Radiation Therapy for Dupuytren's Contracture Following Non-Surgical Release
NCT06330545
Recruiting
The goal of this study is to learn about preventing recurrence of Dupuytren's Contracture. The main question it aims to answer are: • Does targeted radiation therapy decrease recurrence of Dupuytren's contracture after treatment with Collagenase Clostridium Histolyticum? Participants will undergo: * Release of Dupuytren's Contracture after Collagenase Clostridium Histolyticum injection * Daily radiation therapy treatment for 5 days followed by 6-8 week rest period and then another course of 5... Read More
Gender:
ALL
Ages:
45 years and above
Trial Updated:
11/20/2024
Locations: Dartmouth Hitchcock, Lebanon, New Hampshire
Conditions: Dupuytren Contracture
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Implementation of IVS3 for Upper Limb Motor Recovery
NCT06483230
Recruiting
This study measures participant satisfaction and upper extremity function in outpatients with chronic stroke when exposed to the IVS3 device. Investigators hypothesize that treatment with the IVS3 device will be feasible and tolerable for use in the outpatient setting.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/20/2024
Locations: Weill Cornell Medicine, 525 E. 68th St, Baker Pavilion, F-2106, New York, New York
Conditions: Neglect, Hemispatial, Stroke, Cardiovascular, Mirror Movement, Motor Activity
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Acute Intermittent Hypoxia to Improve Airway Protection in Chronic Traumatic Brain Injury
NCT06520358
Recruiting
Acute intermittent hypoxia (AIH) involves 1-2min of breathing low oxygen air to stimulate neuroplasticity. Animal and human studies show that AIH improves motor function after neural injury, particularly when paired with task-specific training. Using a double blind cross-over study we will test whether AIH and task-specific airway protection training improves airway protection more than training alone in individuals with chronic mild-moderate traumatic brain injury (TBI).
Gender:
ALL
Ages:
Between 21 years and 80 years
Trial Updated:
11/20/2024
Locations: University of Florida, Jacksonville, Florida
Conditions: Traumatic Brain Injury
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Psychoeducational Intervention for Patients With Hepatocellular Carcinoma
NCT06541990
Recruiting
This study aims to refine and pilot test HARMONY, a psychoeducational intervention for patients with newly diagnosed hepatocellular carcinoma (HCC).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/20/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Hepatocellular Carcinoma, Cirrhosis
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Dyadic Sleep Study
NCT06569693
Recruiting
The purpose of this study is to learn about sleep behaviors and test different ways to help patients with cancer and caregiver partners.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/20/2024
Locations: University of Miami, Coral Gables, Florida
Conditions: Gastrointestinal Cancer
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Skin Pigment/Pulse Oximeter in Congenital Heart Disease (CHD)
NCT06575270
Recruiting
Recent retrospective studies have demonstrated differences between pulse oximeter values (SpO2) and measured arterial oxygen saturation (SaO2) in patients identifying as Black or Hispanic. These retrospective studies have limitations because self-reported race is likely not an accurate metric for level of skin pigmentation and the retrospective nature of these studies may impact the accuracy of simultaneous measures of arterial oxygen saturation and pulse oximeter values. The few prospective stu... Read More
Gender:
ALL
Ages:
18 years and below
Trial Updated:
11/20/2024
Locations: Mount Sinai Hospital, New York, New York
Conditions: Hypoxemia, Skin Pigment, Congenital Heart Disease
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Olanzapine 2.5 vs 5 mg in Quadruplet Nausea/Vomiting Prophylaxis Before High-Dose Melphalan
NCT06588413
Recruiting
Patients who receive a chemotherapy called melphalan are at high risk of having nausea and vomiting. A medication called olanzapine has been shown to decrease nausea and vomiting after chemotherapy. A previous research study found the 10 mg dose of olanzapine (combined with 3 standard medications used routinely to prevent nausea/vomiting) to be effective for patients who received melphalan chemotherapy, but several other studies have shown many patients have a side effect of sleepiness (e.g., se... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/20/2024
Locations: Wellstar MCG, Augusta, Georgia
Conditions: Multiple Myeloma, Autologous Stem Cell Transplantation
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GERD in Children With Cystic Fibrosis
NCT06617013
Recruiting
The purpose of this study is to use a survey to measure reflux symptoms in patients with Cystic Fibrosis who are on reflux treatment, and to monitor their symptoms after stopping the reflux treatment.
Gender:
ALL
Ages:
Between 6 years and 17 years
Trial Updated:
11/20/2024
Locations: Duke University Hospital, Durham, North Carolina
Conditions: GERD in Children, Cystic Fibrosis in Children
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Sun Protection and Tanning Awareness in Rural Schools
NCT06694571
Recruiting
Drawing from prior school-based skin cancer prevention programs, we have adapted intervention materials to target rural high schoolers. Program components (including in-class education) will be co-implemented by the research team and participating school staff, with a focus on sustainability beyond the immediate study period. Interviews and surveys following initial implementation will evaluate both the effectiveness of the program.
Gender:
ALL
Ages:
Between 11 years and 21 years
Trial Updated:
11/20/2024
Locations: Huntsman Cancer Institute, Salt Lake City, Utah
Conditions: Melanoma, Adolescents
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The Clonal Hematopoiesis & Inflammation in Vasculature Registry and Biorepository
NCT06701214
Recruiting
This study will investigate the association between clonal hematopoiesis and other conditions. Clonal hematopoiesis (CH) refers to the mutations in a person's stem cells which commonly affect people as they get older. These mutations have notably been linked to increased risk of certain cancers as well as increased risk of heart disease.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/20/2024
Locations: Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee
Conditions: Clonal Hematopoiesis
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Mucopolysaccharidosis I (MPS I) Registry
NCT00144794
Recruiting
The Mucopolysaccharidosis I (MPS I) Registry is an ongoing, observational database that tracks the outcomes of patients with MPS I. The data collected by the MPS I Registry will provide information to better characterize the natural history and progression of MPS I as well as the clinical responses of patients receiving enzyme replacement therapy, such as Aldurazyme (Recombinant Human Alpha-L-Iduronidase), or other treatment modalities. The objectives of the Registry are: * To evaluate the lon... Read More
Gender:
ALL
Ages:
All
Trial Updated:
11/19/2024
Locations: Phoenix Children's Hospital- Site Number : 840003, Phoenix, Arizona +179 locations
Conditions: Mucopolysaccharidosis I (MPS I)
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Pompe Pregnancy Sub-Registry
NCT00567073
Recruiting
This Sub-registry is a multicenter, international, longitudinal, observational, and voluntary program designed to track pregnancy outcomes for any pregnant woman enrolled in the Pompe Registry, regardless of whether she is receiving disease-specific therapy (such as ERT with alglucosidase alfa or avalglucosidase alfa) and irrespective of the commercial product with which she may be treated. No experimental intervention is given; thus a patient will undergo clinical assessments and receive standa... Read More
Gender:
FEMALE
Ages:
All
Trial Updated:
11/19/2024
Locations: Barrow Neurol Group- Site Number : 840087, Phoenix, Arizona +25 locations
Conditions: Glycogen Storage Disease Type II (GSD-II), Pompe Disease (Late-onset), Glycogenesis 2 Acid Maltase Deficiency
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