The state of Texas currently has 21 active clinical trials seeking participants for Epilepsy research studies. These trials are conducted in various cities, including Houston, Dallas, San Antonio and Austin.
A Study to Determine if BHV-7000 is Effective and Safe in Adults With Refractory Focal Onset Epilepsy
Recruiting
The purpose of this study is to determine whether BHV-7000 is effective in the treatment of refractory focal epilepsy.
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
03/22/2024
Locations: Clinical Research Solutions LLC, Cypress, Texas +4 locations
Conditions: Focal Epilepsy
PRIME: PReservIng Memory in Epilepsy
Recruiting
In this study, participants will receive unilateral Deep Brain Stimulation (DBS) for treatment of epilepsy, with network-based stimulation targets specifically defined using a stereo-electro-encephalographic evaluation and chronic recordings using the Medtronic Percept™ primary cell (PC) Neurostimulator DBS System with BrainSense™ Technology. The hypothesis is that, compared to no stimulation or to standard duty cycle high frequency stimulation, epilepsy neuromodulation using low frequency stimu... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
03/05/2024
Locations: The University of Texas Science Center at Houston, Houston, Texas
Conditions: Mesial Temporal Lobe Epilepsy
Randomized, Double-Blind Study to Evaluate Efficacy and Safety of Cenobamate Adjunctive Therapy in PGTC Seizures
Recruiting
This trial is intended to study the safety and effectiveness of an new anti-epileptic drug (AED) on Primary Generalized Tonic-Clonic (PGTC) Seizures. Eligible Subjects, adults and adolescents, will continue to take their usual AEDs and receive either cenobamate or placebo. Subjects will have a 50% chance or receiving cenobamate or placebo (sugar pill). Subjects will initially receive 12.5 mg of cenobamate or placebo (study drug) and increase the dose every two weeks until they reach a target dos... Read More
Gender:
All
Ages:
12 years and above
Trial Updated:
02/27/2024
Locations: Child Neurology Consultants of Austin, Austin, Texas +2 locations
Conditions: Primary Generalized Epilepsy
Epilepsy Learning Healthcare System (ELHS)
Recruiting
The Epilepsy Learning Health System (ELHS) is a quality improvement and research network to improve outcomes for people with epilepsy. The ELHS is designed as a model of value-based chronic care for epilepsy as envisioned by the National Academies of Medicine Committee in their landmark reports "The Learning Health System" and "Epilepsy Across the Spectrum: Promoting Health and Understanding". The ELHS network is a collaboration among clinicians, patients and researchers that promotes the use o... Read More
Gender:
All
Ages:
All
Trial Updated:
02/15/2024
Locations: UT Southwestern Children's Dallas, Dallas, Texas
Conditions: Epilepsy, Seizure Disorder, Neurologic Disorder, Rare Diseases
Safety and Efficacy Study of Cenobamate in Pediatric Subjects 2-17 Years of Age With Partial-onset (Focal) Seizures
Recruiting
Primary objective: To evaluate the safety and tolerability of cenobamate in pediatric subjects 2-17 years of age with partial-onset (focal) seizures
Gender:
All
Ages:
Between 2 years and 18 years
Trial Updated:
01/30/2024
Locations: Child Neurology Consultants of Austin, Austin, Texas +1 locations
Conditions: Partial Epilepsy
Human Epilepsy Project 3
Recruiting
By carrying a careful, large-scale and ambitious prospective study of a cohort of participants with generalized epilepsy, the study team hopes to clarify the likelihood of response and remission in this type of epilepsy, and try to explore the underlying biological drivers of treatment response, including novel realms of exploration such as impact of the microbiome, and genetics. The identification of biomarkers that predict the likelihood of disease response would allow epilepsy patients to mak... Read More
Gender:
All
Ages:
13 years and above
Trial Updated:
01/24/2024
Locations: University of Texas Health Science Center, San Antonio, Texas
Conditions: Idiopathic Generalized Epilepsy
FIH Study of NRTX-1001 Neural Cell Therapy in Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy
Recruiting
This clinical trial is designed to test whether a single stereotactic intracerebral administration of inhibitory nerve cells into subjects with drug-resistant mesial temporal lobe epilepsy is safe (frequency of adverse events) and effective (seizure frequency).
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
01/19/2024
Locations: UTHealth Houston, Houston, Texas
Conditions: Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis
Acute Modulation of Stereotyped High-Frequency Oscillations
Recruiting
Overall, this study will investigate the functional utility of stereotyped HFOs by capturing them with a new implantable system (Brain Interchange - BIC of CorTec), which can sample neural data at higher rates >=1kHz and deliver targeted electrical stimulation to achieve seizure control. In contrast to current closed-loop systems (RNS), which wait for the seizure to start before delivering stimulation, the BIC system will monitor the spatial topography and rate of stereotyped HFOs and deliver ta... Read More
Gender:
All
Ages:
Between 3 years and 70 years
Trial Updated:
01/18/2024
Locations: Baylor College of Medicine, Houston, Texas +1 locations
Conditions: Epilepsy
Breathing Rescue for SUDEP Prevention
Recruiting
The purpose of this study is to precisely delineate human brain networks that modulate respiration and identify specific brain areas and stimulation techniques that can be used to prevent seizure-induced breathing failure.
Gender:
All
Ages:
18 years and above
Trial Updated:
12/11/2023
Locations: The University of Texas Health Science Center at Houston, Houston, Texas
Conditions: Focal Epilepsy
A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Lacosamide in Neonates With Repeated Electroencephalographic Neonatal Seizures
Recruiting
The purpose of the study is to evaluate the efficacy of lacosamide (LCM) versus an Active Comparator chosen based on standard of care (StOC) in severe and nonsevere seizure burden (defined as total minutes of electroencephalographic neonatal seizures (ENS) per hour) in neonates with seizures that are not adequately controlled with previous anti-epileptic drug (AED) treatment.
Gender:
All
Ages:
28 days and below
Trial Updated:
11/20/2023
Locations: Sp0968 109, Austin, Texas
Conditions: Electroencephalographic Neonatal Seizures, Epilepsy
SLC13A5 Deficiency Natural History Study - United States Only
Recruiting
SLC13A5 deficiency (Citrate Transporter Disorder, EIEE 25) is a rare genetic disorder with neurodevelopmental delays and seizure onset in the first few days of life. This natural history study is designed to address the lack of understanding of disease progression. Additionally it will identify clinical and biomarker endpoints for use in future clinical trials.
Gender:
All
Ages:
All
Trial Updated:
11/17/2023
Locations: University of Texas Southwestern Dallas, Dallas, Texas
Conditions: Citrate Transporter Deficiency, Epilepsy, Rare Diseases, Movement Disorders, Genetic Disorder, SLC13A5 Deficiency, EIEE25, Kohlschutter-Tonz Syndrome (Non-ROGDI), Citrate Transporter Disorder, DEE25
Brain Metabolism Observed at 7 Tesla
Recruiting
The goal is to develop methodology to monitor flux in the citric acid cycle in brain via 13C nuclear magnetic resonance (NMR) spectroscopy at 7 Tesla.
Gender:
All
Ages:
Between 16 years and 65 years
Trial Updated:
10/23/2023
Locations: UT Southwestern Medical Center, Dallas, Texas
Conditions: Glut1 Deficiency Syndrome 1, Glucose Metabolism Disorders, Epilepsy, Glut1 Deficiency Syndrome 1, Autosomal Recessive, Glucose Transporter Type 1 Deficiency Syndrome, Glucose Transporter Protein Type 1 Deficiency Syndrome, Glucose Transport Defect