Effect of Intraoperative Dexamethasone on Post-op Dry Eye
NCT04184999
Completed
To compare the signs and symptoms of dry eye after cataract surgery between subjects randomized to receive intraoperative dexamethasone in addition to the use of a standard topical post-op treatment regimen.
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
11/20/2023
Locations: Hauser Ross Surgical Center, Sycamore, Illinois
Conditions: Dry Eye Syndromes
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Bortezomib and Pembrolizumab With or Without Pelareorep for the Treatment of Relapsed or Refractory Multiple Myeloma, AMBUSH Trial
NCT05514990
Recruiting
This phase I/II trial studies the safety of the combination of bortezomib, dexamethasone, and pembrolizumab with or without pelareorep in treating patients with multiple myeloma that has come back (relapsed) or does not response to treatment (refractory). Chemotherapy drugs, such as bortezomib and dexamethasone, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Immunotherapy with monoclonal... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/15/2023
Locations: Los Angeles County-USC Medical Center, Los Angeles, California +1 locations
Conditions: Recurrent Plasma Cell Myeloma, Refractory Plasma Cell Myeloma
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DS-1594b With or Without Azacitidine, Venetoclax, or Mini-HCVD for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia or Acute Lymphoblastic Leukemia
NCT04752163
Completed
This phase I/II trial studies the effect of DS-1594b with or without azacitidine, venetoclax, or mini-HCVD in treating patients with acute myeloid leukemia or acute lymphoblastic leukemia that has come back (recurrent) or not responded to treatment (refractory). Chemotherapy drugs, such as azacitidine, venetoclax, and mini-HCVD, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. DS-1594b may... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/14/2023
Locations: M D Anderson Cancer Center, Houston, Texas
Conditions: Hematopoietic and Lymphoid Cell Neoplasm, Recurrent Acute Lymphoblastic Leukemia, Recurrent Acute Myeloid Leukemia, Recurrent Chronic Myelomonocytic Leukemia, Recurrent Myelodysplastic Syndrome, Refractory Acute Lymphoblastic Leukemia, Refractory Acute Myeloid Leukemia, Refractory Chronic Myelomonocytic Leukemia, Refractory Myelodysplastic Syndrome
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A Phase II Trial of Neoadjuvant Laparoscopic Hyperthermic Intraperitoneal Chemotherapy (HIPEC) With Chemoradiation
NCT04308837
Recruiting
Stomach cancer is the fifth most common digestive cancer and third main cause of death from cancer in the world. Modern management of Gastric cancer involves a multi-disciplinary approach involving surgical oncologists, medical oncologists, gastroenterologists and oncological radiologists. The most common clinical approach to Gastric adenocarcinoma is to begin with staging, which usually involves CT scan/ MRI combined with endoscopic US for more accurate T, N staging. Once the patient is deemed... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/13/2023
Locations: Mount Sinai West, New York, New York +2 locations
Conditions: Gastric Cancer, Stomach Cancer
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A Study of BBI608 in Adult Patients With Advanced, Refractory Hematologic Malignancies
NCT02352558
Completed
This is a multicenter, open label, Phase 1 dose-escalation study of BBI608 administered to patients with relapsed, refractory hematologic malignancies, including multiple myeloma, lymphoma, and others.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/13/2023
Locations: Rocky Mountain Cancer Centers, Denver, Colorado +7 locations
Conditions: Hematologic Malignancy
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Low Dose Aprepitant for Patients Receiving Carboplatin
NCT03237611
Terminated
This study evaluates a simple one day prophylaxis of nausea and vomiting for patients who are getting carboplatin based chemotherapy. In addition to standard oral Dexamethasone and oral Ondansetron, participants will be given a third neurokinin 1 (NK1) antagonist agent, either a single dose of oral Aprepitant or intravenous (IV) Fosaprepitant (they have been shown to be equally effective) to improve prevention of nausea and vomiting. No medications need to be taken beyond day 1.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/09/2023
Locations: Jacobi Medical Center, Bronx, New York +1 locations
Conditions: Chemotherapy-induced Nausea and Vomiting
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Pomalidomide and Dexamethasone With or Without Ixazomib in Treating Patients With Relapsed Multiple Myeloma
NCT02004275
Active Not Recruiting
This randomized phase I/II trial studies the side effects and best dose of pomalidomide and ixazomib when given together with dexamethasone and to see how well pomalidomide and dexamethasone with or without ixazomib works in treating patients with multiple myeloma that has come back. Biological therapies, such as pomalidomide and dexamethasone, may stimulate the immune system in different ways and stop cancer cells from growing. Ixazomib may stop the growth of cancer cells by blocking some of th... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/09/2023
Locations: Anchorage Associates in Radiation Medicine, Anchorage, Alaska +335 locations
Conditions: Multiple Myeloma in Relapse
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MUA to Treat Postoperative Stiffness After Total Knee Arthroplasty
NCT02739035
Completed
Compare the outcome following manipulation under anesthesia for stiffness in a randomized controlled fashion with one group receiving IV dexamethasone and oral celecoxib at the time of manipulation to a control group receiving manipulation alone. Outcomes will include pain, range of motion, as well as subjective outcome scores.
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
11/02/2023
Locations: HipKnee Arkansas Foundation, Little Rock, Arkansas +15 locations
Conditions: Stiffness Following Total Knee Arthroplasty
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Hormonal Mechanisms of Sleep Restriction - Axis Study in Older Men and Postmenopausal Women
NCT04037605
Active Not Recruiting
The purpose of this study is to 1) determine how hypothalamic-pituitary-adrenal axis (HPA axis) activation occurs with sleep restriction and 2) evaluate how hypothalamic-pituitary-gonadal axis (HPG axis) deactivation occurs with sleep restriction. The investigator will also examine the cognitive function associated with sleep restriction, including food intake and food cravings.
Gender:
ALL
Ages:
Between 60 years and 80 years
Trial Updated:
11/02/2023
Locations: Los Angeles Biomedical Research Institute, Torrance, California
Conditions: Sleep Restriction
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Transforaminal Versus Lateralized Interlaminar Cervical Epidurals
NCT03389620
Completed
The purpose of this study is to compare two methods of giving epidural steroid injections for nerve pain in the arm that comes from the neck. An epidural steroid injection can be given in two different ways, either in the back of the spine within the neck or in the neck next to the nerve root going to the arm. Both are standard medical treatments. The investigators would like to see how effective these treatments are, and if there are any differences in effectiveness or safety between these two... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/01/2023
Locations: Duke Radiology and Orthopaedic Clinic, Durham, North Carolina
Conditions: Cervicogenic Upper Extremity Radiculopathy
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Rescue Quadratus Lumborum Blocks for Post-cesarean Pain
NCT04397458
Withdrawn
The purpose of this study is to assess whether quadratus lumborum (QL) block performed 1 day after cesarean delivery will provide supplemental post-cesarean analgesia and reduce opioid requirements.
Gender:
FEMALE
Ages:
Between 18 years and 50 years
Trial Updated:
11/01/2023
Locations: The University of Texas Health Science Center at Houston, Houston, Texas
Conditions: Morphine, Analgesics, Analgesics, Opioid, Peripheral Nervous System Agents
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Pomalidomide for Lenalidomide for Relapsed or Refractory Multiple Myeloma Patients
NCT02188368
Terminated
The purpose of this clinical research study is to evaluate the safety and effectiveness (good and bad effects) of pomalidomide given as part of a combination therapy that include more than just steroids to treat subjects with relapsed (subjects whose disease came back) or refractory (subjects whose disease did not respond to past treatment) multiple myeloma (MM). Pomalidomide (alone or in combination with dexamethasone) has been approved by the United States Food and Drug Administration (FDA) f... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/01/2023
Locations: California Cancer Associates for Research & Excellence (cCARE), Encinitas, California +11 locations
Conditions: Multiple Myeloma
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