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Paclitaxel Treatment Options in United Kingdom
A collection of 293 research studies where Paclitaxel is the interventional treatment. These studies are located in the United Kingdom . Paclitaxel is used for conditions such as Breast Cancer, Ovarian Cancer and Non-Small Cell Lung Cancer.
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Study of Efficacy and Safety of NIS793 in Combination With Standard of Care (SOC) Chemotherapy in First-line Metastatic Pancreatic Ductal Adenocarcinoma (mPDAC) - daNIS-2
Completed
The purpose of this study is to evaluate the efficacy and safety of NIS793 in combination with gemcitabine/nab-paclitaxel versus gemcitabine/nab-paclitaxel and placebo in first-line metastatic pancreatic ductal adenocarcinoma (mPDAC).
This study aims to explore whether blockade of Transforming Growth Factor β (TGFβ) in combination with gemcitabine/nab-paclitaxel can reduce fibrosis in PDAC, restore chemo-sensitivity and ultimately lead to improvements in overall survival (OS) and other clinical... Read More
The purpose of this study is to evaluate the efficacy and safety of NIS793 in combination with gemcitabine/nab-paclitaxel versus gemcitabine/nab-paclitaxel and placebo in first-line metastatic pancreatic ductal adenocarcinoma (mPDAC).
This study aims to explore whether blockade of Transforming Growth Factor β (TGFβ) in combination with gemcitabine/nab-paclitaxel can reduce fibrosis in PDAC, restore chemo-sensitivity and ultimately lead to improvements in overall survival (OS) and other clinically relevant outcomes. Read Less
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
01/06/2025
Locations: Highlands Oncology Group, Fayetteville, Arkansas +112 locations
Highlands Oncology Group, Fayetteville, Arkansas
University of California LA, Los Angeles, California
Advent Health Cancer Institute, Orlando, Florida
Fort Wayne Medical Oncology Hematology Inc, Fort Wayne, Indiana
NYU Clinical Cancer Center, New York, New York
US Oncology Research Dallas, Dallas, Texas
Houston Methodist Hospital, Houston, Texas
Huntsman Cancer Institute, Salt Lake City, Utah
Seattle Cancer Care Alliance, Seattle, Washington
Novartis Investigative Site, Adelaide, South Australia
Novartis Investigative Site, Perth, Western Australia
Novartis Investigative Site, Bonheiden, Not set
Novartis Investigative Site, Bruxelles, Not set
Novartis Investigative Site, Edegem, Not set
Novartis Investigative Site, Leuven, Not set
Novartis Investigative Site, Brasilia, Distrito Federal
Novartis Investigative Site, Porto Alegre, Rio Grande Do Sul
Novartis Investigative Site, Ijui, RS
Novartis Investigative Site, Sao Paulo, SP
Novartis Investigative Site, Brampton, Ontario
Novartis Investigative Site, Cambridge, Ontario
Novartis Investigative Site, Toronto, Ontario
Novartis Investigative Site, Guangzhou, Guangdong
Novartis Investigative Site, Harbin, Heilongjiang
Novartis Investigative Site, Nanjing, Jiangsu
Novartis Investigative Site, Dalian, Liaoning
Novartis Investigative Site, Jining, Shandong
Novartis Investigative Site, Xian, Shanxi
Novartis Investigative Site, Chengdu, Sichuan
Novartis Investigative Site, Hangzhou, Zhejiang
Novartis Investigative Site, Beijing, Not set
Novartis Investigative Site, Beijing, Not set
Novartis Investigative Site, Beijing, Not set
Novartis Investigative Site, Shanghai, Not set
Novartis Investigative Site, Shanghai, Not set
Novartis Investigative Site, Shanghai, Not set
Novartis Investigative Site, Shanghai, Not set
Novartis Investigative Site, Tianjin, Not set
Novartis Investigative Site, Brno, Czech Republic
Novartis Investigative Site, Novy Jicin, Czech Republic
Novartis Investigative Site, Hradec Kralove, CZE
Novartis Investigative Site, Praha 4, Not set
Novartis Investigative Site, Helsinki, Not set
Novartis Investigative Site, Tampere, Not set
Novartis Investigative Site, Nice, Alpes Maritimes
Novartis Investigative Site, Avignon, Not set
Novartis Investigative Site, Besancon Cedex, Not set
Novartis Investigative Site, Creteil, Not set
Novartis Investigative Site, Lyon 08, Not set
Novartis Investigative Site, Marseille, Not set
Novartis Investigative Site, Montpellier, Not set
Novartis Investigative Site, Nantes Cedex 1, Not set
Novartis Investigative Site, Paris, Not set
Novartis Investigative Site, Berlin, Not set
Novartis Investigative Site, Bochum, Not set
Novartis Investigative Site, Essen, Not set
Novartis Investigative Site, Frankfurt, Not set
Novartis Investigative Site, Halle S, Not set
Novartis Investigative Site, Hamburg, Not set
Novartis Investigative Site, Ulm, Not set
Novartis Investigative Site, Thessaloniki, Not set
Novartis Investigative Site, Thessaloniki, Not set
Novartis Investigative Site, Budapest, Not set
Novartis Investigative Site, Budapest, Not set
Novartis Investigative Site, Debrecen, Not set
Novartis Investigative Site, Jerusalem, Not set
Novartis Investigative Site, Ramat Gan, Not set
Novartis Investigative Site, Tel Aviv, Not set
Novartis Investigative Site, Firenze, FI
Novartis Investigative Site, Milano, MI
Novartis Investigative Site, Milano, MI
Novartis Investigative Site, Verona, VR
Novartis Investigative Site, Nagoya, Aichi
Novartis Investigative Site, Kashiwa, Chiba
Novartis Investigative Site, Yokohama-city, Kanagawa
Novartis Investigative Site, Osaka-city, Osaka
Novartis Investigative Site, Chuo ku, Tokyo
Novartis Investigative Site, Koto ku, Tokyo
Novartis Investigative Site, Seoul, Seocho Gu
Novartis Investigative Site, Seoul, Not set
Novartis Investigative Site, Seoul, Not set
Novartis Investigative Site, Utrecht, Not set
Novartis Investigative Site, Nordbyhagen, Oslo
Novartis Investigative Site, Oslo, Not set
Novartis Investigative Site, Omsk, Not set
Novartis Investigative Site, Pushkin Saint Petersburg, Not set
Novartis Investigative Site, Singapore, Not set
Novartis Investigative Site, Bratislava, Slovak Republic
Novartis Investigative Site, Banska Bystrica, Not set
Novartis Investigative Site, Kosice, Not set
Novartis Investigative Site, Barcelona, Catalunya
Novartis Investigative Site, Hospitalet de LLobregat, Catalunya
Novartis Investigative Site, Santiago De Compostela, Galicia
Novartis Investigative Site, Madrid, Not set
Novartis Investigative Site, Madrid, Not set
Novartis Investigative Site, Madrid, Not set
Novartis Investigative Site, Malmo, Not set
Novartis Investigative Site, Umea, Not set
Novartis Investigative Site, Bellinzona, Not set
Novartis Investigative Site, Geneve 14, Not set
Novartis Investigative Site, St Gallen, Not set
Novartis Investigative Site, Taipei, Not set
Novartis Investigative Site, Taipei, Not set
Novartis Investigative Site, Taoyuan, Not set
Novartis Investigative Site, Adana, Not set
Novartis Investigative Site, Ankara, Not set
Novartis Investigative Site, Istanbul, Not set
Novartis Investigative Site, Izmir, Not set
Novartis Investigative Site, Sutton, Surrey
Novartis Investigative Site, Cambridge, Not set
Novartis Investigative Site, Liverpool, Not set
Novartis Investigative Site, London, Not set
Novartis Investigative Site, Oxford, Not set
Conditions: Metastatic Pancreatic Ductal Adenocarcinoma
A Study of Pembrolizumab (MK-3475) With or Without Maintenance Olaparib in First-line Metastatic Squamous Non-small Cell Lung Cancer (NSCLC, MK-7339-008/KEYLYNK-008)
Active Not Recruiting
The current study will compare pembrolizumab (MK-3475) plus maintenance olaparib, vs. pembrolizumab plus maintenance olaparib placebo for the treatment of squamous NSCLC. The study's 2 primary hypotheses are:
1. Pembrolizumab plus maintenance olaparib is superior to pembrolizumab plus maintenance olaparib placebo with respect to progression-free survival (PFS) per RECIST 1.1 by blinded independent clinical review (BICR).
2. Pembrolizumab plus maintenance olaparib is superior to pembrolizumab pl... Read More
The current study will compare pembrolizumab (MK-3475) plus maintenance olaparib, vs. pembrolizumab plus maintenance olaparib placebo for the treatment of squamous NSCLC. The study's 2 primary hypotheses are:
1. Pembrolizumab plus maintenance olaparib is superior to pembrolizumab plus maintenance olaparib placebo with respect to progression-free survival (PFS) per RECIST 1.1 by blinded independent clinical review (BICR).
2. Pembrolizumab plus maintenance olaparib is superior to pembrolizumab plus maintenance olaparib placebo with respect to overall survival (OS).
As of Amendment 07, there will be no further analyses for OS and patient-reported outcome assessments. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/06/2025
Locations: Alabama Oncology Bruno Cancer Center ( Site 0001), Birmingham, Alabama +177 locations
Alabama Oncology Bruno Cancer Center ( Site 0001), Birmingham, Alabama
Disney Family Cancer Center ( Site 0005), Burbank, California
Boca Raton Regional Hospital ( Site 0018), Boca Raton, Florida
Mid-Florida Cancer Centers ( Site 0022), Orange City, Florida
H. Lee Moffitt Cancer Center and Research Institute ( Site 0024), Tampa, Florida
Columbus Regional Research Institute ( Site 0099), Columbus, Georgia
Mount Sinai Hospital Medical Center ( Site 0035), Chicago, Illinois
Oncology of Northshore ( Site 0036), Rolling Meadows, Illinois
Methodists Hospitals/Premier Oncology Hematology Associates ( Site 0039), Merrillville, Indiana
MedStar Franklin Square Medical Center ( Site 0044), Baltimore, Maryland
Barbara Ann Karmanos Cancer Institute ( Site 0046), Detroit, Michigan
Hattiesburg Clinic ( Site 0051), Hattiesburg, Mississippi
Frontier Oncology ( Site 0052), Billings, Montana
Bozeman Health Deaconness Cancer Center ( Site 0053), Bozeman, Montana
Waverly Hematology Oncology ( Site 0054), Cary, North Carolina
Thompson Cancer Survival Center ( Site 2812), Knoxville, Tennessee
Renovatio Clinical ( Site 0074), The Woodlands, Texas
Cancer Care Northwest ( Site 0083), Spokane Valley, Washington
Hospital Italiano Regional del Sur ( Site 0509), Bahia Blanca, Buenos Aires
Instituto de Investigaciones Clinicas Mar del Plata ( Site 0516), Mar del Plata, Buenos Aires
Hospital Britanico de Buenos Aires ( Site 0500), Buenos Aires, Caba
Instituto Medico Rio Cuarto ( Site 0501), Rio Cuarto, Cordoba
Sanatorio Parque ( Site 0515), Rosario, Santa Fe
Centro Oncológico de Rosario ( Site 0507), Rosario, Santa Fe
Centro Medico San Roque ( Site 0506), San Miguel de Tucuman, Tucuman
Hospital Italiano de Buenos Aires ( Site 0511), Buenos Aires, Not set
Clínica Universitaria Reina Fabiola ( Site 0505), Cordoba, Not set
Sanatorio Privado San Geronimo S.R.L ( Site 0510), Santa Fe, Not set
Liverpool Hospital ( Site 1201), Liverpool, New South Wales
Southern Medical Day Care Centre ( Site 1200), Wollongong, New South Wales
Townsville General Hospital ( Site 1202), Townsville, Queensland
Monash Cancer Centre ( Site 1205), Clayton, Victoria
Ordensklinikum Linz GmbH Elisabethinen ( Site 1307), Linz, Oberosterreich
Klinikum Wels-Grieskirchen ( Site 1304), Wels, Oberosterreich
Innsbruck LKH ( Site 1302), Innsbruck, Tirol
Social Medical Center - Otto Wagner Hospital ( Site 1301), Vienna, Wien
Krankenhaus Nord - Klinik Floridsdorf ( Site 1300), Wien, Not set
Hospital Sao Rafael ( Site 0258), Salvador - BA, Bahia
Instituto do Cancer do Ceara ( Site 0251), Fortaleza, Ceara
Oncologica do Brasil ( Site 0256), Belem, Para
Hospital Tacchini ( Site 0265), Bento Goncalves, Rio Grande Do Sul
Irmandade da Santa Casa de Misericordia de Porto Alegre ( Site 0255), Porto Alegre, Rio Grande Do Sul
Centro de Novos Tratamentos Itajai - Clinica de Neoplasias Litoral ( Site 0252), Itajai, Santa Catarina
Hospital de Base de Sao Jose de Rio Preto ( Site 0254), Sao Jose Rio Preto, Sao Paulo
Instituto Nacional do Cancer Jose Alencar Gomes da Silva INCA ( Site 0253), Rio de Janeiro, Not set
Instituto do Cancer do Estado de Sao Paulo - ICESP ( Site 0250), Sao Paulo, Not set
Hospital Paulistano - Amil Clinical Research ( Site 0263), Sao Paulo, Not set
Real e Benemerita Associacao Portuguesa de Beneficencia ( Site 0260), Sao Paulo, Not set
Nova Scotia Health Authority ( Site 0103), Halifax, Nova Scotia
Hamilton Health Sciences-Juravinski Cancer Centre ( Site 0107), Hamilton, Ontario
Kingston Health Sciences Centre ( Site 0102), Kingston, Ontario
Stronach Regional Cancer Centre ( Site 0100), Newmarket, Ontario
CISSS de la Monteregie-Centre ( Site 0101), Greenfield Park, Quebec
Hopital Cite de la Sante de Laval ( Site 0105), Laval, Quebec
CIUSSS Ouest de l Ile - St-Mary s Hospital ( Site 0110), Montreal, Quebec
CIUSSS de la Mauricie et du Centre du Quebec ( Site 0106), Trois-Rivieres, Quebec
Centre Hospitalier De Chauny ( Site 1411), Chauny, Aisne
CHU Caen ( Site 1406), Caen, Calvados
CHU Angers ( Site 1405), Angers, Maine-et-Loire
Institut De Cancerologie De Lorraine ( Site 1409), Vandoeuvre les Nancy, Meurthe-et-Moselle
Hopital Robert Schuman ( Site 1402), Vantoux, Moselle
Centre Jean Perrin ( Site 1407), Clermont Ferrand, Puy-de-Dome
Centre Hospitalier de Pau ( Site 1412), Pau, Pyrenees-Atlantiques
CHU de Rouen ( Site 1403), Rouen, Seine-Maritime
Hopital d'Instruction des Armees Begin ( Site 1413), Saint-Mande, Val-de-Marne
Studienzentrum Aschaffenburg ( Site 1575), Aschaffenburg, Bayern
Klinikum Bogenhausen Staedt. Klinikum Muenchen GmbH ( Site 1573), Muenchen, Bayern
Klinikum der LMU ( Site 1550), Munich, Bayern
Universitaetsklinikum Regensburg ( Site 1562), Regensburg, Bayern
Klinikum Wuerzburg Mitte gGmbH ( Site 1559), Wuerzburg, Bayern
Universitaetsklinikum Frankfurt ( Site 1563), Frankfurt, Hessen
Pneumologische Lehrklinik Universitaet Goettingen ( Site 1551), Immenhausen, Hessen
Universitaetsmedizin Goettingen ( Site 1557), Goettingen, Niedersachsen
Universitaetsklinikum Bonn ( Site 1574), Bonn, Nordrhein-Westfalen
Kliniken Essen Mitte ( Site 1567), Essen, Nordrhein-Westfalen
InVo-Institut fuer Versorgungsforschung in der Onkologie ( Site 1564), Koblenz, Rheinland-Pfalz
Helios Klinikum Erfurt GmbH ( Site 1552), Erfurt, Thuringen
Katholisches Marienkrankenhaus gGmbH ( Site 1572), Hamburg, Not set
National Hospital Organization Nagoya Medical Center ( Site 0806), Nagoya, Aichi
Aichi Cancer Center Hospital ( Site 0803), Nagoya, Aichi
National Cancer Center Hospital East ( Site 0801), Kashiwa, Chiba
Kurume University Hospital ( Site 0814), Kurume, Fukuoka
Kanazawa University Hospital ( Site 0811), Kanazawa, Ishikawa
Kanagawa Cancer Center ( Site 0807), Yokohama, Kanagawa
Sendai Kousei Hospital ( Site 0812), Sendai, Miyagi
Kansai Medical University Hospital ( Site 0804), Hirakata, Osaka
National Hospital Organization Kinki-chuo Chest Medical Center ( Site 0813), Sakai, Osaka
Shizuoka Cancer Center Hospital and Research Institute ( Site 0802), Sunto-gun, Shizuoka
National Hospital Organization Kyushu Medical Center ( Site 0805), Fukuoka, Not set
Niigata Cancer Center Hospital ( Site 0808), Niigata, Not set
Okayama University Hospital ( Site 0810), Okayama, Not set
Osaka International Cancer Institute ( Site 0809), Osaka, Not set
The Cancer Institute Hospital of JFCR ( Site 0800), Tokyo, Not set
Chungbuk National University Hospital ( Site 1002), Cheongju si, Chungbuk
National Cancer Center ( Site 1006), Goyang-si, Kyonggi-do
The Catholic University of Korea St. Vincent s Hospital ( Site 1003), Gyeonggi-do, Kyonggi-do
Ajou University Hospital ( Site 1004), Suwon, Kyonggi-do
Gyeongsang National University Hospital ( Site 1005), Jinju, Kyongsangnam-do
Asan Medical Center ( Site 1007), Songpa-gu, Seoul
Seoul National University Hospital ( Site 1000), Seoul, Not set
Severance Hospital Yonsei University Health System ( Site 1001), Seoul, Not set
Korea University Guro Hospital ( Site 1008), Seoul, Not set
Investigacion Onco Farmaceutica S de RL de CV ( Site 0300), La Paz, Baja California Sur
Hospital Civil de Guadalajara Fray Antonio Alcalde ( Site 0334), Guadalajara, Jalisco
Axis Heilsa S. de R.L. de C.V. ( Site 0301), Monterrey, Nuevo Leon
CLIMERS Clinical Medical Research ( Site 0306), Orizaba, Veracruz
Arke Estudios Clinicos ( Site 0333), Cdmx, Not set
FAICIC Clinical Research ( Site 0303), Veracruz, Not set
MidCentral DHB Palmerston North Hospital ( Site 1102), Palmerston North, Manawatu-Wanganui
Capital & Coast District Health Board - Wellington Hospital ( Site 1101), Wellington, Not set
Samodzielny Publiczny Zespol Gruzlicy i Chorob Pluc ( Site 2417), Olsztyn, Dolnoslaskie
Wielospecjalistyczny Szpital SPZOZ w Zgorzelcu ( Site 2404), Zgorzelec, Dolnoslaskie
Krakowski Szpital Specjalistyczny im Jana Pawla II ( Site 2420), Krakow, Malopolskie
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie (, Warszawa, Mazowieckie
Szpital Rejonowy im. dr Jozefa Rostka ( Site 2402), Raciborz, Slaskie
Przychodnia Lekarska Komed ( Site 2416), Konin, Wielkopolskie
MED-POLONIA Sp. z o.o. ( Site 2419), Poznan, Wielkopolskie
Cardiomed SRL Cluj-Napoca ( Site 2504), Cluj Napoca, Cluj
S.C. Radiotherapy Center Cluj S.R.L ( Site 2507), Cluj-Napoca, Cluj
S.C. Centrul de Oncologie Sf. Nectarie SRL ( Site 2508), Craiova, Dolj
Policlinica Oncomed SRL ( Site 2505), Timisoara, Timis
S.C.Focus Lab Plus S.R.L ( Site 2502), Bucuresti, Not set
Spitalul Clinic Judetean de Urgenta Sf Apostol Andrei ( Site 2501), Constanta, Not set
Moscow Regional Oncological Dispensary ( Site 2028), Balashikha, Moskovskaya Oblast
Russian Oncological Research Center n.a. N.N.Blokhin of MoH ( Site 2000), Moscow, Moskva
First Moscow State Medical University n.a. I.M.Sechenov ( Site 2024), Moscow, Moskva
Moscow Research Oncology Institute named after P.A. Hertsen ( Site 2009), Moscow, Moskva
FSAI Treatment and Rehabilitation Centre of the MoH and SD of RF ( Site 2006), Moscow, Moskva
Nizhniy Novgorod Region Oncology Dispensary ( Site 2026), Nizhniy Novgorod, Nizhegorodskaya Oblast
Budgetary Healthcare Institution of Omsk Region Clinical Oncology Dispensary-Chemotherapy #1 ( Site, Omsk, Omskaya Oblast
SBHI Samara Regional Clinical Oncology Dispensary ( Site 2016), Samara, Samarskaya Oblast
SBHI Leningrad Regional Clinical Hospital ( Site 2002), Saint Petersburg, Sankt-Peterburg
SPb Central Clinical Railway Hospital ( Site 2003), Saint Petersburg, Sankt-Peterburg
National Medical Research Center of Oncology N.A. N.N. Petrov ( Site 2004), Saint Petersburg, Sankt-Peterburg
SPb SBHI City Clinical Oncological Dispensary ( Site 2001), Saint Petersburg, Sankt-Peterburg
Republican Clinical Oncology Dispensary of Tatarstan MoH ( Site 2021), Kazan, Tatarstan, Respublika
Hospital Duran i Reynals ( Site 1710), Hospitalet de Llobregat, Barcelona
Complejo Hospitalario de Jaen ( Site 1713), Jaen, La Coruna
Hospital Sant Creu i Sant Pau ( Site 1711), Barcelona, Not set
Hospital Universitario 12 de Octubre ( Site 1716), Madrid, Not set
Complejo Hospitalario de Malaga ( Site 1714), Malaga, Not set
Hospital Universitario Virgen Macarena ( Site 1712), Sevilla, Not set
Chang Gung Medical Foundation. Kaohsiung Branch ( Site 0907), Kaohsiung, Not set
China Medical University Hospital ( Site 0904), Taichung, Not set
National Cheng Kung University Hospital ( Site 0905), Tainan, Not set
National Taiwan University Hospital ( Site 0900), Taipei, Not set
Mackay Memorial Hospital ( Site 0902), Taipei, Not set
Chang Gung Medical Foundation.Linkou Branch ( Site 0903), Taoyuan, Not set
Namik Kemal Universitesi Tip Fakultesi ( Site 2100), Tekirdag, Tekirdas
Baskent Unv. Adana Uyg. ve Arast. Hastanesi ( Site 2101), Adana, Not set
Gazi Universitesi Tip Fakultesi ( Site 2104), Ankara, Not set
Ankara Sehir Hastanesi ( Site 2105), Ankara, Not set
Bezmialem Vakif Univ. Tıp Fakultesi Hastanesi Tibbi Onkoloji Bolumu ( Site 2107), Istanbul, Not set
Göztepe Prof. Dr. Süleyman Yalçın Şehir Hastanesi-oncology ( Site 2103), Istanbul, Not set
Ege Universitesi Tip Fakultesi ( Site 2109), Izmir, Not set
Erciyes Universitesi Tip Fakultesi ( Site 2108), Kayseri, Not set
Ondokuz Mays Üniversitesi Tp Fakültesi Hastanesi-Oncology ( Site 2106), Samsun, Not set
Cherkasy Regional Oncology Dispensary ( Site 2225), Cherkasy, Cherkaska Oblast
City Clinical Hosp.4 of DCC ( Site 2215), Dnipro, Dnipropetrovska Oblast
MI Precarpathian Clinical Oncology Center ( Site 2218), Ivano-Frankivsk, Ivano-Frankivska Oblast
Grigoriev Institute for medical Radiology NAMS of Ukraine ( Site 2226), Kharkiv, Kharkivska Oblast
Regional Centre of Oncology-Thoracic organs ( Site 2219), Kharkiv, Kharkivska Oblast
PP PPC Acinus Medical and Diagnostic Centre ( Site 2223), Kropyvnytskyi, Kirovohradska Oblast
Medical Center Asklepion LLC ( Site 2243), Khodosivka, Kyivska Oblast
Kyiv City Clinical Oncology Centre ( Site 2224), Kyiv, Kyivska Oblast
Medical and Diagnostic Centre LLC Dobryi Prognoz ( Site 2227), Kyiv, Kyivska Oblast
MI Odessa Regional Oncological Centre ( Site 2222), Odesa, Odeska Oblast
Central City Clinical Hospital ( Site 2221), Uzhgorod, Zakarpatska Oblast
Medical Center Verum ( Site 2228), Kyiv, Not set
Southend University Hospital NHS Foundation Trust ( Site 1913), Westcliff-on-Sea, Essex
Barts Health NHS Trust - St Bartholomew s Hospital ( Site 1923), London, London, City Of
Chelsea and Westminster Hospital ( Site 1901), London, London, City Of
Newcastle Freeman Hospital ( Site 1902), Newcastle-upon-Tyne, Newcastle Upon Tyne
West Suffolk Hospitals NHS Trust ( Site 1919), Bury Saint Edmunds, Suffolk
Singleton Hospital ( Site 1909), Swansea, Wales
Colchester General Hospital ( Site 1911), Colchester, Worcestershire
Birmingham Heartlands Hospital ( Site 1910), Birmingham, Not set
Western General Hospital, Edinburgh ( Site 1924), Edinburg, Not set
Conditions: Carcinoma, Squamous Cell, Non-small-cell Lung
A Study of Mirvetuximab Soravtansine vs. Investigator's Choice (IC) of Chemotherapy in Platinum-Resistant, Advanced High-Grade Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancers With High Folate Receptor-Alpha (FRα) Expression
Completed
This Phase 3 study is designed to compare the efficacy and safety of mirvetuximab soravtansine (MIRV) vs. IC chemotherapy in participants with platinum-resistant high-grade epithelial ovarian cancer, primary peritoneal, or fallopian tube cancer, whose tumors express a high-level of FRα. Participants will be, in the opinion of the Investigator, appropriate for single-agent therapy for their next line of therapy. The FRα positivity will be defined by the Ventana FOLR1 (FOLR1-2.1) CDx assay.
This Phase 3 study is designed to compare the efficacy and safety of mirvetuximab soravtansine (MIRV) vs. IC chemotherapy in participants with platinum-resistant high-grade epithelial ovarian cancer, primary peritoneal, or fallopian tube cancer, whose tumors express a high-level of FRα. Participants will be, in the opinion of the Investigator, appropriate for single-agent therapy for their next line of therapy. The FRα positivity will be defined by the Ventana FOLR1 (FOLR1-2.1) CDx assay. Read Less
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
01/05/2025
Locations: University of Alabama at Birmingham (UAB) GYN Oncology, Birmingham, Alabama +213 locations
University of Alabama at Birmingham (UAB) GYN Oncology, Birmingham, Alabama
Alaska Women's Cancer Care, Anchorage, Alaska
Arizona Oncology Associates, PC - HAL - USOR, Phoenix, Arizona
Mayo Clinic, Phoenix, Arizona
USOR: Arizona Oncology Associates, PC - HOPE, Tucson, Arizona
University of Arizona Cancer Center, Tucson, Arizona
UCLA - JCCC Dept of OBGYN - Women's Health Clinical Research Unit, Los Angeles, California
Hoag Cancer Center, Newport Beach, California
University of California San Francisco, San Francisco, California
Olive View - UCLA Medical Center, Sylmar, California
Kaiser Permanente Oncology Clinical Trials, Vallejo, California
USOR: Rocky Mountain Cancer Centers, Lakewood, Colorado
Yale University School of Medicine, New Haven, Connecticut
Florida Cancer Specialist South Division, Fort Myers, Florida
Mayo Clinic Jacksonville, Jacksonville, Florida
Women's Care Florida / Women's Cancer Associates, Saint Petersburg, Florida
Florida Cancer Specialist North Division, Saint Petersburg, Florida
Sarasota Memorial Hospital, Sarasota, Florida
Florida Cancer Specialists, Tallahassee, Florida
Florida Cancer Specialist East Division, West Palm Beach, Florida
Memorial University Medical Center, Savannah, Georgia
Hawaii Pacific Health - Kapiolani Medical Center for Women and Children, Honolulu, Hawaii
Illinois Cancer Specialists, Arlington Heights, Illinois
University of Chicago, Chicago, Illinois
Dr. Sudarshan K. Sharma, Ltd., Hinsdale, Illinois
Community Health Network, Indianapolis, Indiana
University of Kansas Cancer Center, Westwood, Kansas
St. Elizabeth Healthcare, Edgewood, Kentucky
Norton Cancer Institute, Louisville, Kentucky
Ochnser Medical Center Jefferson, New Orleans, Louisiana
WK Physicians Network/Gynecologic Oncology Associates, Shreveport, Louisiana
Holy Cross Hospital, Silver Spring, Maryland
USOR: Maryland Oncology Hematology, P.A., Silver Spring, Maryland
Tufts Medical Center, Boston, Massachusetts
Baystate Medical Center, Springfield, Massachusetts
University of Massachusetts, Worcester, Massachusetts
St. Joseph Mercy Hospital, Ann Arbor, Michigan
Karmanos Cancer Institute, Detroit, Michigan
Mayo Clinic Rochester, Rochester, Minnesota
USOR: Minnesota Oncology Hematology, PA, Woodbury, Minnesota
HCA Midwest Kansas City/ Sarah Cannon, Kansas City, Missouri
Sletten Cancer Institute, Great Falls, Montana
Center of Hope, Reno, Nevada
The Valley Hospital, Inc, Ridgewood, New Jersey
Holy Name Medical Center, Teaneck, New Jersey
Columbia University Medical Center, New York, New York
FirstHealth of the Carolinas Outpatient Cancer Center, Pinehurst, North Carolina
USOR: OHC - Oncology_Hematology Care Clinical Trials, Inc., Cincinnati, Ohio
MetroHealth Medical Center, Cleveland, Ohio
Cleveland Clinic, Cleveland, Ohio
Columbus NCORP, Columbus, Ohio
Zangmeister Cancer Center, Columbus, Ohio
Oncology_Hematology Care Clinical Trials, LLC, Fairfield, Ohio
The Ohio State University Wexner Medical Center, Hilliard, Ohio
Stephenson Cancer Center, Oklahoma City, Oklahoma
Oklahoma Cancer Specialists and Research Institute, Tulsa, Oklahoma
USOR: Willamette Valley Cancer Institute and Research Center, Eugene, Oregon
Legacy Gynecologic Oncology, Portland, Oregon
USOR: Northwest Cancer Specialists, P.C., Portland, Oregon
University of Pennsylvania, Philadelphia, Pennsylvania
Fox Chase Cancer Center, Philadelphia, Pennsylvania
Magee-Women's Hospital-UPMC, Pittsburgh, Pennsylvania
West Penn Hospital, Pittsburgh, Pennsylvania
Women & Infants Hospital of Rhode Island, Providence, Rhode Island
Tennessee Oncology / Sarah Cannon Research Institute, Nashville, Tennessee
USOR: Texas Oncology-South Austin, Austin, Texas
USOR: Texas Oncology - Fort Worth Cancer Center, Fort Worth, Texas
University of Texas, Memorial Hermann, Houston, Texas
USOR: Texas Oncology - McAllen South Second, McAllen, Texas
USOR: Texas Oncology - San Antonio, San Antonio, Texas
USOR: Texas Oncology, P.A., Sugar Land, Texas
USOR: Texas Oncology - The Woodlands, Gynecologic Oncology, The Woodlands, Texas
USOR: Texas Oncology - Tyler, Tyler, Texas
USOR: Texas Oncology, P.A., Webster, Texas
University of Virginia Health System, Charlottesville, Virginia
USOR: Virginia Cancer Specialists, PC, Gainesville, Virginia
Kadlec Clinic Hematology & Oncology, Kennewick, Washington
West Virginia University- MBRCC, Morgantown, West Virginia
Newcastle Private Hospital, New Lambton Heights, New South Wales
Prince of Wales Hospital, Randwick, New South Wales
Monash Health, Clayton, Victoria
Oncology Clinics Victoria (OCV) - Cabrini Malvern Hospital Location, Malvern, Victoria
Royal North Shore Hospital, Saint Leonards, Not set
Burnside War Memorial Hospital - The Brian Fricker Oncology Centre, Toorak Gardens, Not set
OLV Ziekenhuis, Aalst, Not set
AZ Klina, Brasschaat, Not set
Universitair Ziekenhuis Antwerpen (UZA) - Borstkliniek, Edegem, Not set
AZ St-Lucas, Gent, Not set
UZ Leuven, Leuven, Not set
Complex Oncology Center, Burgas, Not set
UMHAT Georgi Stranski, Pleven, Not set
Acibadem City Clinic Tokuda Hospital, Sofia, Not set
UMHAT "Sv. Ivan Rilski", EAD, Sofia, Sofia, Not set
Tom Baker Cancer Centre, Calgary, Alberta
Cross Cancer Institute, Edmonton, Alberta
The Ottawa Hospital General Campus, Ottawa, Ontario
Sunnybrook Health Sciences Center, Toronto, Ontario
Princess Margaret Cancer Centre - University Health Network, Toronto, Ontario
McGill University Health Centre, Montreal, Quebec
Centre Hospitalier de L'Universite de Montreal, Montréal, Quebec
Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec
Anhui Provincial Cancer Hospital, Hefei, Anhui
Fujian Cancer Hospital, Fuzhou, Fujian
Zhongshan Hospital Xiamen University, Xiamen, Fujian
Sun Yat-sen University, Cancer Center, Guangzhou, Guangdong
Wuhan Union Hospital of China, Wuhan, Hubei
Zhongnan Hospital of Wuhan University, Wuhan, Hubei
Hubei Cancer Hospital, Wuhan, Hubei
The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu
The First Hospital of Jilin University, Changchun, Jilin
Liaoning Cancer Hospital, Shenyang, Liaoning
The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shanxi
Peking University First Hospital, Beijing, Not set
Beijing Cancer Hospital, Beijing, Not set
Fudan University Shanghai Cancer Center, Shanghai, Not set
Tianjin Medical University Cancer Institute & Hospital, Tianjin, Not set
Fakultní nemocnice Ostrava, Ostrava, Not set
Všeobecná fakultní nemocnice v Praze, Praha 2, Not set
KNTB a.s. Zlín, Zlín, Not set
Institut Claudius Regaud, Toulouse, Cedex 9
Centre Oscar Lambret, Lille, Cedex B.P 307
Institut de cancérologie de l'ouest, site Angers, Angers, Cedex
CHRU Besançon, Besançon Cedex, Not set
Institut Bergonie, Bordeaux Cedex, Not set
Centre Leon Berard, Lyon Cedex, Not set
Institut Paoli Calmettes, Marseille, Not set
Cochin Hospital, Paris, Not set
Groupe Hospitalier Diaconesses Croix Saint-Simon, Paris, Not set
Centre Hospitalier Lyon Sud, Pierre-Bénite, Not set
Centre Armoricain de radiothérapie, imagerie médicale et oncologie, CARIO, Plerin, Not set
Institut Curie, Saint Cloud, Not set
ICO Centre René Gauducheau, St. Herblain CEDEX, Not set
Institut de cancérologie de Lorraine, Vandoeuvre les Nancy_ Cedex, Not set
Gustave Roussy, Villejuif Cedex, Not set
Ulm University Hospital Klinik für Frauenheilkunde und Geburtshilfe, Ulm, Baden-Württemberg
UMG Göttingen Frauenklinik, Göttingen, Niedersachsen
Universitätsklinikum Carl Gustav Carus Dresden, Dresden, Saxony
Universitätsklinikum Bonn, Bonn, Not set
Städtisches Klinikum Dessau, Zentrum für Klinische Studien, Dessau, Not set
Klinikum Dortmund gGmbH / Frauenklinik, Dortmund, Not set
University Hospital Freiburg, Freiburg, Not set
UKGM Standort Giessen, Giessen, Not set
Mammazentrum Hamburg am Krankenhaus Jerusalem, Hamburg, Not set
Wolfson Medical Center, Holon, Not set
Hadassah Ein Kerem Medical center, Jerusalem, Not set
Meir Medical Center, Kfar Saba, Not set
Sheba Medical Center, Ramat Gan, Not set
Kaplan Medical Center, Rehovot, Not set
Ziv Medical Center, Safed, Not set
IOV Istituto Oncologico, Padova, PD
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia, Brescia, Not set
ASST Lecco- Ospedale A.Manzoni, Lecco, Not set
IRCCS - Istituto Europeo di Oncologia (The European Institute of Oncology) (IEO), Milan, Not set
INT Pascale, Naples, Not set
Centro Operativo Studi Clinici S.C.Oncologia Medica, Perugia, Not set
Oncologia Azienda Osc-IRCCS Reggio Emilia, Reggio Emilia, Not set
Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Not set
Azienda Ospedaliera Città Della Salute E Della Scienza Di Torino, Torino, Not set
Ospedale Mauriziano Umberto I, Torino, Not set
Istituto Oncologico Candiolo, Torino, Not set
National Cancer Center - Center for Uterine Cancer, Gyeonggi-do, Not set
Seoul National University Bundang Hospital, Seongnam-si, Not set
Seoul National University Hospital, Seoul, Not set
Severance Hospital, Seoul, Not set
University of Ulsan College of Medicine - Asan Medical Center, Seoul, Not set
Samsung Medical Center, Seoul, Not set
Amsterdam UMC, Amsterdam, Not set
Maastricht UMC, Maastricht, Not set
Radboud University Medical Center, Nijmegen, Not set
Erasmus Medical Center, Rotterdam, Not set
Medical University of Gdansk, Gdańsk, Not set
Samodzielny publiczny szpital kliniczny nr 1, Lublin, Not set
Wojewódzki Szpital Specjalistyczny, Oddzial Kliniczny Ginekologii Onkologiczne, Olsztyn, Not set
Wielkopolskie Centrum Onkologii, Poznań, Not set
Szpital Kliniczny im. Ks. Anny Mazowieckiej, Warszawa, Not set
Fundação Champalimaud, Lisbon, Not set
Hospital da Luz, S.A, Lisbon, Not set
Centro Hospitalar de Lisboa Norte, E.P.E. - Hospital de Santa Maria, Lisbon, Not set
Hospital Beatriz Angelo, Loures, Not set
BIH of Omsk Region "Clinical Oncology Dispensary", Omsk, Omsk Oblast
LLC "VitaMed", Moscow, Not set
Leningrad regional oncology dispensa, St-Petersburg, Not set
State Autonomous Healthcare Institution Republican Clinical Oncological Dispensary of the MoH of Republic Bashkortostan, Ufa, Not set
Oncology and Radiology Institute Serbia, Belgrade, Not set
Clinical Center Kragujevac, Kragujevac, Not set
Oncology Institute Vojvodina, Surgical Oncology Clinic, Sremska Kamenica, Not set
Hospital Clínico de Santiago, Santiago de Compostela, A Coruña
H. U. de Jaén, Jaén, Andalucia
Hospital Universitario Infanta Sofía, San Sebastián de los Reyes, Madrid
Institut Català d'Oncologia, Badalona, Not set
H. San Pedro de Alcántara, Caceres, Not set
Hospital Provincial de Castellon, Castelló, Not set
Hospital de San Chinarro-Clara Campal, Madrid, Not set
Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Not set
Parc Taulí, Sabadell, Not set
Virgen del Rocío, Sevilla, Not set
Hospital de la Fe, Valencia, Not set
HCU Lozano Blesa, Zaragoza, Not set
Far Eastern Memorial Hospital, New Taipei City, Not set
Mackay Memorial Hospital - Taipei Branch, Taipei City, Not set
Taipei Veterans General Hospital, Taipei City, Not set
Chernihiv Medical Center of Modern Oncology of Chernihiv Regional Council, Chernihiv, Chernihiv Region
Grigoriev Institute for Medical Radiology NAMS of Ukraine, Kharkiv, Kharkiv Region
Communal non-profit enterprise "Khmelnytskyi Regional Antitumor Center" of Khmelnytskoyi Regional Council, Khmelnytskyi, Khmelnytskyi Region
Communal non-profit enterprise "Cherkasy Regional Oncology Dispensary of Cherkasy oblast council", Cherkasy, Not set
Prykarpatskyi Clinical Oncology Center of Ivano-Frankivsk Regional Council, Ivano-Frankivsk, Not set
Peterborough City Hospital, Peterborough, Cambridgeshire
Royal Devon and Exeter Hospital (Wonford), Exeter, Devon
University Hospitals Coventry and Warwickshire, Coventry, Not set
Beatson West of Scotland Cancer Centre, Glasgow, Not set
St Bartholomew's Hospital-Barts Health NHS Trust, London, Not set
University College London Hospital, London, Not set
The Royal Marsden NHS Foundation Trust, London, Not set
The Christie NHS Foundation Trust, Manchester, Not set
Conditions: Epithelial Ovarian Cancer, Peritoneal Cancer, Fallopian Tube Cancer
A Study of NX-1607 in Adults With Advanced Malignancies
Recruiting
This is a first-in-human Phase 1a/1b multicenter, open-label oncology study designed to evaluate the safety and anti-cancer activity of NX-1607 in patients with advanced malignancies.
This is a first-in-human Phase 1a/1b multicenter, open-label oncology study designed to evaluate the safety and anti-cancer activity of NX-1607 in patients with advanced malignancies. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/02/2025
Locations: University of Southern California, Los Angeles, California +17 locations
University of Southern California, Los Angeles, California
University of California, San Francisco, San Francisco, California
University of Colorado School of Medicine, Aurora, Colorado
University of Chicago, Chicago, Illinois
University of North Carolina, Chapel Hill, North Carolina
University of Oklahoma, Oklahoma City, Oklahoma
MD Anderson Cancer Center, Houston, Texas
University of Virginia, Charlottesville, Virginia
Swedish Cancer Institute, Seattle, Washington
Fred Hutchinson Cancer Center, Seattle, Washington
Royal Marsden Hospital NHS Foundation Trust, Sutton, Surrey
University College London Hospitals NHS Foundation Trust, Bloomsbury, Not set
Addenbrookes Cambridge University Hospital, Cambridge, Not set
Beatson West of Scotland Cancer Centre, Glasgow, Not set
Sarah Cannon Research Institute, London, Not set
The Christie NHS Foundation Trust, Manchester, Not set
Northern Centre for Cancer Care, Newcastle, Not set
Churchill Hospital, Oxford, Not set
Conditions: Ovarian Cancer, Epithelial, Gastric Cancer, GastroEsophageal Junction (GEJ) Cancer, Head and Neck Squamous Cell Carcinoma, Non-small Cell Lung Cancer (NSCLC), Metastatic Castration-resistant Prostate Cancer (mCRPC), Malignant Pleural Mesothelioma (MPM), Triple Negative Breast Cancer (TNBC), Metastatic Urothelial Carcinoma, Cervical Cancer, Metastatic or Unresectable Melanoma, Diffuse Large B Cell Lymphoma (DLBCL), Richter Transformation, Microsatellite Stable Colorectal Carcinoma
Tucatinib, Trastuzumab, Ramucirumab, and Paclitaxel Versus Paclitaxel and Ramucirumab in Previously Treated HER2+ Gastroesophageal Cancer
Completed
This study is being done to see if tucatinib with trastuzumab, ramucirumab and paclitaxel works better than ramucirumab and paclitaxel to treat HER2-positive (HER2+) cancer of the gut (stomach or gastroesophageal cancer). This study will also look at what side effects happen when participants take this combination of drugs. A side effect is anything the drug does other than treating cancer.
Study treatment will be given in 28-day cycles.
In the Phase 2 part of the trial, participants and their... Read More
This study is being done to see if tucatinib with trastuzumab, ramucirumab and paclitaxel works better than ramucirumab and paclitaxel to treat HER2-positive (HER2+) cancer of the gut (stomach or gastroesophageal cancer). This study will also look at what side effects happen when participants take this combination of drugs. A side effect is anything the drug does other than treating cancer.
Study treatment will be given in 28-day cycles.
In the Phase 2 part of the trial, participants and their doctors will know what drugs are being given (open-label). In the Phase 3 part, the study is "blinded." This means that participants, their doctor, and the study sponsor will not know which drugs are being given. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/30/2024
Locations: University of Alabama at Birmingham, Birmingham, Alabama +47 locations
University of Alabama at Birmingham, Birmingham, Alabama
Mayo Clinic Arizona, Phoenix, Arizona
Arizona Cancer Center / University of Arizona, Tucson, Arizona
City of Hope National Medical Center, Duarte, California
UCLA Medical Center / David Geffen School of Medicine, Santa Monica, California
Rocky Mountain Cancer Centers - Aurora, Aurora, Colorado
Cancer Centers of Colorado - Denver, Denver, Colorado
SCL Health - St. Mary's Hospital & Medical Center, Grand Junction, Colorado
SCL Health Good Samaritan Medical Center Cancer Centers of Colorado, Lafayette, Colorado
Lutheran Medical Center - Cancer Centers of Colorado, Wheat Ridge, Colorado
Lombardi Cancer Center / Georgetown University Medical Center, Washington, District of Columbia
University of Chicago Medical Center, Chicago, Illinois
Holden Comprehensive Cancer Center / University of Iowa, Iowa City, Iowa
Norton Cancer Institute, Louisville, Kentucky
Dana Farber Cancer Institute, Boston, Massachusetts
Minnesota Oncology Hematology P.A., Saint Paul, Minnesota
Comprehensive Cancer Centers of Nevada, Las Vegas, Nevada
Roswell Park Cancer Institute, Buffalo, New York
Duke University Medical Center, Durham, North Carolina
Cleveland Clinic - Taussig Cancer Institute, Cleveland, Ohio
Oncology Associates of Oregon, Eugene, Oregon
University of Pennsylvania / Perelman Center for Advanced Medicine, Philadelphia, Pennsylvania
Allegheny General Hospital, Pittsburgh, Pennsylvania
University of Tennessee, Knoxville, Tennessee
Tennessee Oncology-Nashville/Sarah Cannon Research Institute, Nashville, Tennessee
Texas Oncology - Baylor Sammons Cancer Center, Dallas, Texas
Texas Oncology - San Antonio Medical Center, San Antonio, Texas
Texas Oncology - Tyler, Tyler, Texas
Huntsman Cancer Institute/University of Utah, Salt Lake City, Utah
Northwest Cancer Specialists, P.C., Vancouver, Washington
Central Coast Local Health District (Gosford and Wyong Hospitals), Gosford, Not set
Austin Health, Heidelberg, Not set
London Regional Cancer Program, London Health Sciences Centre, London, Ontario
Centre Hospitalier de l'Universite de Montreal, Montreal, Quebec
McGill University Department of Oncology / McGill University Health Centre, Montreal, Quebec
Dong-A University Hospital, Busan, Not set
Kyungpook National University Chilgok Hospital, Daegu, Not set
Seoul National University Bundang Hospital, Seongnam-si, Not set
Seoul National University Hospital, Seoul, Not set
Severance Hospital, Yonsei University Health System, Seoul, Not set
Asan Medical Center - Oncology, Seoul, Not set
Samsung Medical Center, Seoul, Not set
Ajou University Hospital, Suwon-si, Not set
Kaohsiung Medical University Hospital, Kaohsiung, Not set
National Taiwan University Hospital, Taipei, Not set
Taipei Veterans General Hospital, Taipei, Not set
Sarah Cannon Research Institute UK, London, Not set
The Christie NHS Foundation Trust, Manchester, Not set
Conditions: Gastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma, Esophageal Adenocarcinoma
A Randomised Trial of ATRA in a Novel Drug Combination for Pancreatic Cancer
Active Not Recruiting
This is an open-label, multi-centre, randomised, stratified, phase IIb clinical trial of ATRA administered in combination with gemcitabine and nab-paclitaxel in patients with laPDAC.
This is an open-label, multi-centre, randomised, stratified, phase IIb clinical trial of ATRA administered in combination with gemcitabine and nab-paclitaxel in patients with laPDAC. Read Less
Gender:
ALL
Ages:
16 years and above
Trial Updated:
12/20/2024
Locations: Barts NHS Trust, London, Not set
Barts NHS Trust, London, Not set
Conditions: Pancreatic Cancer
Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice and Pembrolizumab in Patients With Previously Untreated, Locally Advanced Inoperable or Metastatic Triple-Negative Breast Cancer
Active Not Recruiting
The primary objective of this study is to compare the progression-free survival (PFS) between sacituzumab govitecan-hziy (SG) and pembrolizumab versus treatment of physician's choice (TPC) and pembrolizumab in participants with previously untreated, locally advanced inoperable or metastatic triple-negative breast cancer, whose tumors express programmed cell death ligand 1 (PD-L1).
The primary objective of this study is to compare the progression-free survival (PFS) between sacituzumab govitecan-hziy (SG) and pembrolizumab versus treatment of physician's choice (TPC) and pembrolizumab in participants with previously untreated, locally advanced inoperable or metastatic triple-negative breast cancer, whose tumors express programmed cell death ligand 1 (PD-L1). Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/19/2024
Locations: Alaska Oncology and Hematology, Anchorage, Alaska +503 locations
Alaska Oncology and Hematology, Anchorage, Alaska
Arizona Oncology Associates, PC-Hope,1845 W Orange Grove Rd, Tucson, Arizona
Arizona Oncology Associates, PC-Hope,2070 W. Rudasill Rd., Tucson, Arizona
Arizona Oncology Associates, PC-Hope, Tucson, Arizona
Arizona Oncology Associates, PC-Hope,1620 West St. Mary's Road, Tucson, Arizona
Genesis Cancer and Blood Institute, Hot Springs, Arkansas
Genesis Cancer and Blood Institute,1456 Higdon Ferry Road Suite B., Hot Springs, Arkansas
Saint Bernards Medical Center, Jonesboro, Arkansas
Saint Bernards Medical Center,4000 Linwood Drive, Paragould, Arkansas
University of California Los Angeles - Jonsson Comprehensive Cancer Center,201 S. Buena Vista Street, Suite 200, Burbank, California
University of California Irvine Health Chao Family,1640 Newport Blvd, Costa Mesa, California
City of Hope, Duarte, California
University of California San Diego Moores Cancer, La Jolla, California
University of California Los Angeles - Jonsson Comprehensive Cancer Center,24302 Paseo de Valencia, Suite 200, Laguna Hills, California
Cancer and Blood Specialty Clinic, Los Alamitos, California
City of Hope,1601 Avocado Ave, Newport, California
University of California Irvine Health Chao Family, Orange, California
City of Hope,209 Fair Oaks Ave, Pasadena, California
University of California Los Angeles - Jonsson Comprehensive Cancer Center,892 Aerovista Place, Suite 240, San Luis Obispo, California
Sansum Clinic, Santa Barbara, California
University of California Los Angeles - Jonsson Comprehensive Cancer Center,2020 Santa Monica Blvd, Suite 600, Santa Monica, California
University of California Los Angeles - Jonsson Comprehensive Cancer Center,2336 Santa Monica, Suites 302 and 304, Santa Monica, California
University of California Los Angeles - Jonsson Comprehensive Cancer Center, Santa Monica, California
St. Jude Hospital Yorba dba St. Joseph Heritage Healthcare, Santa Rosa, California
Sansum Clinic,2040 Viborg Road, Solvang, California
City of Hope,5215 Torrance Blvd, Torrance, California
Torrance Memorial Physician Network - Cancer Care, Torrance, California
City of Hope,1100 San Bernardino Rd, Upland, California
University of California Los Angeles - Jonsson Comprehensive Cancer Center,1250 La Venta Dr, Suite 100, Westlake Village, California
Rocky Mountain Cancer Centers,1700 South Potomac Street, Aurora, Colorado
Rocky Mountain Cancer Centers, Boulder, Colorado
Rocky Mountain Cancer Centers,2312 N. Nevada Avenue, Colorado Springs, Colorado
Rocky Mountain Cancer Centers,6031 E. Woodman Rd., Colorado Springs, Colorado
Rocky Mountain Cancer Centers,4700 E. Hale Parkway, Denver, Colorado
Rocky Mountain Cancer Centers,11750 West 2nd Place, Lakewood, Colorado
Rocky Mountain Cancer Centers,22 West Dry Creek Circle, Littleton, Colorado
Rocky Mountain Cancer Centers,10107 Ridge Gate Parkway, Lone Tree, Colorado
Rocky Mountain Cancer Centers,2030 Mountain View Ave Ste 210, Longmont, Colorado
Rocky Mountain Cancer Centers,3676 Parker Blvd, Pueblo, Colorado
Rocky Mountain Cancer Centers,525 W. 15th Street, Pueblo, Colorado
Rocky Mountain Cancer Centers,8820 Huron Street, Thornton, Colorado
Eastern Connecticut Hematology and Oncology Associates, Norwich, Connecticut
Advent Health Medical Group, Altamonte Springs, Florida
SCRI - Florida Cancer Specialists - North Region R,750 Orienta Ave, Altamonte Springs, Florida
University of Miami - Sylvester Comprehensive Cancer Center,2801 NE 213th St, Aventura, Florida
Florida Cancer Specialists,9776 Bonita Beach Road Southeast Suite 201 A, Bonita Springs, Florida
Florida Cancer Specialists,3630 Manatee Avenue West, Bradenton, Florida
Florida Cancer Specialists,5985 Silver Falls Run, Bradenton, Florida
SCRI - Florida Cancer Specialists - North Region R,403 S. Kings Ave., Brandon, Florida
Florida Cancer Specialists,1030 Commerce Creek Blvd, Cape Coral, Florida
SCRI - Florida Cancer Specialists - North Region R,3280 McMullen Booth Road, Clearwater, Florida
University of Miami - Sylvester Comprehensive Cancer Center,5555 Ponce De Leon Blvd, Coral Gables, Florida
SCRI - Florida Cancer Specialists - West Palm Beach,224 Memorial Medical Parkway, Suite 300, Daytona Beach, Florida
University of Miami - Sylvester Comprehensive Cancer Center,1192 East Newport Center Drive, Deerfield Beach, Florida
Florida Cancer Specialists, Fort Myers, Florida
Florida Cancer Specialists,8981 Colonial Center Drive, Fort Myers, Florida
Florida Cancer Specialists,8260 Gladiolus Dr, Fort Myers, Florida
SCRI - Florida Cancer Specialists - North Region R,6420 W. Newberry Road, Gainesville, Florida
University of Miami - Sylvester Comprehensive Cancer Center,3850 Hollywood Blvd, Hollywood, Florida
SCRI - Florida Cancer Specialists - North Region R,100 Highland Avenue, Largo, Florida
SCRI - Florida Cancer Specialists - North Region R,521 North Lecanto Highway, Lecanto, Florida
University of Miami - Sylvester Comprehensive Cancer Center,1400 NW 12th Ave, Miami, Florida
University of Miami - Sylvester Comprehensive Cancer Center, Miami, Florida
University of Miami - Sylvester Comprehensive Cancer Center,8932 S.W. 97 Ave, Miami, Florida
Florida Cancer Specialists,1100 Goodlette Road, Naples, Florida
SCRI - Florida Cancer Specialists - North Region R,4945 SW 49th Place, Ocala, Florida
SCRI - Florida Cancer Specialists - North Region R,2824 Enterprise Rd, Orange City, Florida
Advent Health Medical Group,2501 North Orange Ave, Orlando, Florida
SCRI - Florida Cancer Specialists - North Region R,70 W. Gore Street, Orlando, Florida
University of Miami - Sylvester Comprehensive Cancer Center,8100 SW 10 Street, Plantation, Florida
Florida Cancer Specialists,22395 Edgewater Drive, Port Charlotte, Florida
SCRI - Florida Cancer Specialists - North Region R,1201 Fifth Avenue North, Saint Petersburg, Florida
SCRI - Florida Cancer Specialists - North Region R, Saint Petersburg, Florida
Florida Cancer Specialists,600 North Cattlemen Road, Sarasota, Florida
Florida Cancer Specialists,1970 Golf Street, Sarasota, Florida
SCRI - Florida Cancer Specialists - North Region R,7154 Medical Center Drive, Spring Hill, Florida
SCRI - Florida Cancer Specialists - West Palm Beach,301 SE Ocean Blvd, Suite 102, Stuart, Florida
SCRI - Florida Cancer Specialists - North Region R,3402 West Dr. Martin Luther King Jr. Boulevard, Tampa, Florida
SCRI - Florida Cancer Specialists - North Region R,4100 Waterman Way, Tavares, Florida
SCRI - Florida Cancer Specialists - North Region R,1400 US Highway 441 N, The Villages, Florida
SCRI - Florida Cancer Specialists - North Region R,9320 State Road 54, Trinity, Florida
Florida Cancer Specialists,836 Sunset Lake Blvd, Venice, Florida
SCRI - Florida Cancer Specialists - West Palm Beach,3730 7th Terrace, Suite 101, Vero Beach, Florida
SCRI - Florida Cancer Specialists - West Palm Beach,1037 S. State Road 7, Bldg B, Suite 303, Wellington, Florida
SCRI - Florida Cancer Specialists - West Palm Beach, West Palm Beach, Florida
SCRI - Florida Cancer Specialists - North Region R,460 N Orlando Ave, Winter Park, Florida
Northside Hospital,125 King Avenue, Athens, Georgia
Piedmont Cancer Institute - Atlanta,1267 Hwy 54W, Atlanta, Georgia
Winship Cancer Institute of Emory University,550 Peachtree St NE, Atlanta, Georgia
Piedmont Cancer Institute - Atlanta, Atlanta, Georgia
Winship Cancer Institute of Emory University, Atlanta, Georgia
Northside Hospital,5670 Peachtree Dunwoody Rd., Atlanta, Georgia
Northside Hospital, Atlanta, Georgia
Winship Cancer Institute of Emory University,5665 Peachtree Dunwoody Road, Atlanta, Georgia
Northside Hospital,308 Deep South Farm Rd, Suite 200, Blairsville, Georgia
Northside Hospital,228 Riverstone Dr., Canton, Georgia
Northside Hospital,1505 Northside Blvd, Suite 4600, Cumming, Georgia
Northside Hospital,3855 Pleasant Hill Rd., Suite 480, Duluth, Georgia
Northside Hospital,308 Coliseum Dr., Macon, Georgia
Piedmont Cancer Institute - Atlanta,775 Poplar Road, Newnan, Georgia
Piedmont Cancer Institute - Atlanta,1240 Eagles Landing Pkwy, Stockbridge, Georgia
Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois
University of Illinois Hospital and Health Sciences System (Outpatient Cancer Center), Chicago, Illinois
Orchard Healthcare Research Inc,2845 North Sheridan Road, 1st Floor, Chicago, Illinois
Robert H. Lurie Comprehensive Cancer Center of Northwestern University,1 Kish Hospital Drive, DeKalb, Illinois
Robert H. Lurie Comprehensive Cancer Center of Northwestern University,10 Health Services Drive, DeKalb, Illinois
Orchard Healthcare Research Inc,800 Austin Street, Suite 360, East Tower, Evanston, Illinois
Robert H. Lurie Comprehensive Cancer Center of Northwestern University,300 Randall Road, Geneva, Illinois
Robert H. Lurie Comprehensive Cancer Center of Northwestern University,304 Randall Road, Geneva, Illinois
Robert H. Lurie Comprehensive Cancer Center of Northwestern University,1000 N. Westmoreland Road, Lake Forest, Illinois
Orchard Healthcare Research Inc, Skokie, Illinois
Robert H. Lurie Comprehensive Cancer Center of Northwestern University,4405 Weaver Parkway, Warrenville, Illinois
Robert H. Lurie Comprehensive Cancer Center of Northwestern University,4455 Weaver Parkway, Warrenville, Illinois
Robert H. Lurie Comprehensive Cancer Center of Northwestern University,25 N Winfield Road, Winfield, Illinois
Regulatory Management Only: TRIO-US Central Administration, Fort Wayne, Indiana
The University of Kansas Cancer Center,2000 Olathe Blvd, Kansas City, Kansas
The University of Kansas Cancer Center,12200 W. 110th Street, Overland Park, Kansas
The University of Kansas Cancer Center,10710 Nall Avenue, Overland Park, Kansas
The University of Kansas Cancer Center,10730 Nall Avenue, Overland Park, Kansas
The University of Kansas Cancer Center, Westwood, Kansas
Norton Cancer Institute - Saint Matthews,234 E. Gray Strret, Louisville, Kentucky
Norton Cancer Institute - Saint Matthews,676 S. Floyd Street, Louisville, Kentucky
Norton Cancer Institute - Saint Matthews, Louisville, Kentucky
Norton Cancer Institute - Saint Matthews,4955 Norton Healthcare Blvd, Louisville, Kentucky
Hematology Oncology Clinic - Baton Rouge, Baton Rouge, Louisiana
Hematology Oncology Clinic - Baton Rouge,1673 E Mount Please Drive, Zachary, Louisiana
Cancer Institute Ascension Saint Agnes, Baltimore, Maryland
Beth Israel Deaconess Medical Center, Boston, Massachusetts
Dana-Farber Cancer Institute, Boston, Massachusetts
Massachusetts General Hospital, Boston, Massachusetts
Massachusetts General Hospital,102 Endicott Street, Danvers, Massachusetts
Massachusetts General Hospital,2014 Washington St, Newton, Massachusetts
University of Michigan, Ann Arbor, Michigan
Ascension St. John Hospital, Grosse Pointe Woods, Michigan
Ascension Providence Hospital Southfield Cancer Center, Southfield, Michigan
Mayo Clinic, Rochester, Minnesota
The West Clinic, PLLC dba West Cancer Center,7668 Airways Blvd, Southaven, Mississippi
The University of Kansas Cancer Center,2750 Clay Edwards Drive, Kansas City, Missouri
The University of Kansas Cancer Center,8700 North Green Hills Road, Kansas City, Missouri
The University of Kansas Cancer Center,4881 N.E. Goodview Circle, Lee's Summit, Missouri
Nebraska Cancer Specialists,2730 W. Faidley Ave, Grand Island, Nebraska
Nebraska Cancer Specialists,8303 Dodge Street, Omaha, Nebraska
Nebraska Cancer Specialists, Omaha, Nebraska
Nebraska Cancer Specialists,611 Fenwick Dr, Papillion, Nebraska
Comprehensive Cancer Centers of Nevada - Central V,10001 S. Eastern Avenue, Suite 108, Henderson, Nevada
Comprehensive Cancer Centers of Nevada - Central V,2460 W. Horizon Ridge Parkway, Henderson, Nevada
Comprehensive Cancer Centers of Nevada - Central V,1501 Wigwam Parkway, Suite 1300, Henderson, Nevada
Comprehensive Cancer Centers of Nevada - Central V,653 North Town Center Drive, Suite 402, Las Vegas, Nevada
Comprehensive Cancer Centers of Nevada - Central V,9280 W. Sunset Road Suite 100, Las Vegas, Nevada
Comprehensive Cancer Centers of Nevada - Central V,7445 Peak Drive, Las Vegas, Nevada
Comprehensive Cancer Centers of Nevada - Central V, Las Vegas, Nevada
Summit Medical Group,1 Diamond Hill Road, Berkeley Heights, New Jersey
Regional Cancer Care Associates - East Brunswick, East Brunswick, New Jersey
Summit Medical Group, Florham Park, New Jersey
John Theurer Cancer Center, Hackensack, New Jersey
Rutgers Cancer Institute of New Jersey,2575 Klockner Road, Hamilton, New Jersey
Rutgers Cancer Institute of New Jersey,414 Grand Street, Jersey City, New Jersey
Rutgers Cancer Institute of New Jersey,600 River Avenue, Lakewood, New Jersey
Rutgers Cancer Institute of New Jersey,94 Old Short Hills Road, Livingston, New Jersey
Rutgers Cancer Institute of New Jersey,300 Second Ave, Long Branch, New Jersey
Regional Cancer Care Associates - East Brunswick,9 Centre Drive, Monroe, New Jersey
Regional Cancer Care Associates - East Brunswick,34-36 Progress Street, New Brunswick, New Jersey
Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey
Rutgers Cancer Institute of New Jersey,150 Bergen St., Newark, New Jersey
Rutgers Cancer Institute of New Jersey,201 Lyons Avenue, Newark, New Jersey
Regional Cancer Care Associates - East Brunswick,75 Veronica Avenue, Somerset, New Jersey
Rutgers Cancer Institute of New Jersey,110 Rehill Ave, Somerville, New Jersey
Rutgers Cancer Institute of New Jersey,99 Highway 37 West, Toms River, New Jersey
Rutgers Cancer Institute of New Jersey,100 State Route 36, West Long Branch, New Jersey
New York Cancer & Blood Specialists - Port Jeffers,72 East Main St., Babylon, New York
New York Cancer & Blood Specialists - Port Jeffers,12 East 86th St, Suite 4, Bronx, New York
Montefiore Medical Center - Montefiore Medical Park, Bronx, New York
New York Cancer & Blood Specialists - Port Jeffers,2330 Eastchester Road, Suite 360, Bronx, New York
Perlmutter Cancer Center - Manhattan - 34th Street,259 First Street, Mineola, New York
New York Cancer & Blood Specialists - Port Jeffers,1 Delaware Dr., New Hyde Park, New York
Perlmutter Cancer Center - Manhattan - 34th Street, New York, New York
NYP/Columbia Univeresity Medical Center/Herbert Irving Comprehensive Cancer Center, New York, New York
New York Cancer & Blood Specialists - Port Jeffers,365 East Main St., Patchogue, New York
New York Cancer & Blood Specialists - Port Jeffers,49 Rte. 347, Newconset Hwy, Port Jefferson Station, New York
New York Cancer & Blood Specialists - Port Jeffers, Port Jefferson Station, New York
New York Cancer & Blood Specialists - Port Jeffers,1500 Rte, 112, Building 4, Port Jefferson, New York
New York Cancer & Blood Specialists - Port Jeffers,750 Old County Rd. Suite 4, Riverhead, New York
The Ohio State University Wexner Medical Center Clinical Laboratories, Columbus, Ohio
Zangmeister Cancer Center, Columbus, Ohio
Northwest Cancer Specialists, PC,5050 NE Hoyt St., Portland, Oregon
Northwest Cancer Specialists, PC,265 N. Broadway, Portland, Oregon
Northwest Cancer Specialists, PC, Tigard, Oregon
Magee-Womens Hospital of UPMC,200 Oxford Drive, Bethel Park, Pennsylvania
Magee-Womens Hospital of UPMC,3 St. Francis Way, Cranberry Township, Pennsylvania
Magee-Womens Hospital of UPMC,2500 West 12th Street, Erie, Pennsylvania
Magee-Womens Hospital of UPMC,201 State Street, 6 Main, Erie, Pennsylvania
Magee-Womens Hospital of UPMC,200 Village Drive, Greensburg, Pennsylvania
Magee-Womens Hospital of UPMC,400 Oxford Drive, Monroeville, Pennsylvania
University of Pennsylvania Abramson Cancer Center, Philadelphia, Pennsylvania
Magee-Womens Hospital of UPMC,300 Halket Street, Pittsburgh, Pennsylvania
Magee-Womens Hospital of UPMC, Pittsburgh, Pennsylvania
Magee-Womens Hospital of UPMC,5115 Centre Avenue, Pittsburgh, Pennsylvania
Magee-Womens Hospital of UPMC,9100 Babcock Boulevard, Pittsburgh, Pennsylvania
Magee-Womens Hospital of UPMC,100 Fairfield Dr, Seneca, Pennsylvania
Magee-Womens Hospital of UPMC,470 Johnson Road, Washington, Pennsylvania
Magee-Womens Hospital of UPMC,1703 Innovation Drive, York, Pennsylvania
Rhode Island Hospital, Providence, Rhode Island
Rhode Island Hospital,164 Summit Ave, Fain 275A, Providence, Rhode Island
Tennessee Oncology, PLLC,103 Natchez Park Drive, Dickson, Tennessee
Tennessee Oncology, PLLC,4488 Carothers Parkway, Franklin, Tennessee
Tennessee Oncology, PLLC,225 Big Station Camp Blvd, Gallatin, Tennessee
The West Clinic, PLLC dba West Cancer Center, Germantown, Tennessee
Tennessee Oncology, PLLC,353 New Shackle Island Road, Hendersonville, Tennessee
Tennessee Oncology, PLLC,5653 First Blvd., Hermitage, Tennessee
Tennessee Oncology, PLLC,103 Physicians Way, Lebanon, Tennessee
Tennessee Oncology, PLLC,1840 Medical Center Parkway, Murfreesboro, Tennessee
Tennessee Oncology, PLLC,2004 Hayes Street, Nashville, Tennessee
Tennessee Oncology, PLLC,SCRI Oncology Partners, Nashville, Tennessee
Tennessee Oncology, PLLC, Nashville, Tennessee
Tennessee Oncology, PLLC,4220 Harding Rd, Nashville, Tennessee
Tennessee Oncology, PLLC,3443 Dickerson Road, Nashville, Tennessee
Tennessee Oncology, PLLC,397 Wallace Road, Nashville, Tennessee
Tennessee Oncology, PLLC,120 Frank Martin Road, Shelbyville, Tennessee
Tennessee Oncology, PLLC,300 Stonecrest Blvd, Smyrna, Tennessee
The Center for Cancer and Blood Disorders - Magnolia,515 W. Mayfield Rd., Arlington, Texas
Texas Oncology-Austin,901 West 38th Street, Austin, Texas
Texas Oncology-Austin, Austin, Texas
Texas Oncology-Austin,4101 James Casey, Suite 100, Austin, Texas
The Center for Cancer and Blood Disorders - Magnolia,11805 South Freeway, Burleson, Texas
Texas Oncology-Baylor Charles A. Sammons Cancer Center, Dallas, Texas
Texas Oncology-Denison, Denison, Texas
The Center for Cancer and Blood Disorders - Magnolia, Fort Worth, Texas
Oncology Consultants,1631 North Loop West, Houston, Texas
Oncology Consultants,925 Gessner, Houston, Texas
Oncology Consultants, Houston, Texas
University of Texas MD Anderson Cancer Center,1155 Pressler St, Houston, Texas
University of Texas MD Anderson Cancer Center, Houston, Texas
Mays Cancer Center, San Antonio, Texas
The Center for Cancer and Blood Disorders - Magnolia,920 Santa Fe Drive, Weatherford, Texas
Huntsman Cancer Institute, University of Utah,165 North University Avenue, Farmington, Utah
Huntsman Cancer Institute, University of Utah,1280 E. Stringham Avenue, Salt Lake City, Utah
Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah
Huntsman Cancer Institute, University of Utah,5126 West Daybreak Parkway, South Jordan, Utah
Virginia Oncology Associates,744 N. Battlefield Blvd, Chesapeake, Virginia
Virginia Cancer Institute,7501 Right Flank Road, Mechanicsville, Virginia
Virginia Oncology Associates,1051 Loftis Blvd Suite 100, Newport News, Virginia
Virginia Oncology Associates, Norfolk, Virginia
Virginia Cancer Institute,210 Medical Park Boulevard, Petersburg, Virginia
Virginia Cancer Institute,1401 Johnston-Willis Drive, Richmond, Virginia
Virginia Cancer Institute, Richmond, Virginia
Virginia Oncology Associates,1950 Glenn Mitchell Drive, Virginia Beach, Virginia
Northwest Cancer Specialists, PC,210 SE 136th Avenue, Vancouver, Washington
Hospital Británico de Buenos Aires, Buenos Aires, Not set
Instituto de Oncología Ángel H. Roffo, Caba, Not set
Fundacion CORI para la Investigacioy y Prevención del Cancer, Capital, Not set
Instituto de Oncologia de Rosario, Rosario, Not set
CAIPO Centro Para La Atención Integral Del Pacient, San Miguel de Tucumán, Not set
Clinica Viedma, Viedma, Not set
Border Medical Oncology, Albury, New South Wales
Saint George Hospital - Australia, Kogarah, New South Wales
Mater Hospital - North Sydney, North Sydney, New South Wales
GenesisCare - North Shore, St Leonards, New South Wales
Mater Misericordiae Limited and Mater Research Limited, South Brisbane, Queensland
Princess Alexandra Hospital, Woolloongabba, Queensland
Cancer Research SA (CRSA), Adelaide, South Australia
Icon Cancer Centre Hobart, Hobart, Tasmania
Monash Medical Centre, Clayton, Victoria
Austin Hospital, Melbourne, Victoria
Peter MacCallum Cancer Centre, Parkville, Victoria
Breast Cancer Research Center - Western Australia, Nedlands, Western Australia
Medizinische Universität Innsbruck, Innsbruck, Not set
Ordensklinikum Linz GmbH Barmherzige Schwestern, Linz, Not set
Landeskrankenhaus Salzburg, Salzburg, Not set
Universitätsklinikum Sankt Pölten, Sankt Poelten, Not set
Medizinische Universität Wien, Wien, Not set
Institut Jules Bordet, Anderlecht, Not set
Algemeen Ziekenhuis Klina, Brasschaat, Not set
Cliniques Universitaires Saint-Luc, Brussels, Not set
Universitair Ziekenhuis Brussel, Brussels, Not set
Grand Hopital de Charleroi - Notre Dame, Charleroi, Not set
Universitair Ziekenhuis Gent, Gent, Not set
UZ Leuven, Leuven, Not set
Centre Hospitalier Universitaire Université Cathol, Namur, Not set
Hospital Araújo Jorge - Associacao de Combate ao Cancer em Goias - ACCG, Goiânia, Not set
Centro de Pesquisa Clinica Em Oncologia - ONCOSITE, Ijui, Not set
Hospital de Clinicas de Porto Alegre - HCPA, Itajai, Not set
Centro de Pesquisas Clinicas da Fundacao Doutor Amaral Carvalho - Hospital Amarval Carvalho, Jau, Not set
Associacao Hosptialar Moinos de Vento - Hospital Moinhos de Vento, Porto Alegre, Not set
Hospital de Clínicas de Porto Alegre, Porto Alegre, Not set
Hospital Sao Lucas da PUCRS, Porto Alegre, Not set
Instituto Nacional de Câncer - Brazil, Rio de Janeiro, Not set
Núcleo de Oncologia da Bahia, Salvador, Not set
CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia - Centro Universitário FMABC, Santo Andre, Not set
Real e Benemerita Associacao Portuguesa de Beneficencia - Hospital Beneficencia Portuguesa (BP) - Unidade Paulista, São Paulo, Not set
Clinica de Pesquisas e Centro de Estudos em Oncolo, São Paulo, Not set
Fundação Pio XII - Hospital de Câncer de Barretos, São Paulo, Not set
Nucleo de Pesquisa Clinica da Rede Sao Camilo, São Paulo, Not set
Tom Baker Cancer Centre, Calgary, Not set
Cross Cancer Institute, Edmonton, Not set
QEII Health Sciences Centre, Halifax, Not set
Grand River Regional Cancer Centre at Grand River Hospital, Kitchener, Not set
London Health Sciences Centre, London, Not set
McGill University Health Centre, Montreal, Not set
Jewish General Hospital, Montréal, Not set
Princess Margaret Cancer Centre - University Health Network, Ontario, Not set
Ottawa Hospital - General Campus, Ottawa, Not set
Sunnybrook Research Institute, Toronto, Not set
Mount Sinai Hospital, Toronto, Not set
British Columbia Cancer - Vancouver, Vancouver, Not set
Oncovida - Santiago, Providencia, Not set
Clínica IRAM, Santiago DE CHILE, Not set
Centro de Cancer Pontificia Universidad Catolica, Santiago Region, Not set
Clínica Alemana, Santiago, Not set
James Lind Centro de Investigacion del Cancer, Temuco, Not set
Masarykuv Onkologicky Ustav, Klinika Komplexni Onkologicke Pece, Brno, Not set
Fakultní Thomayerova nemocnice, Hradec Kralove, Not set
Fakultní Nemocnice Hradec Králové, Hradec Králové, Not set
Fakultni nemocnice Olomouc, Onkologicka klinika, Olomouc, Not set
Vseobecna Fakultni Nemocnice v Praze, Onkologicka klinika, Prague, Not set
Fakultní Nemocnice Královské Vinohrady, Radioterapeuticka a onkologicka klinika, Praha, Not set
Sainte Catherine Institut du Cancer Avignon Provence, Avignon, Not set
Centre Hospitalier Régional et Universitaire de Be, Besancon, Not set
Polyclinique Bordeaux Nord Aquitaine, Bordeaux, Not set
Hôpital Morvan, Institut de cancérologie, Brest, Not set
Centre de Lutte contre le Cancer - François Bacles, Caen, Not set
Centre Jean Perrin, Clermont Ferrand, Not set
Centre Leon Berard, Lyon, Not set
Institut Paoli-Calmettes, Marseille CEDEX 9, Not set
Institut Régional du Cancer de Montpellier, Montpellier Cedex 5, Not set
Centre de Cancérologie du Grand Montpellier, Montpellier, Not set
Hôpital Privé du Confluent, Nantes, Not set
Hospices Civils de Lyon, Hôpital Lyon Sud, Pierre-Benite, Not set
Centre Armoricain de Radiothérapie, dImagerie Méd, Plerin, Not set
Centre Eugène Marquis, Rennes Cedex, Not set
Institut Claudius Regaud - IUCT-O, Toulouse, Not set
Institut Gustave Roussy, Villejuif, Not set
Helios Klinikum Berlin-Buch, Berlin, Not set
: Gynakologisches Zentrum Bonn, Schwerpunkt Gyn. Onkologie,, Bonn, Not set
Marienhospital Bottrop, Bottrop, Not set
Universitätsklinikum Erlangen, Frauen klinik, Erlangen, Not set
Kliniken Essen-Mitte - Evangelische Huyssens-Stift, Essen, Not set
Praxis für interdisziplinäre Onkologie & Hämatolog, Freiburg, Not set
: Universitätsklinikum Hamburg-Eppendorf, Hamburg, Not set
Facharztzentrum Eppendorf, Hamburg, Not set
Nationales Centrum für Tumorerkrankungen, Heidelberg, Not set
Klinik Frauenheilkunde, Uniklinik ClO, Studienzentrale, Köln, Not set
Universitätsklinikum Schleswig-Holstein Institut fur Klinische Chermie, Lübeck, Not set
Universitatsklinikum Mannheim GmBH, Frauenklinik, Mannheim, Not set
Universitätsklinikum Münster, Bereich Senologie an der klinik fur Frauenheilkunde und Gerburtschilfe, Munster, Not set
EV. Krankenhaus Bethesda - Johanniter GmbH, Station 1 Brustzentrum Niederrhein, Mönchengladbach, Not set
Rotkreuzklinikum Munchen Frauenklinik, München, Not set
Klinik und Poliklinik für Frauenheilkunde, München, Not set
Universitatsklinikum Tubingen, Tübingen, Not set
St. Josefs-Hospital Wiesbaden GmbH, Gynakologie und Geburtshilfe, Wiesbaden, Not set
Department of Medicine, Queen Mary Hospital, Hong Kong, Not set
Hong Kong Sanatorium and Hospital, Hong Kong, Not set
Tuen Mun Hospital, Hong Kong, Not set
Prince of Wales Hospital - Hong Kong, New Territories, Not set
Orszagos Onkologiai Intezet, Budapest, Not set
Uzsoki Utcai Kórház, Budapest, Not set
Debreceni Egyetem Klinikai Központ, Debrecen, Not set
Petz Aladár Egyetemi Oktató Kórház - Gy?r, Gyor, Not set
Soroka Medical Center, Beer-Sheva, Not set
Rambam Health Care Campus, Haifa, Not set
Shaare Zedek Medical Center, Jerusalem, Not set
Hadassah - Hebrew University Medical Center, Jerusalem, Not set
Meir Medical Center, Kfar Saba, Not set
Rabin Medical Center, Petah Tikva, Not set
Kaplan Medical Center, Rehovot, Not set
Sheba Medical Center Hospital - Tel Hashomer, Tel Aviv, Not set
Tel Aviv Sourasky Medical Center, Tel Aviv, Not set
IRCCS Istituto Tumori "Giovanni Paolo II", Bari, Not set
SSD Oncologia Medica Addarii-Zamagni, IRCSS Azienda Ospedaliero-Universitaria di Bologna - Policlinico di Sant'Orsola, Bologna, Not set
UO Oncologia, ASST degli Spedali Civili di Brescia, Brescia, Not set
IRCCS Ospedale Policlinico San Martino, Genova GE, Not set
S.C. Oncologia medica, ASST di Lecco, Lecco, Not set
Presidio Ospedaliero di Lucca, Lucca, Not set
Ospedale Generale Provinciale - Macerata, Macerata, Not set
Ospedale San Raffaele, Milano, Not set
Fondazione IRCCS - Istituto Nazionale dei Tumori, Milano, Not set
Istituto Europeo di Oncologia, Milan, Not set
Centro Ricerca Fase I, Fondazione IRCSS San Gerado dei Tintori, Monza, Not set
AOU "Luigi Vanvitelli", Napoli, Not set
Oncologia Medica Senologica Sperimentale - Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, Napoli, Not set
AOU Maggiore della Carita, Novara, Not set
Istituto Oncologico Veneto - IRCCS, Padova, Not set
S.O.C Oncologia Medica, Nuovo Ospedale di Prato Santo Stefano, Prato, Not set
Policlinico di Roma, Roma, Not set
Fondazione Policlinico Universitario Agostino Geme, Rome, Not set
Azienda Ospedaliera Universitaria Senese - Losped, Siena, Not set
Aichi Cancer Center Hospital, Aichi, Not set
Tohoku University Hospital, Aoba-ku, Not set
Juntendo University Hospital, Bunkyo-ku, Not set
Chiba Cancer Center, Chuo-ku, Not set
Osaka Prefectural Hospital Organization Osaka International Cancer Institute, Chuo-ku, Not set
NHO Shikoku Cancer Center, Ehime, Not set
Fukushima Medical University Hospital, Fukushima, Not set
Saitama Cancer Center, Inamachi, Not set
Hakuaikai Sagara Hospital, Kagoshima-shi, Not set
Tokai University Hospital, Kanagawa, Not set
National Cancer Center Hospital East, Kashiwa, Not set
The Cancer Institute Hospital of JFCR, Koto-ku, Not set
Kumamoto University Hospital, Kumamoto- shi, Not set
Kure Medical Center And Chugoku Cancer Center, Kure, Not set
Mie University Hospital, Mie, Not set
Nagoya University Hospital, Nagoya, Not set
Nagoya City University Hospital, Nagoya, Not set
Hiroshima City Hiroshima Citizens Hospital, Naka-ku, Not set
NIigata Cancer Center Hospital, Niigata-shi, Not set
Okayama University Hospital, Okayama, Not set
Gunma Prefectural Cancer Center, Ota, Not set
Kyoto University Hospital, Sakyo-ku, Not set
Hokkaido Cancer Center, Sapporo, Not set
Shizuoka General Hospital, Shizuoka-city, Not set
Shizuoka Cancer Center, Shizuoka, Not set
Osaka University Hospital, Suita, Not set
Showa University Hospital, Tokyo, Not set
Kanagawa Cancer Center, Yokohama, Not set
National Cancer Center - Korea, Goyang-si Gyeonggi-do, Not set
Seoul National University Bundang Hospital, Seongnam-si, Not set
Severance Hospital, Seoul, Not set
Asan Medical Center, Seoul, Not set
Samsung Medical Center, Seoul, Not set
Korea University Anam Hospital, Seoul, Not set
Seoul National University Hospital, Seoul, Not set
The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, Not set
Hospital Pulau Pinang, Georgetown, Not set
Hospital Sultan Ismail, Johor Bahru, Not set
Hospital Kuala Lumpur, Kuala Lumpur, Not set
Pantai Hospital Kuala Lumpur, Kuala Lumpur, Not set
University Malaya Medical Centre (UMMC), Kuala Lumpur, Not set
Institut Kanser Negara, Putrajaya, Not set
Hospital Wanita dan Kanak-Kanak Sabah, Sabah, Not set
Sarawak General Hospital, Sarawak, Not set
Icaro Investigaciones en Medicina S.A. de C.V., Chihuahua, Not set
Cryptex Investigación Clínica, Ciudad de Mexico, Not set
Centro para el Desarrollo de la Medicina, Culiacan, Not set
Panamerican Clinical Research Mexico - Guadalajara, Guadalajara, Not set
Medical Care and Research S.A. de C.V, Merida, Not set
Avix Investigacion Clinica S.C., Monterrey, Not set
Fucam A.C., México, Not set
Oncológico Potosino, San Luis Potosi, Not set
FAICIC Clínical Research, Veracruz, Not set
iBiomed - Investigacion Biomedica para el Desarrol, Zapopan, Not set
Amphia Ziekenhuis - Breda Langendijk, Breda, Not set
Universitair Medisch Centrum Groningen, Groningen, Not set
Medisch Centrum Leeuwarden, Leeuwarden, Not set
Erasmus Medisch Centrum, Rotterdam, Not set
Uniwersyteckie Centrum Kliniczne, Klinika Onkologii i Radioterapii, Gdansk, Not set
Narodowy Instytut Onkologii im. Marii Sklodowskiej, Gliwice, Not set
SP ZOZ Opolskie Centrum Onkologii im. prof. Tadeusza Koszarowskiego, Opole, Not set
Wielkopolskie Centrum Onkologii im. Marii Sklodowskiej-Curie, Poznan, Not set
Mazowiecki Szpital Wojewódzki im. w. Jana Pawa II w, Siedlce, Not set
Wojskowy Instytut Medyczny, Warsaw, Not set
Narodowy Instytut Onkologii im.Marii Marii Sklodowskiejs, Warszawa, Not set
Ponce Medical School Foundation Inc., Ponce, Not set
Hopelands Cancer Centre, Hilton, Not set
The Medical Oncology Centre of Rosebank, Johannesburg, Not set
University of Pretoria, Pretoria, Not set
Hospital Teresa Herrera - Materno Infantil, A Coruña, Not set
Hospital Universitari Dexeus, Barcelona, Not set
Hospital Clinic Barcelona, Barcelona, Not set
Hospital Clínic de Barcelona, Barcelona, Not set
Hospital de la Santa Creu i Sant Pau, Barcelona, Not set
Hospital Universitari Vall d'Hebrón, Barcelona, Not set
Hospital Universitario de Basurto, Bilbo, Not set
Hospital Universitari Arnau de Vilanova, Lleida, Not set
Hospital General Universitario Gregorio Marañón, Madrid, Not set
MD Anderson Cancer Centre Madrid, Madrid, Not set
Hospital Universitario Fundación Jiménez Díaz, Madrid, Not set
Hospital Universitario Virgen de la Victoria, Malaga, Not set
Hospital General Universitario Morales Meseguer, Murcia, Not set
Hospital Unviersitario Virgen del Rocio, Sevilla, Not set
Hospital Universitario Virgen Macarena, Sevilla, Not set
Hospital Universitario de Canarias, Tenerife, Not set
Hospital Clínico Universitario de Valencia, Valencia, Not set
Kantonsspital Baden, Baden, Not set
Kantonsspital Baselland - Standort Liestal, Liestal, Not set
Kantonsspital Sankt Gallen, St. Gallen, Not set
Kantonsspital Winterthur, Winterthur, Not set
Brust-Zentrum Zurich, Zürich, Not set
Changhua Christian Hospital, Changhua, Not set
Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Not set
Taipei Medical University-Shuang Ho Hospital, New Taipei City, Not set
Chi Mei Hospital, Liouying, Tainan City, Not set
National Cheng Kung University Hospital, Tainan, Not set
Taipei Veterans General Hospital, Taipei City, Not set
National Taiwan University Hospital, Taipei, Not set
Linkou Chang Gung Memorial Hospital, Taoyuan, Not set
Baskent Uni. Dr Turgut Noyan Uyg. ve Aras. Merkezi, Adana, Not set
Ankara Il Saglik Mudurlugu SBU Gulhane Egitim Ve A, Ankara, Not set
Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Ankara, Not set
Memorial Ankara Hastanesi, Ankara, Not set
Hacettepe Üniversitesi Hastanesi, Ankara, Not set
Trakya Universitesi Tip Fakultesi Hastanesi, Edirne, Not set
Istanbul Il Saglik Mudurlugu Goztepe Prof. Dr. Sul, Istanbul, Not set
Medipol Mega Universite Hastanesi, Istanbul, Not set
Ege Universitesi Hastanesi, Izmir, Not set
Medicana International Izmir Hastanesi, İzmir, Not set
Acibadem Maslak Hastanesi, Sariyer, Not set
VKV Amerikan Hastanesi, Sisli, Not set
NHS Lothian, Edinburgh, Not set
Clinical Trials Unit Lvl 0 Cancer Research UK Beatson Institute, Glasgow, Not set
Leeds Teaching Hospitals NHS Trust, Leeds, Not set
: Barts Health NHS Trust, St Hospital, London, Not set
Royal Free London NHS Foundation Trust, London, Not set
Guy's and Saint Thomas' NHS Foundation Trust, London, Not set
University College London Hospitals, London, Not set
Nottingham University Hospitals NHS Trust, Nottingham, Not set
Conditions: Triple Negative Breast Cancer, PD-L1 Positive
Study of Nivolumab Versus Placebo in Combination With Neoadjuvant Chemotherapy and Adjuvant Endocrine Therapy in Participants With High-risk, Estrogen Receptor-Positive (ER+), Human Epidermal Growth Factor Receptor 2-Negative (HER2-) Primary Breast Cancer
Completed
A randomized multi-arm study evaluating the efficacy and safety of nivolumab versus placebo in combination with neoadjuvant (pre-surgery) chemotherapy and adjuvant (post-surgery) endocrine therapy in participants with high-risk, estrogen receptor-positive, human epidermal growth factor receptor 2-negative (ER+, HER2-) early stage breast cancer.
A randomized multi-arm study evaluating the efficacy and safety of nivolumab versus placebo in combination with neoadjuvant (pre-surgery) chemotherapy and adjuvant (post-surgery) endocrine therapy in participants with high-risk, estrogen receptor-positive, human epidermal growth factor receptor 2-negative (ER+, HER2-) early stage breast cancer. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/16/2024
Locations: Local Institution - 0136, Mobile, Alabama +239 locations
Local Institution - 0136, Mobile, Alabama
Local Institution - 0052, Greenbrae, California
Local Institution - 0051, Whittier, California
Local Institution - 0182, Stamford, Connecticut
Local Institution - 0150, Jacksonville, Florida
Local Institution - 0097, Miami, Florida
Local Institution - 0149, Pensacola, Florida
Local Institution - 0120, Tallahassee, Florida
Local Institution - 0054, Athens, Georgia
Local Institution - 0107, Atlanta, Georgia
Local Institution - 0056, Columbus, Georgia
Local Institution - 0221, Chicago, Illinois
Local Institution - 0227, Fort Wayne, Indiana
Local Institution - 0222, Topsham, Maine
Local Institution - 0146, Bethesda, Maryland
HCA Midwest Division, Kansas City, Missouri
Local Institution - 0109, Florham Park, New Jersey
Local Institution - 0050, Hackensack, New Jersey
Local Institution - 0180, New Brunswick, New Jersey
Local Institution - 0181, Albuquerque, New Mexico
Local Institution - 0041, Bronx, New York
Local Institution - 0283, Charlotte, North Carolina
Duke Cancer Institute, Durham, North Carolina
Local Institution - 0053, Cleveland, Ohio
Local Institution - 0218, Nashville, Tennessee
Local Institution - 0121, Fort Worth, Texas
Local Institution - 0224, Fairfax, Virginia
Local Institution - 0122, Fredericksburg, Virginia
Virginia Cancer Institute, Richmond, Virginia
Local Institution - 0274, Seattle, Washington
Local Institution - 0012, Ciudad Autonoma Beunos Aires, Buenos Aires
Local Institution - 0015, La Plata, Buenos Aires
Local Institution - 0020, Buenos Aires, Ciudad Autónoma De Buenos Aires
Local Institution - 0294, Córdoba, Cordoba
Local Institution - 0303, Río Cuarto, Cordoba
Local Institution - 0011, Caba, Distrito Federal
Local Institution - 0008, Capital Federal, Distrito Federal
Local Institution - 0013, Ciudad Autonoma de Buenos Aires, Distrito Federal
Local Institution - 0014, Rosario Santa Fe, Santa FE
Local Institution - 0021, Cordoba, Not set
Local Institution, La Rioja, Not set
Local Institution, Viedma, Not set
Local Institution - 0071, North Sydney, New South Wales
Local Institution - 0069, Port Macquarie, New South Wales
Local Institution - 0072, Herston, Queensland
Local Institution - 0067, Elizabeth Vale, South Australia
Local Institution - 0066, Clayton, Victoria
Local Institution - 0142, Clayton, Victoria
Local Institution - 0070, Melbourne, Victoria
Local Institution - 0068, North Ballarat, Victoria
Local Institution - 0045, Graz, Not set
Local Institution - 0042, Innsbruck, Not set
Local Institution - 0048, Salzburg, Not set
Local Institution - 0046, Wien, Not set
Local Institution - 0047, Wien, Not set
Local Institution - 0187, Brussels, Not set
Local Institution - 0030, Charleroi, Not set
Local Institution - 0037, Edegem, Not set
Local Institution - 0032, Gent, Not set
Local Institution - 0031, Liege, Not set
Local Institution - 0130, Fortaleza, Ceara
Local Institution - 0225, Brasilia, Distrito Federal
Local Institution - 0287, Goiânia, Goias
Local Institution - 0133, Belo Horizonte, Minas Gerais
Local Institution - 0132, Ijui, RIO Grande DO SUL
Local Institution - 0288, Porto Alegre, RIO Grande DO SUL
Local Institution - 0131, Porto Alegre, Rio Grande Do Sul
Local Institution - 0135, Porto Alegre, RIO Grande DO SUL
Local Institution - 0273, Santa Cruz do Sul, Rio Grande Do Sul
Local Institution - 0134, Barretos, SAO Paulo
Local Institution - 0272, São Paulo, SAO Paulo
Local Institution - 0128, Santo André, São Paulo
Local Institution - 0129, Rio de Janeiro, Not set
Local Institution - 0144, São Paulo, Not set
Local Institution - 0104, São Paulo, Not set
Local Institution - 0194, Montreal, Quebec
Local Institution - 0095, Montréal, Quebec
Local Institution - 0058, Sherbrooke, Quebec
Local Institution - 0197, La Serena, Coquimbo
Local Institution - 0016, Santiago de Chile, Metropolitana
Local Institution - 0019, Santiago Region Metropolitana, Metropolitana
Local Institution - 0318, Santiago, Metropolitana
Local Institution - 0018, Vina del Mar, Valparaiso
Local Institution - 0326, Antofagasta, Not set
Local Institution - 0235, Bengbu, Anhui
Local Institution - 0239, Hefei, Anhui
Local Institution, Beijing, Beijing
Local Institution - 0319, Chongqing, Chongqing
Local Institution - 0232, Chongqing, Chongqing
Local Institution - 0267, Guangzhou, Guangdong
Local Institution - 0241, Guangzhou, Guangdong
Local Institution, Guangzhou, Guangdong
Local Institution - 0312, Zunyi, Guizhou
Local Institution - 0240, Shjiazhuang, Hebei
Local Institution - 0250, Wuhan, Hebei
Local Institution - 0248, Harbin, Heilongjiang
Local Institution, Zhengzhou, Henan
Local Institution - 0255, Changchun, Jilin
Local Institution - 0247, Changchun, Jilin
Local Institution - 0252, Shenyang, Liaoning
Local Institution - 0263, Xian, Shan3xi
Local Institution - 0245, Jinan, Shandong
Local Institution - 0256, Qingdao, Shandong
Local Institution - 0214, YanTai, Shandong
Local Institution - 0127, Shanghai, Shanghai
Local Institution - 0244, Chengdu, Sichuan
Local Institution - 0254, Tianjin, Tianjin
Local Institution - 0311, Urumqi, Xinjiang
Local Institution - 0238, Hangzhou, Zhejiang
Local Institution - 0231, Hangzhou, Zhejiang
Local Institution - 0237, Hangzhou, Zhejiang
Local Institution - 0215, Beijing, Not set
Local Institution - 0261, Barranquilla, Atlántico
Local Institution - 0203, Colombia, Bogota
Local Institution - 0113, Montería, Córdoba
Local Institution - 0094, Bogotá, Distrito Capital De Bogotá
Local Institution - 0098, Piedecuesta, Santander
Local Institution - 0093, Cali, Not set
Local Institution - 0271, Pereira, Not set
Local Institution - 0202, Rionegro, Not set
Local Institution - 0100, Hradec Kralove, Not set
Local Institution - 0103, Novy Jicin, Not set
Local Institution - 0101, Olomouc, Not set
Local Institution - 0099, Praha 10, Not set
Local Institution - 0167, Aarhus N, Midtjylland
Local Institution - 0165, Herlev, Not set
Local Institution - 0164, Kobenhavn O, Not set
Local Institution - 0166, Naestved, Not set
Local Institution - 0001, Helsinki, Not set
Local Institution - 0160, Tampere, Not set
Local Institution - 0216, Le Mans, Sarthe
Local Institution - 0004, Besancon, Not set
Local Institution - 0024, Brest, Not set
Local Institution - 0162, Clermont-Ferrand, Not set
Local Institution - 0153, Lyon, Not set
Local Institution - 0152, Montpellier, Not set
Local Institution - 0161, Paris, Not set
Local Institution - 0195, Plerin, Not set
Local Institution - 0002, Saint Herblain, Not set
Local Institution - 0258, Strasbourg, Not set
Local Institution - 0228, Toulon Cedex, Not set
Local Institution - 0003, Villejuif, Not set
Local Institution - 0084, München, Bayern
Local Institution - 0079, Saarbruecken, Saarland
Local Institution - 0083, Berlin, Not set
Local Institution - 0112, Dresden, Not set
Local Institution - 0081, Essen, Not set
Local Institution - 0158, Frankfurt, Not set
Local Institution - 0223, Hamburg, Not set
Local Institution - 0087, Heidelberg, Not set
Local Institution - 0089, Homburg, Not set
Local Institution - 0080, Köln, Not set
Local Institution - 0196, Leipzig, Not set
Local Institution - 0111, Moenchengladbach, Not set
Local Institution - 0156, Rostock, Not set
Local Institution - 0157, Velbert, Not set
Local Institution - 0105, Würzburg, Not set
Local Institution - 0115, Hong Kong, Not set
Local Institution - 0034, Dublin 8, Dublin
Local Institution - 0035, Beaumont, Not set
Local Institution - 0036, Cork, Not set
Local Institution - 0191, Catanzaro, Not set
Local Institution - 0207, Milano, Not set
Azienda Ospedaliero Universitaria Federico II di Napoli, Napoli, Not set
Local Institution - 0124, Napoli, Not set
Local Institution - 0155, Padova, Not set
Fondazione Irccs - Policlinico San Matteo, Pavia, Not set
Local Institution - 0190, Roma, Not set
Local Institution - 0125, Rozzano (MI), Not set
Local Institution - 0325, Seongnam, Not set
Local Institution - 0295, Seoul, Not set
Local Institution - 0320, Seoul, Not set
Local Institution - 0290, Seoul, Not set
Local Institution - 0291, Seoul, Not set
Local Institution - 0262, Tijuana, BAJA California
Local Institution - 0168, Mexico City, Distrito Federal
Local Institution - 0154, Mexico City, Distrito Federal
Local Institution - 0330, Zapopan, Jalisco
Local Institution - 0137, Monterrey, Nuevo LEON
Local Institution - 0212, Merida, Yucatán
Local Institution - 0280, Campeche, Not set
Local Institution - 0091, Chihuahua, Not set
Local Institution - 0145, Colima, Not set
Local Institution - 0141, Oaxaca, Not set
Local Institution - 0033, Amsterdam, Not set
Local Institution - 0177, Breda, Not set
Local Institution - 0199, Deventer, Not set
Local Institution - 0147, Utrecht, Not set
Local Institution - 0335, Bydgoszcz, Not set
Local Institution - 0061, Koszalin, Not set
Local Institution - 0059, Krakow, Not set
Local Institution - 0063, Lodz, Not set
Local Institution - 0062, Opole, Not set
Local Institution - 0060, Warszawa, Not set
Local Institution - 0334, Gliwice, Śląskie
Local Institution - 0210, Lisboa, Not set
Local Institution - 0211, Lisboa, Not set
Local Institution - 0209, Porto, Not set
Local Institution - 0110, Ponce, Not set
Local Institution - 0029, Bucharest, Not set
Local Institution - 0270, Bucharest, Not set
Local Institution - 0025, Bucuresti, Not set
Local Institution - 0028, Craiova, Not set
Local Institution - 0027, Floresti, Not set
Local Institution - 0026, Suceava, Not set
Local Institution, Krasnodar, Not set
Local Institution - 0119, Moscow, Not set
Local Institution, Moscow, Not set
Local Institution - 0285, Moskva, Not set
Local Institution, Ryazan, Not set
Local Institution - 0284, Saint Petersburg, Not set
Local Institution - 0306, Sankt-Peterburg, Not set
Local Institution, Sochi, Not set
Local Institution - 0078, Singapore, Not set
Local Institution - 0076, Singapore, Not set
Local Institution - 0077, Singapore, Not set
Local Institution - 0205, Elche, Alicante
Local Institution - 0171, Barcelona, Not set
Local Institution - 0172, Barcelona, Not set
Local Institution - 0173, Madrid, Not set
Local Institution - 0176, Madrid, Not set
Local Institution - 0169, Malaga, Not set
Local Institution - 0204, Pamplona, Not set
Local Institution - 0174, Santiago de Compostela, Not set
Local Institution - 0170, Sevilla, Not set
Local Institution - 0175, Valencia, Not set
Local Institution - 0184, Basel, Not set
Local Institution - 0186, Lausanne, Not set
Local Institution - 0185, Thun, Not set
Local Institution - 0301, Kaohsiung, Not set
Local Institution - 0300, Tainan City, Not set
Local Institution - 0298, Tainan, Not set
Local Institution - 0305, Taipei, Not set
Local Institution - 0297, Taipei, Not set
Local Institution - 0073, Adana, Not set
Local Institution - 0257, Ankara, Not set
Local Institution - 0075, Antalya, Not set
Local Institution - 0074, Istanbul, Not set
Local Institution - 0006, Withington, Manchester
Local Institution - 0005, London, Not set
Conditions: Breast Cancer
A Study of Nivolumab and Ipilimumab Combined With Chemotherapy Compared to Chemotherapy Alone in First Line NSCLC
Completed
The purpose of this study is to determine whether Nivolumab, Ipilimumab combined with chemotherapy is more effective than chemotherapy by itself when treating stage IV NSCLC as the first treatment given for the disease
The purpose of this study is to determine whether Nivolumab, Ipilimumab combined with chemotherapy is more effective than chemotherapy by itself when treating stage IV NSCLC as the first treatment given for the disease Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/06/2024
Locations: Memorial Health Systems, Colorado Springs, Colorado +115 locations
Memorial Health Systems, Colorado Springs, Colorado
Local Institution - 0044, Plainville, Connecticut
Local Institution - 0045, Jacksonville, Florida
Local Institution - 0029, Marietta, Georgia
Local Institution - 0091, Wichita, Kansas
Local Institution - 0004, Lexington, Kentucky
Local Institution - 0105, Detroit, Michigan
Local Institution - 0058, Johnson City, New York
Local Institution - 0098, Mineola, New York
Local Institution - 0095, Columbus, Ohio
Local Institution - 0006, Lancaster, Pennsylvania
Local Institution - 0047, Pittsburgh, Pennsylvania
Local Institution - 0093, Pittsburgh, Pennsylvania
Local Institution - 0094, Charleston, South Carolina
Southwest Regional Cancer Clinic, Saint George, Utah
Local Institution - 0099, Madison, Wisconsin
Local Institution - 0014, Ciudad Autónoma de Buenos Aires, Buenos Aires
Local Institution - 0028, Rio Cuarto, Cordoba
Local Institution - 0026, Viedma, Rio Negro
Local Institution - 0027, Rosario, Santa Fe
Local Institution - 0030, Cordoba, Not set
Local Institution - 0086, Gosford, New South Wales
Local Institution - 0040, Bedford Park, South Australia
Local Institution - 0089, Box Hill, Victoria
Local Institution - 0036, Heidelberg, Victoria
Local Institution - 0078, Murdoch, Western Australia
Local Institution - 0002, Gilly, Not set
Local Institution - 0033, Leuven, Not set
Local Institution - 0001, Roeselare, Not set
Local Institution - 0068, Natal, RIO Grande DO Norte
Local Institution - 0063, Ijui, Rio Grande Do Sul
Local Institution - 0067, Porto Alegre, Rio Grande Do Sul
Local Institution - 0069, Blumenau, Santa Catarina
Local Institution - 0064, Barretos, Sao Paulo
Local Institution - 0065, Sao Jose Do Rio Preto, Sao Paulo
Local Institution - 0066, Rio De Janeiro, Not set
Local Institution - 0070, São Paulo, Not set
Local Institution - 0090, Montreal, Quebec
Local Institution - 0083, Montreal, Quebec
Local Institution - 0082, Montreal, Quebec
Local Institution - 0080, Rimouski, Quebec
Local Institution - 0084, Santiago, Metropolitana
Local Institution - 0059, Santiago, Región Metropolitana De Santiago
Local Institution - 0079, Vina Del Mar, Valparaiso
Local Institution - 0139, Beijing, BEI
Local Institution - 0146, Haikou, Hainan
Local Institution - 0148, Zhengzhou, Henan
Local Institution - 0120, Zhengzhou, Henan
Local Institution - 0144, Changsha, Hunan
Local Institution - 0106, Changchun, Jilin
Local Institution - 0108, Xi'an City, Shan3xi
Local Institution - 0110, Hangzhou, Zhejiang
Local Institution - 0111, Zhejiang, Zhejiang
Local Institution - 0113, Beijing, Not set
Local Institution - 0112, Shanghai, Not set
Local Institution - 0010, Bron, Rhone Alpes
Local Institution - 0009, Lyon Cedex08, Rhône-Alpes
Local Institution - 0013, Caen, Not set
Local Institution - 0071, Lille Cedex, Not set
Local Institution - 0012, Montpellier, Not set
Local Institution - 0035, Nantes, Not set
Local Institution - 0011, Paris Cedex 20, Not set
Local Institution - 0097, Saint-Brieuc, Not set
Local Institution - 0073, Berlin, Not set
Local Institution - 0016, Gauting, Not set
Local Institution - 0072, Grosshansdorf, Not set
Local Institution - 0019, Hemer, Not set
Local Institution - 0017, Immenhausen, Not set
Local Institution - 0074, Magdeburg, Not set
Local Institution - 0015, Muenchen, Not set
Local Institution - 0018, Stuttgart, Not set
Local Institution - 0021, Dublin, Not set
Local Institution - 0020, Limerick, Not set
Local Institution - 0042, Lucca, Not set
Local Institution - 0041, Milano, Not set
Local Institution - 0043, Napoli, Not set
Local Institution - 0101, Fukushima-shi, Fukushima
Local Institution - 0118, Maebashi-shi, Gunma
Local Institution - 0128, Ota-shi, Gunma
Local Institution - 0138, Hiroshima-shi, Hiroshima
Local Institution - 0137, Hiroshima-shi, Hiroshima
Local Institution - 0127, Sapporo-shi, Hokkaido
Local Institution - 0131, Akashi-shi, Hyogo
Local Institution - 0119, Himeji-shi, Hyogo
Local Institution - 0104, Kobe-shi, Hyogo
Local Institution - 0115, Kanazawa-shi, Ishikawa
Local Institution - 0100, Shiwa-gun, Iwate
Local Institution - 0129, Yokohama-shi, Kanagawa
Local Institution - 0114, Yokohama-Shi, Kanagawa
Local Institution - 0134, Yokohama-shi, Kanagawa
Local Institution - 0116, Niigata-shi, Niigata
Local Institution - 0136, Okayama-shi, Okayama
Local Institution - 0135, Habikino-shi, Osaka
Local Institution - 0103, Osaka-Sayama, Osaka
Local Institution - 0102, Kitaadachi-gun, Saitama
Local Institution - 0132, Ube-shi, Yamaguchi
Local Institution - 0130, Osaka, Not set
Local Institution - 0077, La Paz, BAJA Californa SUR
Local Institution - 0061, Guadalajara, Jalisco
Local Institution - 0075, Veracruz, Veracruz, Not set
Local Institution - 0087, Bydgoszcz, Not set
Local Institution - 0022, Bytom, Not set
Local Institution - 0085, Gdańsk, Not set
Local Institution - 0034, Bucharest, Not set
Local Institution - 0031, Cluj Napoca, Not set
Local Institution - 0032, Craiova, Not set
Local Institution - 0024, Moscow, Not set
Local Institution - 0025, St.petersburg, Not set
Local Institution - 0054, A Coruña, Not set
Local Institution - 0053, Barcelona, Not set
Local Institution - 0052, Madrid, Not set
Local Institution - 0055, Malaga, Not set
Local Institution - 0056, Valencia, Not set
Local Institution - 0050, Guildford, Not set
Local Institution - 0049, London, Not set
Local Institution - 0048, Tauton, Not set
Conditions: Non-Small Cell Lung Cancer
Induction Chemotherapy Plus Chemoradiation as First Line Treatment for Locally Advanced Cervical Cancer
Active Not Recruiting
Chemoradiation has been the standard treatment for advanced cervical cancer for a decade, but one third of women still die from a failure to control systemic disease. In a recent multicentre phase II trial of 46 women the investigators found that, 68% of women had tumours that responded to weekly induction chemotherapy prior to chemoradiation. The induction chemotherapy had acceptable toxicity and did not compromise the standard chemoradiation treatment. In addition, the overall survival and pro... Read More
Chemoradiation has been the standard treatment for advanced cervical cancer for a decade, but one third of women still die from a failure to control systemic disease. In a recent multicentre phase II trial of 46 women the investigators found that, 68% of women had tumours that responded to weekly induction chemotherapy prior to chemoradiation. The induction chemotherapy had acceptable toxicity and did not compromise the standard chemoradiation treatment. In addition, the overall survival and progression free survival at 3 years was 66% (95% CI 4779). These results, together with acceptable toxicity, provide justification for evaluating induction chemotherapy prior to chemoradiation in a randomised phase III trial. The investigators aim to investigate in a randomised trial whether additional induction chemotherapy given on a weekly schedule immediately before standard chemoradiation leads to an improvement in overall survival. The investigators plan to recruit 770 women with locally advanced cervical cancer who are eligible for standard chemoradiation, they will be randomised to weekly carboplatin and paclitaxel chemotherapy for 6 weeks followed by chemoradiation or to chemoradiation alone. The trial will recruit for 4 years with 5 years of follow up period. Read Less
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
12/04/2024
Locations: Instituto do Câncer do Estado de São Paulo, São Paulo, Not set +34 locations
Instituto do Câncer do Estado de São Paulo, São Paulo, Not set
Chittaranjan National Cancer Institute (CNCI), Kolkata, Not set
Saroj Gupta Cancer Centre and Research Institute, Kolkata, Not set
Istituto Europeo di Oncologia, Milan, Lombardy
Instituto Nacional de Cancerologia (INCAN), Mexico City, Not set
North Devon District Hospital, Barnstaple, Devon
University College London Hospital, London, Greater London
Weston Park Hospital, Sheffield, South Yorkshire
Belfast City Hospital, Belfast, Not set
Pilgrim Hospital, Boston, Not set
Royal Sussex County Hospital, Brighton, Not set
Velindre Cancer Centre, Cardiff, Not set
Cheltenham General Hospital, Cheltenham, Not set
Royal Derby Hospital, Derby, Not set
Royal Devon and Exeter NHS Foundation Trust, Exeter, Not set
Beatson WOSCC, Glasgow, Not set
Gloucester Royal Hospital, Gloucester, Not set
Grantham and District Hospital, Grantham, Not set
Castle Hill Hospital, Hull, Not set
Leicester Royal Infirmary, Leicester, Not set
Lincoln County Hospital, Lincoln, Not set
Guy's and St Thomas' NHS Foundation Trust, London, Not set
Imperial College Healthcare NHS Trust, London, Not set
St Bart's Hospital, London, Not set
The Christie NHS Foundation Trust, Manchester, Not set
James Cook University Hospital, Middlesbrough, Not set
Northampton General Hospital, Northampton, Not set
Norfolk and Norwich University Hospital, Norwich, Not set
Nottingham University Hospitals NHS Trust, Nottingham, Not set
Derriford Hospital, Plymouth, Not set
Southampton General Hospital, Southampton, Not set
Royal Stoke University Hospital, Stoke-On-Trent, Not set
Royal Cornwall Hospital, Truro, Not set
The Clatterbridge Cancer Centre, Wirral, Not set
New Cross Hospital, Wolverhampton, Not set
Conditions: Cervical Cancer
A Study to Evaluate Dostarlimab Plus Carboplatin-paclitaxel Versus Placebo Plus Carboplatin-paclitaxel in Participants With Recurrent or Primary Advanced Endometrial Cancer
Active Not Recruiting
This is a 2 part study. Part 1 is to evaluate the efficacy and safety of dostarlimab plus carboplatin-paclitaxel followed by dostarlimab versus placebo plus carboplatin-paclitaxel followed by placebo; and Part 2 is to evaluate the efficacy and safety of dostarlimab plus carboplatin-paclitaxel followed by dostarlimab plus niraparib versus placebo plus carboplatin-paclitaxel followed by placebo in participants with recurrent or primary advanced (Stage III or IV) endometrial cancer.
This is a 2 part study. Part 1 is to evaluate the efficacy and safety of dostarlimab plus carboplatin-paclitaxel followed by dostarlimab versus placebo plus carboplatin-paclitaxel followed by placebo; and Part 2 is to evaluate the efficacy and safety of dostarlimab plus carboplatin-paclitaxel followed by dostarlimab plus niraparib versus placebo plus carboplatin-paclitaxel followed by placebo in participants with recurrent or primary advanced (Stage III or IV) endometrial cancer. Read Less
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
11/26/2024
Locations: GSK Investigational Site, Phoenix, Arizona +168 locations
GSK Investigational Site, Phoenix, Arizona
GSK Investigational Site, Scottsdale, Arizona
GSK Investigational Site, Tempe, Arizona
GSK Investigational Site, Tucson, Arizona
GSK Investigational Site, Tucson, Arizona
GSK Investigational Site, Newport Beach, California
GSK Investigational Site, Palo Alto, California
GSK Investigational Site, Deerfield Beach, Florida
GSK Investigational Site, Jacksonville, Florida
GSK Investigational Site, Miami, Florida
GSK Investigational Site, Miami, Florida
GSK Investigational Site, Orlando, Florida
GSK Investigational Site, Augusta, Georgia
GSK Investigational Site, Savannah, Georgia
GSK Investigational Site, Savannah, Georgia
GSK Investigational Site, Hinsdale, Illinois
GSK Investigational Site, Zion, Illinois
GSK Investigational Site, Fort Wayne, Indiana
GSK Investigational Site, Indianapolis, Indiana
GSK Investigational Site, Indianapolis, Indiana
GSK Investigational Site, Iowa City, Iowa
GSK Investigational Site, Lexington, Kentucky
GSK Investigational Site, Covington, Louisiana
GSK Investigational Site, New Orleans, Louisiana
GSK Investigational Site, Shreveport, Louisiana
GSK Investigational Site, Boston, Massachusetts
GSK Investigational Site, Springfield, Massachusetts
GSK Investigational Site, Detroit, Michigan
GSK Investigational Site, Saint Louis, Missouri
GSK Investigational Site, Lebanon, New Hampshire
GSK Investigational Site, Albuquerque, New Mexico
GSK Investigational Site, Rio Rancho, New Mexico
GSK Investigational Site, Albany, New York
GSK Investigational Site, Bronx, New York
GSK Investigational Site, Mineola, New York
GSK Investigational Site, New York, New York
GSK Investigational Site, Charlotte, North Carolina
GSK Investigational Site, Durham, North Carolina
GSK Investigational Site, Kernersville, North Carolina
GSK Investigational Site, Mount Airy, North Carolina
GSK Investigational Site, Winston-Salem, North Carolina
GSK Investigational Site, Cincinnati, Ohio
GSK Investigational Site, Cincinnati, Ohio
GSK Investigational Site, Cleveland, Ohio
GSK Investigational Site, Columbus, Ohio
GSK Investigational Site, Hilliard, Ohio
GSK Investigational Site, Tulsa, Oklahoma
GSK Investigational Site, Philadelphia, Pennsylvania
GSK Investigational Site, Pittsburgh, Pennsylvania
GSK Investigational Site, Wexford, Pennsylvania
GSK Investigational Site, Willow Grove, Pennsylvania
GSK Investigational Site, Providence, Rhode Island
GSK Investigational Site, Knoxville, Tennessee
GSK Investigational Site, Austin, Texas
GSK Investigational Site, Dallas, Texas
GSK Investigational Site, Fort Worth, Texas
GSK Investigational Site, Charlottesville, Virginia
GSK Investigational Site, Roanoke, Virginia
GSK Investigational Site, Seattle, Washington
GSK Investigational Site, Grodno, Not set
GSK Investigational Site, Minsk, Not set
GSK Investigational Site, Aalst, Not set
GSK Investigational Site, Leuven, Not set
GSK Investigational Site, LiEge, Not set
GSK Investigational Site, Calgary, Alberta
GSK Investigational Site, Winnipeg, Manitoba
GSK Investigational Site, Ottawa, Ontario
GSK Investigational Site, Sault Ste Marie, Ontario
GSK Investigational Site, Toronto, Ontario
GSK Investigational Site, Montreal, Quebec
GSK Investigational Site, Montreal, Quebec
GSK Investigational Site, QuEbec, Not set
GSK Investigational Site, Brno, Not set
GSK Investigational Site, Praha 2, Not set
GSK Investigational Site, Aalborg, Not set
GSK Investigational Site, Copenhagen, Not set
GSK Investigational Site, Herlev, Not set
GSK Investigational Site, Odense C, Not set
GSK Investigational Site, Roskilde, Not set
GSK Investigational Site, Kuopio, Not set
GSK Investigational Site, Tampere, Not set
GSK Investigational Site, Turku, Not set
GSK Investigational Site, Amberg, Not set
GSK Investigational Site, Bad Homburg, Not set
GSK Investigational Site, Dessau, Not set
GSK Investigational Site, Dresden, Not set
GSK Investigational Site, Essen, Not set
GSK Investigational Site, Essen, Not set
GSK Investigational Site, Frankfurt, Not set
GSK Investigational Site, Giessen, Not set
GSK Investigational Site, Hamburg, Not set
GSK Investigational Site, Hannover, Not set
GSK Investigational Site, Jena, Not set
GSK Investigational Site, Karlsruhe, Not set
GSK Investigational Site, Kiel, Not set
GSK Investigational Site, Koeln, Not set
GSK Investigational Site, Luebeck, Not set
GSK Investigational Site, Mainz, Not set
GSK Investigational Site, Muenchen, Not set
GSK Investigational Site, Offenbach, Not set
GSK Investigational Site, Ravensburg, Not set
GSK Investigational Site, Rosenheim, Not set
GSK Investigational Site, Tuebingen, Not set
GSK Investigational Site, Ulm, Not set
GSK Investigational Site, Wiesbaden, Not set
GSK Investigational Site, Marousi, Not set
GSK Investigational Site, Thessaloniki, Not set
GSK Investigational Site, Budapest, Not set
GSK Investigational Site, Debrecen, Not set
GSK Investigational Site, Ashkelon, Not set
GSK Investigational Site, Beer-Sheva, Not set
GSK Investigational Site, Haifa, Not set
GSK Investigational Site, Jerusalem, Not set
GSK Investigational Site, Petach Tikva, Not set
GSK Investigational Site, Rehovot, Not set
GSK Investigational Site, Tel Aviv, Not set
GSK Investigational Site, Biella, Not set
GSK Investigational Site, Candiolo, Not set
GSK Investigational Site, Carpi MO, Not set
GSK Investigational Site, Lecce, Not set
GSK Investigational Site, Milano, Not set
GSK Investigational Site, Naples, Not set
GSK Investigational Site, Rome, Not set
GSK Investigational Site, Sassuolo, Not set
GSK Investigational Site, Trento, Not set
GSK Investigational Site, Udine, Not set
GSK Investigational Site, Amsterdam, Not set
GSK Investigational Site, Eindhoven, Not set
GSK Investigational Site, Enschede, Not set
GSK Investigational Site, Groningen, Not set
GSK Investigational Site, Maastricht, Not set
GSK Investigational Site, Rotterdam, Not set
GSK Investigational Site, Bergen, Not set
GSK Investigational Site, Oslo, Not set
GSK Investigational Site, Stavanger, Not set
GSK Investigational Site, Troms, Not set
GSK Investigational Site, Trondheim, Not set
GSK Investigational Site, Bialystok, Not set
GSK Investigational Site, Gdynia, Not set
GSK Investigational Site, Lodz, Not set
GSK Investigational Site, Olsztyn, Not set
GSK Investigational Site, Poznan, Not set
GSK Investigational Site, Szczecin, Not set
GSK Investigational Site, Warszawa, Not set
GSK Investigational Site, Barcelona, Not set
GSK Investigational Site, Barcelona, Not set
GSK Investigational Site, Madrid, Not set
GSK Investigational Site, Madrid, Not set
GSK Investigational Site, MAlaga, Not set
GSK Investigational Site, MAlaga, Not set
GSK Investigational Site, Murcia, Not set
GSK Investigational Site, San SebastiAn, Not set
GSK Investigational Site, Valencia, Not set
GSK Investigational Site, Linkoping, Not set
GSK Investigational Site, Lund, Not set
GSK Investigational Site, Stockholm, Not set
GSK Investigational Site, Uppsala, Not set
GSK Investigational Site, Adapazari, Not set
GSK Investigational Site, Ankara, Not set
GSK Investigational Site, Istanbul, Not set
GSK Investigational Site, Istanbul, Not set
GSK Investigational Site, Istanbul, Not set
GSK Investigational Site, Chernihiv, Not set
GSK Investigational Site, Kharkiv, Not set
GSK Investigational Site, Brighton, Not set
GSK Investigational Site, Cambridge, Not set
GSK Investigational Site, London, Not set
GSK Investigational Site, London, Not set
GSK Investigational Site, Truro, Not set
Conditions: Neoplasms
Study of Pembrolizumab (MK-3475) Versus Chemotherapy in Mismatch Repair Deficient (dMMR) Advanced or Recurrent Endometrial Carcinoma (MK-3475-C93/KEYNOTE-C93/GOG-3064/ENGOT-en15)
Active Not Recruiting
The purpose of this study is to assess the safety and efficacy of treatment with pembrolizumab (MK-3475) compared to a combination of carboplatin and paclitaxel in women with mismatch repair deficient (dMMR) advanced or recurrent endometrial carcinoma who have not previously been treated with prior systemic chemotherapy.
The primary study hypotheses are that pembrolizumab is superior to the combination of carboplatin and paclitaxel with respect to Progression Free Survival (PFS) per Response Ev... Read More
The purpose of this study is to assess the safety and efficacy of treatment with pembrolizumab (MK-3475) compared to a combination of carboplatin and paclitaxel in women with mismatch repair deficient (dMMR) advanced or recurrent endometrial carcinoma who have not previously been treated with prior systemic chemotherapy.
The primary study hypotheses are that pembrolizumab is superior to the combination of carboplatin and paclitaxel with respect to Progression Free Survival (PFS) per Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST 1.1) as assessed by Blinded Independent Central Review (BICR) and Overall Survival (OS). Read Less
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
11/19/2024
Locations: HonorHealth-USOR HonorHealth ( Site 8000), Phoenix, Arizona +194 locations
HonorHealth-USOR HonorHealth ( Site 8000), Phoenix, Arizona
Moores Cancer Center ( Site 0037), La Jolla, California
Kaiser Permanente Riverside Medical Center ( Site 0045), Riverside, California
Yale-New Haven Hospital-Smilow Cancer Hospital at Yale-New Haven ( Site 0013), New Haven, Connecticut
Mount Sinai Cancer Center ( Site 0018), Miami Beach, Florida
Sarasota Memorial Hospital ( Site 0005), Sarasota, Florida
Northside Hospital ( Site 0017), Atlanta, Georgia
Southeastern Regional Medical Center ( Site 0046), Newnan, Georgia
Midwestern Regional Medical Center,Inc. DBA CTCA, Chicago ( Site 0003), Zion, Illinois
St. Vincent Hospital and Health Care Center, Inc ( Site 0006), Indianapolis, Indiana
Baptist Health Lexington ( Site 0042), Lexington, Kentucky
Maryland Oncology Hematology, P.A.-USOR Maryland Oncology Hematology, P.A. ( Site 8002), Rockville, Maryland
University of Massachusetts Medical School-Division of Gynecologic Oncology ( Site 0008), Worcester, Massachusetts
Karmanos Cancer Institute ( Site 0029), Detroit, Michigan
St. Dominic's Hospital ( Site 0024), Jackson, Mississippi
John Theurer Cancer Center at Hackensack University Medical Center ( Site 0026), Hackensack, New Jersey
The Blavatnik Family- Chelsea Medical Center at Mount Sinai ( Site 0023), New York, New York
Laura and Isaac Perlmutter Cancer Center at NYU Langone ( Site 0016), New York, New York
Icahn School of Medicine at Mount Sinai ( Site 0052), New York, New York
Memorial Sloan Kettering Cancer Center ( Site 0009), New York, New York
FirstHealth Clinical Trials ( Site 0050), Pinehurst, North Carolina
Sanford Medical Center ( Site 0054), Bismarck, North Dakota
Sanford Fargo Medical Center-Roger Maris Cancer Center ( Site 0055), Fargo, North Dakota
University of Cincinnati Medical Center-University of Cincinnati Cancer Center ( Site 0039), Cincinnati, Ohio
The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive C, Columbus, Ohio
Providence Portland Medical Center ( Site 0031), Portland, Oregon
Sidney Kimmel Cancer Center - Jefferson Health ( Site 0053), Philadelphia, Pennsylvania
University of Pittsburgh Medical Center Magee-Womens Hospital ( Site 0034), Pittsburgh, Pennsylvania
AHN West Penn Hospital ( Site 0011), Pittsburgh, Pennsylvania
Asplundh Cancer Pavilion ( Site 0014), Willow Grove, Pennsylvania
Sanford Cancer Center-Gynecologic Oncology ( Site 0002), Sioux Falls, South Dakota
Texas Oncology - Austin-USOR Texas Oncology - Austin ( Site 8003), Austin, Texas
Texas Oncology - Dallas-USOR Texas Oncology - Dallas (Sammons) ( Site 8005), Dallas, Texas
Texas Oncology - Tyler-USOR Texas Oncology - Northeast Texas ( Site 8004), Tyler, Texas
VCU Health Adult Outpatient Pavillion ( Site 0022), Richmond, Virginia
Northern Cancer Institute ( Site 0206), St Leonards, New South Wales
Westmead Hospital-Department of Gynaecological Oncology ( Site 0201), Westmead, New South Wales
Royal Brisbane and Women's Hospital-Medical Oncology Clinical Trials Unit, Cancer Care Services ( Si, Brisbane, Queensland
Monash Health ( Site 0202), Clayton, Victoria
Peter MacCallum Cancer Centre-Parkville Cancer Clinical Trials Unit (PCCTU) ( Site 0207), Melbourne, Victoria
Epworth Freemasons ( Site 0203), Melbourne, Victoria
St. John of God Subiaco Hospital-Oncology Clinical Trials Unit ( Site 0204), Subiaco, Western Australia
Institut Jules Bordet-Medicine Oncology ( Site 0321), Bruxelles, Bruxelles-Capitale, Region De
Grand Hôpital de Charleroi-Oncology & Hematology ( Site 0323), Charleroi, Hainaut
Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman ( Site 0320), Liège, Liege
Liga Norte Riograndense Contra o Câncer-Centro de Pesquisa Clínica ( Site 3005), Natal, Rio Grande Do Norte
ICESP - INSTITUTO DO CÂNCER DO ESTADO DE SÃO PAULO ( Site 3001), São Paulo, Sao Paulo
A. C. Camargo Cancer Center-CAPEC ( Site 3003), Sao Paulo, Not set
Cross Cancer Institute ( Site 0513), Edmonton, Alberta
BC Cancer Kelowna ( Site 0517), Kelowna, British Columbia
BC Cancer Vancouver-Clinical Trials Unit ( Site 0518), Vancouver, British Columbia
Sunnybrook Health Sciences - Odette Cancer Centre ( Site 0509), Toronto, Ontario
Princess Margaret Cancer Centre ( Site 0510), Toronto, Ontario
Jewish General Hospital ( Site 0504), Montreal, Quebec
Centre Hospitalier de l'Université de Montréal ( Site 0519), Montréal, Quebec
McGill University Health Centre ( Site 0505), Montréal, Quebec
Saskatoon Cancer Center-Clinical Research Department ( Site 0520), Saskatoon, Saskatchewan
FALP-UIDO ( Site 0602), Santiago, Region M. De Santiago
Pontificia Universidad Catolica de Chile-Centro del Cáncer ( Site 0604), Santiago, Region M. De Santiago
Bradfordhill-Clinical Area ( Site 0603), Santiago, Region M. De Santiago
Anhui Provincial Hospital-Obstetrics and Gynecology ( Site 0730), Hefei, Anhui
Beijing Obstetric and Gynecology Hospital ( Site 0740), Beijing, Beijing
Peking University First Hospital ( Site 0723), Beijing, Beijing
Beijing Cancer hospital ( Site 0715), Beijing, Beijing
Southwest Hospital of Third Military Medical University ( Site 0719), Chongqing, Chongqing
2nd Affiliated Hospital Chongqing Medical Universi ( Site 0745), Chongqing, Chongqing
Fuling Central Hospital ( Site 0733), Fulingqu, Chongqing
Fujian Provincial Cancer Hospital ( Site 0720), Fuzhou, Fujian
SUN YAT-SEN UNIVERSITY CANCER CENTRE ( Site 0710), Guangzhou, Guangdong
Cancer Hospital of Shantou University Medical College ( Site 0732), Shantou, Guangdong
Affiliated Hospital of Guangdong Medical College ( Site 0731), Zhanjiang, Guangdong
Guangxi Medical University Affiliated Tumor Hospital-Gynecological oncology ( Site 0704), Nanning, Guangxi
Hainan General Hospital ( Site 0703), Haikou, Hainan
Harbin Medical University Cancer Hospital ( Site 0711), Harbin, Heilongjiang
Henan Cancer Hospital ( Site 0713), Zhengzhou, Henan
Wuhan Union Hospital-Medical Oncology ( Site 0716), Wuhan, Hubei
Xiangya Hospital Central South University-Gynecology ( Site 0708), Changsha, Hunan
Hunan Cancer Hospital ( Site 0709), Changsha, Hunan
Jiangsu Province Hospital-Oncology Department ( Site 0707), Nanjing, Jiangsu
The First Affiliated Hospital of Nanchang University ( Site 0729), Nanchang, Jiangxi
The First Hospital of Jilin University ( Site 0705), Changchun, Jilin
Shaanxi Provincial Cancer Hospital ( Site 0714), XI An, Shaanxi
Binzhou Medical University Hospital-Oncology department ( Site 0735), Binzhou, Shandong
Obstetrics & Gynecology Hospital of Fudan University ( Site 0702), Shanghai, Shanghai
Shanghai First Maternity and Infant Hospital-Gynecology department ( Site 0717), Shanghai, Shanghai
West China Second University Hospital Sichuan University ( Site 0701), Chengdu, Sichuan
Tianjin Medical University Cancer Institute and Hospital ( Site 0706), Tianjin, Tianjin
Yunnan Province Cancer Hospital-Gynecology Department ( Site 0721), Kunming, Yunnan
The Affiliated Women's Hospital of Zhejiang University-Obstetrics and Gynecology ( Site 0726), Hangzhou, Zhejiang
Zhejiang Cancer Hospital-Oncology ( Site 0700), Hangzhou, Zhejiang
The First Affiliated Hospital of Wenzhou Medical University-Gynecology ( Site 0725), Wenzhou, Zhejiang
Fakultní nemocnice Brno Bohunice-Gynekologicko-porodnicka klinika ( Site 0404), Brno, Brno-mesto
Fakultni nemocnice Ostrava-Gynekologicko-porodnicka klinika ( Site 0403), Ostrava, Moravskoslezsky Kraj
Nemocnice AGEL Novy Jicin a.s.-Oddeleni radioterapie a onkologie ( Site 0406), Nový Jiín, Novy Jicin
Fakultni nemocnice Olomouc-Onkologicka klinika ( Site 0402), Olomouc, Olomoucky Kraj
Vseobecna fakultni nemocnice v Praze-Gynekologicko-porodnicka klinika 1.LF a VFN ( Site 0405), Praha, Praha 2
Fakultni nemocnice Bulovka-Gynekologicko-porodnicka klinika ( Site 0401), Praha, Praha 8
Nemocnice Tomase Bati ve Zline-Onkologické oddělení ( Site 0407), Zlín, Zlinsky Kraj
Fakultni nemocnice Kralovske Vinohrady-Gynekologicko-porodnická klinika ( Site 0408), Praha 10, Not set
Rigshospitalet ( Site 0903), Copenhagen, Hovedstaden
Herlev and Gentofte Hospital ( Site 0902), Copenhagen, Hovedstaden
Aalborg Universitetshospital, Syd ( Site 0905), Aalborg, Nordjylland
Roskilde Sygehus-Oncology department ( Site 0904), Roskilde, Sjaelland
Tampereen yliopistollinen sairaala-Gynecology and Obstetrics ( Site 1001), Tampere, Pirkanmaa
Kuopion Yliopistollinen Sairaala ( Site 1002), Kuopio, Pohjois-Savo
Helsinki University Hospital - Comprehensive Cancer Center (HYKS - Syöpäkeskus) ( Site 1003), Helsinki, Uusimaa
Universitaetsklinikum Ulm ( Site 1106), Ulm, Baden-Wurttemberg
Universitätsklinikum Bonn-Gynaecological oncology ( Site 1105), Bonn, Nordrhein-Westfalen
Universitaetsklinikum Carl Gustav Carus Dresden-Klinik und Poliklinik für Frauenheilkunde und Gebur, Dresden, Sachsen
Charité Campus Virchow-Klinikum ( Site 1103), Berlin, Not set
Országos Onkológiai Intézet-Ngyógyászat ( Site 1201), Budapest, Not set
Bon Secours Cork Hospital ( Site 1305), Cork, Not set
St. James's Hospital-Cancer clinical trials office ( Site 1301), Dublin, Not set
Soroka Medical Center ( Site 1403), Be'er Sheva, Not set
Rambam Health Care Campus-Gyneco-oncology unit ( Site 1402), Haifa, Not set
Edith Wolfson Medical Center-Obstetrics & Gynecology ( Site 1405), Holon, Not set
Shaare Zedek Medical Center ( Site 1404), Jerusalem, Not set
Sheba Medical Center ( Site 1401), Ramat Gan, Not set
Istituto Nazionale Tumori IRCCS Fondazione Pascale-S.C. Oncologia Sperimentale Uro-Genitale ( Site 1, Napoli, Campania
IRCCS - AOU di Bologna-SSD Oncologia medica Addarii ( Site 1503), Bologna, Emilia-Romagna
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori-Oncologia Medica ( Site 1513), Meldola, Emilia-Romagna
Fondazione Policlinico Universitario Agostino Gemelli-Ginecologia Oncologica ( Site 1502), Roma, Lazio
Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Chirurgia Ginecologica ( Site 150, Milan, Lombardia
Ospedale Mauriziano-SCDU ONCOLOGIA MEDICA ( Site 1514), Torino, Piemonte
Istituto Nazionale Tumori Regina Elena-Oncologia Medica 1 ( Site 1504), Rome, Roma
Azienda Ospedaliera Universitaria Careggi-SOD ONCOLOGIA MEDICA ( Site 1509), Firenze, Toscana
AULSS8 Berica-Ospedale S.Bortolo-ONCOLOGIA CLINICA ( Site 1510), Vicenza, Veneto
Istituto Europeo di Oncologia IRCCS-Divisione di Ginecologia Oncologica ( Site 1506), Milano, Not set
National Cancer Center Hospital East ( Site 1604), Kashiwa, Chiba
National Hospital Organization Shikoku Cancer Center ( Site 1611), Matsuyama, Ehime
Ehime University Hospital ( Site 1614), Toon, Ehime
Kurume University Hospital ( Site 1612), Kurume, Fukuoka
Gunma Prefectural Cancer Center-Gynecology ( Site 1603), Ota, Gunma
Hokkaido University Hospital ( Site 1601), Sapporo, Hokkaido
Tsukuba University Hospital ( Site 1618), Tsukuba, Ibaraki
Iwate Medical University Hospital ( Site 1602), Shiwa-gun Yahaba-cho, Iwate
Niigata University Medical & Dental Hospital ( Site 1613), Chuo-ku, Niigata, Niigata
Saitama Medical University International Medical Center ( Site 1605), Hidaka-shi, Saitama
Shizuoka Cancer Center ( Site 1609), Nagaizumi-cho,Sunto-gun, Shizuoka
National Cancer Center Hospital ( Site 1607), Chuo-ku, Tokyo
Japanese Foundation for Cancer Research ( Site 1616), Koto, Tokyo
The Jikei University Hospital ( Site 1615), Minato-ku, Tokyo
Keio university hospital ( Site 1606), Shinjyuku-ku, Tokyo
National Hospital Organization Kyushu Cancer Center ( Site 1608), Fukuoka, Not set
Osaka International Cancer Institute ( Site 1617), Osaka, Not set
Seoul National University Hospital ( Site 2302), Seoul, Not set
Severance Hospital, Yonsei University Health System-Gynecologic cancer center ( Site 2301), Seoul, Not set
Asan Medical Center-Division of Gynecologic Oncology, Dept. of Obstetrics & Gynecology ( Site 2303), Seoul, Not set
Gangnam Severance Hospital ( Site 2304), Seoul, Not set
Radboudumc-Medical Oncology ( Site 1703), Nijmegen, Gelderland
Maastricht UMC+ ( Site 1709), Maastricht, Limburg
Catharina Ziekenhuis-Oncology ( Site 1704), Eindhoven, Noord-Brabant
Amsterdam UMC, locatie AMC ( Site 1706), Amsterdam, Noord-Holland
Leids Universitair Medisch Centrum-Medical Oncology ( Site 1702), Leiden, Zuid-Holland
Erasmus Medisch Centrum-Medical Oncology ( Site 1701), Rotterdam, Zuid-Holland
University Medical Center Groningen ( Site 1707), Groningen, Not set
Universitair Medisch Centrum Utrecht-Medical Oncology ( Site 1705), Utrecht, Not set
Auckland City Hospital-Cancer & Blood Research ( Site 1801), Auckland, Not set
Oslo universitetssykehus, Radiumhospitalet ( Site 1901), Oslo, Not set
Centrum Onkologii Ziemi Lubelskiej ( Site 2006), Lublin, Lubelskie
Mazowiecki Szpital Wojewódzki w Siedlcach-Siedleckie Centrum Onkologii ( Site 2007), Siedlce, Mazowieckie
Szpital Kliniczny im. Księżnej Anny Mazowieckiej ( Site 2009), Warsaw, Mazowieckie
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Ginekologii Onkologicznej ( Sit, Warszawa, Mazowieckie
Bialostockie Centrum Onkologii-Oddzial Onkologii Ginekologicznej ( Site 2003), Bialystok, Podlaskie
Narodowy Instytut Onkologii - Oddzial w Gliwicach-III Klinika Radioterapii i Chemioterapii ( Site 20, Gliwice, Slaskie
Swietokrzyskie Centrum Onkologii, Samodzielny Publiczny Zaklad Opieki Zdrowotnej ( Site 2010), Kielce, Swietokrzyskie
Szpital Kliniczny im. Heliodora Święcickiego Uniwersytetu Me-Oddzial Ginekologii Onkologicznej ( Sit, Poznan, Wielkopolskie
Moscow City Oncology Hospital #62 ( Site 2204), Krasnogorsk, Moskovskaya Oblast
Yaroslavl Regional Cancer Hospital-Oncology ( Site 2202), Yaroslavl, Yaroslavskaya Oblast
Institut Català d'Oncologia - L'Hospitalet-Medical Oncology ( Site 2406), Hospitalet, Barcelona
CHUAC-Complejo Hospitalario Universitario A Coruña ( Site 2405), A Coruña, La Coruna
Hospital Universitario Ramón y Cajal-Medical Oncology ( Site 2402), Madrid, Madrid, Comunidad De
COMPLEJO HOSPITALARIO DE NAVARRA ( Site 2407), Pamplona, Navarra
Fundación Instituto Valenciano de Oncología-Oncologico ( Site 2404), Valencia, Valenciana, Comunitat
Hospital Universitari Vall d'Hebron ( Site 2403), Barcelona, Not set
HOSPITAL UNIVERSITARIO VIRGEN DEL ROCIO ( Site 2401), Sevilla, Not set
Skånes Universitetssjukhus Lund-Department of Hematology ( Site 2504), Lund, Skane Lan
Karolinska Universitetssjukhuset Solna ( Site 2502), Solna, Stockholms Lan
Norrlands universitetssjukhus-Cancercentrum ( Site 2503), Umeå, Vasterbottens Lan
Taichung Veterans General Hospital ( Site 2602), Taichung, Not set
NATIONAL CHENG-KUNG UNI. HOSP. ( Site 2604), Tainan, Not set
National Taiwan University Hospital ( Site 2603), Taipei, Not set
Mackay Memorial Hospital ( Site 2601), Taipei, Not set
Taipei Veterans General Hospital ( Site 2605), Taipei, Not set
Istanbul Universitesi Cerrahpasa ( Site 2702), Fatih, Istanbul
Hacettepe Universite Hastaneleri-oncology hospital ( Site 2704), Ankara, Not set
Ankara Bilkent Şehir Hastanesi-Medical Oncology ( Site 2706), Ankara, Not set
Akdeniz Universitesi Hastanesi ( Site 2701), Antalya, Not set
Istanbul University Capa Campus-department of obstetrics and gynaecology ( Site 2705), Istanbul, Not set
T.C. Saglik Bakanligi Turkiye Kamu Hastaneleri Kurumu - Bakirkoy Dr. Sadi Konuk Egitim ve Arastirma, Istanbul, Not set
St Bartholomew's Hospital ( Site 2804), London, England
The Christie ( Site 2807), Manchester, England
The Beatson West of Scotland Cancer Centre ( Site 2805), Glasgow, Glasgow City
ROYAL MARSDEN HOSPITAL (CHELSEA) ( Site 2806), London, London, City Of
Hammersmith Hospital-Medical Oncology ( Site 2808), London, London, City Of
Conditions: Endometrial Neoplasms
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