Vaginal Estradiol vs Oral Beta-3 Agonist for Overactive Bladder Syndrome
NCT05221021
Recruiting
A single site, double-blinded, randomized controlled trial for postmenopausal women with urinary frequency, urgency, nocturia with or without urgency urinary incontinence symptoms. Patient's will be randomized between 0.01% vaginal estradiol cream with placebo oral pill or daily 50 milligrams oral Mirabegron with a placebo vaginal cream for 12 weeks.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
08/15/2024
Locations: Walter Reed National Military Medical Center, Bethesda, Maryland
Conditions: Overactive Bladder Syndrome
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Aveir VR Real-World Evidence Post-Approval Study
NCT05270499
Recruiting
The purpose of this post-approval study is to evaluate the long-term safety of the single-chamber Aveir VR leadless pacemaker using real-world evidence methods.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/15/2024
Locations: Abbott, Sylmar, California
Conditions: Cardiac Pacemaker, Arrythmia, Bradycardia
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South Asians and Coronary Plaque Registry
NCT05367297
Recruiting
Individuals who self-report as SAs will be recruited to participate in this registry as well as non-SA controls for comparison. All individuals who consent to participate will 1) complete a survey assessing demographics, medical history, family medical history; 2) have blood collection; 3) and CCTA assessment. These data will be combined with clinical data from the electronic health record and, if applicable, the Dallas Hearts and Mind Study and other research studies, for research purposes. The... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/15/2024
Locations: University of Texas Southwestern Medical Center, Dallas, Texas
Conditions: Coronary Artery Disease, Heart Diseases
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Androgen Receptor Signaling and Prostate-Specific Membrane Antigen Expression
NCT05683964
Recruiting
The goal of this research study is to determine whether hormonal therapies used early in the course of prostate cancer could increase the amount of Prostate-Specific Membrane Antigen (PSMA) as detected by PET/CT scans for participants with recurrent prostate cancer. This study will measure PSMA levels using standard PET/CT scans and participants will receive standard-of-care androgen receptor antagonist monotherapy. The names of the treatment interventions involved in this study are: * Androge... Read More
Gender:
MALE
Ages:
40 years and above
Trial Updated:
08/15/2024
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Prostate Adenocarcinoma, Prostate Cancer, Metastatic Hormone-Sensitive Prostate Cancer (mHSPC)
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Adapting a Sepsis Transition and Recovery Program for Optimal Scale Up
NCT05997420
Recruiting
The Adapting a Sepsis Transition and Recovery Program for Optimal Scale Up (ASTROS) study is an effectiveness-implementation hybrid design. The effectiveness evaluation is designed as a multiple interrupted time series (mITS) analysis to test the impact of implementing an adapted Sepsis Transition and Recovery (STAR) program on enhancing post sepsis outcomes in new hospital settings.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/15/2024
Locations: Atrium Health, Charlotte, North Carolina
Conditions: Sepsis
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Cardiovascular Health & Early Stress
NCT06557707
Recruiting
Childhood adversity is highly prevalent, with 59% of the U.S. population reporting at least one adverse childhood experience (ACE). Substantial evidence links childhood adversity to cardiometabolic disease later in the life course, including heart disease, diabetes, and stroke, which are 3 of the top 10 causes of mortality in the United States. ACEs encompass many possible traumatic and distressing experiences, including abuse, neglect, or severe household dysfunctions. It is not surprising tha... Read More
Gender:
ALL
Ages:
Between 9 years and 30 years
Trial Updated:
08/15/2024
Locations: Virginia Commonwealth University, Richmond, Virginia
Conditions: Stress
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VicorderCS NIBP Validation Study to Review The Ability to Capture Blood Pressure Measurements
NCT06560034
Recruiting
80 Beats Medical introduces the VicorderCS, the next generation of our Vicorder technology designed to manage hypertension and cardiovascular risks. This advanced diagnostic equipment offers non-invasive collection and computation of a plethora of cardiovascular markers. It is faster, easier to use, and more portable than its predecessor, with enhanced connectivity options for extended marker collection and analysis. These markers enable early diagnosis of cardiovascular disease, ensuring positi... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/15/2024
Locations: Manos Health Study Site, Breckenridge, Colorado
Conditions: Cardiovascular Diseases, Blood Pressure, Hypertension
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A Phase 1 Safety and Tolerability Study of TML-6 in Healthy and Elderly Volunteers for Alzheimer's Disease Treatment
NCT06562114
Recruiting
The purpose of this study is to evaluate the safety, tolerability, single-ascending dose (SAD), multiple-ascending dose (MAD), food effect, and pharmacokinetic (PK) Study of TML-6.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
08/15/2024
Locations: Parexel International, Glendale, California
Conditions: Healthy
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Low Frequency Ultrasound for Osteoarthritis Healing and Rehabilitation
NCT06562374
Recruiting
The purpose of this study is to determine the safety and effectiveness (how well it works) of a new experimental ultrasound bath device that uses low frequency ultrasound (LFU) that may or may not help healing.
Gender:
ALL
Ages:
40 years and above
Trial Updated:
08/15/2024
Locations: University of Texas Medical Branch, Galveston, Galveston, Texas
Conditions: Osteo Arthritis Knee, Age Related Osteoporosis, Pain, Knee Joint Contracture
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Study of Selected X-Linked Disorders: Aicardi Syndrome
NCT00697411
Recruiting
Based on our current understanding of Aicardi syndrome, the condition is hypothesized to occur due to a genetic change on the X-chromosome. The research team is investigating Aicardi syndrome to identify the specific gene location associated with the disorder. The investigators are collecting blood and skin biopsy samples from patients and their parents. A permanent cell line is prepared and DNA from the blood and skin samples and cell lines is isolated and then used for genetic testing. The cur... Read More
Gender:
ALL
Ages:
All
Trial Updated:
08/14/2024
Locations: Baylor College of Medicine, Houston, Texas
Conditions: Aicardi Syndrome, Brain Disorders
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Arizona Cancer Center Biospecimen Repository
NCT00896935
Recruiting
RATIONALE: Collecting and storing samples of tissue and blood from patients with cancer to test in the laboratory may help the study of cancer in the future. PURPOSE: This research study is collecting and storing tumor, tissue, and blood samples from patients with pancreatic cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/14/2024
Locations: Arizona Cancer Center at University of Arizona Health Sciences Center, Tucson, Arizona
Conditions: Cancer
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Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer
NCT03678025
Recruiting
This phase III trial studies how well standard systemic therapy with or without definitive treatment (prostate removal surgery or radiation therapy) works in treating participants with prostate cancer that has spread to other places in the body. Addition of prostate removal surgery or radiation therapy to standard systemic therapy for prostate cancer may lower the chance of the cancer growing or spreading.
Gender:
MALE
Ages:
18 years and above
Trial Updated:
08/14/2024
Locations: Banner MD Anderson Cancer Center, Gilbert, Arizona +337 locations
Conditions: Castration Levels of Testosterone, Metastatic Prostatic Adenocarcinoma, Stage IV Prostate Cancer AJCC v8, Stage IVA Prostate Cancer AJCC v8, Stage IVB Prostate Cancer AJCC v8
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