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Houston, TX Clinical Trials

A listing of Houston, TX Clinical Trials actively recruiting patient volunteers.

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3135 trials found

CBT Augmentation to Promote Medication Discontinuation in Pediatric OCD

NCT05609916

The purpose of this study is to examine whether youth with OCD who benefit from CBT augmentation to SRI can discontinue their medication without relapse over 24 weeks.

Conditions: Cognitive Behavioral Therapy, Obsessive-Compulsive Disorder, Obsessive-Compulsive Disorder in Children, Obsessive-Compulsive Disorder in Adolescence
Phase: Not Applicable
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Feasibility, Safety, and Efficacy of Stereotactic MRI-Guided Adaptive Radiation Therapy (SMART) for Central Lung Tumors

NCT05609331

To learn if using MRI (magnetic resonance imaging) to guide radiation therapy can help to control central lung cancer. The results of the MRI-guided radiation therapy will be compared to conventional radiation therapy (guided by CT scans) during this study.

Conditions: Lung Cancer
Phase: Not Applicable
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A Phase 3, Randomized, Double-Blind Study to Assess the Efficacy of Difamilast Ointment in Mild to Moderate AD

NCT05608343

This is a Phase 3 Double Blind multi-center study conducted at 40 US investigational sites to assess the efficacy and safety of Difamilast Ointment 1% in subjects ≥2 years of age with mild to moderate atopic dermatitis.

Conditions: Atopic Dermatitis
Phase: Phase 3
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Pressure Enabled Intrapancreatic Delivery of SD-101 With Checkpoint Blockade for Locally Advanced Pancreatic Adenocarcinoma

NCT05607953

This study is an open-label, phase 1/1b study of the pressure-enabled intrapancreatic infusion of SD-101, a TLR 9 agonist, alone or in combination with intravenous checkpoint blockade in adults with locally advanced pancreatic cancer.

Conditions: Locally Advanced Pancreatic Adenocarcinoma
Phase: Phase 1
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Network Effects of Therapeutic Deep Brain Stimulation

NCT05600738

The purpose of this study is to map the acute, short-term cortical evoked responses to thalamic electrical stimulation in persons with intractable epilepsy

Conditions: Intractable Epilepsy
Phase: Not Applicable
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A Study to Evaluate the Efficacy and Safety of ESK-001 in Patients With Plaque Psoriasis

NCT05600036

This is a multi-center, randomized, double-blind, placebo-controlled study in patients with moderate to severe plaque psoriasis.

Conditions: Plaque Psoriasis
Phase: Phase 2
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A Phase 1 Trial of ZN-A-1041 Enteric Capsules or Combination in Patients With HER2-Positive Advanced Solid Tumors

NCT05593094

This will be a Phase 1, multicenter, open-label trial to evaluate the safety, tolerability, PK and efficacy of ZN-A-1041 as a monotherapy or in combination in patients with HER2-positive advanced solid tumors with or without brain metastases. The study will consist of three phases: Phase 1a (dose escalation with ZN-A-1041 monotherapy), Phase 1b (dose escalation with ZN-A-1041 combination therapy) and Phase 1c (dose expansion with ZN-A-1041 combination therapy).

Conditions: Advanced Solid Tumors, HER2-positive Breast Cancer
Phase: Phase 1
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Study of Daxdilimab (HZN-7734) in Patients With Moderate-to-Severe Primary Discoid Lupus Erythematosus

NCT05591222

A Phase 2, double-blind, randomized, placebo-controlled parallel-group study to evaluate the efficacy and safety of daxdilimab in participants with moderate-to-severely active primary Discoid Lupus Erythematosus (DLE) refractory to standard of care.

Conditions: Discoid Lupus Erythematosus
Phase: Phase 2
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CERENOVUS Neurothrombectomy Devices Registry

NCT05591183

A post-market registry evaluating the EmboTrap® Revascularization Device and CERENOVUS Large Bore Catheter/ EMBOVAC Aspiration Catheter in acute ischemic stroke patients with confirmed intracranial large vessel occlusion.

Conditions: Cerebral Stroke
Phase: N/A
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International, Multicentric, Observational Study to Characterize Subpopulations of Patients With Autism Spectrum Disorder

NCT05590715

To determine sufficient number of biological and clinical markers to identify subgroups of potential best responders to a specific medication

Conditions: Autism Spectrum Disorder
Phase: N/A
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A Phase 1/2a Study of IMM-1-104 in Participants With Previously Treated, RAS-Mutant, Advanced or Metastatic Solid Tumors

NCT05585320

This is an open-label, dose-exploration and expansion study to determine the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary anti-tumor activity of IMM-1-104 when administered as monotherapy in participants with RAS-mutated advanced or metastatic solid tumors. The dose exploration will identify the candidate recommended Phase 2 dose (RP2D) of IMM-1-104 to further explore the anti-tumor activity of IMM-1-104 as monotherapy in 4 Phase 2a tumor-specific cohorts.

Conditions: Advanced Solid Tumor (Phase 1), Pancreatic Adenocarcinoma, Malignant Melanoma (Cutaneous), Non-small Cell Lung Cancer (NSCLC), Colorectal Cancer (CRC)
Phase: Phase 1/2
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Study of Novel Antiretrovirals in Participants With HIV-1

NCT05585307

Master protocol: The goal of this master (umbrella) clinical trial study is to learn how novel antiretrovirals affect the HIV-1 infection in people living with HIV (PWH). The safety and how well the study drugs are tolerated will be determined by using physical exams, laboratory tests, and any symptoms or problems a participant might experience during the study. Substudy-01 (GS-US-544-5905-01) will evaluate GS-5894 in people with HIV PWH.

Conditions: HIV-1-infection
Phase: Phase 1
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