Rituximab, Cyclophosphamide, Bortezomib, and Dexamethasone in Treating Patients With Relapsed or Refractory Low-Grade Follicular Lymphoma, Waldenstrom Macroglobulinemia, or Mantle Cell Lymphoma
NCT00711828
Completed
This phase II trial is studying how well giving rituximab and cyclophosphamide together with bortezomib and dexamethasone (R-CyBor-D) works in treating patients with relapsed or refractory low-grade follicular lymphoma, Waldenstrom macroglobulinemia, or mantle cell lymphoma. Monoclonal antibodies, such as rituximab, can block cancer growth in different ways. Some block the ability of cancer cells to grow and spread. Others find cancer cells and help kill them or carry cancer-killing substances t... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/04/2019
Locations: Mayo Clinic in Arizona, Scottsdale, Arizona +1 locations
Conditions: Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue, Nodal Marginal Zone Lymphoma, Recurrent Grade 1 Follicular Lymphoma, Recurrent Grade 2 Follicular Lymphoma, Recurrent Mantle Cell Lymphoma, Recurrent Small Lymphocytic Lymphoma, Refractory Chronic Lymphocytic Leukemia, Splenic Marginal Zone Lymphoma, Waldenstrom Macroglobulinemia
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Carfilzomib, Pegylated Liposomal Doxorubicin Hydrochloride, and Dexamethasone in Treating Patients With Relapsed or Refractory Multiple Myeloma
NCT01246063
Completed
The aim of this phase I/II trial is to determine the maximal tolerated dose (MTD) of carfilzomib together with pegylated liposomal doxorubicin hydrochloride (PLD) with or without dexamethasone, and then to establish the efficacy and safety of this novel combination in patients with relapsed or refractory multiple myeloma
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/04/2019
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Multiple Myeloma
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A Study Comparing the Combination of Trabectedin (YONDELIS) and DOXIL/CAELYX With DOXIL/CAELYX for the Treatment of Advanced-Relapsed Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancer
NCT01846611
Completed
The purpose of this study is to assess the efficacy and safety of trabectedin+DOXIL as a third-line chemotherapy regimen (treatment) in patients with platinum-sensitive advanced-relapsed epithelial ovarian, primary peritoneal, or fallopian tube cancer who received 2 previous lines of platinum-based chemotherapy.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
03/29/2019
Locations: Not set, Birmingham, Alabama +141 locations
Conditions: Ovarian Neoplasms, Peritoneal Neoplasms, Fallopian Tube Neoplasms
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Study of Oral IXAZOMIB in Combination With Lenalidomide and Dexamethasone in Participants With Newly Diagnosed Multiple Myeloma
NCT01383928
Completed
The purpose of this study is to determine the safety, tolerability, maximum tolerated dose (MTD), and recommended phase 2 dose (RP2D) in phase 1 and to determine the combined response rate of clinical response CR and very good partial response (VGPR) in phase 2 of oral (PO) ixazomib administered twice-weekly in combination with lenalidomide and low-dose dexamethasone in a 21-day cycle in participants with newly diagnosed multiple myeloma (NDDM).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/20/2019
Locations: UCSF Medical Center, Berkeley, California +19 locations
Conditions: Multiple Myeloma
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Diagnosing Natriuretic Peptide Deficiency
NCT03035929
Completed
In this pilot study, the investigators will determine the response of the natriuretic peptide (NP) hormone system after a dose of intravenous dexamethasone (a steroid medication). The goal of the proposed project is to generate preliminary data that will be used to develop power calculations, inform cutoff ranges, and inform the timing of the NP response for larger subsequent studies. Aim: To determine the range of distribution and time course of natriuretic peptide (NP) responses to a single d... Read More
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
03/20/2019
Locations: Vanderbilt University Medical Center, Nashville, Tennessee
Conditions: Healthy, Lean
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Dexamethasone Therapy in VLBW Infants at Risk of CLD
NCT00011362
Completed
Infants who are on breathing support are often treated with steroids (dexamethasone); however, the best timing of therapy is not known. This trial looked at the benefits and hazards of starting dexamethasone therapy at two weeks of age and four weeks of age in premature infants.
Gender:
ALL
Ages:
Between 13 days and 15 days
Trial Updated:
03/20/2019
Locations: Stanford University, Palo Alto, California +12 locations
Conditions: Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature, Bronchopulmonary Dysplasia
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Lenalidomide (Revlimid®) Plus Low-dose Dexamethasone (Ld x 4 Cycles) Then Stem Cell Collection Followed by Randomization to Continued Ld or Stem Cell Transplantation (SCT) Plus Maintenance L
NCT00807599
Completed
The purpose of this study is to compare the effects, good and bad, of two ways to treat patients with standard-risk symptomatic multiple myeloma. Patients with standard-risk myeloma have myeloma with specific features: levels of 2 blood tests have to be in a specific range and there can be no myeloma tumors found outside of the bones or bone marrow, the areas where myeloma is usually discovered. In past clinical studies, patients with standard-risk myeloma have done well with intensive therapy i... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
03/14/2019
Locations: Memoral Sloan Kettering Cancer Center, Basking Ridge, New Jersey +6 locations
Conditions: Multiple Myeloma
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Re-Induction Therapy for Relapsed Pediatric T-Cell Acute Lymphoblastic Leukemia or Lymphoma
NCT02518750
Terminated
This is a phase-II study to evaluate the efficacy of a salvage regimen in children with relapsed T-cell ALL or lymphoma. Peg-asparaginase, mitoxantrone, intrathecal triples (IT) (intrathecal methotrexate/hydrocortisone/cytarabine) (ITMHA) and dexamethasone are commonly used drugs to treat relapsed or refractory acute lymphocytic leukemia or lymphoma (ALL). In this study, the investigators want to know if adding three drugs called panobinostat, bortezomib and liposomal vincristine (VSLI) to this... Read More
Gender:
ALL
Ages:
21 years and below
Trial Updated:
03/08/2019
Locations: St. Jude Children's Research Hospital, Memphis, Tennessee
Conditions: Acute Lymphoblastic Leukemia, Lymphoma, Non-Hodgkin's, Leukemia, T-Cell, Leukemia, B-Cell
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Real-time Decision Support for Postoperative Nausea and Vomiting (PONV) Prophylaxis
NCT02625181
Completed
The purpose of this study is to determine how automated recommendations are best presented to optimize the adherence to guidelines on prophylaxis for nausea and vomiting after surgery.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/05/2019
Locations: Vanderbilt University Medical Center, Nashville, Tennessee
Conditions: Postoperative Nausea and Vomiting
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Combination Therapy of Lenalidomide/Bortezomib/Dexamethasone and Panobinostat in Transplant Eligible New Diagnosed Multiple Myeloma (MM) Patients
NCT01440582
Completed
The goal of this clinical research study is to find the highest tolerable dose of the drug panobinostat that can be given in combination with the drugs Velcade (bortezomib), Revlimid (lenalidomide), and Decadron (dexamethasone) to patients with MM. The safety of this drug combination will also be studied. Panobinostat is designed to cause chemical changes in different groups of proteins that are attached to DNA (the genetic material of cells), which may slow the growth of cancer cells or cause... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/01/2019
Locations: University of Texas MD Anderson Cancer Center, Houston, Texas
Conditions: Myeloma
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Trial of One Versus Two Doses of Dexamethasone for Pediatric Asthma Exacerbation
NCT02725008
Completed
Comparing one versus two doses of oral dexamethasone for the treatment of asthma in the pediatric emergency department.
Gender:
ALL
Ages:
Between 18 months and 20 years
Trial Updated:
02/25/2019
Locations: New York Methodist Hospital, Brooklyn, New York
Conditions: Asthma
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Long Term Effectiveness of Trigger Finger Injections With Triamcinolone vs. Dexamethasone
NCT03641508
Completed
Trigger finger (stenosing tenosynovitis) is a very common condition and in office treatment with corticosteroid injection is widely accepted to be first line treatment. Previous studies have reported resolution of triggering after injection at rates ranging from 50% to 93%. Many factors contribute to this variability, including duration of symptoms, presence of diabetes, etc. This study will be a single center, prospective, randomized control trial. Patients will be collected into two different... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
02/14/2019
Locations: University of Iowa, Iowa City, Iowa
Conditions: Trigger Finger Disorder
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