Genome Environment Microbiome and Metabolome in Autism Study
Recruiting
GEMMA is a multicenter longitudinal observational study that follows children who are genetically at-risk of developing autism for their first three years of life, seeking to identify potential biomarkers predictive of autism development in the blood, stool, urine and saliva. The biomarkers identified in this project will contribute to a better understanding of the pathogenesis of ASD in at-risk children and possible solutions for alleviating and/or preventing ASD and ASD-related symptoms in pat... Read More
Gender:
ALL
Ages:
6 months and below
Trial Updated:
11/19/2024
Locations: Massachusetts General Hospital for Children, Boston, Massachusetts +2 locations
Conditions: Autism Spectrum Disorder
Brain-Computer Interfaces in Laryngeal Dystonia
Recruiting
The researchers will develop and evaluate the use of adaptive closed-loop brain-computer interface therapeutic intervention in laryngeal dystonia.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
11/19/2024
Locations: Massachusetts Eye and Ear Infirmary, Boston, Massachusetts
Conditions: Laryngeal Dystonia
Effects of Nicotinamide Riboside on Bioenergetics and Oxidative Stress in Mild Cognitive Impairment/Alzheimer's Dementia
Recruiting
The primary aim of this study is to investigate the effects of exogenously administered nicotinamide riboside (NR) on brain energy metabolism, oxidative stress, and cognitive function in individuals with mild cognitive impairment (MCI) and mild Alzheimer's dementia (AD).
Gender:
ALL
Ages:
Between 55 years and 89 years
Trial Updated:
11/19/2024
Locations: McLean Hospital, Belmont, Massachusetts
Conditions: Mild Cognitive Impairment, Mild Alzheimer Disease
Functional Outcomes of Cannabis Use (FOCUS) in Veterans With Posttraumatic Stress Disorder
Recruiting
Posttraumatic stress disorder (PTSD) is a disabling psychiatric disorder that affects 20%-30% of U.S. Veterans. PTSD is strongly associated with increased risk for substance abuse comorbidity, including cannabis use disorder. Multiple states now include PTSD as a condition for which patients can be legally prescribed medical marijuana, despite the fact that there has not been a single large-scale randomized clinical trial demonstrating the efficacy of cannabis to treat PTSD to date. The overall... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/19/2024
Locations: Durham VA Medical Center, Durham, NC, Durham, North Carolina
Conditions: PTSD, Cannabis-Related Disorder
PurIST Classification-Guided Adaptive Neoadjuvant Chemotherapy by RNA Expression Profiling of EUS Aspiration Samples
Recruiting
This is an open-label, phase II study in patients with resectable and borderline resectable pancreatic cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/19/2024
Locations: HonorHealth Medical Group, Scottsdale, Arizona +1 locations
Conditions: Pancreatic Cancer
An mHealth Strategy to Improve Medication Adherence in Adolescents With Sickle Cell Disease
Recruiting
The primary objective of this study is to evaluate a potential behavioral intervention (MED-Go app). To meet this objective, the researchers will conduct a pilot randomized controlled trial to test the feasibility and acceptability of MED-Go app in adolescents and young adults (AYA) with sickle cell disease (SCD). The long-term goal of this research is to promote medication adherence behavior and improve health outcomes in AYA with SCD.
Gender:
ALL
Ages:
Between 12 years and 21 years
Trial Updated:
11/19/2024
Locations: Ann & Robert H Lurie Children's Hospital of Chicago, Chicago, Illinois
Conditions: Sickle Cell Disease, Sickle Beta Zero Thalassemia, Sickle B+ Thalassemia, Sickle Cell Hemoglobin C
TATE and Pembrolizumab (MK3475) in mCRC and NSCLC
Recruiting
Patients with refractory metastatic colorectal cancer or non-small cell lung cancer with liver metastasis treated with Trans-arterial Tirapazamine Embolization along with Pembrolizumab.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/19/2024
Locations: University of California, Irvine Medical Center, Orange, California +2 locations
Conditions: Colorectal Cancer; Lung Cancer
A Study of ZN-c3 in Women With Recurrent or Persistent Uterine Serous Carcinoma
Recruiting
This is a Phase 2 study to evaluate the clinical activity and safety of ZN-c3 (azenosertib) in adult women with recurrent or persistent uterine serous carcinoma (USC).
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
11/19/2024
Locations: Alaska Women's Cancer Care, Anchorage, Alaska +51 locations
Conditions: Uterine Serous Carcinoma
Promoting Independence With Compensatory Cognitive Rehabilitation
Recruiting
Alzheimer's disease (AD) is one of the leading causes of disability in older adults. Because pharmacological approaches do not seem to prevent or slow the disease, clinicians need non-pharmacological interventions that might help people with AD remain independent for as long as possible. This study aims to evaluate the effects of a new behavioral treatment, the Structured External Memory Aid Treatment (SEMAT), for adults with mild cognitive impairment (MCI) designed to promote independent living... Read More
Gender:
ALL
Ages:
Between 60 years and 90 years
Trial Updated:
11/19/2024
Locations: University of Delaware, Newark, Delaware
Conditions: Mild Cognitive Impairment, Alzheimer Disease
Transcranial Direct Current Stimulation and Rehabilitation to Ameliorate Impairments in Neurocognition After Stroke
Recruiting
The purpose of this study is to determine whether a non-invasive brain stimulation technique, transcranial direct current stimulation (tDCS), combined with traditional cognitive therapy will improve cognitive function in patients with subacute stroke.
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
11/19/2024
Locations: Penn Medicine Rehabilitation, Philadelphia, Pennsylvania
Conditions: Ischemic Stroke, Cognitive Impairment
Real World Evidence with the Debritom+ TM Novel Micro Water Jet Technology At a Single Wound Center
Recruiting
Prospective, single-blinded, single-center, parallel group, randomized controlled trial (RCT) to assess rate and frequency of wound healing and associated financial savings, when using Medaxis debritom+ versus standard of care as a choice of debridement method, where both arms follow normal wound care practice in use of advanced wound care treatments.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/19/2024
Locations: MCR Health, Inc., Bradenton, Florida
Conditions: Diabetic Foot Ulcer, Venous Leg Ulcer, Surgical Wound Dehiscence, Traumatic Wounds
Taletrectinib Phase 2 Global Study in ROS1 Positive NSCLC
Recruiting
The main purpose of the study is to evaluate safety and efficacy of taletrectinib (also known as AB-106 or DS-6051b) monotherapy in the treatment of advanced NSCLC.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/19/2024
Locations: Beverly Hills Cancer Center, Beverly Hills, California +72 locations
Conditions: Non Small Cell Lung Cancer