Steroids in Children Hospitalized With Asthma
NCT02780479
Terminated
Asthma is the most common chronic disease of children. A short (3-5 day) course of a short-acting steroid such as Prednisone or Prednisolone has long been the standard of care for asthma exacerbation. Dexamethasone efficacy in asthma exacerbation has been studied in the outpatient setting and was found to be as effective as Prednisone. Dexamethasone has the advantage of shorter course, more compliance, and more tolerable. This has led many emergency departments to provide a 1-2 dose course of De... Read More
Gender:
ALL
Ages:
Between 2 years and 18 years
Trial Updated:
06/20/2019
Locations: Wolfson Children Hospital, Jacksonville, Florida
Conditions: Asthma, Status Asthmaticus, Wheezes
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Study of Pomalidomide, Cyclophosphamide, Dexamethasone in Relapsed/Refractory Multiple Myeloma
NCT02176213
Completed
This study is being done to learn more about the drug, pomalidomide and to gather data on its safety and side effects when used in combination with commercially available cyclophosphamide and dexamethasone. This combination is considered experimental and has not been approved by the FDA. Pomalidomide is a third generation immunomodulatory (IMiDs) agent, which is a more potent version of thalidomide and lenalidomide drugs that have been approved by the United States Food and Drug Administration... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/14/2019
Locations: Icahn School of Medicine at Mount Sinai, New York, New York
Conditions: Multiple Myeloma in Relapse, Multiple Myeloma, Refractory
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Study Evaluating Chemotherapy in Combination With Inotuzumab Ozogamicin In Subjects With Non-Hodgkin's Lymphoma
NCT01055496
Completed
This is a phase 1 trial designed to evaluate safety and tolerability of chemotherapy in combination with inotuzumab ozogamicin, an investigational product, in adults with CD22-positive non-Hodgkin's lymphoma. The trial will involve two arms. In one arm, subjects will receive chemotherapy regimen R-CVP (rituximab, cyclophosphamide, vincristine and prednisone). In the other arm, subjects will receive R-GDP (rituximab, gemcitabine, cisplatinum and dexamethasone). Subjects in both arms will also rec... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/13/2019
Locations: Davis Cancer Pavillion and Shands Medical Plaza, Gainesville, Florida +27 locations
Conditions: Lymphoma, B-Cell
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To Study Efficacy and Safety of Tobradex Eye Drop Suspension vs Tobramycin/Dexamethasone Ophthalmic Suspension
NCT03975374
Unknown
The objective of the study is to compare and describe efficacy and safety of Tobradex ophthalmic suspension versus generic Tobramycin/dexamethasone Suspension in treatment of Blepharoconjuctivitis through clinical parameters
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/04/2019
Locations: Sutphin Drugs, Jamaica, New York
Conditions: Blepharo Conjunctivitis
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Study of Decadron, Biaxin, and Pomalidomide in Relapsed/Refractory Myeloma
NCT01159574
Completed
This study is intended to investigate the combination of the combination of dexamethasone (Decadron®), Clarithromycin (Biaxin®), and pomalidomide (CC-4047®) \[ClaPd\] in multiple myeloma patients who have relapsed or refractory disease who have failed prior treatment with lenalidomide when used alone or in combination with corticosteroids. Primary endpoint will be response rate to treatment. Secondary endpoints will include toxicity of the combination, time to maximum response, and time to disea... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/28/2019
Locations: Weill Cornell Medical College, New York, New York
Conditions: Multiple Myeloma
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A Clinical Study to Assess the Efficacy and Safety of Dexamethasone Suspension for Cataract Surgery
NCT03687931
Completed
Patients at least 40 years of age who are undergoing cataract surgery will be randomized to receive treatment with one of two dose levels of dexamethasone ophthalmic suspension eye drops to determine if the drops decrease inflammation inside the eye and are safe after cataract surgery.
Gender:
ALL
Ages:
40 years and above
Trial Updated:
05/23/2019
Locations: Arizona Eye Center, Chandler, Arizona
Conditions: Inflammation Eye
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Study of Chemotherapy With or Without Hepatic Arterial Infusion for Patients With Unresectable Metastatic Colorectal Cancer to the Liver
NCT03069950
Withdrawn
The purpose of this study is to see if patients treated with both regional chemotherapy using the HAI pump and intravenous chemotherapy are able to have their liver tumors removed surgically (resected), versus treatment with only intravenous chemotherapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/17/2019
Locations: Memorial Sloan Kettering Basking Ridge, Basking Ridge, New Jersey +4 locations
Conditions: Colorectal Adenocarcinoma Metastatic to the Liver
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Clinical Study of CWP232291 in Relapsed or Refractory Myeloma Patients
NCT02426723
Completed
This is a Phase 1a/1b, multicenter, open-label, two-part study in subjects with relapsed or refractory MM: * Phase 1a: single agent CWP232291. Dose-finding followed by cohort expansion at the maximum tolerated dose (MTD) or optimal dose as determined by the Safety Review Committee (SRC). * Phase 1b: CWP232291 in combination with lenalidomide and dexamethasone. Dose-finding followed by cohort expansion at the combination therapy MTD or optimal dose as determined by the SRC.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/15/2019
Locations: The University of Texas MD Anderson Cancer Center, Houston, Texas +3 locations
Conditions: Multiple Myeloma
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Theca Cell Function in Adolescents With Polycystic Ovary Syndrome (PCOS)
NCT01154192
Completed
In women with polycystic ovary syndrome (PCOS), the cardinal physiological abnormality is excessive ovarian androgen production marked by increased serum testosterone (T) and androstenedione (A) levels. Studies to determine the alteration in ovarian steroidogenesis that lead to abnormal production of ovarian androgens have revealed increased CYP17 gene expression with accentuated 17-hydroxylase activity leading to exaggerated 17-hydroxyprogesterone (17P) responses to luteinizing hormone (LH) sti... Read More
Gender:
FEMALE
Ages:
Between 12 years and 18 years
Trial Updated:
04/22/2019
Locations: UCSD School of Medicine, La Jolla, California
Conditions: PCOS
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Dexamethasone for Treatment of Radiation-related Fatigue in Patients Receiving RT for Head-neck and Lung Cancer
NCT02410382
Terminated
This study will look at how dexamethasone and placebo influence radiation fatigue, quality of life and number of treatment days missed during radiation therapy or radiation therapy and chemotherapy for cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/22/2019
Locations: University of Arizona, Tucson, Arizona
Conditions: Head and Neck Cancer, Non-small Cell Lung Cancer
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A Comparison of Ropivacaine Alone Versus Combination of Dexamethasone and Clonidine for Block
NCT02151487
Completed
The aim of this randomized, observer-blinded study is to evaluate the postoperative analgesic efficacy of adding dexamethasone and clonidine to ropivacaine in supraclavicular nerve block. The investigators hypothesized that addition of dexamethasone and clonidine to ropivacaine would prolong the duration of analgesia in supraclavicular nerve block compared with ropivacaine alone.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
04/15/2019
Locations: Parkland Health Hospital System, Dallas, Texas
Conditions: Upper Extremity Surgery
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A Study of the Safety and Efficacy of a New Treatment for Macular Edema Resulting From Retinal Vein Occlusion
NCT00168298
Completed
This study will evaluate the safety and efficacy of an intravitreal implant of dexamethasone for the treatment of macular edema associated with retinal vein occlusion.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/11/2019
Locations: Not set, Houston, Texas +12 locations
Conditions: Macular Edema, Retinal Vein Occlusion
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