Study of Daily Application of Nestorone® (NES) and Testosterone (T) Combination Gel for Male Contraception
NCT03452111
Completed
The long term objective is to develop a gel to be used as a male contraceptive.
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
02/14/2025
Locations: UC Davis Health, Sacramento, California +16 locations
Conditions: Healthy, Men, Male Contraception
Register for Updates
Evaluate the Pharmacokinetics and Gonadotropin Suppression of Nestorone®-Testosterone (NES/T) Combination Gel in Men
NCT02432261
Completed
This is a prospective, randomized, double-blinded, two-center trial to evaluate the gonadotropin suppressive activity of transdermal treatment with a combined NES/T gel, or T gel alone, for 28 days.
Gender:
MALE
Ages:
Between 18 years and 50 years
Trial Updated:
02/12/2025
Locations: LA Biomedical Research Institute, Torrance, California +1 locations
Conditions: Healthy
Register for Updates
Testosterone Replacement Therapy for the Treatment of Low Testosterone in Hypogonadal Men With Localized Prostate Cancer on Active Surveillance
NCT06733350
Recruiting
This phase IV trial studies the effects of testosterone replacement therapy (TRT) on treatment outcomes in hypogonadal men with prostate cancer that has not spread to other parts of the body (localized) and who are on active surveillance (AS). AS in prostate cancer involves closely watching the patient's condition through regular physical exams and blood tests, but not giving treatment unless there are changes in test results. It can be a practical alternative to treatment in localized prostate... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
02/03/2025
Locations: Roswell Park Cancer Institute, Buffalo, New York
Conditions: Localized Prostate Carcinoma, Stage I Prostate Cancer AJCC v8, Stage II Prostate Cancer AJCC v8, Stage III Prostate Cancer AJCC v8
Register for Updates
Abiraterone Acetate and Antiandrogen Therapy With or Without Cabazitaxel and Prednisone in Treating Patients With Metastatic, Castration-Resistant Prostate Cancer Previously Treated With Docetaxel
NCT03419234
Active Not Recruiting
This randomized phase II trial studies how well abiraterone acetate and antiandrogen therapy, with or without cabazitaxel and prednisone, work in treating patients with castration-resistant prostate cancer previously treated with docetaxel that has spread to other parts of the body. Androgens can cause the growth of prostate cancer cells. Hormone therapy using abiraterone acetate and antiandrogen therapy may fight prostate cancer by lowering and/or blocking the use of androgens by the tumor cell... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
01/28/2025
Locations: Fairbanks Memorial Hospital, Fairbanks, Alaska +671 locations
Conditions: Castration Levels of Testosterone, Castration-Resistant Prostate Carcinoma, Metastatic Prostate Carcinoma in the Soft Tissue, Prostate Carcinoma Metastatic in the Bone, Stage IV Prostate Adenocarcinoma AJCC v7
Register for Updates
Improving Quality of Life of Prostate Cancer Survivors With Androgen Deficiency
NCT03716739
Active Not Recruiting
The purpose of this phase II trial is to determine the efficacy and safety of testosterone replacement therapy (TRT) in improving the symptoms of androgen deficiency and health-related quality of life in men with prostate cancer who have undergone radical prostatectomy.
Gender:
MALE
Ages:
40 years and above
Trial Updated:
01/27/2025
Locations: Johns Hopkins University, Baltimore, Maryland +2 locations
Conditions: Prostate Cancer
Register for Updates
Bipolar Androgen Therapy to Restore Sensitivity to Androgen Deprivation Therapy for Patients With Metastatic Castration Resistant Prostate Cancer
NCT06305598
Recruiting
This phase I trial tests the change in androgen receptor sensitivity, side effects and effectiveness of bipolar androgen therapy, using testosterone, in patients with castration resistant prostate cancer that has spread to other places is the body (metastatic). Bipolar androgen therapy is the regulation of testosterone between castration levels (lower than what would be normally present) and supraphysiological levels (amounts greater than normally found in the body). This may suppress cancer cel... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
01/16/2025
Locations: Roswell Park Cancer Institute, Buffalo, New York
Conditions: Castration-Resistant Prostate Carcinoma, Metastatic Prostate Carcinoma, Stage IVB Prostate Cancer AJCC v8
Register for Updates
Testosterone in Treating Postmenopausal Patients With Arthralgia Caused by Adjuvant Aromatase Inhibitor Treatment
NCT01573442
Completed
This randomized phase III trial studies testosterone to see how well it works compared to placebo in treating postmenopausal patients with arthralgia (joint pain) caused by anastrozole or letrozole. Testosterone may help relieve moderate or severe arthralgia associated with the use of aromatase inhibitors, such as anastrozole or letrozole.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
01/14/2025
Locations: Anchorage Associates in Radiation Medicine, Anchorage, Alaska +528 locations
Conditions: Arthralgia, Breast Cancer, Hot Flashes, Musculoskeletal Complications, Sexual Dysfunction
Register for Updates
Starting a Testosterone and Exercise Program After Hip Injury
NCT02938923
Completed
This study is a randomized controlled double-blinded multi-center clinical trial enrolling female hip fracture patients who are 65 and older. It will compare the effects of six months of supervised exercise training combined with daily topical testosterone gel, to six months of supervised exercise and inactive gel, and to Enhanced Usual Care. The randomization protocol is that for every nine participants randomized, 4 will be assigned to the topical testosterone gel and supervised exercise train... Read More
Gender:
FEMALE
Ages:
65 years and above
Trial Updated:
01/09/2025
Locations: University of Colorado, Denver, Aurora, Colorado +7 locations
Conditions: Hip Fracture, Frailty, Sarcopenia
Register for Updates
Randomized Phase II Trial of Targeted Radiation With no Castration for Mcrpc
NCT06084338
Recruiting
This trial tests if the combination of comprehensive metastasis directed therapy delivered by a precision form of external beam radiotherapy (stereotactic ablative radiotherapy), combined with PSMA targeted radiopharmaceutical therapy and cessation of castration, and then followed by testosterone replacement, is an effective treatment for metastatic castration resistant prostate cancer. All patients will be treated with stereotactic ablative radiotherapy and PSMA targeted radiopharmaceutical th... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
12/27/2024
Locations: VA Long Beach Healthcare System, Long Beach, CA, Long Beach, California +2 locations
Conditions: Prostate Cancer
Register for Updates
Perioperative Testosterone Replacement Therapy for the Improvement of Post-Operative Outcomes in Patients With Low Testosterone
NCT04731376
Recruiting
This phase I trial investigates the safety of testosterone replacement therapy around the time of major urologic surgery (perioperative) in order to improve quality of life and post-operative outcomes such as decreased length of hospital stay, complications, and mortality in patients with low testosterone levels. Studies have demonstrated that patients undergoing testosterone replacement therapy have increased lean body mass, decreased fat mass and have improved physical function. Testosterone r... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
12/20/2024
Locations: Emory University Hospital/Winship Cancer Institute, Atlanta, Georgia
Conditions: Hypogonadism, Malignant Urinary System Neoplasm, Urinary System Disorder, Urinary System Neoplasm
Register for Updates
Muscle Anabolic Interventions to Accelerate Recovery From Hospitalization in Geriatric Patients
NCT02990533
Completed
The goal of this pilot study is to collect preliminary data on the feasibility and effect size of interventions to modify the physiological recovery trajectory from hospitalization in community dwelling older adults.
Gender:
ALL
Ages:
65 years and above
Trial Updated:
12/13/2024
Locations: Jennie Sealy Hospital, Galveston, Texas
Conditions: Aging
Register for Updates
Comparing Direct and Indirect Detection Methods of Multiple Routes of Testosterone Administration
NCT06393634
Completed
Testosterone abuse is extremely prevalent in athletes globally and especially in the United States professional sporting leagues
Gender:
MALE
Ages:
Between 18 years and 60 years
Trial Updated:
11/27/2024
Locations: Sports Medicine Research and Testing Laboratory, South Jordan, Utah
Conditions: Healthy
Register for Updates