Transforaminal Versus Lateralized Interlaminar Cervical Epidurals
NCT03389620
Completed
The purpose of this study is to compare two methods of giving epidural steroid injections for nerve pain in the arm that comes from the neck. An epidural steroid injection can be given in two different ways, either in the back of the spine within the neck or in the neck next to the nerve root going to the arm. Both are standard medical treatments. The investigators would like to see how effective these treatments are, and if there are any differences in effectiveness or safety between these two... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/01/2023
Locations: Duke Radiology and Orthopaedic Clinic, Durham, North Carolina
Conditions: Cervicogenic Upper Extremity Radiculopathy
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Weekly 70 mg/m2 Carfilzomib for Multiple Myeloma Patients Refractory to 27 mg/m2 Carfilzomib
NCT02294357
Terminated
The purpose of this Phase II study is to evaluate the safety and effectiveness (good and bad effects) of carfilzomib given as a 30-minute infusion and at a dose of 70 mg/m2 to treat patients with multiple myeloma (MM), who are currently showing progressive disease (worsening) and had progressed (did not respond to treatment) within 8 weeks of receiving treatment with twice weekly 27mg/m2 of carfilzomib. Carfilzomib is approved by the U.S. Food and Drug Administration (FDA) to be used only in cer... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/30/2023
Locations: California Cancer Associates for Research & Excellence (cCARE), Encinitas, California +6 locations
Conditions: Multiple Myeloma
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Ixazomib as a Replacement for Carfilzomib and Bortezomib for Multiple Myeloma Patients
NCT02206425
Completed
The goal of this clinical research study is to evaluate the safety and effectiveness (good and bad effects) of ixazomib given as part of a combination therapy to treat subjects with relapsed (subjects whose disease came back) or refractory (subjects whose disease did not respond to past treatment) multiple myeloma. More specifically, the study is focused on subjects who were previously treated with bortezomib (Velcade®) or carfilzomib (Kyprolis®) and showed worsening of their myeloma while recei... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/30/2023
Locations: Comprehensive Blood and Cancer Center, Bakersfield, California +11 locations
Conditions: Multiple Myeloma
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Pomalidomide, Ixazomib Citrate, and Dexamethasone in Treating Patients With Previously Treated Multiple Myeloma or Plasma Cell Leukemia
NCT02547662
Completed
This phase II trial studies how well pomalidomide, ixazomib citrate, and dexamethasone work in treating patients with previously treated multiple myeloma or plasma cell leukemia. Biological therapies, such as pomalidomide and dexamethasone, use substances made from living organisms that may stimulate or suppress the immune system in different ways and stop cancer cells from growing. Ixazomib citrate may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Givin... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/26/2023
Locations: Mayo Clinic, Rochester, Minnesota +1 locations
Conditions: Plasma Cell Leukemia, Plasma Cell Myeloma, Plasmacytoma
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Evaluation of Adrenal Androgens in Normal and Obese Girls After Suppression and Stimulation
NCT01421797
Active Not Recruiting
Women with polycystic ovary syndrome (PCOS) often have irregular menstrual periods, too much facial and body hair, and weight gain. Women with PCOS also have a hard time becoming pregnant. Girls with high levels of the male hormone testosterone often develop PCOS as adults. Some girls with high levels of male hormone will develop normal hormone levels as they grow up, but most girls continue to have high levels of male hormone as adults. The purpose of this study is to understand where the male... Read More
Gender:
FEMALE
Ages:
Between 7 years and 18 years
Trial Updated:
10/25/2023
Locations: University of Virginia Center for Research in Reproduction, Charlottesville, Virginia
Conditions: Hyperandrogenemia, Polycystic Ovary Syndrome, Obesity
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Ovarian Contribution to Androgen Production in Adolescent Girls
NCT01421810
Active Not Recruiting
Women with polycystic ovary syndrome (PCOS) can have unwanted facial or male-patterned body hair, irregular menstrual periods, or no menstrual periods excess body weight, and infertility. It also results in elevated androgen levels such as testosterone. In women with PCOS, the majority of excess androgens are produced by the ovaries. However, it is unknown whether the ovaries are fully active during early puberty. The purpose of this study is to determine how the ovaries contribute to the produc... Read More
Gender:
FEMALE
Ages:
Between 7 years and 18 years
Trial Updated:
10/25/2023
Locations: University of Virginia Center for Research in Reproduction, Charlottesville, Virginia
Conditions: Polycystic Ovary Syndrome, Obesity, Hyperandrogenism
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Chemoimmunotherapy and Allogeneic Stem Cell Transplant for NK T-cell Leukemia/Lymphoma
NCT03719105
Recruiting
Patients are in 2 cohorts: Cohort 1: dexamethasone, methotrexate, ifosfamide, pegaspargase, and etoposide (modified SMILE) chemotherapy regimen alone and pembrolizumab in children, adolescents, and young adults with advanced stage NK lymphoma and leukemia Cohort 2: combining pralatrexate (PRX) (Cycles 1, 2, 4, 6) and brentuximab vedotin (BV) (Cycles 3, 5) to cyclophosphamide, doxorubicin, and prednisone in children, adolescent, and young adults with advanced peripheral T-cell lymphoma (non-anap... Read More
Gender:
ALL
Ages:
Between 1 year and 31 years
Trial Updated:
10/24/2023
Locations: University of Alabama, Birmingham, Alabama +5 locations
Conditions: NK-Cell Lymphoma, NK-Cell Leukemia, Peripheral T Cell Lymphoma
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APG-2575 in Combination With Novel Therapeutic Regimens in Subjects With Relapsed or Refractory Multiple Myeloma
NCT04942067
Recruiting
This is a Phase Ib/II, open-label, multi-center study evaluating the safety, tolerability, efficacy, and PK/ Pharmacodynamics of APG-2575 in combination with Pd/DRd in patients with relapsed/refractory (RR) multiple myeloma (MM). The study consists of dose escalation and dose expansion phases. The study consists of will start with 2 arms noted below, both arms are independent
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/23/2023
Locations: Mayo Clinic, Jacksonville, Florida +2 locations
Conditions: Multiple Myeloma, Amyloidosis
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Randomized Controlled Trial Assessing the Effect of Dexamethasone on Postoperative Function After Distal Radius Fixation
NCT04889547
Completed
The study is designed to assess the use of intraoperative dexamethasone on postoperative analgesia and stiffness after open reduction and internal fixation of distal radius fractures. The idea is that the dexamethasone will aid in reducing postoperative swelling which will then improve pain control as well as overall function.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/19/2023
Locations: North Shore University Hospital, Manhasset, New York
Conditions: Distal Radius Fracture
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Perivenous Dexamethasone Therapy: Examining Reduction of Inflammation After Thrombus Removal to Yield Benefit in Subacute and Chronic Iliofemoral DVT
NCT04858776
Recruiting
This is a study of a medical procedure that utilizes a commercially available catheter (the Bullfrog® Micro-Infusion Device) to locally deliver a commercially available anti-inflammatory drug (dexamethasone sodium phosphate injection) around the deep veins after DVT recanalization, where DVT symptoms were present for at least 14 days and no more than 60 days prior to recanalization. The goal of the study is to see if local anti-inflammation helps prevent re-thrombosis of the blood vessel and imp... Read More
Gender:
ALL
Ages:
Between 18 years and 89 years
Trial Updated:
10/17/2023
Locations: Vascular Care Connecticut, Darien, Connecticut +14 locations
Conditions: Iliofemoral; Thrombosis
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RAD001 Plus Docetaxel in Patients With Metastatic Breast Cancer
NCT00253318
Terminated
Primary: * To assess the safety and tolerability and to find the maximum tolerated dose of the combination administration of RAD001 plus docetaxel when given to patients with metastatic breast cancer who are being considered for standard docetaxel treatment (phase I). * To characterize the pharmacokinetics of RAD001 and docetaxel when co-administered (phase I). Secondary: * To determine the phosphorylation status of the components of the mTOR signaling pathway and the expression of modifiers... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/11/2023
Locations: UT MD Anderson Cancer Center, Houston, Texas
Conditions: Breast Cancer
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Blinatumomab in Combination With AMG 404 for the Treatment of Adults With Relapsed or Refractory B Cell Precursor ALL
NCT04524455
Completed
The primary objective of this phase 1b study is to evaluate the safety and tolerability of blinatumomab and AMG 404 in combination in adults with R/R B-ALL and to estimate the maximum tolerated dose (MTD) and recommended phase 2 dose (RP2D) of AMG 404 when combined with continuous intravenous infusion (cIV) blinatumomab.
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
10/11/2023
Locations: City of Hope National Medical Center, Duarte, California +18 locations
Conditions: Acute Lymphoblastic Leukemia
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