Pittsburgh, PA Clinical Trials

A listing of Pittsburgh, PA clinical trials actively recruiting patient volunteers.

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1470 trials found

The Pitt Center for Emergency Responder Wellness

NCT05357586

Emergency responders protect the public despite occupational hazards that threaten their mental health. The Pitt Center for Emergency Responder Wellness will be a clinical innovation hub that: 1) delivers accessible interventions for promoting mental health and overall wellbeing; 2) trains the next generation of students to provide mental health care for emergency responders; and 3) informs scientific understanding of post-trauma recovery processes. Goals for the seed phase are to establish our ...

Conditions: Posttraumatic Stress Disorder, Depression, Anxiety, Alcohol Use Disorder
Phase: Not Applicable

Intercostal Nerve Cryotherapy in Patients Undergoing Minimally Invasive Pulmonary Resection

NCT05348447

This is a research study designed to test whether a treatment called Intercostal Nerve Cryotherapy is an effective way to help control post-surgical pain for patients undergoing minimally invasive pulmonary resection. There are two treatment groups in this study, a cryotherapy group and control group. Cryotherapy is a method of controlling pain by freezing nerves between the ribs that would transmit pain impulses to the brain.

Conditions: Cryotherapy Effect, Pain, Postoperative
Phase: Not Applicable

A Study of JNJ-68284528 Out-of-Specification (OOS) for Commercial Release in Participants With Multiple Myeloma

NCT05347485

The purpose of this study is to evaluate the efficacy and safety of cilta-cel out-of-specification (OOS).

Conditions: Multiple Myeloma

A Phase II Study of Pre-Op SRS Followed by Surgical Resection for Brain Metastases

NCT05341739

This is a research study to determine if performing stereotactic radiosurgery (SRS) prior to surgical resection of the brain metastasis (tumor) will improve local control, in other words, increase the possibility of total removal of the primary tumor without local recurrence on longterm follow up. This research study will also determine if pre-operative SRS will lower the risk of radionecrosis that is the breakdown of body tissue at the original tumor site, and the development of leptomeningeal ...

Conditions: Brain Metastases, Adult
Phase: Not Applicable

REINVENT Registry (Registry of the Nerve Gap Repair From Integra)

NCT05339594

This is a prospective, multi-center, observational registry designed to evaluate two of Integra's collagen nerve gap repair products (NeuraGen and NeuraGen 3D). This registry will collect data on the outcome measures throughout the follow-up period for each patient. Data will be collected per standard of care.

Conditions: Peripheral Nerve Injuries

Circadian Rhythms and Homeostatic Sleep Drive and Their Effect on Reward and Cognitive Control Systems in Adolescents

NCT05336084

Adolescence is a time of heightened reward sensitivity and greater impulsivity. On top of this, many teenagers experience chronic sleep deprivation and misalignment of their circadian rhythms due to biological shifts in their sleep/wake patterns paired with early school start times, which may increase the risk for substance use (SU). However, what impact circadian rhythm and sleep disruption either together or independently have on the neuronal circuitry that controls reward and cognition, or if ...

Conditions: Sleep
Phase: Not Applicable

Safety and Efficacy of Lacutamab in Patients With Relapse Peripheral T-cell Lymphoma That Express KIR3DL2

NCT05321147

This is a multi-center phase Ib sutdy, which evaluates the safety and efficacy of lacutamab monotherpy in patients with relapse peripheral T-cell lymphoma that express KIR3DL2.

Conditions: Peripheral T Cell Lymphoma

Transcutaneous Auricular Vagus Nerve Stimulation to Enhance Motor Learning

NCT05316519

Vagus nerve stimulation (VNS) activates neural pathways leading to the release of chemicals that promote plasticity and learning. Previous work has shown that the auricular branch of the vagus nerve innervates landmarks on the external ear. Work from the PI's laboratory has shown that electrical current applied to the external ear activates neural pathways implicated in the therapeutic effects of VNS. The broad objective of this project is to better understand physiological mechanisms that are m ...

Conditions: Neurological Injury, Motor Disorders, Paresis
Phase: Not Applicable

Electronic Nicotine Delivery Devices and Potential Progression to Acute Lung Injury

NCT05316727

This is an observational - data and specimen collection study. There have been increasing reports of vaping-induced lung injury, including severe lung injury and rare cases of death. The mechanism by which vaping contributes to lung injury in susceptible persons is unknown, as is impact on chronic lung disease. The investigators aim to identify individuals with chronic electronic nicotine delivery device (ENDD) exposure and matched controls within our ongoing cohort of HIV+ and HIV-uninfected in ...

Conditions: Acute Lung Injury, Pulmonary Injury, Electronic Cigarette Use, Electronic Cigarette Related Lung Injury

Prevalence of Multidrug Resistant Micro-organism Carriage in Patients Undergoing an ERCP in Four Different Countries

NCT05303662

The duodenoscopes currently used for ERCP (Endoscopic Retrograde Cholangio - and Pancreaticography) examinations are reusable and are therefore washed and disinfected after each use. Despite this, these endoscopes sometimes remain contaminated with bacteria. Several reports of outbreaks linked to contaminated duodenoscopes have been published worldwide. Recently, the FDA advised manufacturers and health care professionals to transition away from fixed endcap duodenoscopes and instead focus more ...

Conditions: Drug Resistance, Multiple, Bacterial, Cholangiopancreatography, Endoscopic Retrograde

EyeConic: Qualification for Cone-Optogenetics

NCT05294978

This study aims to prepare for the first-in-human clinical trial of cone optogenetics vision restoration. As a first step, this worldwide multicenter ocular imaging study (EyeConic Study) is performed to identify eligible patients.

Conditions: Retinal Dystrophies

Posterior cerebraL ArTery Occlusion Study

NCT05291637

For this retrospective study, the investigators will collect and analyze data of patients who presented with posterior artery occlusion and underwent mechanical thrombectomy (the type of endovascular stroke treatment) and intravenous thrombolysis (the type of non-endovascular stroke treatment). The electronic health records will be queried for the demographic, medical history, and outcomes data of all patients with posterior cerebral artery occlusion who underwent mechanical thrombectomy, intra ...

Conditions: Stroke, Acute Ischemic