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Testosterone Replacement Therapy (TRT) Treatment Options
A collection of 324 research studies where Testosterone Replacement Therapy (TRT) is the interventional treatment. These studies are located in the United States . Testosterone Replacement Therapy (TRT) is used for conditions such as .
37 - 48 of 324
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¹ Kandzari DE, et al. J Am Coll Cardiol. Nov 7, 2023;82(19):1809-1823.
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There's a big difference between the price on a landing page and what you actually pay. We went all the way through checkout so you know exactly what to expect.
📋 5 providers ranked by true monthly cost
💵 Options starting as low as $149/month
🏥 Only licensed providers using FDA-registered pharmacies
⭐ Real Trustpilot scores included — including the ones with mixed reviews
🔒 Includes cancellation policy warnings so you don't get stuck
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Healthy Participants Needed (Colonoscopy + Cancer Screening)
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Earn $325 - $475 in electronic payment card compensation for your time and effort by participating in a clinical study to develop a blood test that may one day help screen for colon cancer. Take a quick quiz to see if you qualify.
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Healthy Participants
Novel Approaches for Minimizing Drug-Induced QT Interval Lengthening
Completed
This research will determine if: 1) Oral progesterone attenuates drug-induced QT interval, J-Tpeak and Tpeak-Tend lengthening in postmenopausal women 50 years of age or older, and 2) Transdermal testosterone attenuates drug-induced QT interval, J-Tpeak and Tpeak-Tend lengthening in men 65 years of age or older. This investigation will consist of two concurrent prospective, randomized, double-blind, placebo-controlled crossover-design studies in a) Postmenopausal women, and b) Men 65 years of age... Read More
Gender:
ALL
Ages:
Between 50 years and 99 years
Trial Updated:
04/28/2025
Locations: Indiana Clinical Research Center, Indianapolis, Indiana +2 locations
Conditions: Long QT Syndrome, Abnormalities, Drug-Induced
EndoPAT Device for Endothelial Dysfunction in ED
Not Yet Recruiting
To assess endothelial dysfunction in young men (aged 30-50) with vasculogenic ED identified through penile Doppler ultrasound.
To evaluate changes in endothelial function using EndoPAT before and 3-6 months after daily low-dose phosphodiesterase type 5 (PDE5) inhibitor therapy.
To investigate endothelial function alterations in hypogonadal patients before and 3-6 months after initiating testosterone (T) therapy
Gender:
MALE
Ages:
18 years and above
Trial Updated:
04/09/2025
Locations: UCI Urology | Men's Health Center, Newport Beach, California
Conditions: Erectile Dysfunction, Hypogonadism, Male, Endothelial Dysfunction
Puberty, Testosterone, and Brain Development
Recruiting
Transmasculine youth (female sex assigned at birth, male gender identity) who begin clinical gender affirming hormone therapy (GAHT) with testosterone (T) may experience changes in headache. Researchers think this because studies published on effects of giving testosterone to cisgender females (female sex, female gender identity) and transmasculine adults seem to show an effect on pain.
This research will help us learn more about changes in headache and in brain structure and function in transm... Read More
Gender:
ALL
Ages:
Between 12 years and 20 years
Trial Updated:
04/02/2025
Locations: Children's Hospital Colorado, Aurora, Colorado
Conditions: Gender Identity, Gender Dysphoria in Adolescents and Adults, Headache, Transgender
Testosterone Treatment in Men with Chronic Kidney Disease
Recruiting
This study in being conducted in men who have low testosterone and chronic kidney disease. The investigators will evaluate the effects of an oral testosterone preparation, JATENZO, on testosterone levels and hemoglobin (red blood cells).
Gender:
MALE
Ages:
Between 18 years and 85 years
Trial Updated:
03/25/2025
Locations: Saint Louis Univeristy, Saint Louis, Missouri
Conditions: Hypogonadism, Male, Kidney Disease, Chronic
[18F]-Fluoro-2-Deoxy-D-Glucose and -[18F] Dihydro-Testosterone Pet Imaging in Patients With Progressive Prostate Cancer
Recruiting
This study will use PET scans, which is a type of x-ray test that uses a radiotracer, to see whether these scans may be better able to find places in the body where your prostate cancer may have spread.
Gender:
MALE
Ages:
All
Trial Updated:
03/20/2025
Locations: Memorial Sloan Kettering Basking Ridge (Consent Only), Basking Ridge, New Jersey +6 locations
Conditions: Prostate Cancer
Testosterone Therapy in Castration Resistant Prostate Cancer
Active Not Recruiting
This is an open-labeled, single-arm, interventional pilot study. It is being done to determine the feasibility of the administration of transdermal testosterone alternating with enzalutamide, as well as the safety and efficacy.
Gender:
MALE
Ages:
Between 18 years and 100 years
Trial Updated:
03/20/2025
Locations: University of Colorado Hospital, Aurora, Colorado
Conditions: Prostate Cancer, Castration-Resistant Prostate Cancer
Testosterone and Neural Function
Recruiting
Spinal cord injury (SCI) disrupts the nerves controlling movement, along with those that regulate functions like heart rate and blood pressure (known as the autonomic nervous system, or ANS). Testosterone (T) plays a significant role in brain health and ANS reflex function in non-neurologically impaired men. However, little is known about the relationships between T, nerve function, and ANS dysfunction after SCI. Interestingly, up to 60% of men with SCI exhibit persistently low T concentrations,... Read More
Gender:
MALE
Ages:
Between 18 years and 80 years
Trial Updated:
03/07/2025
Locations: James J. Peters VA Medical Center, Bronx, NY, Bronx, New York
Conditions: Spinal Cord Injury
Improving Cancer-related Fatigue, Sexual Dysfunction and Quality of Life in Older Men With Cancer and Androgen Deficiency
Recruiting
This is a large randomized, double-blind, placebo-controlled trial to determine the efficacy of testosterone replacement on cancer-related fatigue in older men with solid or hematologic (blood) cancer who report fatigue and have low testosterone levels.
Gender:
MALE
Ages:
55 years and above
Trial Updated:
03/06/2025
Locations: Georgia Cancer Center at Augusta University, Augusta, Georgia +2 locations
Conditions: Hypogonadism, Male, Cancer, Fatigue
A Trial of Pembrolizumab in Combination With Chemotherapy and Radiotherapy in Stage III NSCLC (KEYNOTE-799, MK-3475-799)
Completed
This is a trial in adult participants with unresectable, locally advanced, Stage III non-small cell lung cancer (NSCLC) treated with pembrolizumab in combination with platinum doublet chemotherapy and standard thoracic radiotherapy followed by pembrolizumab monotherapy. The primary hypothesis of the trial is that within each platinum doublet chemotherapy cohort, the percentage of participants who develop Grade 3 or higher pneumonitis is ≤10% and estimation of objective response rate (ORR) by bli... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/06/2025
Locations: St Joseph Heritage Healthcare ( Site 1403), Santa Rosa, California +55 locations
Conditions: Non-small Cell Lung Cancer
Testosterone Replacement in Male Cancer Survivors with Fatigue and Low Testosterone
Recruiting
The overall goal of this study is to evaluate the effect of a testosterone drug called Depo-Testosterone (or 'testosterone cypionate'), an FDA-approved drug for improving fatigue, sexual function, quality of life, body composition, muscle strength, and physical activity in young cancer survivors who report fatigue and have low testosterone. Main hypothesis is that Testosterone administration in young male cancer survivors who are in remission for at least 1 year, report cancer-related fatigue an... Read More
Gender:
MALE
Ages:
Between 18 years and 54 years
Trial Updated:
03/06/2025
Locations: Brigham and Women's Hospital, Boston, Massachusetts +1 locations
Conditions: Hypogonadism, Male, Fatigue Syndrome, Chronic
A Study of the Effect of Testosterone Replacement Therapy on Blood Pressure in Adult Male Participants With Hypogonadism
Completed
Testosterone is the principal androgen produced by the male testes. Male Hypogonadism is the result of inadequate production of testosterone by the Leydig cells of the testes and is reflected by total serum concentrations of testosterone of \< 300 nanograms (ng)/deciliters (dL), with no discernible diurnal pattern. The etiology of hypogonadism may be primary or secondary. The treatment of males with primary, and in some cases, secondary hypogonadism includes administration of testosterone.
Test... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
03/04/2025
Locations: Endo Clinical Trial Site #8, Birmingham, Alabama +34 locations
Conditions: Hypogonadism, Hypogonadism, Male, Hypogonadotropic Hypogonadism
Difluoromethylornithine and High Dose Testosterone With Enzalutamide in Metastatic Castration-Resistant Prostate Cancer
Recruiting
Asymptomatic patients with metastatic castrate resistant prostate cancer (mCRPC) without pain due to prostate cancer will be treated on an open label study to evaluate effectiveness of sequential treatment with the combination of difluoromethylornithine (DFMO) and high dose testosterone in sequence with enzalutamide to improve primary and secondary outcomes.
Gender:
MALE
Ages:
18 years and above
Trial Updated:
02/21/2025
Locations: Johns Hopkins University: Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland
Conditions: Prostate Cancer
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