A Study to Assess the Safety, Reactogenicity and Immune Response of GlaxoSmithKline (GSK) Biologicals' Investigational Respiratory Syncytial Virus (RSV) Vaccine (GSK3844766A) in Older Adults
Completed
The purpose of this study is to assess the safety, reactogenicity and immune responses of two doses of the investigational RSV vaccines (with different formulations), when administered intramuscularly (IM) according to a 0, 2 month schedule, in older adults aged 60 to 80 years. As the investigational vaccines have not yet been tested in humans before, the study will first assess the safety, reactogenicity and immune responses in young adults aged 18 to 40 years. The study will thus be conducted... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
08/04/2022
Locations: GSK Investigational Site, Jacksonville, Florida +20 locations
Conditions: Respiratory Syncytial Virus Infections
Apalutamide and Gonadotropin-Releasing Hormone Analog With or Without Abiraterone Acetate in Treating Participants With Prostate Cancer
Completed
This phase II trial studies how well apalutamide and gonadotropin-releasing hormone analog with or without abiraterone acetate work in treating participants with prostate cancer prior to surgery. Apalutamide and abiraterone acetate may stop the growth of cancer cells either by killing the cells or by blocking some of the enzymes needed for cell growth. Hormone therapy, using gonadotropin-releasing hormone analog, may fight prostate cancer by lowering the amount of testosterone the body makes. Gi... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
07/14/2022
Locations: M D Anderson Cancer Center, Houston, Texas
Conditions: Prostate Adenocarcinoma, Stage IIB Prostate Cancer AJCC v8, Stage IIC Prostate Cancer AJCC v8, Stage IIIA Prostate Cancer AJCC v8, Stage IIIC Prostate Cancer AJCC v8
Examination of Idiopathic Hypogonadotropic Hypogonadism (IHH)and Kallmann Syndrome (KS)
Completed
The purpose of the study is to examine how Kallmann syndrome (KS) and idiopathic hypogonadotropic hypogonadism (IHH) affect reproductive hormones. These disorders are caused by a defect in Gonadotropin Releasing Hormone (GnRH) secretion. GnRH is a hormone released by a small gland in the brain called the hypothalamus. When GnRH is released, it signals another gland in the brain, the pituitary, to secrete the reproductive hormones that influence sex hormone (testosterone, estrogen) levels and gam... Read More
Gender:
ALL
Ages:
16 years and above
Trial Updated:
07/07/2022
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Kallmann Syndrome, Hypogonadotropic Hypogonadism, GnRH Deficiency
Studying the Effects of 7 Days of Gonadotropin Releasing Hormone (GnRH) Treatment in Men With Hypogonadism
Completed
Men with Idiopathic Hypogonadotropic Hypogonadism (IHH) lack a hormone called gonadotropin releasing hormone (GnRH). This hormone is important for starting puberty, maintaining testosterone levels, and fertility. The purpose of this study is to research the effects of treating IHH men with GnRH for 7 days.
Gender:
MALE
Ages:
Between 18 years and 65 years
Trial Updated:
06/29/2022
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Kallmann Syndrome, Idiopathic Hypogonadotropic Hypogonadism, GnRH Deficiency
Study of Multiple Candidate Agents for the Treatment of COVID-19 in Hospitalized Patients
Completed
The primary objective of this study is to evaluate the time to confirmed clinical recovery in participants hospitalized with COVID-19. Candidate agents will be evaluated frequently for efficacy and safety, with candidate agents being added to and/or removed from the study on an ongoing basis, depending on the results of their evaluation.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/23/2022
Locations: Pinnacle Research Group LLC, Anniston, Alabama +58 locations
Conditions: COVID-19
Comparison of Low and Intermediate Dose Low-molecular-weight Heparin to Prevent Recurrent Venous Thromboembolism in Pregnancy
Completed
This is a randomized-controlled open-label trial comparing two different doses of low-molecular-weight heparin (LMWH) in pregnant patients with a history of previous venous thromboembolism (VTE). Both doses are recommended doses in the 2012 guidelines of the American College of Chest Physicians (ACCP), but it is not known which dose is more efficacious in preventing recurrent venous thromboembolism in pregnancy. Patients enter the study and will be randomized as soon as a home test confirms pre... Read More
Gender:
FEMALE
Ages:
Between 18 years and 50 years
Trial Updated:
05/21/2022
Locations: Weill Cornell Medicine | NewYork-Presbyterian, New York, New York +71 locations
Conditions: Deep Venous Thrombosis, Pulmonary Embolism
A Study of Lanadelumab to Prevent Hereditary Angioedema (HAE) Attacks in Children
Completed
The main aims of this study are to learn how lanadelumab moves through a child's body and if the children have any medical problems from lanadelumab. Other aims are to learn if prophylactic treatment with lanadelumab reduces the number and severity of HAE attacks in children, how lanadelumab affects the child's body, and if the children develop antibodies to lanadelumab. The study doctors will treat acute HAE attacks according to their standard practice. Participants will receive lanadelumab f... Read More
Gender:
ALL
Ages:
Between 2 years and 11 years
Trial Updated:
04/29/2022
Locations: AIRE Medical of Los Angeles, Santa Monica, California +16 locations
Conditions: Hereditary Angioedema
Comparative Effectiveness of Pharmacogenomics for Treatment of Depression
Completed
The overall goal of this study is to assess the effectiveness of a widely available and widely used combinatorial pharmacogenomic (PGx) test for the treatment of major depressive disorder. Pharmacogenomic tests use genetic information to guide medication treatment decisions. The tests inform clinicians and patients of potential gene-drug interactions by analyzing pharmacokinetic (PK) genes (how drugs are metabolized) as well as pharmacodynamic (PD) genes (how drugs work). While combinatorial PGx... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
04/05/2022
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Major Depressive Disorder
Safety and Immunogenicity of Different Dosages of High-Dose Quadrivalent Influenza Vaccine in Children 6 Months to 17 Years of Age
Completed
The objectives of this study were: * To describe the safety of each dosage of high-dose quadrivalent influenza vaccine (QIV-HD) used in the study during the 28 days following each vaccination, and serious adverse events (including adverse events of special interest throughout the study). * To describe the antibody response induced by each dosage of QIV-HD used in the study compared with unadjuvanted standard-dose quadrivalent influenza vaccine (QIV-SD) by hemagglutination inhibition (HAI) measu... Read More
Gender:
ALL
Ages:
Between 6 months and 17 years
Trial Updated:
03/24/2022
Locations: Investigational Site Number 8400004, San Diego, California +15 locations
Conditions: Influenza
Safety and Efficacy of Silicone Oil Tamponade for Surgical Attenuation of Radiation Damage in Choroidal Melanoma
Completed
A prospective, experimental, case series of 20 patients, with choroidal melanoma, in which pars plana vitrectomy and Silicone oil as vitreous substitute will be used as intraocular shielding for attenuating the deleterious effects of radiation dose delivered to healthy ocular tissue during Iodine-125 plaque brachytherapy treatment and assess if the treatment can reduce the incidence and severity of radiation-induced adverse effects like radiation retinopathy and permanent loss of vision.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/04/2022
Locations: University of Colorado Eye Center, Aurora, Colorado
Conditions: Choroidal Melanoma
SeRenade Parent-Child Music Class Program
Completed
This pilot study examines the impact of the SeRenade Parent-Child Music Class Program, which emphasizes parent training, peer inclusion, and musical play combined with established behavioral techniques, on the development of child social engagement, positive behavior, and parental well-being.
Gender:
ALL
Ages:
Between 20 months and 72 months
Trial Updated:
02/05/2022
Locations: Vanderbilt University Medical Center, Nashville, Tennessee
Conditions: Autism Spectrum Disorder
A Study to Determine the Safety, Tolerability, and Pharmacokinetics of Lanadelumab Administered Intravenously in Healthy Adult Volunteer Participants
Completed
The purpose of this study to evaluate the safety, tolerability and pharmacokinetics (PK) of lanadelumab administered by Intravenous (IV) infusion in healthy adult volunteers.
Gender:
ALL
Ages:
Between 19 years and 55 years
Trial Updated:
12/14/2021
Locations: Celerion, Lincoln, Nebraska
Conditions: Healthy Volunteers