Phase 1b/2 Study Testing Radium-223 Dichloride/Bortezomib/Dexamethasone Combination in Relapsed Multiple Myeloma
Withdrawn
This study will be conducted in 2 parts. The phase 1b part will be an international, phase 1b, open-label, dose-escalation assessment of radium-223 dichloride administered with bortezomib and dexamethasone in subjects with relapsed multiple myeloma. The primary endpoint of the phase 1b part is to determine the optimal dose of radium-223 dichloride in combination with bortezomib/dexamethasone for the Phase 2 portion of the study. The phase 2 part will be an international, phase 2, double-blind,... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/06/2016
Locations: Not set, Scottsdale, Arizona +57 locations
Conditions: Multiple Myeloma
Extinction of Fear Memories With Glucocorticoids in Veterans With PTSD
Completed
The purpose of this study is to examine the effects of glucocorticoid administration following traumatic memory reactivation on psychiatric symptoms in veterans with combat-related PTSD, in addition to examining the effects of glucocorticoid administration following traumatic memory reactivation on physiological responses to veteran's personal combat memories. The following hypotheses will be tested: 1. Subjects who receive an exogenous glucocorticoid after traumatic memory reactivation will de... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
10/04/2016
Locations: VA North Texas Health Care System, Dallas, Dallas, Texas
Conditions: Posttraumatic Stress Disorder
Multiple Ascending Dose (MAD) Combination in Subjects With Multiple Myeloma
Completed
To evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of BMS-833923 administered alone, in combination with lenalidomide plus dexamethasone, or in combination with bortezomib in subjects with relapsed or refractory multiple myeloma.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/28/2016
Locations: City Of Hope National Medical Center, Duarte, California +7 locations
Conditions: Advanced Cancer, Various, NOS
Disrupting the Bone Marrow Microenvironment With G-CSF in Acute Lymphoblastic Leukemia
Completed
The purpose of this study is to determine the ability of G-CSF to disrupt the bone marrow microenvironment as a means to increase the efficacy of chemotherapy in patients with relapsed or refractory acute lymphoblastic leukemia (ALL).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/19/2016
Locations: University of Chicago Medical Center, Chicago, Illinois +1 locations
Conditions: Precursor Cell Lymphoblastic Leukemia-Lymphoma
Carfilzomib in Treating Patients With Multiple Myeloma in First Relapse or Refractory to First-Line Therapy
Terminated
This phase II trial studies how well carfilzomib works in treating patients with multiple myeloma in first relapse or refractory to first-line therapy. Carfilzomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/14/2016
Locations: Indiana University Cancer Center, Indianapolis, Indiana
Conditions: Refractory Multiple Myeloma
Revlimid / All-Trans Retinoic Acid (ATRA) / Dexamethasone in Relapsed/Refractory Multiple Myeloma
Terminated
The goal of the Phase I portion of this clinical research study is to find the highest tolerated dose of the combination of lenalidomide, all-trans retinoic acid (ATRA), and dexamethasone that can be given to patients with relapsed or refractory multiple myeloma (MM). The goal of the Phase II portion of this study is to learn if ATRA when given in combination with lenalidomide alone or with lenalidomide and dexamethasone can help to control multiple myeloma. In September 2015, the study was te... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/12/2016
Locations: University of Texas MD Anderson Cancer Center, Houston, Texas
Conditions: Myeloma
Lenalidomide, Rituximab, Cyclophosphamide, and Dexamethasone in Treating Patients With Previously Untreated Low-Grade Non-Hodgkin Lymphoma
Completed
RATIONALE: Lenalidomide may stop the growth of cancer cells by blocking blood flow to the cancer. Monoclonal antibodies, such as rituximab, can block cancer growth in different ways. Some block the ability of cancer cells to grow and spread. Others find cancer cells and help kill them or carry cancer-killing substances to them. Drugs used in chemotherapy, such as cyclophosphamide and dexamethasone, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopp... Read More
Gender:
ALL
Ages:
Between 18 years and 120 years
Trial Updated:
08/25/2016
Locations: Mayo Clinic in Arizona, Scottsdale, Arizona +1 locations
Conditions: Lymphoma
Diabetic Macular Edema Treated With Ozurdex (DMEO)
Completed
To measure various pro-permeability factors in the aqueous humor of patients with persistent/recurrent diabetic macular edema
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
08/23/2016
Locations: Wilmer Eye Institute, Baltimore, Maryland
Conditions: Diabetic Macular Edema
Decreasing Narcotics in Advanced Pelvic Surgery
Completed
In recent years, there has been an emphasis on the creation of "enhanced-recovery", "fast-track" or "multi-modal" pathways to improve perioperative care (1-4). The goal of these programs is to reduce the length of hospital stay, decrease narcotic usage while improving pain control, accelerate post-operative recovery, and expedite return to baseline functional status. Pathways often are developed by a team of surgeons, nurses, pain specialists, anesthesiologists and other support staff. Postopera... Read More
Gender:
FEMALE
Ages:
Between 18 years and 100 years
Trial Updated:
08/15/2016
Locations: Hartford Hosptial, Hartford, Connecticut
Conditions: Narcotic Use, Pain, Constipation, Nausea
Open-label, Multli-center, Phase 1b/2a Clinical Trial Designed to Evaluate the Safety and Efficacy of Iontophoretic Dexamethasone Phosphate Ophthalmic Solution in Patients With Macular Edema
Terminated
To evaluate the safety and efficacy of ocular iontophoresis with dexamethasone phosphate ophthalmic solution, EGP-437, using the EyeGate® II Drug Delivery System (EGDS) in patients with macular edema (ME)
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
08/01/2016
Locations: Ophthalmic Consultants of Boston, Boston, Massachusetts
Conditions: Macular Edema
Dexamethasone Intravitreal Implant After Vitrectomy For Epiretinal Membrane
Terminated
The purpose of this study is to evaluate the effect of dexamethasone intravitreal implant (Ozurdex) in combination with pars plana vitrectomy and membrane peeling for idiopathic epiretinal membrane (ERM).
Gender:
ALL
Ages:
All
Trial Updated:
07/26/2016
Locations: St. Lukes Hospital, Chesterfield, Missouri +2 locations
Conditions: Epiretinal Membrane, Macular Edema
Chemotherapy and Whole-Brain Radiation Therapy in Treating Patients With Primary Central Nervous System Non- Hodgkin's Lymphoma
Completed
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining radiation therapy with chemotherapy may kill more tumor cells and may be an effective treatment for non-Hodgkin's lymphoma. PURPOSE: Phase II trial to study the effectiveness of combination chemotherapy and whole-brain radiation therapy in patients with primary central nervous system non-Hodgkin's lymph... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
07/12/2016
Locations: CCOP - Scottsdale Oncology Program, Scottsdale, Arizona +20 locations
Conditions: Lymphoma