Breast Cancer Clinical Trials in United Kingdom

A listing of 45 Breast Cancer clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.

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There are currently 45 active clinical trials seeking participants for Breast Cancer research studies. The states with the highest number of trials for Breast Cancer participants are .

Study to Assess Clinical Activity of Zelenectide Pevedotin in Participants With Advanced Breast Cancer

NCT06840483

Recruiting

This is a global, multicenter, open-label study that aims to assess the efficacy and safety of zelenectide pevedotin in participants with NECTIN4-amplified recurrent, unresectable, or metastatic breast cancer who have received prior therapy (see inclusion criteria below). The study will comprise of 2 cohorts. Cohort A will include participants with hormone receptor positive/ human epidermal growth factor receptor 2 negative \[HR+/HER2-\] breast cancer, whereas Cohort B will include participants... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

08/20/2025

Locations: Yale New Haven Hospital - Yale Cancer Center, New Haven, Connecticut +24 locations

Yale New Haven Hospital - Yale Cancer Center, New Haven, Connecticut

Massachusetts General Hospital, Boston, Massachusetts

Dana-Farber Cancer Institute, Boston, Massachusetts

University of Michigan, Ann Arbor, Michigan

Siteman Cancer Center, Saint Louis, Missouri

Icahn School of Medicine at Mount Sinai, New York, New York

Memorial Sloan Kettering Cancer Center - Main Campus, New York, New York

Duke Cancer Institute, Durham, North Carolina

Compass Oncology - Rose Quarter Cancer Center, Portland, Oregon

SCRI Oncology Partners, Nashville, Tennessee

Texas Oncology San Antonio, San Antonio, Texas

Virginia Cancer Specialists, Fairfax, Virginia

Virginia Oncology Associates, Norfolk, Virginia

Fred Hutchinson Cancer Center, Seattle, Washington

Centre de Lutte Contre le Cancer - Centre Eugene Marquis, Rennes, Not set

Oncopole Claudius Regaud, Toulouse, Not set

Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRCCS IRST, Meldola, Forli/Cesena

Clinica Oncologica-Azienda Ospedaliero Universitaria delle Marche, Ancona, Not set

Hospital Quironsalud Barcelona, Barcelona, Not set

Hospital Beata Maria Ana, Madrid, Not set

Hospital Universitario 12 de Octubre, Madrid, Not set

Centro Integral Oncologico Clara Campal, Madrid, Not set

Barts Health NHS Trust, London, Not set

The Royal Marsden NHS Foundation Trust, London, Not set

The Royal Marsden NHS Foundation Trust, Sutton, Not set

Conditions: Breast Cancer

Learn More ›

Audit of Targeted Sentinel Node Biopsy (TSNB) in Patients With Limited Nodal Disease Undergoing Primary Surgery

NCT07085442

Recruiting

Axillary ultrasound scan (AUS) is routinely employed in the UK for preoperative axillary staging and can diagnose approximately 50 - 80% of node positive patients when combined with percutaneous needle biopsy techniques (either core-biopsy or fine-needle aspiration cytology). It is recognised that nodal burden is generally higher in clinically node negative patients with abnormal nodes on AUS and confirmed on needle-biopsy to be histologically positive than patients diagnosed as node positive on sentinel node biopsy (SNB). However, up to 40% of biopsy-proven node positive patients are found to have fewer than 3 involved nodes on subsequent axillary lymph node dissection (ALND) and are potential candidates for less extensive axillary surgery with axillary radiotherapy (ART) rather than ALND. The total number of abnormal nodes on ultrasound is a key predictor of overall nodal tumour burden. The AMAROS and OTOASOR trials randomised patients with up to 2 positive sentinel nodes to either ALND or ART. These trials were conducted around the turn of the millennium and before routine use of AUS and therefore would have included a significant number of patients who were radiologically node positive (cN1). Likewise, the ACOSOG Z0011 trial that randomised a similar group of patients to either ALND or observation only, did not incorporate routine AUS and would have included some (radiological) cN1 patients. These trials revealed no adverse impact on disease-free or overall survival from omission of completion ALND. Targeted axillary dissection (TAD) was introduced a few years ago to reduce the false negative rate of SNB following neoadjuvant chemotherapy (NACT) and has been standardised as part of the ongoing ATNEC trial \[ClinicalTrials.govNCT04109079\]. This technique for axillary staging after NACT is increasingly being adopted in the UK and elsewhere. TAD is technically more straightforward and less challenging in patients undergoing primary surgery with no concerns about clip migration consequent to nodal shrinkage as part of treatment response to NACT. Furthermore, the risk of under-treating the axilla is offset by the protocol: if no disease is identified in the targeted nodes (false-negative case), then patients proceed to ALND, thereby ensuring adequate treatment. Unlike TAD following NACT, the presence of viable tumour within the sampled nodes is mandatory and finding fibrosis is irrelevant except as a response to nodal biopsy per se. Current ASCO guidelines support both SNB and TAD as staging options for patients with ultrasound-detected, biopsy-confirmed nodal disease. The Edinburgh randomised trials comparing four-node sampling with ALND demonstrated significantly lower arm morbidity with node sampling, supporting TAD as a clinically appropriate alternative in this patient population. The UK-ANZ POSNOC trial randomised 1,900 patients with \<3 macrometastases to either no further axillary treatment or additional axillary treatment. The study included cN1 patients with biopsy-confirmed nodal metastases who underwent sentinel node biopsy or TAD. Patients with \<3 macrometastases on final histology were randomised to receive no further axillary treatment or proceed with additional axillary treatment (ALND or ART). POSNOC trial will answer whether further axillary treatment provides any benefit in patients with low volume nodal disease on SNB or TAD. Notably, patients with biopsy-confirmed metastases and \<3 macrometastases on SNB/TAD are biologically and clinically similar to patients with normal AUS who are later found to have low-volume disease on SNB. Clinical decision-making and patient outcomes are driven by tumour biology and overall disease burden rather than the method of nodal disease detection. Furthermore, AUS sensitivity is operator dependent and whether FNA or core biopsy was used to sample the node. A patient considered node negative on AUS by one radiologist may be diagnosed with core biopsy confirmed nodal metastases with another radiologist. Pending the results of POSNOC trial, patients with less than 3 macrometastases are generally advised further axillary treatment, and ART is preferred over ALND to reduce the risk of lymphoedema. NodeSMART is a prospective audit collecting data on all patients undergoing TAD in the primary surgery setting. Its goal is to audit surgical outcomes and benchmark them against - a) Comparing technical outcomes with those from sentinel node biopsy in the primary surgery setting and TAD performed after neoadjuvant chemotherapy. b) Assessing rates of arm lymphoedema and disease progression relative to findings from the AMAROS and Z11 trials, and the POSNOC trial once results are available. The term "Targeted Axillary Dissection" is somewhat misleading in this context, as the marked (biopsied) node is removed alongside sentinel nodes - not in isolation. NodeSMART therefore refers to the procedure more accurately as Targeted Sentinel Node Biopsy (TSNB). Read Less

Gender:

ALL

Ages:

18 years and above

Trial Updated:

08/18/2025

Locations: Burnley General Teaching Hospital, Burnley, Not set +4 locations

Conditions: Breast Cancer, Axillary Lymph Nodes Dissection, Axillary Metastases, Sentinel Lymph Node Biopsy (SLNB), Node Positive Breast Cancer, Axilla; Breast, Axillary Ultrasound

Learn More ›

A Study to Learn About Study Medicine ALTA2618 in Adults With AKT1 E17K-Mutant Solid Tumors

NCT06533059

Recruiting

The purpose of this study is to characterize the safety and tolerability of ALTA2618 in adults with AKT1 E17K-mutant advanced solid tumors.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

08/15/2025

Locations: Research Site, La Jolla, California +45 locations

Research Site, La Jolla, California

Research Site, Los Angeles, California

Research Site, Denver, Colorado

Research Site, Sarasota, Florida

Research Site, Atlanta, Georgia

Research Site, Boston, Massachusetts

Research Site, Saint Louis, Missouri

Research Site, Mineola, New York

Research Site, New York, New York

Research Site, Maumee, Ohio

Research Site, Nashville, Tennessee

Research Site, Dallas, Texas

Research Site, Houston, Texas

Research Site #2, San Antonio, Texas

Research Site, San Antonio, Texas

Research Site, Fairfax, Virginia

Research Site, Madison, Wisconsin

Research Site, Blacktown, New South Wales

Research Site, Randwick, New South Wales

Research Site, South Brisbane, Queensland

Research Site, Malvern, Victoria

Research Site, Nedlands, Western Australia

Research Site, Saint-Herblain, Not set

Research Site, Villejuif, Not set

Research Site, Kyoto, Not set

Research Site, Matsuyama, Not set

Research Site, Shizuoka, Not set

Research Site, Tokyo, Not set

Research Site, Seoul, Not set

Research Site, Barcelona, Not set

Research Site, Madrid, Not set

Research Site, Valencia, Not set

Research Site, Changhua, Not set

Research Site, Taipei, Not set

Research Site, London, Not set

Research Site, Manchester, Not set

Conditions: Cancer, Breast Cancer, Endometrial Cancer, Metastatic Cancer, Advanced Solid Tumor

Learn More ›

MIBREAST Making in Immediate Breast REconstruction And the Measurement of the EffectS of RadioTherapy

NCT07136753

Recruiting

Patients who require a removal of a breast (mastectomy) for breast cancer or future risk reduction often have immediate breast reconstruction (IBR). This can be performed using either an implant or the patient's own body fat to recreate the breast shape. Patients can find it difficult to imagine their own post-surgery appearance. Using 3D surface imaging (3D-SI) can change a patient's pictures to show them how they might look after surgery, known as a simulation. Some patients may find 3D-SI and simulation gives them confidence in their expectations and others may not feel it helps much. This study will investigate the following 3 questions: 1. Whether 3D-SI and simulation can improve patient confidence about their likely post-surgery appearance 2. Whether 3D-SI measurement of breast shape helps in surgical planning and reduces the need for later adjustment surgery to improve symmetry, especially in patients having a mastectomy on one side only 3. How much radiotherapy changes breast reconstructions over time using 3D- SI to objectively measure this. For this study the follow up for some women who do and some who do not have radiotherapy after breast reconstruction. 3D surface imaging may improve surgeon understanding of breast shape, prior to surgery. In cases where there is a high risk of breast cancer recurrence patients are offered radiotherapy to the breast, either before or after surgery. Radiotherapy has a negative impact on the reconstructed breast, and may cause it to shrink and change position but the effect of radiotherapy has never been accurately quantified. This study will be investigating the following: 1. Whether 3D-SI measurement of breast shape helps in surgical planning and reduces the need for later adjustment surgery to improve symmetry, especially in patients having a mastectomy on one side only 2. How much radiotherapy changes breast reconstructions over time using 3D- SI to objectively measure this. For this study the follow up some women who do and some who do not have radiotherapy after breast reconstruction. Read Less

Gender:

FEMALE

Ages:

18 years and above

Trial Updated:

08/14/2025

Locations: Royal Marsden NHS Foundation Trust, London, Not set

Conditions: Breast Cancer

Learn More ›

A Study Evaluating the Efficacy and Safety of Inavolisib Plus CDK4/6 Inhibitor and Letrozole vs Placebo + CDK4/6i and Letrozole in Participants With Endocrine-Sensitive PIK3CA-Mutated, Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer

NCT06790693

Recruiting

This study will evaluate the efficacy and safety of the combination of inavolisib plus a cyclin-dependent kinase 4 and 6 inhibitor (CDK4/6i) and letrozole versus placebo plus a CDK4/6i and letrozole in the first-line setting in participants with endocrine-sensitive PIK3CA-mutated hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-), advanced breast cancer (ABC).

Gender:

ALL

Ages:

18 years and above

Trial Updated:

08/13/2025

Locations: Northwest Georgia Oncology Centers PC - Marietta, Marietta, Georgia +116 locations

Northwest Georgia Oncology Centers PC - Marietta, Marietta, Georgia

Cancer Care Specialists of Central Illinois, O'Fallon, Illinois

Springfield Clinic, Springfield, Illinois

Carle Cancer Center, Urbana, Illinois

Baptist Health Lexington, Lexington, Kentucky

Baptist Health Hamburg, Lexington, Kentucky

Baptist Health Louisville, Louisville, Kentucky

Cancer & Hematology Centers of Western Michigan, Grand Rapids, Michigan

Nebraska Cancer Specialists, Grand Island, Nebraska

Nebraska Cancer Specialists, Omaha, Nebraska

West Cancer Center, Germantown, Tennessee

Northwest Medical Specialties, Tacoma, Washington

Centro Oncologico Korben, Caba, Not set

Centro Médico Fleischer, Capital Federal, Not set

Hospital Privado Centro Medico de Cordoba, Cordoba, Not set

Instituto de Oncologia de Rosario, Rosario, Not set

Centro Oncológico de Excelencia, San Juan, Not set

Royal North Shore Hospital, St Leonards, New South Wales

Lyell McEwin Hospital, Elizabeth Vale, South Australia

Obras Sociais Irma Dulce - Osid, Salvador, Bahia

Crio - Centro Regional Integrado de Oncologia, Fortaleza, Ceará

Hospital Santa Rita de Cassia Vitoria, Vitoria, Espírito Santo

Hospital Araujo Jorge, Goiania, Goiás

Centro de Oncologia de Alfenas, Alfenas, Minas Gerais

Hospital do Câncer de Londrina, Londrina, Paraná

Hospital do Cancer de Pernambuco - HCP, Recife, Pernambuco

Vencer Oncoclínica - Centro de Pesquisa do Piauí, Teresina, Piauí

Santa Casa de Misericordia de Porto Alegre, Porto Alegre, Rio Grande Do Sul

Hospital de Cancer de Barretos, Barretos, São Paulo

Instituto do Cancer do Estado de Sao Paulo - ICESP, Sao Paulo, São Paulo

Clinica de Pesquisa e Centro de Estudos em Oncologia Ginecologica e Mamaria Ltda, Sao Paulo, São Paulo

Instituto Nacional de Cancer - INCa, Rio de Janeiro, Not set

The Moncton Hospital, Moncton, New Brunswick

The Ottawa Hospital Cancer Center, Ottawa, Ontario

St. Joseph's Health Centre, Toronto, Ontario

Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Quebec

Jewish General Hospital, Montreal, Quebec

Unité de Recherche Clinique du CISSS de Laurentides, Saint-jerome, Quebec

Xiangyang Central Hospital, Xiangyang, Hubei

Peking Union Medical College Hospital, Beijing City, Not set

Hunan Cancer Hospital, Changsha CITY, Not set

West China Hospital - Sichuan University, Chengdu City, Not set

Sichuan Provincial People's Hospital, Chengdu, Not set

Sun yat-sen University Cancer Center, Guangzhou, Not set

Sun Yat-Sen University Cancer Center - Huangpu Campus, Guangzhou, Not set

Zhejiang Cancer Hospital, Hangzhou City, Not set

Harbin Medical University Cancer Hospital, Harbin, Not set

Jiangmen Central Hospital, Jiangmen, Not set

Shandong Cancer Hospital, Jinan, Not set

Jinhua municipal central hospital, Jinhua City, Not set

Yunnan Cancer Hospital, Kunming City, Not set

Guangxi Cancer Hospital of Guangxi Medical University, Nanning City, Not set

Shantou Center Hospital, Shantou City, Not set

Tianjin Cancer Hospital, Tianjin, Not set

Tianjin Cancer hospital Airport hospital, Tianjin, Not set

Xinjiang Medical University Cancer Hospital, Urumqi City, Not set

The Second Affiliated Hospital of Xi'an Jiao Tong University, Xi'an City, Not set

Shanxi Provincial People's Hospital, Xian, Not set

A.O. S. Anna e San Sebastiano, Caserta, Campania

U.O.C. Oncologia Medica Senologica, Napoli, Campania

Università degli Studi Federico II, Napoli, Campania

Policlinico S.Orsola-Malpighi, Bologna, Emilia-Romagna

IRST Istituto Scientifico Romagnolo Per Lo Studio E Cura Dei Tumori, Sede Meldola, Meldola, Emilia-Romagna

Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Lazio

Asst Papa Giovanni XXIII, Bergamo, Lombardia

Ospedale San Raffaele, Milano, Lombardia

Irccs Istituto Nazionale Dei Tumori (Int), Milano, Lombardia

Istituto Clinico Humanitas, Rozzano, Lombardia

Az. Osp. G. Panico, Tricase (LE), Puglia

Humanitas Centro Catanese Di Oncologia, Misterbianco (CT), Sicilia

Ospedale Civile - Livorno, Livorno, Toscana

Azienda Sanitaria dell'Alto Adige;U.O.C. Oncologia Medic, Bolzano, Trentino-Alto Adige

University of Eastern Piedmont - Maggiore della Carità University Hospital, Novara, Umbria

Azienda Ospedaliera Santa Maria di Terni, Terni, Umbria

Kyungpook National University Chilgok Hospital, Daegu, Not set

Soon Chun Hyang University Cheonan Hospital, Dongnam-gu, Cheonan-si, Not set

National Cancer Center, Goyang-si, Not set

Seoul National University Bundang Hospital, Seongnam-si, Not set

Seoul National University Hospital, Seoul, Not set

Severance Hospital, Yonsei University Health System, Seoul, Not set

Asan Medical Center, Seoul, Not set

Gangnam Severance Hospital, Seoul, Not set

Samsung Medical Center, Seoul, Not set

Instytut "Centrum Zdrowia Matki Polki", ?ód?, Not set

Bialostockie Centrum Onkologii, Bialystok, Not set

Przychodnia Lekarska KOMED, Roman Karaszewski, Konin, Not set

Szpital Wojewódzki im. Miko?aja Kopernika, Koszalin, Not set

Szpital Miejski Specjalistyczny Narutowicza, Kraków, Not set

COZL Oddzial Onkologii Klinicznej z pododdzialem Chemioterapii Dziennej, Lublin, Not set

Wielkopolskie Centrum Onkologii im. Marii Sk?odowskiej-Curie, Pozna?, Not set

MRUKMED Lekarz Beata Madej-Mruk i Partner Spolka Partnerska Oddzial nr 1 w Rzeszowie, Rzeszow, Not set

Narodowy Inst.Onkologii im.Sklodowskiej-Curie Panstw.Inst.Bad, Warszawa, Not set

PanOncology Trials, San Juan, Not set

Abraham Oncology, Richards Bay, Not set

Wits Clinical Research, Soweto, Not set

Hospital General Universitario de Elche, Elche, Alicante

ICO L'Hospitalet, L'Hospitalet de Llobregat, Barcelona

Hospital de Basurto, Bilbao, Vizcaya

Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Barcelona, Not set

Hospital Clinico Universitario Virgen de la Victoria;Servicio de Oncologia, Malaga, Not set

Hospital Clinico Universitario de Valencia, Valencia, Not set

Chia-Yi Christian Hospital, Chiayi, Not set

Taichung Veterans General Hospital, Taichung, Not set

National Cheng Kung Uni Hospital, Tainan, Not set

National Taiwan Uni Hospital, Taipei, Not set

Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Not set

Taipei Veterans General Hospital, Taipei, Not set

Abdurrahman Yurtarslan Onkoloji Training and Research Hospital, Ankara, Not set

Ankara City Hospital, Ankara, Not set

Bakirkoy Dr. Sadi Konuk Egitim ve Arastirma Hastanesi, Tibbi Onkoloji, Bakirkoy / Istanbul, Not set

Ba?c?lar Medipol Mega Üniversite Hastanesi, Istanbul, Not set

Katip Celebi University Ataturk Training and Research Hospital, Izmir, Not set

Mersin City Education and Research Hospital, Mersin, Not set

Princess Alexandra Hospital, Harlow, Not set

St Bartholomew's Hospital, London, Not set

Royal Free Hospital, London, Not set

Churchill Hospital - Oxford Cancer & Haematology Centre, Oxford, Not set

Conditions: Breast Cancer

Learn More ›

A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

NCT06172478

Recruiting

This is a proof-of-concept study designed to investigate HER3-DXd monotherapy in locally advanced unresectable or metastatic solid tumors. The study is enrolling cohorts of participants with melanoma \[cutaneous/acral\], squamous cell carcinomas of the head and neck (SCCHN), HER2-negative gastric cancer ovarian carcinoma, cervical cancer, endometrial cancer, bladder cancer, esophageal carcinoma, pancreatic carcinoma, prostate cancer, second-line gastric cancer, lung cancer, and breast cancer.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

08/12/2025

Locations: City of Hope, Duarte, California +74 locations

City of Hope, Duarte, California

Yale Cancer Center, New Haven, Connecticut

AdventHealth Medical Group Oncology Research at Celebration, Kissimmee, Florida

University of Illinois Cancer Center, Chicago, Illinois

Johns Hopkins University, Baltimore, Maryland

Health Partners Frauenshuh Cancer Center, Saint Louis Park, Minnesota

Health Partners Cancer Center at Regions Hospital, Saint Paul, Minnesota

Washington University, School of Medicine, Saint Louis, Missouri

Roswell Park Cancer Institute IDS, Buffalo, New York

Memorial Sloan Kettering Hospital, New York, New York

SCRI Oncology Partners, Nashville, Tennessee

The University of Texas MD Anderson Cancer Center, Houston, Texas

Fred Hutchinson Cancer Center, Seattle, Washington

Chris O'Brien Lifehouse, Camperdown, Not set

Icon Cancer Centre Chermside, Chermside, Not set

Monash Medical Centre Clayton, Clayton, Not set

Icon Cancer Centre Hobart, Hobart, Not set

Icon Cancer Centre Townsville, Hyde Park, Not set

Cliniques Universitaires Saint-Luc, Bruxelles, Not set

UZA, Edegem, Not set

Universitair Ziekenhuis Gent, Gent, Not set

Universitair Ziekenhuis Brussel, Jette, Not set

UZ Leuven, Leuven, Not set

Sunnybrook Research Institute, Toronto, Not set

Princess Margaret Cancer Centre, Toronto, Not set

BC Cancer - Vancouver, Vancouver, Not set

Chu Bordeaux, Bordeaux, Not set

Centre Georges Franăois Leclerc, Dijon, Not set

Hopital Claude Huriez - Chu Lille, Lille, Not set

Centre Léon Bérard, Lyon, Not set

Hăpital de La Timone, Marseille, Not set

Chu Nantes - Hătel Dieu, Nantes, Not set

Institut Claudius Regaud, Toulouse, Not set

Institut Gustave Roussy, Villejuif, Not set

IRCCS Ospedale Policlinico San Martino, Genova, Not set

AOU Federico II - Oncologia Clinica, Napoli, Not set

Centro Ricerche Cliniche di Verona s.r.l., Verona, Not set

Saitama Medical University International Medical Center, Hidaka, Not set

National Cancer Center Hospital East, Kashiwa-shi, Not set

NHO Shikoku Cancer Center, Matsuyama-shi, Not set

Shizuoka Cancer Center, Nagaizumi-cho, Not set

Aichi Cancer Center Hospital, Nagoya, Not set

Kindai University Hospital, Osakasayama-shi, Not set

National Cancer Center Hospital, Tokyo, Not set

Cancer Institute Hospital of JFCR, Tokyo, Not set

Yokohama City University Medical Center, Yokohama, Not set

Cha Bundang Medical Center, Cha University, Seongnam, Not set

Seoul National University Bundang Hospital, Seongnam, Not set

Seoul National University Hospital, Seoul, Not set

Severance Hospital, Yonsei University Health System, Seoul, Not set

Asan Medical Center, Seoul, Not set

Samsung Medical Center, Seoul, Not set

Amsterdam UMC locatie Vumc, Amsterdam, Not set

Universitair Medisch Centrum Groningen, Groningen, Not set

Maastricht University Medical Center, Maastricht, Not set

Radboud University Medical Center, Nijmegen, Not set

Oslo Universitetssykehus HF, Radiumhospitalet, Oslo, Not set

Hospital Universitari Vall D'Hebron, Barcelona, Not set

Hospital Clinic de Barcelona, Barcelona, Not set

Hospital de La Santa Creu I Sant Pau, Barcelona, Not set

Hospital General Universitario Gregorio Marañon, Madrid, Not set

Hospital Universitario Ramon Y Cajal, Madrid, Not set

Hospital Universitario 12 de Octubre, Madrid, Not set

HOSPITAL REGIONAL UNIVERSITARIO de MALAGA AVDA., Málaga, Not set

Hospital Universitario Virgen Macarena, Sevilla, Not set

Hospital Clinico Universitario de Valencia, Valencia, Not set

Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Not set

National Cheng Kung University Hospital, Tainan, Not set

National Taiwan University Hospital, Taipei, Not set

Taipei Veterans General Hospital, Taipei, Not set

Chang Gung Memorial Hospital, Taoyuan, Not set

University Hospital Coventry, Coventry, Not set

Barts Hospital, London, Not set

Royal Free Hospital, London, Not set

Nottingham City Hospital Campus, Nottingham, Not set

Conditions: Advanced Solid Tumor, Melanoma, Head and Neck Cancer, Gastric Cancer, Ovarian Carcinoma, Cervical Cancer, Endometrial Cancer, Bladder Cancer, Esophageal Cancer, Pancreatic Carcinoma, Prostate Cancer, Non-small Cell Lung Cancer (NSCLC), Lung Cancer, Breast Cancer

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A Phase III Study of Dato-DXd With or Without Durvalumab Compared With Investigator's Choice of Chemotherapy in Combination With Pembrolizumab in Patients With PD-L1 Positive Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer

NCT06103864

Recruiting

This is a Phase III, randomised, open-label, 3-arm, multicentre, international study assessing the efficacy and safety of Dato-DXd with or without durvalumab compared with investigator's choice chemotherapy in combination with pembrolizumab in participants with PD-L1 positive locally recurrent inoperable or metastatic TNBC.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

08/11/2025

Locations: Research Site, Daphne, Alabama +307 locations

Research Site, Daphne, Alabama

Research Site, Springdale, Arkansas

Research Site, Duarte, California

Research Site, Glendale, California

Research Site, Sacramento, California

Research Site, Santa Rosa, California

Research Site, Aurora, Colorado

Research Site, New Haven, Connecticut

Research Site, Jacksonville, Florida

Research Site, Miami, Florida

Research Site, Palm Bay, Florida

Research Site, Plantation, Florida

Research Site, Atlanta, Georgia

Research Site, Honolulu, Hawaii

Research Site, Chicago, Illinois

Research Site, Decatur, Illinois

Research Site, Elmhurst, Illinois

Research Site, Naperville, Illinois

Research Site, New Albany, Indiana

Research Site, Des Moines, Iowa

Research Site, Lexington, Kentucky

Research Site, Louisville, Kentucky

Research Site, Baton Rouge, Louisiana

Research Site, Baltimore, Maryland

Research Site, Columbia, Maryland

Research Site, Boston, Massachusetts

Research Site, Worcester, Massachusetts

Research Site, Detroit, Michigan

Research Site, Grand Rapids, Michigan

Research Site, Saint Paul, Minnesota

Research Site, Hattiesburg, Mississippi

Research Site, Saint Louis, Missouri

Research Site, Albuquerque, New Mexico

Research Site, Albany, New York

Research Site, New York, New York

Research Site, Stony Brook, New York

Research Site, Cincinnati, Ohio

Research Site, Cleveland, Ohio

Research Site, York, Pennsylvania

Research Site, Providence, Rhode Island

Research Site, Chattanooga, Tennessee

Research Site, Nashville, Tennessee

Research Site, Dallas, Texas

Research Site, El Paso, Texas

Research Site, Flower Mound, Texas

Research Site, Fort Worth, Texas

Research Site, Houston, Texas

Research Site, Kingwood, Texas

Research Site, McKinney, Texas

Research Site, Sugar Land, Texas

Research Site, Charlottesville, Virginia

Research Site, Fairfax, Virginia

Research Site, Midlothian, Virginia

Research Site, Norfolk, Virginia

Research Site, Roanoke, Virginia

Research Site, Tacoma, Washington

Research Site, Madison, Wisconsin

Research Site, Buenos Aires, Not set

Research Site, Caba, Not set

Research Site, Ciudad de Buenos Aires, Not set

Research Site, Rosario, Not set

Research Site, San Nicolas de Los Arroyos, Not set

Research Site, Camperdown, Not set

Research Site, Darlinghurst, Not set

Research Site, Heidelberg, Not set

Research Site, Melbourne, Not set

Research Site, Nedlands, Not set

Research Site, Waratah, Not set

Research Site, Barretos, Not set

Research Site, Curitiba, Not set

Research Site, Florianópolis, Not set

Research Site, Goiânia, Not set

Research Site, Itajai, Not set

Research Site, Porto Alegre, Not set

Research Site, Recife, Not set

Research Site, Sao Paulo, Not set

Research Site, São Paulo, Not set

Research Site, Teresina, Not set

Research Site, Barrie, Ontario

Research Site, Hamilton, Ontario

Research Site, Toronto, Ontario

Research Site, Greenfield Park, Quebec

Research Site, Montréal, Quebec

Research Site, Regina, Saskatchewan

Research Site, Saskatoon, Saskatchewan

Research Site, Quebec, Not set

Research Site, Anyang, Not set

Research Site, Beijing, Not set

Research Site, Bengbu, Not set

Research Site, Changchun, Not set

Research Site, Changsha, Not set

Research Site, Chengdu, Not set

Research Site, Chongqing, Not set

Research Site, Fuzhou, Not set

Research Site, Guangzhou, Not set

Research Site, Hangzhou, Not set

Research Site, Harbin, Not set

Research Site, Hefei, Not set

Research Site, Ji Nan, Not set

Research Site, Nanchang, Not set

Research Site, Nanjing, Not set

Research Site, Nanning, Not set

Research Site, Shandong, Not set

Research Site, Shanghai, Not set

Research Site, Shenyang, Not set

Research Site, Tianjin, Not set

Research Site, Wenzhou, Not set

Research Site, Wuhan, Not set

Research Site, Xi'an, Not set

Research Site, Xiamen, Not set

Research Site, Xintai, Not set

Research Site, Xuzhou, Not set

Research Site, Zhanjiang, Not set

Research Site, Zhengzhou, Not set

Research Site, Lille, Not set

Research Site, Lyon, Not set

Research Site, Montpellier Cedex 5, Not set

Research Site, Paris, Not set

Research Site, Saint Herblain Cedex, Not set

Research Site, Toulouse Cedex 9, Not set

Research Site, Vandoeuvre-lès-nancy, Not set

Research Site, Villejuif, Not set

Research Site, Düsseldorf, Not set

Research Site, Essen, Not set

Research Site, Georgsmarienhütte, Not set

Research Site, Hamburg, Not set

Research Site, Hannover, Not set

Research Site, Heidelberg, Not set

Research Site, Heilbronn, Not set

Research Site, Leipzig, Not set

Research Site, Hong Kong, Not set

Research Site, Shatin, Not set

Research Site, Calicut, Not set

Research Site, Chennai, Not set

Research Site, Jaipur, Not set

Research Site, Kochi, Not set

Research Site, Kolkata, Not set

Research Site, Marg Jaipur, Not set

Research Site, Mohali, Not set

Research Site, Mysuru, Not set

Research Site, Nagpur, Not set

Research Site, Nashik, Not set

Research Site, New Delhi, Not set

Research Site, Pondicherry, Not set

Research Site, Surat, Not set

Research Site, Thiruvananthapuram, Not set

Research Site, Vadodara, Not set

Research Site, Vishakapatnam, Not set

Research Site, Bergamo, Not set

Research Site, Empoli, Not set

Research Site, Milano, Not set

Research Site, Milan, Not set

Research Site, Modena, Not set

Research Site, Napoli, Not set

Research Site, Padova, Not set

Research Site, Reggio Emilia, Not set

Research Site, Roma, Not set

Research Site, Rozzano, Not set

Research Site, Akashi-shi, Not set

Research Site, Bunkyo-ku, Not set

Research Site, Chiba-shi, Not set

Research Site, Chuo-ku, Not set

Research Site, Fukuoka-shi, Not set

Research Site, Fukushima-shi, Not set

Research Site, Gifu-shi, Not set

Research Site, Hidaka-shi, Not set

Research Site, Hiroshima-shi, Not set

Research Site, Isehara-shi, Not set

Research Site, Kamogawa-shi, Not set

Research Site, Kashiwa, Not set

Research Site, Kitaadachi-gun, Not set

Research Site, Koto-ku, Not set

Research Site, Kumamoto-shi, Not set

Research Site, Kurume-shi, Not set

Research Site, Matsuyama-shi, Not set

Research Site, Nagoya-shi, Not set

Research Site, Niigata-shi, Not set

Research Site, Nishinomiya-shi, Not set

Research Site, Okayama-shi, Not set

Research Site, Osaka-shi, Not set

Research Site, Osakasayama-shi, Not set

Research Site, Ota-shi, Not set

Research Site, Sapporo-shi, Not set

Research Site, Sendai-shi, Not set

Research Site, Shinagawa-ku, Not set

Research Site, Shinjuku-ku, Not set

Research Site, Tsu-shi, Not set

Research Site, Tsukuba, Not set

Research Site, Yokohama-shi, Not set

Research Site, Busan, Not set

Research Site, Daegu, Not set

Research Site, Goyang-si, Not set

Research Site, Seongnam-si, Not set

Research Site, Seoul, Not set

Research Site, CD Mexico, Not set

Research Site, Guadalajara, Not set

Research Site, Mexico City, Not set

Research Site, Mexico, Not set

Research Site, México, Not set

Research Site, Tuxtla Gutierrez, Not set

Research Site, Bacolod, Not set

Research Site, Cebu City, Not set

Research Site, Manila, Not set

Research Site, Muntinlupa City, Not set

Research Site, Quezon City, Not set

Research Site, San Juan, Not set

Research Site, Białystok, Not set

Research Site, Bydgoszcz, Not set

Research Site, Gdańsk, Not set

Research Site, Gdynia, Not set

Research Site, Konin, Not set

Research Site, Kraków, Not set

Research Site, Legnica, Not set

Research Site, Lublin, Not set

Research Site, Przemysl, Not set

Research Site, Warszawa, Not set

Research Site, Wroclaw, Not set

Research Site, Łódź, Not set

Research Site, Singapore, Not set

Research Site, Cape Town, Not set

Research Site, Johannesburg, Not set

Research Site, Paarl, Not set

Research Site, Pretoria, Not set

Research Site, Barcelona, Not set

Research Site, Granada, Not set

Research Site, Hospitalet deLlobregat, Not set

Research Site, Madrid, Not set

Research Site, Pamplona, Not set

Research Site, Santander, Not set

Research Site, Hsinchu, Not set

Research Site, Kaohsiung, Not set

Research Site, Taichung, Not set

Research Site, Tainan, Not set

Research Site, Taipei, Not set

Research Site, Taoyuan, Not set

Research Site, Bangkok, Not set

Research Site, Chiang Mai, Not set

Research Site, Dusit, Not set

Research Site, Khon Kaen, Not set

Research Site, Songkhla, Not set

Research Site, Ankara, Not set

Research Site, Besevler Ankara, Not set

Research Site, Izmir, Not set

Research Site, Küçükçekmece, Not set

Research Site, Samsun, Not set

Research Site, Cardiff, Not set

Research Site, Chelsea, Not set

Research Site, Leicester, Not set

Research Site, Liverpool, Not set

Research Site, London, Not set

Research Site, Oxford, Not set

Research Site, Surrey, Not set

Research Site, Sutton, Not set

Research Site, Taunton, Not set

Research Site, Hanoi, Not set

Research Site, Ho Chi Minh City, Not set

Research Site, Hue, Not set

Research Site, Hồ Chí Minh, Not set

Research Site, Viet Tri, Not set

Research Site, Vinh, Not set

Conditions: Breast Cancer

Learn More ›

A Study of MGC026 in Participants With Advanced Solid Tumors

NCT06242470

Recruiting

The study is designed to understand the safety, tolerability, pharmacokinetics, immunogenicity, and preliminary antitumor activity of MGC026 in participants with relapsed or refractory, unresectable, locally advanced or metastatic solid tumors The study has a dose escalation portion and a cohort expansion portion of the study. Participants will receive MGC026 by intravenous (IV) infusion. The dose of MGC026 will be assigned at the time of enrollment. Participants may receive up to 35 treatments... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

08/11/2025

Locations: The Angeles Clinic and Research Institute, Los Angeles, California +10 locations

Conditions: Advanced Solid Tumor, Advanced Cancer, Metastatic Cancer, Squamous Cell Carcinoma of Head and Neck, Non Small Cell Lung Cancer, Small-cell Lung Cancer, Bladder Cancer, Sarcoma, Endometrial Cancer, Melanoma, Castration Resistant Prostatic Cancer, Cervical Cancer, Colorectal Cancer, Gastric Cancer, Gastro-esophageal Cancer, Pancreas Cancer, Clear Cell Renal Cell Carcinoma, Hepatocellular Carcinoma, Platinum-resistant Ovarian Cancer, Breast Cancer, Ovarian Cancer, Esophageal Squamous Cell Cancer (SCC)

Learn More ›

A Study to Investigate Mechanisms of Resistance to Breast Cancer Therapies

NCT06274515

Recruiting

This study will evaluate mechanisms of resistance to anti-breast cancer therapies in tumor and blood samples from participants with human epidermal growth factor receptor (HER2) positive, hormone receptor (HR) positive or triple negative breast cancer.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

08/05/2025

Locations: Institut Jules Bordet, Anderlecht, Not set +25 locations

Institut Jules Bordet, Anderlecht, Not set

CHU de Liège (Sart Tilman), Liège, Not set

AZ Delta (Campus Rumbeke), Roeselare, Not set

Aalborg Universitetshospital, Aalborg, Not set

Sjællands Universitetshospital, Næstved, Naestved, Not set

Helsinki University Central Hospital, Helsinki, Not set

Tampere University Hospital, Tampere, Not set

KEM/Evang. Kliniken Essen Mitte gGmbH, Essen, Not set

ViDia Christliche Kliniken Karlsruhe, Vincentius-Diakonissen-Kliniken gAG, Karlsruhe, Not set

St. Elisabeth Krankenhaus Köln GmbH, Koeln, Not set

Universitätsklinikum Mannheim, Mannheim, Not set

I.R.S.T Srl IRCCS, Meldola, Emilia-Romagna

Azienda Ospedaliero - Universitaria di Modena Policlinico, Modena, Emilia-Romagna

RCCS - Centro di Riferimento, Aviano (PN), Friuli-Venezia Giulia

Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Lazio

Ospedale San Raffaele S.r.l. - PPDS, Milano, Lombardia

Irccs Istituto Nazionale Dei Tumori (Int), Milano, Lombardia

Irccs Istituto Europeo Di Oncologia (IEO), Milano, Lombardia

Oslo university hospital Radiumhospitalet, Oslo, Not set

Hospital Universitario 12 de Octubre, Madrid, Not set

HM Sanchinarro ? CIOCC, Madrid, Not set

Hospital Universitario Virgen del Rocio, Sevilla, Not set

Hospital Clínico Universitario de Valencia, Valencia, Not set

Basingstoke and North Hampshire Hospital, Basingstoke, Not set

Imperial College Healthcare NHS Trust, London, Not set

Christie Hospital NHS Trust, Manchester, Not set

Conditions: Breast Cancer

Learn More ›

A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence

NCT06492616

Recruiting

The primary goal of this study is to evaluate the effectiveness of elacestrant versus standard endocrine therapy in participants with node-positive, Estrogen Receptor-positive (ER+), Human Epidermal Growth Factor-2 negative (HER2-) early breast cancer with high risk of recurrence.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

08/05/2025

Locations: Southern Cancer Center, PC, Daphne, Alabama +368 locations

Southern Cancer Center, PC, Daphne, Alabama

Ironwood Cancer and Research Centers, Chandler, Arizona

Banner MD Anderson Cancer Center, Gilbert, Arizona

Mayo Clinic, Scottsdale, Arizona

Arizona Clinical Research Center, Inc., Tucson, Arizona

Highlands Oncology Group, PA, Springdale, Arkansas

UC San Diego Moores Cancer Center, La Jolla, California

Cancer and Blood Research Center, LLC, Los Alamitos, California

UCLA Department of Medicine - Hematology/Oncology, Los Angeles, California

Hoag Memorial Hospital Presbyterian, Newport Beach, California

Dignity Health dba Health Research Institute, Sacramento, California

Sutter Institute for Medical Research, Sacramento, California

University of California, San Francisco (UCSF), San Francisco, California

Southern California Kaiser Medical Center-San Marcos Medical, San Marcos, California

Sansum Clinic, Solvang, California

St.Joseph Hospital- Cancer Centers of Colorado, Denver, Colorado

Rocky Mountain Cancer Centers, LLP, Lone Tree, Colorado

AHMG Hematology and Oncology, Parker, Colorado

Cancer Care at CommonSpirit St. Anthony North Hospital, Westminster, Colorado

Yale New Haven Hospital- Yale Cancer Center, New Haven, Connecticut

The George Washington Medical Faculty Associates, Washington, District of Columbia

Boca Raton Regional Hospital (BRRH) - Lynn Cancer Institute, Boca Raton, Florida

Florida Cancer Specialists, Fort Myers, Florida

Mayo Clinic, Jacksonville, Florida

Miami Cancer Institute at Baptist Health Inc., Miami, Florida

AdventHealth Orlando Infusion Center, Orlando, Florida

Cancer Care Centers of Brevard (CCCB) - Palm Bay, Palm Bay, Florida

Memorial Healthcare System, Pembroke Pines, Florida

Miami Cancer Institute at Plantation, Plantation, Florida

Florida Cancer Specialists, Saint Petersburg, Florida

Comprehensive Hematology Oncology, Saint Petersburg, Florida

Moffitt Cancer Center, Tampa, Florida

Florida Cancer Specialists, West Palm Beach, Florida

University Blood & Cancer Center, LLC, Athens, Georgia

Winship Cancer Institute, Atlanta, Georgia

Northside Hospital, Atlanta, Georgia

Kaiser Permanente Hawaii Moanalua Medical Center, Honolulu, Hawaii

Illinois Cancer Specialists, Arlington Heights, Illinois

Northwest Cancer Centers, PC, Dyer, Indiana

Mission Cancer and Blood, Des Moines, Iowa

Cancer Center of Kansas, Wichita, Kansas

University Medical Center-New Orleans, New Orleans, Louisiana

Mercy Medical Center, Baltimore, Maryland

Ascension St. Agnes Hospital, Baltimore, Maryland

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland

Maryland Oncology Hematology, P.A., Columbia, Maryland

Massachusetts General Hospital, Boston, Massachusetts

Boston Medical Center, Boston, Massachusetts

Beth Israel Deaconess Medical Center, Boston, Massachusetts

Dana Farber Cancer Institute, Boston, Massachusetts

The Cancer & Hematology Centers, Grand Rapids, Michigan

Allina Health Cancer Institute - Abbott Northwestern Hospital, Minneapolis, Minnesota

Mayo Clinic, Rochester, Minnesota

Siteman Cancer Center, Saint Louis, Missouri

NHO Revive Research Institute LLC, Lincoln, Nebraska

Oncology Hematology West, PC dba Nebraska Cancer Specialists - Legacy, Omaha, Nebraska

Summit Medical Group, Florham Park, New Jersey

John Theurer Ctr-Hackensack UMC, Hackensack, New Jersey

Rutgers Cancer Institute, New Brunswick, New Jersey

Exigent Research LLC/New Mexico Oncology Hematology Consultants Ltd., Albuquerque, New Mexico

Hematology Oncology Associates of Central New York, PC, East Syracuse, New York

Cayuga Medical Center, Ithaca, New York

Laura and Isaac Perlmutter Cancer Center/NYU Langone Health, New York, New York

Columbia University Medical Center, New York, New York

Cape Fear Valley Medical Center, Fayetteville, North Carolina

Miami Valley Hospital South, Centerville, Ohio

Oncology_Hematology Care Clinical Trials, LLC, Fairfield, Ohio

Oregon Oncology Specialists, Salem, Oregon

Northwest Cancer Specialists, P.C., Tigard, Oregon

Lehigh Valley Health Network - Cedar Crest, Allen, Pennsylvania

Consultants In Medical Oncology and Hematology, P.C., Broomall, Pennsylvania

Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania

Alliance Cancer Specialists, PC, Media, Pennsylvania

Lankenau Medical Center, Wynnewood, Pennsylvania

Cancer Care Associates of York, Inc., York, Pennsylvania

Rhode Island Hospital, Providence, Rhode Island

Hollings Cancer Center, Charleston, South Carolina

Baptist Cancer Center, Memphis, Tennessee

SCRI Oncology Partners, Nashville, Tennessee

Tennessee Oncology, PLLC, Nashville, Tennessee

Henry - Joyce Cancer Clinic, Nashville, Tennessee

Hendrick Cancer Center, Abilene, Texas

Texas Oncology-Northeast Texas, Allen, Texas

Texas Oncology - DFW, Dallas, Texas

Oncology Consultants, P.A., Houston, Texas

The University of Texas MD Anderson Cancer Center, Houston, Texas

Texas Oncology - San Antonio, New Braunfels, Texas

Texas Oncology-Gulf Coast, Pearland, Texas

Mays Cancer Center, San Antonio, Texas

Texas Oncology- Central South, Weslaco, Texas

Utah Cancer Specialists, Salt Lake City, Utah

University of Vermont Medical Center, Burlington, Vermont

Inova Schar Cancer Institute, Fairfax, Virginia

Virginia Oncology Associates, Newport News, Virginia

Virginia Cancer Institute, Richmond, Virginia

Oncology & Hematology Associates of Southwest Virginia, Inc, Wytheville, Virginia

Virginia Mason Medical Center, Seattle, Washington

Swedish Cancer Institute, Seattle, Washington

Cancer Care Northwest, Spokane Valley, Washington

Northwest Medical Specialties PLLC, Tacoma, Washington

University of Wisconsin Carbone Cancer Center- University Hospital, Madison, Wisconsin

UW Cancer Center at ProHealth Care, Waukesha, Wisconsin

Fundacion Respirar, Buenos Aires, Ciudad Autónoma De Buenos Aires

Organizacion Medica de Investigacion (OMI), Buenos Aires, Ciudad Autónoma De Buenos Aires

Centro de Investigación CIPREC, C.a.b.a., Ciudad Autónoma De Buenos Aires

Centro Oncológico Korben, Caba, Ciudad Autónoma De Buenos Aires

Centro Medico Privado CEMAIC, Cordoba, Córdoba

Inst Med Fund Estudios Clinicos, Rosario, Santa Fe

Instituto de Oncologia de Rosario, Rosario, Santa Fe

Clinica Adventista Belgrano, Buenos Aires, Tucumán

Instituto Argentino de Diagnostico y Tratamiento, Buenos Aires, Not set

St Vincent's Hospital Sydney, Darlinghurst, New South Wales

Lake Macquarie Private Hospital - Oncology, Gateshead, New South Wales

Lismore Base Hospital - Cancer Care , Haematology Unit, Lismore, New South Wales

Macquarie University, Macquarie Park, New South Wales

Mater Hospital Sydney, North Sydney, New South Wales

Westmead Hospital, Westmead, New South Wales

Icon Cancer Centre Townsville, Hyde Park, Queensland

Icon Cancer Centre Southport, Southport, Queensland

Icon Cancer Centre Wesley, Auchenflower, Quuensland

Cancer Research SA, Adelaide, South Australia

Royal Adelaide Hospital - Oncology, Adelaide, South Australia

Icon Cancer Centre Kurralta Park, Kurralta Park, South Australia

The Queen Elizabeth Hospital, Woodville, South Australia

Box Hill Hospital, Box Hill, Victoria

Monash Medical Centre, Clayton, Victoria

Goulburn Valley Health, Shepparton, Victoria

Breast Cancer Research Centre, Nedlands, Western Australia

Icon Cancer Centre Hobart, Hobart, Not set

Mid North Coast Cancer Institute, Port Macquarie, Not set

Universitatsklinikum St. Polten, St. Poelten, Niederösterreich

Hanusch Krankenhaus, Wien, Not set

Clnique Saint Pierre Ottignies - Oncologie-Hématologie, Ottignies, Brabant Wallon

CHU Saint-Pierre, Bruxelles, Brussels Capital Region

Grand Hopital de Charleroi - Site Les Viviers, Charleroi, Hainaut

Jessa Ziekenhuis - Campus Virga Jesse - Medische Oncologie, Hasselt, Limburg

VITAZ Campus Sint-Niklaas Moerland, Sint-Niklaas, Oost-Vlaanderen

UZ Leuven, Leuven, Vlaams Brabant

Institut Jules Bordet, Brussels, Not set

CHC - Oncologie - Hémato-Immunopatho, Liège, Not set

CHU UCL Namur - Site Ste Elisabeth - Oncologie, Namur, Not set

Centro de Pesquisas Clínicas em Oncologia, Cachoeiro De Itapemirim, Espírito Santo

CEDOES - Centro de Pesquisa Clinica e Diagnostico do Espirito Santo LTDA, Vitória, Espírito Santo

Hospital Araujo Jorge, Goiânia, Goiás

CETUS Oncologia S.A, Belo Horizonte, Minas Gerais

Centro Integrado Oncologia Curitiba, Curitiba, Paraná

Instituto de Câncer de Londrina, Londrina, Paraná

Sociedade Beneficência e Caridade de Lajeado (Hospital Bruno Born), Lajeado, Rio Grande Do Sul

Futtura Oncologia, Porto Alegre, Rio Grande Do Sul

Centro Gaucho Integrado de Oncologia, Hematologia, Ensino e Pesquisa - Hospital Mae de Deus, Porto Alegre, Rio Grande Do Sul

Fundação PIO XII - Hospital de Amor Amazônia, Porto Velho, Rondônia

Centro de Pesquisas Oncologicas - CEPON, Florianópolis, Santa Catarina

Clinica de Neoplasias Litoral, Itajai, Santa Catarina

Fundação Pio XII - Hospital de Amor de Barretos, Barretos, Sao Paulo

Universidade de Sao Paulo (USP) - Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto (HCFMRP), Ribeirão Preto, São Paulo

Instituto Brasileiro de Controle do Cancer - ibcc - Hematology / Oncology, Sao Paulo, São Paulo

Hospital de Base de São José do Rio Preto - CIP, São José Do Rio Preto, São Paulo

PUCRS - Hospital São Lucas, Porto Alegre, Not set

Clínica de Pesquisas e Centro de Estudos em Oncologia Ginecológica e Mamária Ltda, São Paulo, Not set

Instituto de Assistencia Medica ao Servidor Publico Estadual (IAMSPE), São Paulo, Not set

Hospital Universitario y Politecnico La Fe - Oncología Médica, Valencia, Not set

BC Cancer -Surrey, Surrey, British Columbia

BC Cancer Agency, Vancouver, British Columbia

Jewish General Hospital, Montreal, Quebec

Regional Hospital Saint-Jerome, Saint-Jerome, Quebec

Hôpital du Saint-Sacrement, Quebec, Not set

Masarykuv onkologicky ustav - Klinika komplexni onkol. pece, Brno, Brno-město

Multiscan s.r.o., Hořovice, Stredoceský Kraj

FN Kralovske Vinohrady - Radioterapeuticka a onkologicka klinika, Praha 10, Not set

Fakultni Thomayerova nemocnice - Onkologicka klinika, Praha 4, Not set

Hillerod Hospital, Hillerød, Capital

Odense Universitetshospital - Oncology, Odense, South Denmark

Soenderborg Sygehus, Sønderborg, South Denmark

Centre Hospitalier Regional et Universitaire (CHRU) de Besancon - L'Hopital Jean Minjoz, Besancon, Alpes-Maritimes

Inst Cancerologie Strasbourg Europe, Strasbourg, Alsace

Ct Oncologie Radiotherapie CORT 37, Chambray-lès-Tours, Indre-et-Loire

Hopital Universitaire Dupuytren, Limoges, Limousin

Polyclinique de Blois, La Chaussée-Saint-Victor, Loir-et-Cher

Institut de Cancerologie de l'Ouest - Oncology, St. Herblain, Loire-Atlantique

ICONE, Bezannes, Marne

CRLCC Jean Godinot, Reims, Marne

Centre Hospitalier De Pau, Pau Cedex, Pyrénées-Atlantiques

Institut de Cancerologie Bourgogne, Dijon, Saône-et-Loire

CHU Amiens - Picardie Site Sud, Amiens, Somme

Institut Gustave Roussy, Villejuif, Val-de-Marne

CHI De Fréjus / Saint-Raphael, Fréjus, Var

Institut Sainte Catherine, Avignon, Vaucluse

Centre Hospitalier Universitaire De Poitiers - Pôle Régional de Cancérologie, Poitiers, Not set

Institut de Cancérologie de Lorraine, Vandœuvre-Lès-Nancy Cedex 03, Not set

Hopital Tenon, Paris Cedex 20, Île-de-France

Universitätsmedizin Mannheim (UMM), Mannheim, Baden-Württemberg

Hämatologie-Onkologie Zentrum MVZ, Augsburg, Bayern

Studienzentrale für das MVZ e.K, Eggenfelden, Bayern

Klinikum rechts der Isar, TUM München, München, Bayern

Immanuel Klinik Rüdersdorf, Rüdersdorf, Brandenburg

'Klinikum Esslingen GmbH, Esslingen am Neckar, Esslingen a.N.

'Schwerpunktpraxis Fuer Gynaekologie und Onkologie, Brandenburg, Fuerstenwalde /Spree

Klinikum Frankfurt Höchst GmbH, Frankfurt am Main, Hessen

GynOnco Duesseldorf, Duesseldorf, Nordrhein-Westfalen

Evangelisches Krankenhaus Bethesda, Mönchengladbach, Nordrhein-Westfalen

Marien Hospital Witten, Witten, Nordrhein-Westfalen

Klinikum Worms gGmbH, Worms, Rheinland-Pfalz

Gemeinschaftspraxis Haematologie - Onkologie, Dresden, Sachsen

University Hospital Of Leipzig - Frauen- und Kindermedizin, Leipzig, Sachsen

Helios Klinikum Berlin-Buch, Berlin, Not set

Mammazentrum Hamburg MVZ GbR, Hamburg, Not set

University Of Pécs - Oncology dept., Pécs, Baranya

Bacs-Kiskun Varmegyei Oktatakorhaz, Kecskemét, Bács-Kiskun

Debreceni Egyetem Klinikai Kozpont, Debrecen, Hajdú-Bihar

Nograd Varmegyei Szent Lazar Korhaz, Salgótarján, Szabolcs-Szatmár-Bereg

Budapesti Uzsoki Utcai Korhaz, Budapest, Not set

Ist.Oncologico del Mediterraneo, Viagrande, Catania

SSD Oncologia Medica Zamagni, IRCCS Azienda Ospedaliero- Universitaria di Bologna, Policlinico di Sant'Orsola, Bologna, Emilia-Romagna

IRST Dino Amadori IRCCS, Meldola, Forli-Cesena

IRCCS San Gerardo dei Tintori, Monza, Monza E Brianza

Azienda Sanitaria Locale Napoli 2 Nord, Frattamaggiore, Napoli

Centro di Riferimento Oncologico, IRCCS, Aviano, Pordenone

Ospedale Casa Sollievo della Sofferen IRCCS, Opera di San Pio da Pietrelcina, San Giovanni Rotondo, Puglia

Fond. Piemonte per l'Oncologia - Istituto di Candiolo IRCCS, Candiolo, Torino

Divisione di Oncologia Medica ASST Spedali Civili di Brescia, Brescia, Not set

Ospedale di Cremona, ASST Cremona, Cremona, Not set

SOD Radioterapia Oncologica, AOU Careggi, Firenze, Not set

Ospedale San Martino IRCCS, Genova, Not set

Azienda Unità Sanitaria Locale Toscana Nord Ovest, Livorno, Not set

Ospedale Generale Provinciale di Macerata, Macerata, Not set

Istituto Nazionale dei Tumori,IRCCS, Milano, Not set

Istituto Europeo di Oncologia IRCCS, Milano, Not set

Azienda Ospedaliera Universitaria Federico II, Napoli, Not set

IRCCS Istituto Nazionale Tumori Fondazione Pascale, Napoli, Not set

UOC Oncologia - A.O.R.N. "A. Cardarelli", Napoli, Not set

AOU Maggiore della Carità - Oncologia, Novara, Not set

Istituto Oncologico Veneto, Padova, Not set

Azienda USL Toscana Centro, Prato, Not set

Azienda Unita Sanitaria Locale della Romagna, Rimini, Not set

Irccs Crob, Rionero In Vulture, Not set

Fondazione PU Campus Biomedico, Roma, Not set

U.O. Ginecologia Oncologica - Fondazione Policlinico A. Gemelli, Roma, Not set

IRCCS Istituto Nazionale Tumori Regina Elena,UOSD Sperimentazioni di fase IV, Roma, Not set

Azienda Ospedaliero Universitaria Di Sassari, Sassari, Not set

Azienda Ospedaliera Universitaria Senese, Siena, Not set

Ospedale Sacro cuore Don Calabria- Negrar di Valpolicella, Verona, Not set

Chungbuk National University Hospital, Cheongju-si, Chungcheongbugdo [Ch'ungch'ongbuk-do]

CHA Bundang Medical Center, CHA University, Seongnam-si, Gyeonggido

Gachon University Gil Medical Center, Incheon, Incheon Gwang'yeogsi [Inch'n-Kwangyokshi]

Severance Hospital, Yonsei University Health System, Seoul, Seoul Teugbyeolsi [Seoul-T'ukpyolshi]

Asan Medical Center, Seoul, Seoul Teugbyeolsi [Seoul-T'ukpyolshi]

Gangnam Severance Hospital - Oncology, Seoul, Seoul Teugbyeolsi [Seoul-T'ukpyolshi]

Korea University Guro Hospital, Seoul, Seoul Teugbyeolsi [Seoul-T'ukpyolshi]

Korea University Anam Hospital, Seoul, Seoul Teugbyeolsi [Seoul-T'ukpyolshi]

Ewha Womans University Mokdong Hospital, Seoul, Seoul Teugbyeolsi [Seoul-T'ukpyolshi]

Inje University Haeundae Paik Hospital, Busan, Not set

National Cancer Center, Gyeonggi-do, Not set

Ajou University Hospital, Gyeonggi-do, Not set

Seoul National University Hospital, Seoul, Not set

The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, Not set

Ulsan University Hospital, Ulsan, Not set

Universiti Sains Malaysia /ID# 200101, Kota Bahru, Kelantan

Hospital Raja Permaisuri Bainun, Ipoh, Perak

Hospital Pulau Pinang - Rheumatology, George Town, Pulau Pinang

Institut Perubatan & Pergigian Termaju (IPPT) - USM (Kepala Batas, Pulau Pinang), Kepala Batas, Pulau Pinang

Pantai Hospital Kuala Lumpur, Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur

UKM Medical Centre, Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur

Beacon Hospital, Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur

Universiti Malaya Medical Centre, Kuala Lumpur, Wilayah Persekutuan

Institut Kanser Negara, Putrajaya, Wilayah Persekutuan

Hospital Sultan Ismail, Johor Bahru, Not set

Hospital Kuala Lumpur, Kuala Lumpur, Not set

Mahkota Medical Center, Melaka, Not set

Elisabeth-TweeSteden Ziekenhuis, Tilburg, Noord-Brabant

Haga Ziekenhuis - Internal Medicine, Den Haag, Zuid-Holland

Albert Schweitzer Ziekenhuis Locatie Dordwijk, Dordrecht, Zuid-Holland

Catharina Ziekenhuis, Eindhoven, Not set

IP Clinic Sp. z o.o., Łódź, Lodz

Europejskie Centrum Zdrowia Otwock, Szpital im. F. Chopina - Oddział Onkologii Klinicznej, Otwock, Mazowieckie

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie Panstwowy Instytut Badawczy, Warszawa, Mazowieckie

Szpitale Pomorskie Sp. z o.o. Oddzial Onkologii Klinicznej, Gdynia, Pomorskie

Pratia Poznan, Poznan, Wielkopolskie

Wielkopolskie Centrum Onkologii Oddzial Onkologii Klinicznej i Immunoonkologii, Poznan, Wielkopolskie

Hospital Beatriz Ângelo. Hospital de Loures - Oncologia Medica, Loures, Lisboa

Hospital De Vila Franca De Xira E.P.E., Vila Franca De Xira, Lisboa

IPO Porto FG, EPE, Porto, Região Autónoma Da Madeira

CHUC - Centro Hospitalar e Universitário de Coimbra, Coimbra, Not set

Instituto Portugues de Oncologia de Lisboa Francisco Gentil - Oncologia Medica, Lisboa, Not set

ULS Lisboa Ocidental (ULSLO), Lisboa, Not set

Hospital CUF Descobertas, Lisboa, Not set

Unidade Local de Saúde de Arrábida, Setúbal, Not set

Centro Hospitalar de Trás-os-Montes e Alto Douro, EPE, Vila Real, Not set

Institutul Oncologic Prof Dr Ion Chiricuta Cluj-Napoca, Cluj-Napoca, Cluj

Oncolab - Medical Oncology, Craiova, Dolj

Onco Clinic Consult - Ambulatory, Craiova, Dolj

Centrul de Oncologie Sf. Nectarie, Craiova, Dolj

Oncomed - Medical Oncology, Timisoara, Timis

Spitalul Clinic Filantropia, Bucuresti, Not set

Spitalul Clinic CF Nr 2 Bucuresti, Bucuresti, Not set

Memorial Healthcare International, Bucuresti, Not set

Radiotherapy Center Cluj, Floreşti, Not set

Institutul Regional de Oncologie Iasi - Medical Oncology, Iasi, Not set

Raffles Hospital, Singapore, Not set

Curie Oncology (Farrer), Singapore, Not set

Hospital Alvaro Cunqueiro, Vigo, A Coruña

Hospital Universitario Virgen del Rocío, Sevilla, Andalucia

H. Virgen de Valme, Sevilla, Andalucia

Hospital Universitari General de Catalunya, Sant Cugat Del Valles, Barcelona

Hospital de Sant Joan Despi Moises Broggi, Sant Joan Despí, Barcelona

Hospital Universitario de Canarias, San Cristobal de la Laguna, Canarias

Hospital Universitario Rey Juan Carlos, Móstoles, Madrid

Hospital Clínico Universitario Virgen De La Arrixaca, El Palmar, Murcia

Fundación Instituto Valenciano Oncologia, Valencia, Navarra

Complexo Hospitalario Universitario A Coruña, A Coruña, Not set

Hospital Universitari Vall D Hebron, Barcelona, Not set

Hospital Clinic De Barcelona - Oncología Médica, Barcelona, Not set

Hospital de La Santa Creu i Sant Pau, Barcelona, Not set

Hospital Universitario Reina Sofia, Córdoba, Not set

Hospital Universitario de Jaén, Jaén, Not set

H.U. Insular Gran Canaria, Las Palmas De Gran Canaria, Not set

H.U Arnau De Vilanova Lleida, Lleida, Not set

Hospital Universitario Lucus Augusti, Lugo, Not set

Hospital Beata Maria Ana, Madrid, Not set

Hospital General Universitario Gregorio Marañón - Oncology, Madrid, Not set

Hospital Universitario Ramón y Cajal, Madrid, Not set

Hospital Clínico San Carlos, Madrid, Not set

Hospital Universitario Fundacion Jimenez Diaz, Madrid, Not set

Hospital Universitario 12 de Octubre, Madrid, Not set

Hospital Universitario La Paz, Madrid, Not set

Hospital Universitario Virgen De La Victoria, Málaga, Not set

Hospital Regional Universitario de Málaga (Hospital Civil), Málaga, Not set

Hospital Universitario de Santiago, Santiago De Compostela, Not set

Hospital Universitario Virgen de la Macarena - Oncología Médica, Sevilla, Not set

Hospital Clinico Universitario De Valencia, Valencia, Not set

Hospital Quironsalud Valencia, Valencia, Not set

Tumor Zentrum Aarau, Aarau, Aargau (de)

Kantonsspital Badenv, Baden, Aargau (de)

Kantonsspital Baselland, Liestal, Basel-Landschaft (de)

HOCH Health Ostschweiz - Kantonsspital St.Gallen, Saint Gallen, Sankt Gallen (de)

Brust-Zentrum AG Zurich, Zürich, Zürich (de)

Inselspital, Universitätsspital Bern, Bern, Not set

Spitaeler Schaffhausen Kantonspital, Schaffhausen, Not set

Kuang Tien General Hospital - Shalu Xiangshang Division - Hemato-Oncology, Taichung City, Taichung

Taipei Medical University - Shuang Ho Hospital Ministry of Health and Welfare - Hematology & Oncology, New Taipei City, Taipei

National Defense Medical Center (NDMC) - Tri-Service General Hospital - Neihu Branch, Taipei City, Taipei

Koo Foundation Sun Yat-Sen Cancer Center - Hematology, Taipei City, Taoyuan

Chang Gung Medical Foundation - LinKou Chang Gung Memorial Hospital - Breast Surgery, Taiyuan, Taoyuan

Changhua Christian Medical Foundation Changhua Christian Hospital, Changhua City, Not set

China Medical University Hospital - Breast Surgery, Taichung, Not set

Chi Mei Medical Center - Liouying - Oncology, Tainan, Not set

National Taiwan University Hospital - Surgery, Taipei, Not set

Baskent Universitesi Adana Uygulama ve Arastirma Merkezi, Adana, Adana/ Yuregir

Sakarya Egit ve Aras Hast, Sakarya, Adapazari

VM MedicalPark Pendik Hospital, Istanbul, Istanbul/Pendik

Prof. Dr. Suleyman Yalcin Sehir Hastanesi, Kadikoy, Istanbul

Kocaeli Uni Egt ve Uyg Hast, İzmit, Kocaeli

Necmettin Erbakan Universitesi Tip Fakultesi Hastanesi, Konya, Meram/Konya

VM Medical Park Mersin Hastanesi, Mersin, Mersin/Mezitli

Medical Park Seyhan Hospital, Adana, Seyhan/Adana

Gazi Uni Hast, Ankara, Yenimahalle/Ankara

Hacettepe University Medical Faculty - Medical Oncology, Ankara, Not set

Gulhane Training and Research Hospital, Ankara, Not set

Ankara Universitesi Tip Fakultesi Cebeci Arastirma Ve Uygulama Hastanesi, Ankara, Not set

Adnan Menderes Universitesi - Uygulama ve Arastirma Hastanesi, Aydin, Not set

Dicle Universitesi Hastanesi, Diyarbakır, Not set

Medical Park Florya Hastanesi, Istanbul, Not set

VM Medical Park Samsun Hospital - Medical oncology, Samsun, Not set

Royal Cornwall Hospital (RCH) - Sunrise Centre, Truro, Cornwall

Whittington Health NHS Trust - Whittington Hospital, London, England

Royal Preston Hospital, Preston, Lancashire

University College London Hospitals, London, London, City Of

Musgrove Park Hospital, Taunton, Somerset

St Bartholomew's Hospital, London, Not set

Maidstone Hospital Kent Oncology Centre, Maidstone, Not set

Conditions: Breast Cancer

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The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

NCT04585750

Recruiting

The Phase 2 monotherapy portion of this study is currently enrolling and will evaluate the efficacy and safety of PC14586 (INN rezatapopt) in participants with locally advanced or metastatic solid tumors harboring a TP53 Y220C mutation. The Phase 1 portion of the study will assess the safety, tolerability and preliminary efficacy of multiple dose levels of rezatapopt as monotherapy and in Phase 1b in combination with pembrolizumab.

Gender:

ALL

Ages:

12 years and above

Trial Updated:

08/04/2025

Locations: Hoag Cancer Center, Irvine, California +80 locations

Hoag Cancer Center, Irvine, California

University of California Irvine Chao Family Comprehensive Cancer Center, Irvine, California

UCLA Jonsson Comprehensive Cancer Center, Los Angeles, California

USC Norris Comprehensive Cancer Center, Los Angeles, California

University of San Francisco, San Francisco, California

Rocky Mountain Cancer Center, Denver, Colorado

Yale Cancer Center, New Haven, Connecticut

Medical Oncology Hematology Consultants, Newark, Delaware

University of Miami - Sylvester Comprehensive Cancer Center, Miami, Florida

Advent Health, Orlando, Florida

Florida Cancer Specialists South, Port Charlotte, Florida

Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois

Indiana University, Indianapolis, Indiana

Massachusetts General Hospital, Boston, Massachusetts

Dana Farber Cancer Institute, Boston, Massachusetts

Karmanos Cancer Institute, Detroit, Michigan

New York University - Long Island Hospital, Mineola, New York

New York University Perlmutter Cancer Center, New York City, New York

Memorial Sloan Kettering, New York, New York

Duke University, Durham, North Carolina

The Cleveland Clinic Taussig Cancer Center, Cleveland, Ohio

University of Oklahoma, Oklahoma City, Oklahoma

Oregon Health & Science University (OHSU), Portland, Oregon

Abramson Cancer Center of the University of Pennsylvania, Philadelphia, Pennsylvania

University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania

WellSpan York Cancer Center, York, Pennsylvania

Medical University of South Carolina, Charleston, South Carolina

Sarah Cannon Research Institute, Nashville, Tennessee

Vanderbilt University Medical Center - Ingram Cancer Center, Nashville, Tennessee

New Experimental Therapeutics - NEXT Oncology, Austin, Texas

UTSW - Moody Outpatient Center - Parkland Health, Dallas, Texas

UT Southwest Simmons Cancer Center, Dallas, Texas

The University of Texas MD Anderson Cancer Center, Houston, Texas

New Experimental Therapeutics of San Antonio - NEXT Oncology, San Antonio, Texas

Virginia Cancer Specialists, Fairfax, Virginia

University of Washington, Fred Hutchinson Cancer Center, Seattle, Washington

Swedish Medical Center, Seattle, Washington

University of Wisconsin Carbone Cancer Center, Madison, Wisconsin

Chris O'Brien Lifehouse Hospital, Camperdown, New South Wales

Mater Cancer Care Centre, South Brisbane, Queensland

Flinders Medical Center, Bedford Park, South Australia

Monash Medical Centre, Clayton, Victoria

Linear Clinical Research, Nedlands, Western Australia

ICANS - Institut de cancérologie Strasbourg Europe, Strasbourg, Bas-Rhin

Institut Bergonie, Bordeaux, Gironde

Institut Claudius Regaud, Toulouse, Haute-Garonne

EDOG Institut de Cancerologie de l'Ouest, Saint-Herblain, Loire-Atlantique

Centre Jean Perrin, Clermont-Ferrand, Puy-de-Dôme

Institut Gustave Roussy, Villejuif, Val-de-Marne

Centre Léon Bérard Centre Régional de Lutte Contre Le Cancer, Lyon, Not set

CHU de Nîmes, Nîmes, Not set

Institute Cancer De Lorraine, Vandœuvre-lès-Nancy, Not set

Nationale Centrum für Tumorerkrankungen (NCT) Heidelberg, Heidelberg, Baden-Württemberg

Universitätsklinikum Augsburg, Augsburg, Bayern

Universitätsklinikum Frankfurt, Frankfurt, Hessen

Universitätsklinikum Essen, Essen, Nordrhein-Westfalen

Asklepios Klinik Altona, Hamburg, Not set

Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Lazio

Istituti Fisioterapici Ospitalieri - Istituto Nazionale Tumori Regina Elena, Rome, Lazio

ASST Grande Ospedale Metropolitano Niguarda, Milano, Lombardia

Fondazione IRCCS Istituto Nazionale Dei Tumori, Milano, Lombardia

Istituto Europeo Di Oncologia, Milano, Lombardia

Istituto Clinico Humanitas, Rozzano, Lombardia

Fondazione del Piemonte per l'Oncologia (IRCCS), Candiolo, Torino

IRCCS - lstituto Nazionale Tumori - Fondazione G. Pascale, Napoli, Not set

Asan Medical Center, Seoul, Not set

National Cancer Center, Seoul, Not set

Samsung Medical Center, Seoul, Not set

Seoul University Hospital, Seoul, Not set

Severance Hospital Yonsei University, Seoul, Not set

National University Hospital, Kent Ridge, Not set

National Cancer Center of Singapore, Singapore, Not set

Instituto de Investigacion Oncologica Vall d'Hebron (VHIO) - EPON, Barcelona, Not set

NEXT Oncology-Hospital Quironsalud Barcelona, Barcelona, Not set

Hospital Universitario 12 de Octubre, Madrid, Not set

START MADRID_Hospital Universitario Fundacion Jimenez Diaz, Madrid, Not set

START MADRID_Hospital Universitario HM Sanchinarro - CIOCC, Madrid, Not set

START Rioja, Rioja, Not set

Hospital Clinico Universitario de Valencia, Valencia, Not set

Sarah Cannon Research Institute UK, London, Middlesex

Freeman Hospital, Newcastle Upon Tyne, Tyne and Wear

Conditions: Advanced Solid Tumor, Advanced Malignant Neoplasm, Metastatic Cancer, Metastatic Solid Tumor, Lung Cancer, Ovarian Cancer, Endometrial Cancer, Prostate Cancer, Colorectal Cancer, Breast Cancer, Other Cancer, Locally Advanced, Head and Neck Cancer, Gall Bladder Cancer, Small Cell Lung Cancer, Small Cell Lung Cancer ( SCLC ), Small Cell Lung Carcinoma, NSCLC, NSCLC (non-small Cell Lung Cancer), SCLC, Non-Small Cell Lung Carcinoma, Triple Negative Breast Cancer, TNBC, HER2+ Breast Cancer, Non-Small Cell Lung Cancer, ER/PR Positive Breast Cancer, HER2- Breast Cancer, HER2-positive Breast Cancer, HER2-negative Breast Cancer, ER/PR(+), Her2(-) Breast Cancer

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Open-Label Umbrella Study To Evaluate Safety And Efficacy Of Elacestrant In Various Combination In Participants With Metastatic Breast Cancer

NCT05563220

Recruiting

This is a multicenter, Phase 1b/2 trial in participants with estrogen receptor positive/human epidermal growth factor receptor 2 negative (ER+/HER2-) advanced/metastatic breast cancer. The phase 1b part of the trial will determine the recommended Phase 2 dose (RP2D) of elacestrant when administered in combination with alpelisib, everolimus, palbociclib, capivasertib, and ribociclib. The Phase 2 part of the trial will evaluate the efficacy and safety of the various combinations.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

08/01/2025

Locations: Dothan Hematology and Oncology, Dothan, Alabama +117 locations

Dothan Hematology and Oncology, Dothan, Alabama

Mayo Clinic - Arizona, Phoenix, Arizona

Highlands Oncology Group, Springdale, Arkansas

OPN Healthcare (Arcadia Location), Arcadia, California

City of Hope National Medical Center, Duarte, California

Glendale Adventist, Glendale, California

OPN Healthcare (Los Alamitos Location), Los Alamitos, California

Cedars Sinai, Los Angeles, California

UCLA UCLA Hem/Onc - Clinical Research Unit, Los Angeles, California

UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California

TOI Clinical Research, Whittier, California

Rocky Mountain Cancer Centers, Lone Tree, Colorado

Yale School Of Medicine - Smilow Cancer Hospital - Breast Center, New Haven, Connecticut

George Washington Cancer Center, Washington, District of Columbia

Advent Health (Florida Hospital) - Altamonte Springs, Altamonte Springs, Florida

Mayo Clinic - Jacksonville, Jacksonville, Florida

Ocala Oncology, Ocala, Florida

Northside Hospital Atlanta Cancer Care, Cumming, Georgia

Northwestern Feinberg Scholl of Medicine Prentice Women's Hospital, Chicago, Illinois

Fort Wayne Medical Oncology and Hematology, Fort Wayne, Indiana

MD Alliance for Multispecialty Research, LLC, Merriam, Kansas

New England Cancer Specialists, Scarborough, Maine

Johns Hopkins School of Medicine, Baltimore, Maryland

Massachusetts General Hospital, Boston, Massachusetts

Dana Farber Cancer Institute, Boston, Massachusetts

Barbara Ann Karmanos Cancer Institute, Detroit, Michigan

Minnesota Oncology Hematology, Minneapolis, Minnesota

Mayo Clinic - Rochester, Rochester, Minnesota

Washington University School of Medicine in St. Louis, Saint Louis, Missouri

Astera Cancer Care, East Brunswick, New Jersey

Summit Medical Group, Florham Park, New Jersey

Cooperman Barnabas Medical Center, New Brunswick, New Jersey

NYU Langone Health, New York, New York

New York Cancer and Blood Specialists, Port Jefferson Station, New York

W&IH of RI Breast Health Center of Women and Infants Hospital of Rhode Island, Providence, Rhode Island

Sarah Cannon Research Institute / Tennessee Oncology, Nashville, Tennessee

Texas Oncology - Baylor Charles A. Sammons Cancer Center, Dallas, Texas

MD Anderson Cancer Center Texas, Houston, Texas

UT Health San Antonio, San Antonio, Texas

Inova Schar Cancer Institute, Fairfax, Virginia

Virginia Cancer Specialists, Fairfax, Virginia

Virginia Oncology Associates, Norfolk, Virginia

Cancer Care Northwest, Spokane Valley, Washington

Northwest Medical Specialties (Nwms) - Puyallup - Medical Oncology (Rainier Hematology-Oncology)/Exigent Research Network; LLC, Tacoma, Washington

University of WI - Carbone Cancer Center (Phase II only), Madison, Wisconsin

Centro Medico Austral, Buenos Aires, Not set

Hospital Britanico De Buenos Aires, Buenos Aires, Not set

Cemaic - Centro De Especialidades Medicas Ambulatorias E Investigacion Clinica, Cordoba, Not set

Centro Oncologico Riojano Integral (Cori), La Rioja, Not set

Macquarie University, Sydney, Not set

Institut Jules Bordet, Anderlecht, Not set

Grand Hôpital de Charleroi - Site Notre Dame, Charleroi, Not set

Universitaire Ziekenhuizen (Uz) Leuven - Campus Gasthuisberg - Multidisciplinair Borstcentrum (Multidisciplinary Breast Center) (Mbc), Leuven, Not set

Algemeen Ziekenhuis Nikolaas; VITAZ; Oncologie Klinisch Studiecentrum, Sint-Niklaas, Not set

ACCG - Hospital Araujo Jorge, Goiania, Not set

Clinica Neoplasias Litoral, Itajai, Not set

Hospital Sao Lucas da PUCRS, Porto Alegre, Not set

Centro Gaucho Integrado de Oncologia; Hematologia; Ensino e Pesquisa - Hospital Mae de Deus/AESC, Porto Alegre, Not set

Hospital Sirio-Libanes (HSL) - Centro De Oncologia - Sao Paulo, Sao Paulo, Not set

Nemocnice Horovice Hospital, Hořovice, Not set

Fakultni Nemocnice Olomouc, Olomouc, Not set

Centre Hospitalier Lyon SUD- HCL, Lyon, Not set

Centre de Cancérologie du Grand Montpellier, Montpellier, Not set

Centre de Cancérologie du Grand Montpellier, Rouen, Not set

Centre Hospitalier Universitaire (Chu) De Toulouse - Institut Universitaire Du Cancer De Toulouse-Oncopole (Iuct-Oncopole) (Institut Claudius Regaud), Toulouse, Not set

Institut Gustave-Roussy-Umr 981, Villejuif, Not set

Universitaetsklinikum Mannheim, Mannheim, Baden-Wuerttemberg

Technischen Universitaet Muenchen (TUM), Klinikum Rechts der Isar, Muenchen, Bayern

Universitatskinikum Carl Gustav Carus Dresden, Dresden, Sachsen

Marienhospital Bottrop, Bottrop, Not set

Universitatskinikum Carl Gustav Carus Dresden, Dresden, Not set

Kliniken Essen-Mitte (KEM), Essen, Not set

Gesundheit Nordhessen Klinikum Kassel, Kassel, Not set

Universitaetsklinikum Tuebingen, Tübingen, Not set

Semmelweis Egyetem Klinikai Kozpont - Onkologiai Intezet, Budapest, Not set

Orszagos Onkologiai Intezet, Budapest, Not set

Samson Assuta Ashdod University Hospital - The Institute of Oncology, Ashdod, Not set

Rambam Heath, Haifa, Not set

Shaare Zedek Medical Center, Jerusalem, Not set

Davidoff Rabin Medical Center, Petah Tikva, Not set

Sheba Medical Center; Center Israel, Ramat Gan, Not set

ASST degli Spedali Civili di Brescia, Brescia, Not set

Azienda Ospedaliera "Istituti Ospitalieri" Di Cremona, Cremona, Not set

Istituto Europeo di Oncologia (IEO), Milano, Not set

Istituto Nazionale Tumori "Fondazione PASCALE", Napoli, Not set

Azienda Ospedaliero-Universitaria Pisana, Pisa, Not set

Ospedale Infermi di Rimini - Azienda Unita Sanitaria Locale Della Romagna, Rimini, Not set

Seoul National University Bundang Hospital, Seongnam-si, Not set

Asan Medical Center, Seoul, Not set

Gangnam Severance Hospital, Seoul, Not set

The Catholic University of Korea - Seoul St. Mary's Hospital, Seoul, Not set

Korea University Anam Hospital, Seoul, Not set

Ulsan University Hospital, Ulsan, Not set

Centre Hospitalier De L'Ardenne, Libramont, Not set

Klinika Onkologii; Wojskowy Instytut Medyczny - Państwowy Instytut Badawczy, Warszawa, Mazowieckie

Przychodnia Lekarska "Komed" Roman Karaszewski, Konin, Not set

Med-Polonia Sp. Z o.o., Poznań, Not set

Instytut Centrum Zdrowia Matki Polki, Łódź, Not set

Complejo Hospitalario Universitario A Coruna, A Coruña, Not set

Hospital Universitari Vall d'Hebron, Barcelona, Not set

Hospital Clinic Barcelona, Barcelona, Not set

Hospital General Universitario Gregorio Maranon, Madrid, Not set

IOB Madrd Institute of Oncology Hospital Beata Maria Ana de Jesus, Madrid, Not set

Hospital Clinico San Carlos, Madrid, Not set

Hospital Universitario 12 de Octubre, Madrid, Not set

Hospital Universitario La Paz, Madrid, Not set

Hospital Universitario Virgen de la Victoria, Malaga, Not set

NEXT Madrid, Pozuelo de Alarcon, Not set

Fundacion Instituto Valeciano De Oncologia, Valencia, Not set

Hospital Clinico Universitario de Valencia, Valencia, Not set

Hospital Arnau De Vilanova, Valencia, Not set

Abdurrahman Yurtaslan Oncology Hospital, Ankara, Not set

Ankara Bilkent City Hospital, Bilkent Campus, Universiteler Mh. (old: Ankara Yildirim Beyazit Universitesi), Ankara, Not set

The Clatterbridge Cancer Centre NHS Foundation Trust, Liverpool, Not set

Liverpool Hospital, Liverpool, Not set

North Middlesex University Hospital, London, Not set

Sarah Cannon Research Institute UK; Ltd, London, Not set

University College London Hospitals NHS Foundation Trust; The London Clinic - Main Hospital, London, Not set

Conditions: Breast Cancer, Metastatic Breast Cancer

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