment (MCI), or Have Mild-to-Moderate AD Dementia
NCT06584357
Recruiting
Bio-Hermes-002 is a 120-day cross-sectional study that will result in a blood, CSF, retinal, digital, MRI, and PET brain imaging biomarker database that can be used to determine the primary objective. Digital biomarkers and blood-based biomarkers will be tested to determine whether a meaningful relationship exists between biomarkers alone or in combination with tau or amyloid brain pathology identified through PET images.
Gender:
ALL
Ages:
Between 60 years and 90 years
Trial Updated:
07/11/2025
Locations: Flourish Research - Philadelphia, Philadelphia, Pennsylvania
Conditions: Mild Cognitive Impairment, Alzheimer's Disease, Alzheimer's Disease, Early Onset, Memory Loss, Memory Disorders, Memory Impairment
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