The state of Texas currently has 25 active clinical trials seeking participants for Epilepsy research studies. These trials are conducted in various cities, including Houston, Dallas, San Antonio and Austin.
A Study to Determine if BHV-7000 is Effective and Safe in Adults With Idiopathic Generalized Epilepsy With Generalized Tonic-clonic Seizures
Recruiting
The purpose of this study is to determine whether BHV-7000 is effective in the treatment of idiopathic generalized epilepsy with generalized tonic-clonic seizures and includes an additional open-label extension (OLE) phase.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
04/14/2025
Locations: Clinical Research Solution LLC, Cypress, Texas +3 locations
Conditions: Generalized Epilepsy
A Study to Determine if BHV-7000 is Effective and Safe in Adults With Refractory Focal Onset Epilepsy
Recruiting
The purpose of this study is to determine whether BHV-7000 is effective in the treatment of refractory focal epilepsy.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
04/11/2025
Locations: Clinical Research Solutions LLC, Cypress, Texas +5 locations
Conditions: Focal Epilepsy
Study to Determine if BHV-7000 is Effective and Safe in Adults With Refractory Focal Onset Epilepsy
Recruiting
The purpose of this study is to determine whether BHV-7000 is effective in the treatment of refractory focal epilepsy.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
04/09/2025
Locations: ANESC Research, El Paso, Texas +1 locations
Conditions: Focal Epilepsy
FIH Study of NRTX-1001 Neural Cell Therapy in Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy
Recruiting
This clinical trial is designed to test whether a single image-guided intracerebral administration of inhibitory nerve cells, called interneurons (NRTX-1001), into subjects with drug-resistant unilateral mesial temporal lobe epilepsy (MTLE), with or without mesial temporal sclerosis (MTS), is safe (frequency of adverse events) and effective (seizure frequency). NRTX-1001 comprises human interneurons that secrete a neurotransmitter, gamma-aminobutyric acid (GABA).
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
04/03/2025
Locations: UTHealth Houston, Houston, Texas
Conditions: Mesial Temporal Lobe Epilepsy
An Open Label Trial to Evaluate the Efficacy and Safety of PRAX-628 in Adults With Focal Onset or Tonic-Clonic Seizures
Recruiting
An Open Label Clinical Trial to Evaluate the Efficacy and Safety of PRAX-628 in Adult Patients With Focal Onset or Primary Generalized Tonic-Clonic Seizures
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
03/26/2025
Locations: Praxis Research Site, Round Rock, Texas +1 locations
Conditions: Focal Onset Seizure, Primary Generalized Epilepsy
Safety and Efficacy Study of Cenobamate in Pediatric Subjects 2-17 Years of Age With Partial-onset (Focal) Seizures
Recruiting
Primary objective: To evaluate the safety and tolerability of cenobamate in pediatric subjects 2-17 years of age with partial-onset (focal) seizures
Gender:
ALL
Ages:
Between 2 years and 18 years
Trial Updated:
03/20/2025
Locations: Child Neurology Consultants of Austin, Austin, Texas +1 locations
Conditions: Partial Epilepsy
Acute Recording of Stereotyped High-Frequency Oscillations
Recruiting
Overall, this study will investigate the functional utility of stereotyped HFOs by capturing them with a new implantable system (Brain Interchange - BIC of CorTec), which can sample neural data at higher rates \>=1kHz and deliver targeted electrical stimulation to achieve seizure control. In contrast to current closed-loop systems (RNS), which wait for the seizure to start before delivering stimulation, the BIC system will monitor the spatial topography and rate of stereotyped HFOs and deliver t... Read More
Gender:
ALL
Ages:
Between 3 years and 70 years
Trial Updated:
03/20/2025
Locations: Baylor College of Medicine, Houston, Texas
Conditions: Epilepsy
Intracranial Investigation of Neural Circuity Underlying Human Mood
Recruiting
Depression is one of the most common disorders of mental health, affecting 7-8% of the population and causing tremendous disability to afflicted individuals and economic burden to society. In order to optimize existing treatments and develop improved ones, the investigators need a deeper understanding of the mechanistic basis of this complex disorder. Previous work in this area has made important progress but has two main limitations. (1) Most studies have used non-invasive and therefore impreci... Read More
Gender:
ALL
Ages:
Between 21 years and 70 years
Trial Updated:
02/11/2025
Locations: Baylor College of Medicine, Houston, Texas
Conditions: Depression, Epilepsy
Stopping TSC Onset and Progression 2B: Sirolimus TSC Epilepsy Prevention Study
Recruiting
This trial is a Phase II randomized, double-blind, placebo controlled multi-site study to evaluate the safety and efficacy of early sirolimus to prevent or delay seizure onset in TSC infants. This study is supported by research funding from the Office of Orphan Products Division (OOPD) of the US Food and Drug Administration (FDA).
Gender:
ALL
Ages:
Between 1 day and 6 months
Trial Updated:
01/17/2025
Locations: University of Texas HSC at Houston, Houston, Texas
Conditions: Tuberous Sclerosis Complex, Epilepsy
Neurobehavioral Therapy For Epilepsy And Major Depressive Disorder
Recruiting
The purpose of this study is to examine the feasibility and acceptability of an online group Neuro-behavioral Therapy (NBT) with text messaging intervention for Veterans with epilepsy and major depressive disorder (MDD).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/08/2025
Locations: Michael E. DeBakey VA Medical Center, Houston, Texas +1 locations
Conditions: Major Depressive Disorder, Epilepsy
Diffusion Tensor and Functional Connectivity Imaging in Pediatric Epilepsy: Imaging/Histology Correlation
Recruiting
To determine the utility of diffusion tensor magnetic resonance imaging in the preoperative workup of children with intractable epilepsy referred for surgery.
Gender:
ALL
Ages:
Between 0 days and 18 years
Trial Updated:
12/05/2024
Locations: UTHealth & Children's Memorial Hermann Hospital, Houston, Texas
Conditions: Intractable Epilepsy
PRIME: PReservIng Memory in Epilepsy
Recruiting
In this study, participants will receive unilateral Deep Brain Stimulation (DBS) for treatment of epilepsy, with network-based stimulation targets specifically defined using a stereo-electro-encephalographic evaluation and chronic recordings using the Medtronic Percept™ primary cell (PC) Neurostimulator DBS System with BrainSense™ Technology. The hypothesis is that, compared to no stimulation or to standard duty cycle high frequency stimulation, epilepsy neuromodulation using low frequency stimu... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
12/04/2024
Locations: The University of Texas Science Center at Houston, Houston, Texas
Conditions: Mesial Temporal Lobe Epilepsy