Lanadelumab in Long-term Prophylaxis of Acquired Angioedema
Recruiting
use of lanadelumab in patients with acquired angioedema
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/24/2025
Locations: Bernstein Clinical Research Center, LLC, Cincinnati, Ohio
Conditions: Angioedema
Effects of NAD3 Supplementation on Biomarkers of Aging
Completed
This is a randomized, parallel-group, placebo-controlled, clinical trial in middle-aged and older male and female subjects from Ohio. Subjects will take an over-the-counter dietary supplement or a placebo for 12 weeks. Outcome measures will include body weight, systolic and diastolic blood pressure, standard blood chemistries (e.g. chemistry panel, lipid panel, CBC with differential), changes in mood, vitality, energy, fatigue, productivity, digestive wellness (via anchored Visual Analogue Scale... Read More
Gender:
ALL
Ages:
Between 40 years and 60 years
Trial Updated:
11/10/2022
Locations: The Center for Applied Health Sciences, Canfield, Ohio
Conditions: Aging
Drug and Non-Drug Treatment Of Severe Migraine
Completed
The purpose of this study is to determine if the addition of preventive medication, behavior migraine management or the combination of preventive medication and behavior migraine management improves the outcome of optimal acute therapy for frequent migraines.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
10/07/2016
Locations: Ohio University, Athens, Ohio +1 locations
Conditions: Migraine Headache
Secondary Prophylaxis of Gastrointestinal Bleeding in Cirrhotic Patients Using THALIDOMIDE
Withdrawn
The natural history of cirrhosis has a symptomatic and asymptomatic stage. The symptoms include the development of ascites, hepatic encephalopathy, or variceal bleeding. The development of portal hypertension represents a critical transition point in the natural history of cirrhosis, contributing to, or directly responsible for all of these events. It is defined by an increase in intrahepatic vascular resistance to portal venous inflow, with the subsequent development of collateral vessels, such... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/29/2013
Locations: Cleveland Clinic Foundation, Cleveland, Ohio
Conditions: Gastrointestinal Hemorrhage, Portal Hypertension
An Expanded Access Program of Cretostimogene Grenadenorepvec for Treatment of NMIBC for Patients Unresponsive to BCG
Available
This is an open-label, expanded access trial designed to provide access to cretostimogene in patients with NMIBC (specifically CIS with or without HG Ta/T1) unresponsive to BCG.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/20/2025
Locations: Michael G. Oefelein Clinical Trials, Bakersfield, California +13 locations
Conditions: Non-Muscle Invasive Bladder Cancer, Urothelial Carcinoma, Urologic Cancer, Bladder Cancer
Efficacy and Safety of Subcutaneous Dupilumab for the Treatment of Adult Participants With Chronic Pruritus of Unknown Origin (CPUO) (LIBERTY-CPUO-CHIC)
Recruiting
The main objective of the study is to assess efficacy and safety of dupilumab given up to 24 weeks in adults with CPUO. This is a master protocol which includes 2 parallel-treatment, double-blind, 2- arm Phase 3 staggered studies of similar design (Study A and Study B) in male and female participants aged 18 to 90 years with CPUO. Study B design was to be adapted based on the results of Study A. For both Study A and B, after an up-to-4-week screening period, participants with severe pruritus (... Read More
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
08/19/2025
Locations: Kern Allergy and Medical Research- Site Number : 8400016, Bakersfield, California +79 locations
Conditions: Pruritus
A Trial to Evaluate Intravesical Nadofaragene Firadenovec Alone or in Combination With Chemotherapy or Immunotherapy in Participants With High-grade BCG Unresponsive Non-muscle Invasive Bladder Cancer
Recruiting
The pivotal phase 3 trial (rAd-IFN-CS 003) evaluating the efficacy of nadofaragene firadenovec showed that 55 (53.4%) of 103 subjects with CIS ± high-grade Ta/T1 achieved a complete response (CR) at 3 months. In this trial, the safety and efficacy of intravesical instillation of nadofaragene firadenovec alone or in combination with chemotherapy or immunotherapy will be evaluated in participants with NMIBC CIS (± high-grade Ta/T1).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/18/2025
Locations: Urology Associates of Central California, Fresno, California +17 locations
Conditions: Non-muscle Invasive Bladder Cancer With Carcinoma in Situ
Trial of Nadofaragene Firadenovec vs. Observation in Participants With Intermediate Risk Non-Muscle Invasive Bladder Cancer
Recruiting
A phase 3b, Randomized, Controlled Trial of Nadofaragene Firadenovec vs. Observation in Participants with Intermediate Risk Non-Muscle Invasive Bladder Cancer (IR NMIBC)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/13/2025
Locations: University of South Alabama (USA) Health System - USACM, Mobile, Alabama +32 locations
Conditions: Intermediate Risk Non-Muscle Invasive Bladder Cancer
Prochlorperazine vs Imitrex for Acute Migraine in the Emergency Department
Withdrawn
ED patients with acute migraine will be randomized to either prochlorperazine and Bendaryl OR imitrex. VAS for pain will be monitored, along with side effects. Primary outcome measure is improvement in pain scales between the groups.
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
08/13/2025
Locations: Naval Medical Center Portsmouth, Portsmouth, Virginia
Conditions: Acute Migraine Headache
Comparison of Two Qualia NAD⁺ Formulations on Intracellular NAD⁺ Levels
Not Yet Recruiting
This is a randomized, double-blind, placebo-controlled, parallel-group study evaluating the effects of two distinct Qualia NAD⁺ formulations on intracellular NAD⁺ levels in healthy adults aged 35-75 years. Approximately 180 participants will be randomized to one of three study arms: Qualia NAD⁺ version 1, Qualia NAD⁺ version 2, or placebo. Each participant will take two capsules of their assigned product once daily in the morning, with or without food, over a 28-day period. The primary outcome i... Read More
Gender:
ALL
Ages:
Between 35 years and 75 years
Trial Updated:
08/13/2025
Locations: Qualia Life Sciences, Carlsbad, California
Conditions: NAD, NAD+ Levels in the Blood
Low-grade UTUC Treated With Nadofaragene Firadenovec Administered to Renal Pelvis
Recruiting
The primary purpose of this trial is to evaluate the safety \& tolerability of Nadofaragene Firadenovec in subjects with LG-UTUC. To help with this evaluation, a safety lead-in period will be conducted for the first 6 subjects. Complete response is at 3 or 6 months defined as absence of any UTUC in the renal pelvis.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/13/2025
Locations: Indiana University, Indianapolis, Indiana +2 locations
Conditions: Low-grade Upper Tract Urothelial Carcinoma
Excipient Effect on Drug Absorption in Humans
Active Not Recruiting
The purpose of this study is to determine if sodium lauryl sulfate (SLS), a non-drug ingredient commonly added in drug products, affect absorption of drugs that are given together with the ingredient. Investigators want to find out if drug absorption is different in people taking the drug alone compared to people taking the drug with low and high amounts of sodium lauryl sulfate at the same time.
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
08/08/2025
Locations: Ucsf Ctsi Crc, San Francisco, California
Conditions: The Impact of Excipients on Drug Absorption