Ixazomib, Cyclophosphamide and Dexamethasone for Multiple Myeloma
Unknown
The goal of this proposal is to develop a more effective and better tolerated regimen. Ixazomib appears to have greater activity than bortezomib with less peripheral neuropathy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/21/2022
Locations: Memorial Hospital of Rhode Island, Pawtucket, Rhode Island +2 locations
Conditions: Multiple Myeloma
Liposomal Bupivacaine vs Dexamethasone ISB
Completed
In this study, patients receiving shoulder arthroscopy will receive an interscalene block for pain management containing either liposomal bupivacaine and standard bupivacaine or standard bupivacaine and dexamethasone. Patients will be followed up with to determine postoperative pain and block duration.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
07/07/2022
Locations: Hospital for Special Surgery, New York, New York
Conditions: Shoulder Pain
Pro-permeability and Pro-fibrosis Factors in the Aqueous of Patients With Retinal Diseases
Terminated
This study will examine potential factors in the aqueous humor that may contribute to the development or progression of macular edema or fibrosis (due to any underlying disease) in patients suffering from these conditions.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/05/2022
Locations: Wilmer Eye Institute, Baltimore, Maryland
Conditions: Macular Edema, Fibrosis of the Retina
Adaptive COVID-19 Treatment Trial 4 (ACTT-4)
Completed
ACTT-4 will evaluate the combination of baricitinib and remdesivir compared to dexamethasone and remdesivir. Subjects will be assessed daily while hospitalized. If the subjects are discharged from the hospital, they will have a study visit at Days 15, 22, and 29. For discharged subjects, it is preferred that the Day 15 and 29 visits are in person to obtain safety laboratory tests, oropharyngeal (OP) swabs, plasma (Day 29), and serum for secondary research as well as clinical outcome data. Howeve... Read More
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
06/22/2022
Locations: University of Alabama at Birmingham School of Medicine - Infectious Disease, Birmingham, Alabama +71 locations
Conditions: COVID-19
A Comparison of Dexamethasone and Triamcinolone for Ultrasound-guided Occipital C2 Nerve Blocks
Withdrawn
Greater occipital nerve (GON) injection is a commonly performed diagnostic and therapeutic procedure in headache patients. GON blocks have been shown to be effective in the treatment of a variety of headaches including occipital neuralgia, migraine, vascular headache, cluster headache, cervicogenic headache, and post-concussive headache. Local anesthetic and steroids have been successfully used for diagnostic and or therapeutic nerve pain such as lumbar radicultis with great success. Dexamethaso... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
06/17/2022
Locations: Northwestern University, Feingberg School of Medicine, Chicago, Illinois
Conditions: Headache
Daratumumab, Pomalidomide, and Dexamethasone in Treating Patients With Relapsed Multiple Myeloma
Withdrawn
This phase II trial studies how well daratumumab, pomalidomide, and dexamethasone work in treating patients with multiple myeloma that has come back (relapsed). Immunotherapy with daratumumab may induce changes in body's immune system and may interfere with the ability of cancer cells to grow and spread. Drugs used in chemotherapy, such as pomalidomide and dexamethasone, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/13/2022
Locations: Cancer Center of Kansas - Wichita, Wichita, Kansas +4 locations
Conditions: Recurrent Plasma Cell Myeloma
Study of Pembrolizumab With Pemetrexed and Oxaliplatin in Chemo-Refractory Metastatic Colorectal Cancer Patients
Unknown
This is a Phase Ib study to evaluate the safety and preliminary anti-tumor activity of pembrolizumab in combination with pemetrexed with or without oxaliplatin in patients with chemo-refractory microsatellite stable (MSS) metastatic colorectal cancer (mCRC) without any further standard treatment options.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/08/2022
Locations: UF Health Davis Cancer Pavilion & Shands Medical Plaza, Gainesville, Florida +14 locations
Conditions: Metastatic Colorectal Cancer
NHL16: Study For Newly Diagnosed Patients With Acute Lymphoblastic Lymphoma
Completed
This is a phase II clinical trial using risk-adapted therapy. The treatment is acute lymphoblastic leukemia (ALL)-based therapy, using multi-agent regimens comprising of induction, consolidation, and continuation (maintenance) phases delivered over 24-30 months. Participants will be classified into 3 treatment stratums, based on bone marrow/peripheral blood lymphoma cells involvement at diagnosis and day 8 for T-lymphoblastic lymphoma and bone marrow/peripheral blood lymphoma cells involvement a... Read More
Gender:
ALL
Ages:
21 years and below
Trial Updated:
06/07/2022
Locations: Rady Children's Hospital San Diego, San Diego, California +1 locations
Conditions: Lymphoblastic Lymphoma
Hormone Therapy and Radiation Therapy or Hormone Therapy and Radiation Therapy Followed by Docetaxel and Prednisone in Treating Patients With Localized Prostate Cancer
Completed
RATIONALE: Androgens can cause the growth of prostate cancer cells. Hormone therapy using drugs, such as leuprolide, goserelin, flutamide, or bicalutamide, may fight prostate cancer by lowering the amount of androgens the body makes. Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as docetaxel and prednisone, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. It is not yet known... Read More
Gender:
MALE
Ages:
Between 18 years and 120 years
Trial Updated:
05/23/2022
Locations: UAB Comprehensive Cancer Center, Birmingham, Alabama +253 locations
Conditions: Prostate Cancer
Intravenous Dexamethasone on Supraclavicular Brachial Plexus Block for Shoulder Arthroscopy
Completed
Previous studies have confirmed that IV dexamethasone prolongs brachial plexus blocks. However, these studies only used fixed doses of IV dexamethasone at relatively high doses, which could potentially lead to increased glucose levels, delayed wound healing, and unintended side effects. There remains a paucity of research on the effective dose range of IV dexamethasone for the prolongation of supraclavicular blocks. The optimal dosage of IV dexamethasone for prolongation of analgesia vs. motor b... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
05/11/2022
Locations: Hospital for Special Surgery, New York, New York
Conditions: Shoulder Arthroscopy, Pain
Panobinostat, Carfilzomib, and Dexamethasone in Patients With Relapsed or Refractory Multiple Myeloma
Terminated
This phase II trial studies how well panobinostat, carfilzomib, and dexamethasone work in treating patients with multiple myeloma that has come back (relapsed) or does not respond to treatment (refractory). Panobinostat may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Chemotherapy drugs, such as carfilzomib and dexamethasone, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by sto... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/06/2022
Locations: Fred Hutch/University of Washington Cancer Consortium, Seattle, Washington
Conditions: Recurrent Plasma Cell Myeloma, Refractory Plasma Cell Myeloma
Phase III Study of Lenalidomide and Dexamethasone With or Without Elotuzumab to Treat Relapsed or Refractory Multiple Myeloma
Completed
The purpose of the study is to determine whether the addition of Elotuzumab to Lenalidomide/low-dose Dexamethasone will increase the progression free survival (PFS).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/05/2022
Locations: Northwest Alabama Cancer Center, Pc, Muscle Shoals, Alabama +215 locations
Conditions: Lymphoma, Multiple Myeloma