Carboxylesterase 1 Genetic Variation and Methylphenidate in ADHD
NCT03781752
Recruiting
The study team will determine the association between d,l-methylphenidate (MPH) therapeutic outcomes in ADHD patients and genetic variants of CES1 and reveal key associations between CES1 genotypes and the PK and PD of MPH.
Gender:
ALL
Ages:
Between 6 years and 17 years
Trial Updated:
08/06/2024
Locations: University of Florida, Gainesville, Florida +3 locations
Conditions: ADHD, Attention Deficit Hyperactivity Disorder
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BFR Therapy for Post-Op Rehab of ACL Reconstruction With Quadriceps Tendon Autograft
NCT04519801
Recruiting
The overall objective of the proposed research is to conduct a prospective, randomized controlled trial to investigate whether the addition of BFR therapy to standard post-operative rehabilitation regimen significantly improves clinical outcomes following anterior cruciate ligament reconstruction (ACLR) standardized with respect to both surgical technique and graft selection. Patients indicated for ACLR will be screened and offered enrollment into this prospective, randomized controlled trial. M... Read More
Gender:
ALL
Ages:
Between 15 years and 45 years
Trial Updated:
08/06/2024
Locations: Brooke Army Medical Center- Clinical Research Center, San Antonio, Texas
Conditions: ACL Injury
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The Effects of Terrain Variation on Intrinsic Foot Musculature in Healthy Individuals and Individuals With Plantar Fasciitis
NCT05075005
Recruiting
Modern footwear has been implicated as a contributor to foot pathology and changes in the biomechanics of gait. In addition to footwear, the investigators propose that the lack of terrain variation may directly contribute to the development of common foot pathologies, resulting from decreased intrinsic foot muscle function. This study will examine the current understanding of terrain variation on foot musculature strength and its possible correlation with structural and functional changes within... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
08/06/2024
Locations: UF Health Orthopaedics and Sports Medicine Institute, Gainesville, Florida
Conditions: Plantar Fasciitis
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ABTECT - Maintenance
NCT05535946
Recruiting
This is a multicenter, randomized, placebo-controlled study to evaluate the long-term efficacy and safety of ABX464 50mg and 25mg administered once daily (QD) as maintenance therapy in subjects with moderately to severely active ulcerative colitis who have inadequate response, no response, a loss of response, or an intolerance to either conventional therapies \[corticosteroids, immunosuppressant (i.e. azathioprine, 6-mercaptopurine, methotrexate)\] and/or advanced therapies \[biologics (TNF inhi... Read More
Gender:
ALL
Ages:
16 years and above
Trial Updated:
08/06/2024
Locations: University of Alabama -Birmingham, Birmingham, Alabama +553 locations
Conditions: Ulcerative Colitis
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Clinical Trial of the ATM-Inhibitor WSD0628 in Combination With Radiation Therapy for Recurrent Brain Tumors
NCT05917145
Recruiting
The purpose of this study is to test WSD0628 in combination with radiation therapy for recurrent brain tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/06/2024
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Glioblastoma
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Developing a Learning COmmunity to Increase eNgagemeNt and Enrollment in Cardiovascular Clinical Trials (CONNECT)
NCT06347484
Recruiting
The CONNECT: "Developing a learning COmmunity to increase eNgagemeNt and Enrollment in cardiovascular Clinical Trials" is comprehensive, participant-centered learning platform designed to increase diversity in cardiovascular disease research among women and Black and Latino adults. CONNECT will deploy electronic health record (EHR)-informed and community-engaged recruitment approaches to identify and recruit adults with cardiovascular disease or a cardiovascular disease risk factor to join CONNE... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/06/2024
Locations: Johns Hopkins University School of Nursing, Baltimore, Maryland
Conditions: Cardiovascular Diseases, Hypertension, Diabetes Type 2, Stroke, Recruitment, Overweight and Obesity, Hyperlipidemias
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Stimulant vs. Non-stimulant Treatments and Reward Processing in Drug-naive Youth at SUD Risk
NCT03781765
Recruiting
The study team will examine the effects of FDA approved stimulant and non-stimulant medications for ADHD, among youth with ADHD and with and without Oppositional Defiant Disorder (ODD) or Conduct Disorder (CD), on reward systems of the brain using fMRI.
Gender:
ALL
Ages:
Between 7 years and 12 years
Trial Updated:
08/06/2024
Locations: Icahn School of Medicine at Mount Sinai, New York, New York
Conditions: ADHD, Attention Deficit Hyperactivity Disorder
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A Developmental Framework For Linking Phonological And Morpho-syntactic Sequential Pattern Rules In DLD: Production
NCT04558541
Recruiting
The broad aim of this clinical study is to assess the hypothesis that morphological and phonological deficits are linked by a broader deficit in sequential pattern learning. This hypothesis applies to learning in general, but is especially critical as an avenue for developing earlier assessments and more powerful interventions for children with developmental language disorder (DLD; also known as specific language impairment). Other populations, such as at-risk toddlers, may also benefit from thi... Read More
Gender:
ALL
Ages:
Between 4 years and 8 years
Trial Updated:
08/06/2024
Locations: University of Arizona, Tucson, Arizona +1 locations
Conditions: Developmental Language Disorder, Speech Sound Disorder, Specific Language Impairment
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Improving Visual Field Deficits With Noninvasive Brain Stimulation
NCT05085210
Recruiting
This is a randomized, pilot interventional study in participants with visual field deficit (VFD) caused by cortical lesion. Damage to the primary visual cortex (V1) causes a contra-lesional, homonymous loss of conscious vision termed hemianopsia, the loss of one half of the visual field. The goal of this project is to elaborate and refine a rehabilitation protocol for VFD participants. It is hypothesized that visual restoration training using moving stimuli coupled with noninvasive current stimu... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
08/06/2024
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Visual Field Defect, Peripheral, Stroke, Visual Impairment, Hemianopsia, Quadrantanopia, Cortical Blindness, Visual Field Defect Homonymous Bilateral, Occipital Lobe Infarct, Visual Fields Hemianopsia
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Hydrogen's Feasibility and Safety as a Therapy in ECPR
NCT05574296
Recruiting
The purpose of this project is to test the feasibility and safety of inhaled hydrogen gas (H2) administration as a rescue therapy during cardiac arrest requiring extracorporeal cardiopulmonary resuscitation (ECPR, i.e. mechanical circulatory support). Under exemption from informed consent, patients undergoing refractory cardiac arrest in the cardiac ICU at a participating center will be randomized to standard therapy with or without the administration of 2% hydrogen in gases administered via the... Read More
Gender:
ALL
Ages:
All
Trial Updated:
08/06/2024
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Cardiac Arrest, Extracorporeal Membrane Oxygenation, Reperfusion Injury
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Goal Setting to Promote Physical Activity Adherence in Midlife Adults
NCT05980052
Recruiting
Engaging in regular physical activity during midlife is a key lifestyle behavior associated with reduced risk for Alzheimer's disease and related dementias (AD/ADRD). Yet nearly half of midlife adults (48%) do not meet national physical activity guidelines. The purpose of this mechanistic trial is to identify effective goal setting techniques to enhance psychosocial processes of self-regulation for the successful promotion of PA and adherence to national PA guidelines among midlife adults, with... Read More
Gender:
ALL
Ages:
Between 45 years and 65 years
Trial Updated:
08/06/2024
Locations: Arizona State University, Phoenix, Arizona
Conditions: Physical Activity, Exercise
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An Imaging-based Quantitative Biomarker Assay for NAFLD in Children
NCT06354491
Recruiting
This study will validate recently developed Magnetic Resonance Imaging (MRI) and Ultrasound (US) based methods for liver fat quantification in children with obesity and healthy range of body mass index (BMI).
Gender:
ALL
Ages:
Between 10 years and 14 years
Trial Updated:
08/06/2024
Locations: University of Wisconsin, Madison, Madison, Wisconsin
Conditions: NAFLD, NASH
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