The state of Texas currently has 79 active clinical trials seeking participants for Pain research studies. These trials are conducted in various cities, including Houston, Dallas, San Antonio and Austin.
A Single-arm Study Evaluating the Effectiveness and Safety of Suzetrigine (SUZ) for Acute Pain After Selected Surgeries
Recruiting
The purpose of this study is to evaluate the effectiveness, safety, and tolerability of SUZ for acute pain after laparoscopic procedures of the intraperitoneal or retroperitoneal cavities or arthroscopic orthopedic procedures.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/20/2025
Locations: HD Research LLC | First Surgical Hospital, Bellaire, Texas +1 locations
Conditions: Acute Pain
Clinical Utility of Neurophysiological Measurements of ECAP-controlled Closed-loop SCS to Guide Treatment of Chronic Pain
Recruiting
The purpose of this study is to evaluate the clinical utility of neurophysiological measurements of ECAP-controlled closed-loop SCS (i.e., neural panel metrics) to guide treatment of chronic pain of the trunk and/or limbs.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/19/2025
Locations: Institute of Precision Pain Medicine, Corpus Christi, Texas +1 locations
Conditions: Chronic Pain
MOTIVATE to Improve Outcomes for Older Veterans With Musculoskeletal Pain and Depression
Recruiting
The proposed study seeks to evaluate effectiveness, implementation processes, and cost of MOTIVATE among older Veterans with chronic musculoskeletal (MSK) pain and comorbid depressive symptoms.
Gender:
ALL
Ages:
Between 60 years and 99 years
Trial Updated:
08/15/2025
Locations: VA North Texas Health Care System Dallas VA Medical Center, Dallas, TX, Dallas, Texas +1 locations
Conditions: Chronic Back Pain, Depression, Aging, Musculoskeletal Pain
Study Assessing Pain Relief After Replacement of the Knee
Recruiting
The goal of the ATX101-TKA-004 clinical trial aims to evaluate the efficacy and safety of ATX101 1,500 mg in participants undergoing primary unilateral total knee arthroplasty. The study will compare the effectiveness of ATX101 with a saline placebo and bupivacaine, an active comparator. Additionally, it will assess opioid consumption among participants receiving ATX101 versus those given the saline placebo and bupivacaine. The trial will also focus on the safety and tolerability of ATX101 in th... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
08/15/2025
Locations: First Surgical Hospital, Bellaire, Texas +4 locations
Conditions: Total Knee Arthroplasty (postoperative Pain)
Reducing Foot Pain and Peak Plantar Pressure in Patients With Foot Pain
Recruiting
The research project aims to evaluate the effectiveness of OrthoFeet Hands-Free therapeutic shoes and prefabricated inserts in patients with foot pain.
Gender:
ALL
Ages:
Between 50 years and 70 years
Trial Updated:
08/13/2025
Locations: Hafizur Rahman, Harlingen, Texas
Conditions: Foot Pain
Peripheral Nerve Stimulation of Genicular Nerves Versus Conventional Therapy With Intra-articular Steroid Injection for Chronic Knee Pain: A Prospective, Randomized Pilot Study
Recruiting
To compare the effects of the following types of therapy on knee range of motion when given to patients with chronic knee pain: * A standard steroid injection * Peripheral nerve stimulation (PNS) therapy in combination with a standard steroid injection * PNS therapy in combination with a placebo injection Steroid injections are given directly into the knee joints and are considered to be the standard therapy for chronic knee pain. In this study, the injection will be made of the steroid drugs... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/12/2025
Locations: M D Anderson Cancer Center, Houston, Texas
Conditions: Peripheral Nerve Stimulation, Genicular Nerves, Chronic Knee Pain
Patient Retrospective Outcomes (PRO)
Recruiting
This study will evaluate de-identified (anonymous) data in subject medical charts to review the clinical outcomes of various treatment approaches in the treatment of chronic pain.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/11/2025
Locations: Pain Center Physicians, Austin, Texas +6 locations
Conditions: Chronic Pain
RELIEF - A Global Prospective Observational Post-Market Study to Evaluate Long-Term Effectiveness of Neurostimulation Therapy for Pain
Recruiting
To compile characteristics of real-world clinical outcomes for Boston Scientific commercially approved neurostimulation systems for pain in routine clinical practice, when used according to the applicable Directions for Use - and - To evaluate the economic value and technical performance of Boston Scientific commercially approved neurostimulation systems for pain in routine clinical practice
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/11/2025
Locations: Balcones Pain Consultants, Austin, Texas +3 locations
Conditions: Pain
MAD Study to Assess the Safety, Tolerability, PKs and Efficacy of YJ001 for Spray Use in Patients With DPNP
Recruiting
This Phase I, randomized, double-blind and placebo controlled study is to evaluate the safety, tolerability, and PK, and to preliminarily assess the efficacy of topically administered YJ001 in a multiple-ascending dose (MAD) fashion in the patients with DPNP. The study will be conducted at a single study center. In this study, 2 cohorts (N=24, 12 subjects for each cohort), each cohort will consist of 10 active and 2 placebo, with approximately equal numbers of male and female subjects. Each su... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
08/11/2025
Locations: Clinical Trials of Texas,LLC, Fredericksburg, Texas
Conditions: Diabetic Peripheral Neuropathic Pain
Efficacy of Guided Imagery Therapy Mobile Application for Functional Abdominal Pain
Recruiting
Chronic abdominal pain is common among children, and the majority of cases are attributed to functional abdominal pain disorders. One approach to treating these disorders is by using psychological therapies. This clinical trial aims to see how well pre-recorded guided imagery therapy sessions help children's abdominal pain when delivered via a mobile application (app) on a smartphone or tablet. Participants will complete a baseline abdominal pain and stooling diary to determine eligibility and... Read More
Gender:
ALL
Ages:
Between 7 years and 12 years
Trial Updated:
08/07/2025
Locations: Baylor College of Medicine / Texas Children's Hospital, Houston, Texas
Conditions: Functional Abdominal Pain Disorders, Irritable Bowel Syndrome (IBS), Functional Gastrointestinal Disorders, Functional Colonic Disease, Gastrointestinal Disease, Digestive System Diseases, Neurological Manifestations, Signs and Symptoms, Digestive, Pain, Abdominal Pain/ Discomfort
An Efficacy and Safety Study of LTG-001 Following Abdominoplasty
Recruiting
The goal of this clinical trial is to learn if LTG-001 works to treat post-operative / acute pain after an abdominoplasty procedure. It will also learn more information on the safety of LTG-001. The main questions it aims to answer are: Does drug LTG-001 treat the acute pain after surgical abdominoplasty over 48 hours? How tolerable is LTG-001 over 48 hours? What dose of LTG-001 is better for treating post-operative / acute pain? Participants will: Take LTG-001 bid after the surgical abdomin... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
08/07/2025
Locations: HD Research LLC, Houston, Texas +1 locations
Conditions: Acute Pain, Postoperative Pain Control
Progressive Achilles Loading Via Clinician E-support
Recruiting
This is a randomized controlled trial with individuals who have Achilles tendon pain. This study is designed to identify an effective rehabilitation program for Achilles tendon pain that expands access to care for military personnel and to predict treatment response. Limited or delayed access to healthcare can exacerbate the severity of pain and duration of disability due to AT. This is particularly relevant for individuals deployed to battlefield settings or are being seen in busy military trea... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
08/05/2025
Locations: Carl R. Darnall Army Medical Center (CRDAMC), Fort Cavazos, Texas
Conditions: Achilles Tendon Pain, Achilles Tendinopathy