The city of Pittsburgh, Pennsylvania, currently has 20 active clinical trials seeking participants for Pain research studies.
Cervical Spine Focused Treatment for Patients with Persistent Concussion Symptoms and Neck Pain
Recruiting
Assess the feasibility of recruiting, enrolling and randomizing patients with concussion symptoms and neck pain to receive manual therapy and cervical rehabilitative exercises in addition to standard concussion treatment. In the usual care workflow provided at the participating concussion clinic, cervical spine rehab is not typically introduced until after week 4. The rationale is that neck pain is often a self-limiting condition that may resolve spontaneously, without the need for specific cer... Read More
Gender:
ALL
Ages:
Between 12 years and 50 years
Trial Updated:
03/25/2025
Locations: UPMC sports medicine, Pittsburgh, Pennsylvania
Conditions: Brain Concussion, Neck Pain
Peer Support for Adolescents and Emerging Adults With Sickle Cell Pain
Recruiting
The study, known as the Peer suppoRt for adolescents and Emerging adults with Sickle cell pain: promoting ENgagement in Cognitive behavioral thErapy (PRESENCE), aims to determine the effectiveness of digital CBT in reducing pain, opioid use, and healthcare utilization among AYAs with SCD. It also seeks to understand the role of personalized peer support in enhancing engagement and outcomes of digital CBT interventions. By leveraging existing infrastructure for delivering virtual peer support in... Read More
Gender:
ALL
Ages:
Between 16 years and 30 years
Trial Updated:
03/20/2025
Locations: UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Pain, Sickle Cell Disease
Managing Chronic Tendon Pain by Metformin
Recruiting
The purpose of the current exploratory clinical trial is to determine the effect of oral ingestion of metformin (OIM) in non-diabetic patients with chronic Achilles tendon pain. The trial has two aims; 1) to assess the effects of OIM treatment on tendon pain, and 2) to determine the effects of OIM capsules on tendon healing and repair. Twenty participants will be treated with metformin capsules for 16 weeks combined with a home exercise program. A comparison group of 20 participants will be trea... Read More
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
03/03/2025
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Tendinopathy, Chronic Pain, Achilles Tendinopathy
Pain Self-Management and Treatment Engagement for Patients Taking Opioids
Recruiting
The goal of this study is to learn if Pain Self-Management (PSM) can improve chronic pain care in individuals with opioid misuse or opioid use disorder (OUD) The main questions it aims to answer are: * Does PSM help participants manage their chronic pain more effectively? * Does PSM help participants engage in treatment for opioid use? Researchers will compare PSM to standard care to see if PSM is effective in managing chronic pain and engagement in treatment. Participants will: * Take part... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/26/2025
Locations: Community Medicine, Inc., Pittsburgh, Pennsylvania +2 locations
Conditions: Chronic Pain, Opioid Use Disorder, Opioid Misuse and Addiction
Nitrous Oxide Neuroimaging
Recruiting
The purpose of this study is to determine the effects of acute pain on long-term memory and conditioned physiologic responses in the presence and absence of low dose nitrous oxide. Functional magnetic resonance imaging will be used to identify the neural correlates of these phenomena. The study will occur over 2 visits and involves no long-term follow up.
Gender:
ALL
Ages:
Between 18 years and 59 years
Trial Updated:
02/03/2025
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Anesthesia, Pain, Amnesia
Auriculo-Nerve Stimulation on Post-Operative Opioid Requirement
Recruiting
The NSS-2 BRIDGE® device (NSS stands for Neuro-Stimulation System) is a disposable device that stimulates the branches of cranial nerves and of the superficial cervical plexus innervating the ear. Because the stimulation of the nerves of the ear by the NSS-2 BRIDGE® device (NBD®) has been shown to modulate pain pathways in rodents, decrease abdominal pain in adolescents with inflammatory bile syndrome and due to the results of our preliminary pilot study, the investigators hypothesized that this... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/03/2025
Locations: University of Pittsburgh Medical Center - Magee-Womens Hospital, Pittsburgh, Pennsylvania +3 locations
Conditions: Opioid Use, Auriculotherapy, Pain, Abdominal, Cancer Pain, Liver Transplant
QST Study: Predicting Treatment Response in Chronic Pancreatitis Using Quantitative Sensory Testing
Recruiting
Quantitative Sensory Testing (QST) is a novel investigative technique used in other pain conditions to evaluate patterns of chronic pain, and in this study will be used to elucidate pain patterns in patients with Chronic Pancreatitis (CP). QST uses a specific series of standardized stimulations to map the pain system. QST has the potential to change and improve the treatment paradigm for patients with CP and may eventually be able to predict response to invasive CP therapies.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/07/2025
Locations: University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
Conditions: Chronic Pancreatitis, Chronic Pain
Pancreatic Quantitative Sensory Testing (P-QST) to Predict Treatment Response for Pain in Chronic Pancreatitis
Recruiting
Abdominal pain in chronic pancreatitis (CP) affects up to 90% of patients during the course of their disease, and response to currently available therapies is suboptimal and unpredictable. The proposed clinical trial will evaluate the predictive capability of Pancreatic Quantitative Sensory Testing (P-QST) - a novel assessment of neurosensory phenotyping- for improvement in pain in patients with CP who are undergoing medically-indicated invasive treatment with endoscopic therapy or surgery.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/07/2025
Locations: University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
Conditions: Chronic Pancreatitis, Chronic Pain
Blue Light As an Anti-inflammatory and Analgesic Strategy in Thoracic Trauma
Recruiting
The main goal of this clinical trial is to learn if light therapy improves pain and inflammation in adults with painful rib fractures. The main question it aims to answer is: - Does bright blue light therapy in addition to standard pain treatments improve pain with breathing in adults with painful rib fractures? Researchers will compare participants who receive bright blue light therapy to participants who receive white light therapy and participants who receive only usual lighting conditions... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/27/2024
Locations: Presbyterian Hospital, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
Conditions: Rib Fractures, Pain, Acute
Sevoflurane's Effect on Neurocognition Study
Recruiting
The purpose of this study is to determine the effects of acute pain on long-term memory and conditioned physiologic responses in the presence and absence of low dose sevoflurane. Functional magnetic resonance imaging will be used to identify the neural correlates of these phenomena. The study will occur over 2 visits and involves no long-term follow up.
Gender:
ALL
Ages:
Between 18 years and 59 years
Trial Updated:
11/19/2024
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Anesthesia, Pain, Amnesia
STTEPP: Safety, Tolerability and Dose Limiting Toxicity of Lacosamide in Patients With Painful Chronic Pancreatitis
Recruiting
The investigators propose to conduct a dose-escalation trial of an FDA-approved antiepileptic drug, lacosamide, added to opioid therapy in patients with chronic abdominal pain from chronic pancreatitis (CP). This pilot trial will test the feasibility of the study design and provide reassurance regarding the tolerability and safety of lacosamide used concomitantly with opioids in this patient population to reduce the condition known clinically as opioid-induced hyperalgesia (OIH).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/21/2024
Locations: University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
Conditions: Chronic Pain, Chronic Pain Syndrome, Chronic Pancreatitis, Hyperalgesia, Opioid Use Disorder, Opioid-Related Disorders, Opioid Dependence, Chronic Abdominal Pain, ERCP, Pancreatic Surgery
EPPIC-Net: Novaremed Painful Diabetic Peripheral Neuropathy ISA
Recruiting
The purpose of this study is to investigate the safety and efficacy of the current hard gelatin capsule formulation of NRD135S.E1 80 mg once daily in the treatment of PDPN when administered for 13 weeks.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/16/2024
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Painful Diabetic Neuropathy