Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Cross-Linking
NCT03918408
Recruiting
To determine whether the Peschke PXL-330 system is safe and effective in the treatment of corneal thinning conditions.
Gender:
ALL
Ages:
Between 12 years and 45 years
Trial Updated:
11/09/2024
Locations: Pacific Clear Vision Institute, Eugene, Oregon
Conditions: Keratoconus, Unstable, Bacterial Keratitis, Ectasia of Cornea
Register for Updates
Effectiveness of Empowerment Group Sessions for Treating Suicidal African American Women in Abusive Relationships
NCT00601939
Recruiting
This study will evaluate the effectiveness of culturally competent psychoeducational empowerment sessions in treating suicidal African-American women who are in abusive relationships.
Gender:
FEMALE
Ages:
Between 18 years and 64 years
Trial Updated:
11/08/2024
Locations: Grady Hospital, Atlanta, Georgia
Conditions: Battered Women, Suicide, Attempted
Register for Updates
Tesamorelin to Improve Functional Outcomes After Peripheral Nerve Injury
NCT03150511
Recruiting
The aim of this clinical trial is to evaluate the efficacy of tesamorelin as a therapy for peripheral nerve injuries. The investigators hypothesize that treatment with tesamorelin will result in faster and more substantial recovery of motor and sensory function following surgical repair of injured peripheral nerves. Patients with upper extremity nerve injuries will be randomly assigned to receive either tesamorelin treatment or no treatment. Assessments for nerve regeneration, muscle function, a... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/08/2024
Locations: Sami Tuffaha, Baltimore, Maryland
Conditions: Peripheral Nerve Injuries
Register for Updates
Escitalopram and Language Intervention for Subacute Aphasia
NCT03843463
Recruiting
In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke).
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
11/08/2024
Locations: Johns Hopkins School of Medicine, Baltimore, Maryland +2 locations
Conditions: Aphasia, Stroke
Register for Updates
The Impact of Dietary Pattern on Erectile Function
NCT04349059
Recruiting
The goal of this study is to determine whether erectile function is impacted by dietary patterns in healthy men with normal erectile function.
Gender:
MALE
Ages:
Between 18 years and 35 years
Trial Updated:
11/08/2024
Locations: Montefiore Medical Center, Department of Medicine, Division of Cardiology, Bronx, New York
Conditions: Erectile Dysfunction
Register for Updates
NOX4 and Related Biomarkers in ADPKD
NCT04630613
Recruiting
To determine the value of NOX4, markers of mitochondria injury and function, and oxidative stress as real-time biomarkers to assess disease severity in patients with early autosomal dominant polycystic kidney disease (ADPKD).
Gender:
ALL
Ages:
Between 15 years and 40 years
Trial Updated:
11/08/2024
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Autosomal Dominant Polycystic Kidney Disease
Register for Updates
Isatuximab, Lenalidomide, Bortezomib, and Dexamethasone in NDMM
NCT04653246
Recruiting
This research is testing whether the investigational drug isatuximab is safe and effective when used in combination with standard agents for the treatment of newly diagnosed multiple myeloma.
Gender:
ALL
Ages:
75 years and above
Trial Updated:
11/08/2024
Locations: Dana Farber Cancer Institute, Boston, Massachusetts
Conditions: Multiple Myeloma, Newly Diagnosed Multiple Myeloma (NDMM), Autologous Stem Cell Transplant
Register for Updates
Assessment of the Efficacy of Medrol Dose Pack for Acute Post-Concussive Headaches
NCT04685772
Recruiting
This novel pilot project will assess the effectiveness of corticosteroids in treatment of acute post-concussion headache. The investigators hypothesize that the use of corticosteroids will cause significant headache reduction in frequency and/or intensity than individuals who undergo the current standard of care. Additionally, the investigators hypothesize that corticosteroid use will lead to a reduction in other somatic symptoms including vestibular symptoms, leading to quicker return to school... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/08/2024
Locations: Northwell Health - North Shore University Hospital, Manhasset, New York
Conditions: Post-Concussion Syndrome, Headache
Register for Updates
Tamibarotene Plus Azacitidine in Participants With Newly Diagnosed RARA-positive Higher-Risk Myelodysplastic Syndrome
NCT04797780
Recruiting
This study compares the efficacy of Tamibarotene in combination with azacitidine to azacitidine in combination with placebo in participants who are Retinoic Acid Receptor Alpha (RARA) positive, and newly diagnosed with higher-risk myelodysplastic syndrome (HR-MDS), and who have not received treatment for this diagnosis. The primary goal of the study is to compare the complete remission rate between the two treatment arms.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/08/2024
Locations: University of Arizona, Tucson, Arizona +136 locations
Conditions: Myelodysplastic Syndromes
Register for Updates
Ketamine for the Treatment of Depression in Parkinson's Disease
NCT04944017
Recruiting
The main purpose of this study is to examine the efficacy and safety of a repeated dosing ketamine infusion paradigm compared to placebo in individuals with PD. A subset of participants in each arm will undergo baseline and post-treatment PET and fMRI scans, to examine whether changes in synaptic density and reorganization of functional networks underlie ketamine's putative antidepressant effects in PD.
Gender:
ALL
Ages:
Between 40 years and 80 years
Trial Updated:
11/08/2024
Locations: Yale New Haven Hospital, New Haven, Connecticut
Conditions: Parkinson's Disease, Depression
Register for Updates
The Effects of Dietary Supplementation on Serum Protein Glycosylation
NCT05040204
Recruiting
Two randomized double-blind placebo-controlled clinical studies to assess the effects of dietary glycan monomer supplementation on the immune system, especially antibody glycosylation in healthy adults. Immune profiling and glycoproteomics will be performed on serum isolated at these same time points.
Gender:
ALL
Ages:
Between 18 years and 45 years
Trial Updated:
11/08/2024
Locations: University of California, Davis Medical Center, Sacramento, California
Conditions: Healthy
Register for Updates
Post Mortem Tissue Donation of Pediatric Tumor Tissues and Cells
NCT05120518
Recruiting
The objective of this study is to utilize all donated pediatric tumor tissues and cells obtained from autopsy to prospectively develop novel patient derived orthotopic xenograft (PDOX) mouse models as well as in vitro cell culture model systems for pediatric cancers, and also provide tissue samples to other researchers and organizations (eg, CBTN, DIPG Registry, COG).
Gender:
ALL
Ages:
All
Trial Updated:
11/08/2024
Locations: Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois
Conditions: Pediatric Cancer
Register for Updates