NA-831, Atazanavir and Dexamethasone Combination Therapy for the Treatment of COVID-19 Infection
Unknown
This Phase 2/3 trial evaluates four treatment strategies for non-critically ill hospitalized participants (not requiring ICU admission and/or mechanical ventilation) with SARS CoV-2 infection, in which participants will receive NA-831 or Atazanavir with or without Dexamethasone.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
01/31/2022
Locations: Coronavirus Research Institute- Testing Site, Los Angeles, California +30 locations
Conditions: Coronavirus Infection, Severe Acute Respiratory Infection, Severe Acute Respiratory Syndrome Coronavirus 2
Bortezomib, Rituximab and Combination Chemotherapy in Treating Participants With Mantle Cell Lymphoma
Completed
This phase I/II trial studies the side effects and best dose of bortezomib when given with rituximab and chemotherapy drugs and to see how well they work in treating participants with mantle cell lymphoma. Bortezomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Monoclonal antibodies, such as rituximab, may interfere with the ability of cancer cells to grow and spread. Drugs used in chemotherapy, such as cyclophosphamide, doxorubicin, vincristine, de... Read More
Gender:
ALL
Ages:
Between 18 years and 79 years
Trial Updated:
01/27/2022
Locations: M D Anderson Cancer Center, Houston, Texas
Conditions: Mantle Cell Lymphoma
Dexamethasone to Prevent Oral Chronic Graft-versus-Host Disease
Completed
This study will determine if a dexamethasone mouth rinse can reduce the risk of developing oral chronic graft-versus-host disease (cGVHD) in patients who have undergone a bone marrow (stem cell) transplant procedure. cGVHD is a common complication of stem cell transplantation, resulting from the donor cells attacking the transplant recipient's tissues. In oral cGVHD, the tissues in the mouth are damaged, causing painful mouth sores. Dexamethasone is a corticosteroid that is commonly used to trea... Read More
Gender:
ALL
Ages:
Between 12 years and 110 years
Trial Updated:
01/20/2022
Locations: National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda, Maryland
Conditions: Graft vs Host Disease
Evaluate Use of Caudal Nerve Blocks in Adult Penile Prosthesis
Completed
During penile prosthesis surgery, patients are given general anesthesia in combination with other pain drugs. A caudal nerve block (CNB) is a local anesthetic injected near the tailbone, in addition to general anesthesia, which can lower the need for pain drugs. The goal of this clinical research study is to learn how effective CNBs are in patients who are having penile prosthesis surgery compared to patients who only have general anesthesia by studying how long you stay in the hospital and the... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
01/20/2022
Locations: University of Texas MD Anderson Cancer Center, Houston, Texas
Conditions: Malignant Neoplasms of Male Genital Organs
Melphalan and Dexamethasone With or Without Bortezomib in Treating Patients With Previously Untreated Systemic Light-Chain Amyloidosis
Completed
This randomized phase III trial is studying melphalan and dexamethasone to see how well they work with or without bortezomib in treating patients with previously untreated systemic amyloidosis. Drugs used in chemotherapy, such as melphalan and dexamethasone, work in different ways to stop the growth of plasma cells, either by killing the cells or by stopping them from dividing. Bortezomib may stop the growth of plasma cells by blocking some of the enzymes needed for cell growth. It is not yet kn... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/12/2022
Locations: Mayo Clinic in Arizona, Scottsdale, Arizona +208 locations
Conditions: Light Chain Deposition Disease, Primary Systemic Amyloidosis
4-drug Nerve Block Versus Plain Local Anesthetic for Knee and Hip Arthroplasty Analgesia in Veterans
Completed
After total joint replacement, early hospital discharge to home (with patients capable of continuing a home-based rehabilitation program) is a cost- effective management strategy. This project will use improved local anesthetic nerve block techniques to enhance technical capability and clinical practice by (i) reducing pain and other morbidities during recovery, (ii) improving weight-bearing achievement during in-hospital physical therapy to allow for earlier return home, and (iii) continued reh... Read More
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
01/05/2022
Locations: VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania
Conditions: Pain
The DEPOT Study (Dry Eye Prescription Options for Therapy)
Completed
Assessing DEXTENZA efficacy and safety when placed within the lower eyelid canaliculus for dry eye flares in comparison to topical loteprednol suspension.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/30/2021
Locations: Inland Eye Specialists, Hemet, California +2 locations
Conditions: Dry Eye
Vorinostat,Lenalinomide and Dexamethasone in Multiple Myeloma Refractory to Previous Lenalinomide Containing Regimens
Completed
Phase IIb clinical trial to determine if resistance to a lenalidomide containing regimen can be overcome by the addition of vorinostat, in patients with relapsed and refractory multiple myeloma.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/21/2021
Locations: John Theurer Cancer Center at Hackensack University Medical Center, Hackensack, New Jersey
Conditions: Multiple Myeloma
Evaluation of Dextenza in Patients With Ocular GVHD and Effects on Ocular Surface Disease Outcomes
Withdrawn
To evaluate the safety and efficacy of Dextenza intracanalicular insert in patients with ocular graft-versus-host disease (GVHD).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/14/2021
Locations: Mass Eye and Ear, Boston, Massachusetts
Conditions: Graft Vs Host Disease
Stem Cell Transplant With Lenalidomide Maintenance in Patients With Multiple Myeloma (BMT CTN 0702)
Completed
The study is designed as a Phase III, multicenter trial of tandem autologous transplants plus maintenance therapy versus the strategy of single autologous transplant plus consolidation therapy with lenalidomide, bortezomib and dexamethasone (RVD) followed by maintenance therapy or single autologous transplant plus maintenance therapy as part of upfront treatment of multiple myeloma (MM). Lenalidomide will be used as maintenance therapy for three years in all arms.
Gender:
ALL
Ages:
70 years and below
Trial Updated:
12/08/2021
Locations: Arizona Cancer Center, Tucson, Arizona +53 locations
Conditions: Multiple Myeloma
Dexamethasone and Postoperative Delirium
Terminated
Postoperative delirium is commonly observed in elderly patients in the postanesthesia care unit (PACU) and during the first 2-3 days following surgical procedures. This is an important clinical problem in the geriatric surgical patient; morbidity and mortality rates are significantly higher in patients who develop delirium. At the present time, the etiology of delirium has not been precisely defined. However, studies suggest that inflammation related to the surgical stress response is an importa... Read More
Gender:
ALL
Ages:
Between 70 years and 100 years
Trial Updated:
12/06/2021
Locations: NorthShore University HealthSystem, Evanston, Illinois
Conditions: Delirium, Postoperative Cognitive Dysfunction
Study of BTK Inhibitor, Ibrutinib in Combination With Carfilzomib in Subjects With Relapsed and Refractory Multiple Myeloma
Completed
A MULTICENTER PHASE 1/2B STUDY OF THE BRUTON'S TYROSINE KINASE INHIBITOR, IBRUTINIB (PCI-32765), IN COMBINATION WITH CARFILZOMIB (KYPROLIS™) IN SUBJECTS WITH RELAPSED OR RELAPSED AND REFRACTORY MULTIPLE MYELOMA
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/24/2021
Locations: City of Hope, Duarte, California +16 locations
Conditions: Multiple Myeloma