There are currently 17 active clinical trials seeking participants for Constipation research studies. The states with the highest number of trials for Constipation participants are Florida, California, Texas and North Carolina.
Posterior Tibial Nerve Stimulation for Children With Pelvic Floor Dyssynergia
Recruiting
The overall objective of this study is to determine the effect of posterior tibial nerve stimulation (PTNS) on children with constipation due to pelvic floor dyssynergia. Our main hypothesis is that PTNS effectively treats children with constipation secondary to pelvic floor dyssynergia through modulation of anorectal function. We will perform a single-center, randomized controlled pilot study comparing PTNS to sham stimulation in children with constipation secondary to pelvic floor dyssynergia.
Gender:
ALL
Ages:
Between 8 years and 18 years
Trial Updated:
07/25/2024
Locations: Nationwide Children's Hospital, Columbus, Ohio
Conditions: Constipation, Fecal Incontinence in Children, Pelvic Floor Dyssynergia
Pre-operative Polyethylene Glycol 3350 for Minimally Invasive Urogynecologic Surgery
Recruiting
The goal of this clinical trial is to test the use of a laxative before surgery in women having surgery to fix pelvic prolapse that do not have constipation. The main question it aims to answer is: Does use of a laxative before surgery lessen the discomfort of bowel movements after surgery? Participants will be asked to complete questionnaires before and after surgery. Researchers will compare using the laxative before and after surgery versus only after surgery to see if there is less discomfo... Read More
Gender:
FEMALE
Ages:
Between 18 years and 89 years
Trial Updated:
07/18/2025
Locations: University Hospitals Cleveland Medical Center, Cleveland, Ohio
Conditions: Constipation, Surgical Procedure, Unspecified, Prolapse; Female
Understanding Mechanisms of Normal and Disordered Defecation
Recruiting
Researchers are trying to better understand why constipation occurs and improve the tests for diagnosing these conditions.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
08/04/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Constipation
A Study of Herbal Supplements in Cancer Survivors With Constipation
Recruiting
The purpose of this study is to find out whether MZRW is an effective treatment for constipation in cancer survivors. The researchers will compare MZRW with placebo, a pill that looks like MZRW and is given in the same way, but contains no medication. The researchers will also study the effect MZRW has on the gut microbiome. The gut microbiome is a diverse community of microorganisms living in the digestive system, essential for digestion and immune function.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/21/2025
Locations: Memorial Sloan Kettering Basking Ridge (All Protocol Activities), Basking Ridge, New Jersey +6 locations
Conditions: Constipation, Cancer, Functional Constipation
Evaluation of Fecal Microbiome Changes After Antegrade Continence Enema Placement and Initiation of Bowel Flush Regimen
Recruiting
This study will evaluate changes in the fecal microbiome in constipated pediatric patients before and after antegrade continence enema placement and initiation of antegrade enema flushes. Subjects will have their microbiome sequenced prior to placement by obtaining a fecal sample. Pre-antegrade continence enema placement results will be compared to fecal samples obtained at 0, 4, 8 months after placement of the antegrade continence enema and initiation of miralax or golytely flushes to look for... Read More
Gender:
ALL
Ages:
Between 2 years and 18 years
Trial Updated:
07/01/2025
Locations: IU North Hospital, Carmel, Indiana +1 locations
Conditions: Constipation
Interrogating the Pathophysiological Mechanisms of Constipation in Patients With Systemic Sclerosis
Recruiting
The purpose of this study is to determine whether transcutaneous electrical acustimulation (TEA) alters systemic sclerosis (SSc)-related colonic and anorectal physiology by enhancing autonomic nervous system (ANS) function. The study will examine the effects of TEA on slow colonic transit (SCT) and rectal hyposensitivity (RH), to examine whether TEA improves autonomic dysfunction and modulates inflammatory pathways.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/21/2025
Locations: The University of Texas Health Science Center at Houston, Houston, Texas
Conditions: Systemic Sclerosis, Constipation, Gastrointestinal Motility Disorder, Autonomic Dysfunction
A Study of Microbiome Transplantation for the Treatment of Constipation and/or Significant Bloating in Patients With Systemic Sclerosis
Recruiting
The purpose of this study is to characterize the intestinal flora in subjects with systemic sclerosis-related constipation and/or significant bloating and to determine safety and trends in improvements in the diversity of colonic microbiome and patient symptoms following the administration of either frozen or lyophilized PRIM-DJ2727 microbiota.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/21/2025
Locations: The University of Texas Health Science Center at Houston, Houston, Texas
Conditions: Constipation, Bloating
Assessing Tenapanor as a Treatment of CF-related Constipation.
Recruiting
Tenapanor is the newest FDA-approved drug for IBS with constipation (IBS-C). This study seeks to understand tenapanor as a treatment for cystic fibrosis-related constipation (CFrC) in CF patients. Participants will ingest one 50 mg tablet of tenapanor, twice daily, for a 4-week treatment period. They will also complete three questionnaires, the PAC-SYM, PAC-QoL, and IBS-SSS, and daily diaries to characterize GI symptom burden and spontaneous bowel movement (SBM) frequency.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
06/12/2025
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Cystic Fibrosis, Constipation
Preop Laxatives in Robotic Urologic Surgery
Recruiting
Minimally-invasive surgery, either laparoscopic or robotic, is commonly used in urology. Several urologic procedures including prostatectomy, radical nephrectomy, and partial nephrectomy are now commonly performed robotically. Patients undergoing these procedures often have delayed return of bowel function and persistent gastrointestinal symptoms including nausea/vomiting, abdominal distension, and bloating for several days to weeks after surgery. Postoperative stool softeners and laxatives are... Read More
Gender:
ALL
Ages:
Between 30 years and 100 years
Trial Updated:
05/23/2025
Locations: University of Iowa Hospitals & Clinics, Iowa City, Iowa
Conditions: Prostate Cancer, Kidney Cancer, Constipation
Effects of Constipation Treatment in Chronic Kidney Disease: A Pilot Feasibility Trial
Recruiting
Constipation is one of the most prevalent gastrointestinal disorders in patients with chronic kidney disease (CKD) and has been associated with their adverse kidney and cardiovascular outcomes; however, little is known about the effects of constipation treatment on clinical outcomes nor on outcome-related biochemical and microbiological parameters in patients with CKD. The investigators aim to test the feasibility of delivering an intervention with constipation treatment and determine its effect... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/12/2025
Locations: Memphis VA Medical Center, Memphis, Tennessee
Conditions: Chronic Kidney Disease, Constipation
Optimization of Postoperative Bowel Habits
Recruiting
Project is a trial, in which women undergoing vaginal surgery for pelvic organ prolapse will be randomized 1:1 to a postoperative bowel regimen of either oral senna or rectal bisacodyl suppository.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
03/18/2025
Locations: Wake Forest University Health Sciences, Winston-Salem, North Carolina
Conditions: Constipation
Fecobionics in Biofeedback Therapy in Dyssynergia Patients
Recruiting
Constipation affects 12-19% of Americans. Pelvic floor dyssynergia is considered to play an important role in constipation but the underlying mechanisms are not well understood in individual patients. The investigators have developed a novel device named Fecobionics that provide detailed mapping of physiological parameters during defecation. The aim of the study is to use Fecobionics to assess anorectal function in dyssynergia patients and monitor and predict the outcome of the biofeedback thera... Read More
Gender:
ALL
Ages:
Between 21 years and 75 years
Trial Updated:
02/12/2025
Locations: California Medical Innovations Institute, San Diego, California
Conditions: Dyssynergia, Constipation