Tamibarotene Plus Azacitidine in Participants With Newly Diagnosed RARA-positive Higher-Risk Myelodysplastic Syndrome
NCT04797780
Recruiting
This study compares the efficacy of Tamibarotene in combination with azacitidine to azacitidine in combination with placebo in participants who are Retinoic Acid Receptor Alpha (RARA) positive, and newly diagnosed with higher-risk myelodysplastic syndrome (HR-MDS), and who have not received treatment for this diagnosis. The primary goal of the study is to compare the complete remission rate between the two treatment arms.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/08/2024
Locations: University of Arizona, Tucson, Arizona +136 locations
Conditions: Myelodysplastic Syndromes
Register for Updates
Therapeutic Strategies for Microvascular Dysfunction in Type 1 Diabetes
NCT05478707
Recruiting
The investigators will test the hypothesis that, in adults with type 1 diabetes (T1D), glucagon-like peptide-1 receptor agonism (GLP-1RA, i.e. dulaglutide) and exercise training each enhance insulin-mediated skeletal muscle microvascular perfusion via attenuating endothelial oxidative stress and thereby improving endothelial function.
Gender:
ALL
Ages:
Between 18 years and 40 years
Trial Updated:
11/08/2024
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Diabetes Mellitus, Type 1, Endothelial Dysfunction
Register for Updates
Connecting Friends and Health Workers to Boost COVID-19 Vaccination in Latino Communities
NCT06128928
Recruiting
The goal of this clinical trial is to find out which approach works better in getting more of the friends and connections of Latino adults get vaccinated against COVID-19. The main questions this study aims to answer are: 1. Can teaching people to use motivational interviewing help more friends and connections of Latino adults get the COVID-19 vaccine compared to just giving information about the vaccine? 2. What are the things that make it easier or harder for Latinos and networks to get the... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/08/2024
Locations: Johns Hopkins University, Baltimore, Maryland
Conditions: COVID-19, Vaccine
Register for Updates
Ketamine for the Treatment of Depression in Parkinson's Disease
NCT04944017
Recruiting
The main purpose of this study is to examine the efficacy and safety of a repeated dosing ketamine infusion paradigm compared to placebo in individuals with PD. A subset of participants in each arm will undergo baseline and post-treatment PET and fMRI scans, to examine whether changes in synaptic density and reorganization of functional networks underlie ketamine's putative antidepressant effects in PD.
Gender:
ALL
Ages:
Between 40 years and 80 years
Trial Updated:
11/08/2024
Locations: Yale New Haven Hospital, New Haven, Connecticut
Conditions: Parkinson's Disease, Depression
Register for Updates
Hospital Airway Resuscitation Trial
NCT05520762
Recruiting
The Hospital Airway Resuscitation Trial (HART) is a cluster-randomized, pragmatic trial of advanced airway management with a strategy of first choice supraglottic airway vs. first choice endotracheal intubation during in-hospital cardiac arrest.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/08/2024
Locations: Montefiore Medical Center, New York, New York
Conditions: Cardiac Arrest, Respiratory Failure
Register for Updates
Changes in Microbial Status From Dentate, Edentulous and After Dental Implant Placement
NCT06149585
Recruiting
The objectives of this study are to analyze the oral microbiome modulations occurring during the transition from partial (with some residual teeth) to full edentulous (without remaining teeth) status and implant placement in subjects affected by severe periodontitis; to evaluate if microbiome changes in relation to the used of different implant material/surface; and to assess the variance of the changes to determine the sample size for future longitudinal prospective studies.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
11/08/2024
Locations: Case Western Reserve University Department of Periodontics, Cleveland, Ohio
Conditions: Edentulous Mouth, Periodontal Diseases, Periodontitis, Adult, Microbial Colonization
Register for Updates
The Effects of Dietary Supplementation on Serum Protein Glycosylation
NCT05040204
Recruiting
Two randomized double-blind placebo-controlled clinical studies to assess the effects of dietary glycan monomer supplementation on the immune system, especially antibody glycosylation in healthy adults. Immune profiling and glycoproteomics will be performed on serum isolated at these same time points.
Gender:
ALL
Ages:
Between 18 years and 45 years
Trial Updated:
11/08/2024
Locations: University of California, Davis Medical Center, Sacramento, California
Conditions: Healthy
Register for Updates
A Platform Study of Novel Immunotherapy Combinations in Participants With Previously Untreated, Advanced/Metastatic Non-Small-Cell Lung Cancer
NCT05565378
Recruiting
This study will evaluate the efficacy, safety, pharmacokinetics (PK), and pharmacodynamics (PDy) of novel immunotherapy combinations compared with immunotherapy monotherapy in participants with Programmed death ligand-1 (PD L-1) high (Tumor cells \[TC\]/ Tumor proportion score \[TPS\] \>= 50%), previously untreated, unresectable, locally advanced or metastatic non-small cell lung cancer (NSCLC). Drug name mentioned as Belrestotug, GSK4428859A, and EOS884448 are all interchangeable for the same c... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/08/2024
Locations: GSK Investigational Site, Plantation, Florida +111 locations
Conditions: Lung Cancer, Non-Small Cell
Register for Updates
Randomized Controlled Comparison of Pre-op TLIP Vs Intra-op TLIP
NCT06154980
Recruiting
Single-center, randomized study will enroll 50 subjects who are scheduled for 1-3 level posterior laminectomy \& fusion. Study participants who are eligible for the posterior lumbar laminectomy and fusion procedure will be scheduled and also consented as a part of the study. Participants will be stratified based on age and gender to ensure equal distribution.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/08/2024
Locations: William Beaumont Hospital, Royal Oak, Michigan
Conditions: Pain, Spine Fusion
Register for Updates
Effectiveness of Empowerment Group Sessions for Treating Suicidal African American Women in Abusive Relationships
NCT00601939
Recruiting
This study will evaluate the effectiveness of culturally competent psychoeducational empowerment sessions in treating suicidal African-American women who are in abusive relationships.
Gender:
FEMALE
Ages:
Between 18 years and 64 years
Trial Updated:
11/08/2024
Locations: Grady Hospital, Atlanta, Georgia
Conditions: Battered Women, Suicide, Attempted
Register for Updates
JAK Inhibition in Food Allergy
NCT05069831
Recruiting
This study will assess the role for an oral targeted medication, abrocitinib, as a new treatment option for food allergy patients that would avoid injections. Abrocitinib, which has successfully completed phase three trials for atopic dermatitis, could serve as a single therapy for two conditions in many patients with multiple atopic conditions.
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
11/08/2024
Locations: Icahn School of Medicine at Mount Sinai, New York, New York
Conditions: Food Allergy
Register for Updates
An Extension Study to Assess Long-Term Safety of Eplontersen in Adults With Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR-CM)
NCT05667493
Recruiting
The purpose of this study is to evaluate the safety and tolerability of extended dosing with eplontersen in participants with ATTR-CM.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/08/2024
Locations: Mayo Clinic, Scottsdale, Arizona +97 locations
Conditions: Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR CM)
Register for Updates