The city of Seattle, Washington, currently has 11 active clinical trials seeking participants for Autism research studies.
Iterative Redesign of a Multifaceted Implementation Strategy for a School-based Behavioral Skills Intervention (RUBI)
Recruiting
The increased prevalence of autism spectrum disorder (1 in 36 youth) in the United States along with the exorbitant cost of care of supporting one autistic individual with and without intellectual disability across their lifespan ($2.4 and $1.4 million, respectively) creates a sense of urgency to improve outcomes for autistic youth. Schools are the primary setting in which autistic children receive intervention. Despite a growing array of evidence-based interventions (EBI) such as behavioral man... Read More
Gender:
ALL
Ages:
5 years and above
Trial Updated:
03/25/2025
Locations: University of Washington, Seattle, Washington
Conditions: Autism Spectrum Disorder
ML-004 in Adolescents and Adults with Autism Spectrum Disorders (ASD)
Recruiting
ML-004-002 is a multi-center, randomized, double-blind, parallel-group, placebo-controlled study that will enroll approximately 150 adolescent and adult subjects with ASD. The primary objective is to evaluate the efficacy of ML-004 compared with placebo in the improvement of social communication deficits in subjects with ASD.
Gender:
ALL
Ages:
Between 12 years and 45 years
Trial Updated:
03/19/2025
Locations: Seattle Children's Autism Center, Seattle, Washington
Conditions: Autism Spectrum Disorder
The Autism Biomarkers Consortium for Clinical Trials: Confirmation Study
Recruiting
This is a multicenter longitudinal study that aims to validate a set of measures that were previously identified as promising candidate biomarkers and/or sensitive and reliable objective measures of social function in ASD for potential use in clinical trials. The confirmation study will repeat the data collection and analysis protocols from the original ABC-CT study. This confirmation study will recruit 200 ASD and 200 TD comparison participants who are 6-11 years old, matching the overall sampl... Read More
Gender:
ALL
Ages:
Between 6 years and 11 years
Trial Updated:
02/18/2025
Locations: Unviersity of Washington, Seattle, Washington
Conditions: Autism Spectrum Disorder
A Comparison of Two Brief Suicide Prevention Interventions Tailored for Youth on the Autism Spectrum
Recruiting
Rates of suicide have increased significantly over the past two decades, particularly among youth. Compared to the general population, autistic people are significantly more likely to think about suicide, attempt suicide, and die by suicide. Autistic individuals have identified suicide prevention as a top research priority; however, little is known about how to best help autistic youth at risk for suicide. The purpose of this study is to compare the effectiveness, feasibility, and acceptability... Read More
Gender:
ALL
Ages:
Between 12 years and 99 years
Trial Updated:
01/13/2025
Locations: Seattle Children's Hospital, Seattle, Washington
Conditions: Suicidal Ideation, Suicidal and Self-injurious Behavior, Suicide, Autism Spectrum Disorder
Improving the Part C Early Intervention Service Delivery System for Children with ASD
Recruiting
Despite strong consensus that early, specialized intervention for children with autism spectrum disorder (ASD) can have a dramatic impact on outcomes, the public health system's capacity to provide such services is severely challenged by the rapid rise in ASD prevalence. The goal of this research project is to increase timely and equitable access to ASD-specialized early intervention during the critical first three years of life by capitalizing on the existing infrastructure of the Part C Early... Read More
Gender:
ALL
Ages:
Between 16 months and 33 months
Trial Updated:
11/21/2024
Locations: Carol A Schubert, Seattle, Washington
Conditions: Autism Spectrum Disorder
ABC-CT Pre-School Feasibility Study
Recruiting
This is a multicenter study that aims to determine whether the EEG and ET experiments studied in the ABC-CT Phase 1 and ABC-CT Confirmation studies can be successfully used with 3-5-year-old children and to determine the viability of these measures as potential biomarkers in 3-5-year-old children with ASD. Blood (DNA) samples will be collected from participants with ASD and biological parents for future genomic analyses, and raw, processed, and analyzed data will be shared to create a community... Read More
Gender:
ALL
Ages:
Between 3 years and 5 years
Trial Updated:
10/01/2024
Locations: University of Washington, Seattle, Washington
Conditions: Autism Spectrum Disorder
School-based Paraeducator Education for Engagement At Recess
Recruiting
The purpose of the proposed three-site study is to test whether an educator-level implementation strategy, coaching, with or without a school-level implementation strategy, school-based teams, will maximize paraeducators' use (fidelity and sustainment) of an evidence-based social engagement intervention, Remaking Recess (RR). RR aims to improve peer related social skills for autistic students and their non-autistic peers who are socially isolated or peripheral and need support during recess.
Gender:
ALL
Ages:
5 years and above
Trial Updated:
09/16/2024
Locations: University of Washington, Seattle, Washington
Conditions: Autism Spectrum Disorder, Neurodevelopmental Disorders
Pilot Trial of the RUBI Program for Autistic Adults
Recruiting
The goal of this clinical trial is to evaluate if a redesigned version of the RUBI parenting intervention can reduce challenging behaviors and improve adaptive skills in autistic adults with co-occurring challenging behaviors. The main questions it aims to answer are: * Is the redesigned RUBI intervention feasible and acceptable for autistic adults and their families? * Does the redesigned RUBI intervention reduce challenging behaviors and enhance the quality of life for autistic adults? * Rese... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/09/2024
Locations: Seattle Children's Autism Center, Seattle, Washington
Conditions: Autism Spectrum Disorder, Behavior, Parenting
Effectiveness Trial of Mobile ESI for Toddlers With Autism Identified by Early Screening in Primary Care
Recruiting
The goal of this collaborative R01 is to demonstrate the therapeutic value and community-wide implementability of an early intervention (EI) platform for toddlers with autism spectrum disorder (ASD) that is completely virtual, from recruitment through intervention. This platform-Early Social Interaction Mobile Coaching (ESI-MC) deploys individual telehealth sessions with coaching and feedback to help families embed intervention in everyday activities. Specifically, the investigators will conduct... Read More
Gender:
ALL
Ages:
Between 15 months and 20 months
Trial Updated:
05/15/2024
Locations: Seattle Children's Hospital, Seattle, Washington
Conditions: Autism Spectrum Disorder
Testing a Mobile App to Improve Toothbrushing Skills and Habits in Teens With Autism
Recruiting
The goal of this proposed trial will modify an existing toothbrushing app for teens with autism and compare toothbrushing outcomes with a control app. We have 2 specific aims: * During the 2-year UG3 phase, we will use the Discover, Design+Build, and Test Framework to modify our existing app and pilot the intervention. * During the 4-year UH3 phase, we will recruit 270 pre-adolescents and teens with autism ages 10 to 17 years, randomize participants to one of two arms, and compare outcomes. Pa... Read More
Gender:
ALL
Ages:
Between 10 years and 17 years
Trial Updated:
05/06/2024
Locations: University of Washington, Seattle, Washington
Conditions: Autism
RUBIES in Educational Settings
Recruiting
The proposed three-year pilot randomized trial aims to test the effectiveness of the newly-redesigned paraeducator-delivered RUBI for use in Educational Settings (RUBIES) intervention compared to usual care training in reducing disruptive behavior in 80 elementary-school children with ASD. Given the critical need to understand not just whether, but also how interventions work, this study also will examine paraeducator- and child-level mechanistic pathways of the RUBIES intervention.
Gender:
ALL
Ages:
5 years and above
Trial Updated:
05/05/2023
Locations: Seattle Children's Research Institute, Seattle, Washington
Conditions: Autism Spectrum Disorder, Disruptive Behavior