The city of Houston, Texas, currently has 15 active clinical trials seeking participants for Epilepsy research studies.
A Study to Determine if BHV-7000 is Effective and Safe in Adults With Refractory Focal Onset Epilepsy
Recruiting
The purpose of this study is to determine whether BHV-7000 is effective in the treatment of refractory focal epilepsy.
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
05/15/2024
Locations: Michael E. DeBakey VA Medical Center, Houston, Texas
Conditions: Focal Epilepsy
Study to Determine if BHV-7000 is Effective and Safe in Adults With Refractory Focal Onset Epilepsy
Recruiting
The purpose of this study is to determine whether BHV-7000 is effective in the treatment of refractory focal epilepsy.
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
05/14/2024
Locations: UTHealth Houston, Houston, Texas
Conditions: Focal Epilepsy
Intracranial Investigation of Neural Circuity Underlying Human Mood
Recruiting
Depression is one of the most common disorders of mental health, affecting 7-8% of the population and causing tremendous disability to afflicted individuals and economic burden to society. In order to optimize existing treatments and develop improved ones, the investigators need a deeper understanding of the mechanistic basis of this complex disorder. Previous work in this area has made important progress but has two main limitations. (1) Most studies have used non-invasive and therefore impreci... Read More
Gender:
All
Ages:
Between 21 years and 70 years
Trial Updated:
04/04/2024
Locations: Baylor College of Medicine, Houston, Texas
Conditions: Depression, Epilepsy
Randomized, Double-Blind Study to Evaluate Efficacy and Safety of Cenobamate Adjunctive Therapy in PGTC Seizures
Recruiting
This trial is intended to study the safety and effectiveness of an new anti-epileptic drug (AED) on Primary Generalized Tonic-Clonic (PGTC) Seizures. Eligible Subjects, adults and adolescents, will continue to take their usual AEDs and receive either cenobamate or placebo. Subjects will have a 50% chance or receiving cenobamate or placebo (sugar pill). Subjects will initially receive 12.5 mg of cenobamate or placebo (study drug) and increase the dose every two weeks until they reach a target dos... Read More
Gender:
All
Ages:
12 years and above
Trial Updated:
04/03/2024
Locations: Baylor College of Medicine, Houston, Texas
Conditions: Primary Generalized Epilepsy
PRIME: PReservIng Memory in Epilepsy
Recruiting
In this study, participants will receive unilateral Deep Brain Stimulation (DBS) for treatment of epilepsy, with network-based stimulation targets specifically defined using a stereo-electro-encephalographic evaluation and chronic recordings using the Medtronic Percept™ primary cell (PC) Neurostimulator DBS System with BrainSense™ Technology. The hypothesis is that, compared to no stimulation or to standard duty cycle high frequency stimulation, epilepsy neuromodulation using low frequency stimu... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
03/07/2024
Locations: The University of Texas Science Center at Houston, Houston, Texas
Conditions: Mesial Temporal Lobe Epilepsy
FIH Study of NRTX-1001 Neural Cell Therapy in Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy
Recruiting
This clinical trial is designed to test whether a single stereotactic intracerebral administration of inhibitory nerve cells into subjects with drug-resistant mesial temporal lobe epilepsy is safe (frequency of adverse events) and effective (seizure frequency).
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
01/19/2024
Locations: UTHealth Houston, Houston, Texas
Conditions: Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis
Acute Modulation of Stereotyped High-Frequency Oscillations
Recruiting
Overall, this study will investigate the functional utility of stereotyped HFOs by capturing them with a new implantable system (Brain Interchange - BIC of CorTec), which can sample neural data at higher rates >=1kHz and deliver targeted electrical stimulation to achieve seizure control. In contrast to current closed-loop systems (RNS), which wait for the seizure to start before delivering stimulation, the BIC system will monitor the spatial topography and rate of stereotyped HFOs and deliver ta... Read More
Gender:
All
Ages:
Between 3 years and 70 years
Trial Updated:
01/18/2024
Locations: Baylor College of Medicine, Houston, Texas +1 locations
Conditions: Epilepsy
Breathing Rescue for SUDEP Prevention
Recruiting
The purpose of this study is to precisely delineate human brain networks that modulate respiration and identify specific brain areas and stimulation techniques that can be used to prevent seizure-induced breathing failure.
Gender:
All
Ages:
18 years and above
Trial Updated:
12/11/2023
Locations: The University of Texas Health Science Center at Houston, Houston, Texas
Conditions: Focal Epilepsy
Stopping TSC Onset and Progression 2B: Sirolimus TSC Epilepsy Prevention Study
Recruiting
This trial is a Phase II randomized, double-blind, placebo controlled multi-site study to evaluate the safety and efficacy of early sirolimus to prevent or delay seizure onset in TSC infants. This study is supported by research funding from the Office of Orphan Products Division (OOPD) of the US Food and Drug Administration (FDA).
Gender:
All
Ages:
Between 1 day and 6 months
Trial Updated:
08/21/2023
Locations: University of Texas HSC at Houston, Houston, Texas
Conditions: Tuberous Sclerosis Complex, Epilepsy
The Neural Code and Dynamics of the Reading Network.
Recruiting
The purpose of this study is to compare organization of normal brain function as detected using Functional magnetic resonance imaging (fMRI) in normal subjects as opposed to patients with epilepsy or brain tumors, to ascribe precise anatomic labels (including Brodmann Areas) and functional significance to each region involved in cognitive processes as detected by cortical stimulation mapping (CSM) in patients with implanted subdural electrodes (SDE) or depth (sEEG) electrodes, to describe the lo... Read More
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
08/04/2023
Locations: The University of Texas Health Science Center at Houston, Houston, Texas
Conditions: Epilepsy, Brain Tumor
Mapping and Modulating the Spatiotemporal Dynamics of Socio-Affective Processing
Recruiting
The overall goal of this study is to map the spatiotemporal dynamics of social affective processing and to examine selective modulation of these dynamics in humans undergoing invasive intracranial monitoring for treatment-resistant epilepsy and depression. Pursuing this signal from a novel platform with invasive intracranial recording electrodes provides much-needed spatial and temporal resolution to characterize the neural dynamics of socio-affective processing. The investigators will leverage... Read More
Gender:
All
Ages:
Between 22 years and 70 years
Trial Updated:
07/11/2023
Locations: Baylor College of Medicine, Houston, Texas
Conditions: Treatment Resistant Depression, Epilepsy
Understanding Prefrontal and Medial Temporal Neuronal Responses to Algorithmic Cognitive Variables in Epilepsy Patients
Recruiting
Humans have a remarkable ability to flexibly interact with the environment. A compelling demonstration of this cognitive flexibility is human's ability to respond correctly to novel contextual situations on the first attempt, without prior rehearsal. The investigators refer to this ability as 'ad hoc self-programming': 'ad hoc' because these new behavioral repertoires are cobbled together on the fly, based on immediate demand, and then discarded when no longer necessary; 'self-programming' becau... Read More
Gender:
All
Ages:
Between 10 years and 64 years
Trial Updated:
04/14/2023
Locations: Baylor College of Medicine, Houston, Texas
Conditions: Epilepsy