Fecal Microbial Transplants for the Treatment of Pancreatic Cancer
Recruiting
This early phase I trial examines the safety and effects of fecal microbial transplants in treating patients with pancreatic cancer. scheduled for surgery to remove tumors. Fecal microbial transplant contains the normal microbes found in fecal (stool) material. Giving fecal microbial transplant may help control the disease.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/19/2024
Locations: M D Anderson Cancer Center, Houston, Texas
Conditions: Pancreatic Ductal Adenocarcinoma
A Study to Measure the Effect of Brain Stimulation on Hand Strength and Function in Patients with Brain Tumors
Recruiting
The neurosurgical standard of care for treating a patient with a tumor invading hand primary motor cortex (M1) includes performing a craniotomy with intraoperative direct electrical stimulation (DES) mapping and to resect as much tumor as possible without a resultant permanent neurological deficit. However, the subjective nature of current intraoperative hand motor assessments do not offer a comprehensive understanding of how hand strength and function may be impacted by resection. Additionally,... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
11/19/2024
Locations: Medical College of Wisconsin, Milwaukee, Wisconsin
Conditions: Brain Tumor, Brain Cancer, Motor Cortex; Lesion
Study to Evaluate the Efficacy, Immunogenicity, and Safety of RSVpreF in Adults.
Recruiting
Efficacy Study: This randomized, double-blinded, placebo-controlled Phase 3 study is designed to assess the safety, immunogenicity, and efficacy of a single dose of RSVpreF in the prevention of LRTI-RSV in adults: * At a dose of 120µg. * In adults 60 years of age and older. * The duration of the study for each participant will be up to approximately 24 months. * The study will be conducted in the United States, Canada, Netherlands, Finland, Argentina, Japan and South Africa. Substudy A: This s... Read More
Gender:
ALL
Ages:
60 years and above
Trial Updated:
11/19/2024
Locations: St. Vincent's Birmingham (Pharmacy), Birmingham, Alabama +327 locations
Conditions: Lower Respiratory Tract Illness
Postoperative Opt-In Narcotics Treatment in Breast
Recruiting
In a recent study, researchers let patients choose what medications to go home with after endocrine surgery. This has not been done in outpatient breast surgery, though several institutions have moved towards avoiding opioids altogether after breast surgery. These institutions only prescribed rescue opioids upon request. The aim of this study is to compare a similar "opt-in" protocol for narcotics to usual care (where patients are routinely discharged with opioids) for outpatient breast surgery... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/19/2024
Locations: UCLA Ronald Reagan Medical Center, Los Angeles, California +1 locations
Conditions: Breast Cancer, Breast Surgery, Opioid Use
Characterization of Clinical Phenotypes of Laryngeal Dystonia and Voice Tremor
Recruiting
The researchers will systematically evaluate current and novel clinical voice assessment tools and measures to elucidate distinct clinical phenotypes of those with laryngeal dystonia and voice tremor.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
11/19/2024
Locations: Massachusetts Eye and Ear and University of Utah, Boston, Massachusetts
Conditions: Laryngeal Dystonia, Spasmodic Dysphonia, Tremor
Deep Brain Stimulation in Laryngeal Dystonia and Voice Tremor
Recruiting
The goals of this project are 1) to determine the incidence of neurological voice disorders in patients with dystonia and essential tremor undergoing deep brain stimulation (DBS), 2) investigate the neuroimaging and intracranial neurophysiology correlates of voice dysfunction in these subjects, and subsequently 3) determine the effects of DBS on voice function.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
11/19/2024
Locations: Massachusetts General Hospital, University of California San Francisco, University of Utah, Boston, Massachusetts
Conditions: Laryngeal Dystonia, Spasmodic Dysphonia, Tremor, Dystonia
DBS Recordings to Characterize Movement Facilitation in Parkinson's Disease
Recruiting
Several strategies or contexts help patients with Parkinson's disease to move more quickly or normally, however the brain mechanisms underlying these phenomena are poorly understood. The proposed studies use intraoperative recordings during DBS surgery for Parkinson's disease to understand the brain mechanisms supporting improved movements elicited by external cues. The central hypothesis is that distinct networks are involved in movement improvement depending on characteristics of the facilitat... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/19/2024
Locations: University of California Los Angeles, Los Angeles, California
Conditions: Parkinson Disease
Repeat BCG Vaccinations for the Treatment of Pediatric Type 1 Diabetes
Recruiting
The purpose of this study is to investigate if repeat bacillus Calmette-Guérin (BCG) vaccinations can confer a beneficial immune and metabolic effect on pediatric Type 1 diabetes.
Gender:
ALL
Ages:
Between 12 years and 17 years
Trial Updated:
11/19/2024
Locations: Immunobiology Labs CNY 149, Charlestown, Massachusetts
Conditions: Diabetes Mellitus, Type 1, Diabetes type1, Autoimmune Diabetes
Daily Adaptive Radiation Therapy an Individualized Approach for Carcinoma of the Cervix
Recruiting
This is a single-arm, prospective, multi-center clinical trial designed to demonstrate that adaptive radiotherapy for locally advanced cervical cancer will translate into a decreased rate of acute gastrointestinal toxicity compared with the historically reported rate for non-adaptive intensity modulated radiation therapy (IMRT). The timepoint for this assessment will be at week 5 of external beam radiotherapy (EBRT) and will use the Patient-Reported Outcomes version of the Common Terminology Cri... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
11/19/2024
Locations: University of Alabama Birmingham, Birmingham, Alabama +4 locations
Conditions: Cervical Cancer by FIGO Stage 2018
Understanding Disorder-specific Neural Pathophysiology in Laryngeal Dystonia and Voice Tremor
Recruiting
The researchers will examine functional neural correlates that differentiate between laryngeal dystonia and voice tremor and contribute to disorder-specific pathophysiology using a cross-disciplinary approach of multimodal brain imaging.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
11/19/2024
Locations: Massachusetts Eye and Ear and University of California San Francisco, Boston, Massachusetts
Conditions: Laryngeal Dystonia, Spasmodic Dysphonia, Tremor
Clinical Validation of DystoniaNet Deep Learning Platform for Diagnosis of Isolated Dystonia
Recruiting
This research involves retrospective and prospective studies for clinical validation of a DystoniaNet deep learning platform for the diagnosis of isolated dystonia.
Gender:
ALL
Ages:
All
Trial Updated:
11/19/2024
Locations: Massachusetts Eye and Ear Infirmary, Boston, Massachusetts
Conditions: Dystonia, Drug Induced Dystonia, Parkinson Disease, Essential Tremor, Dyskinesias, Myoclonus, Tic Disorders, Torticollis, Ulnar Nerve Entrapment, Temporomandibular Joint Disorders, Dysphonia
Abatacept in Immune Checkpoint Inhibitor Myocarditis
Recruiting
The primary aim is to test whether abatacept, as compared to placebo, is associated with a reduction in major adverse cardiac events (MACE) among participants hospitalized with myocarditis secondary to an immune checkpoint inhibitor (ICI). The primary outcome, MACE, is a composite of first occurrence of cardiovascular death, non-fatal sudden cardiac arrest, cardiogenic shock, significant ventricular arrythmias, significant bradyarrythmias, or incident heart failure.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/19/2024
Locations: Cedars-Sinai Medical Center, Los Angeles, California +30 locations
Conditions: Myocarditis Acute, Cancer