Developing a Positive Approach to Substance Use Prevention in North American Indian Adolescents
NCT05380765
Recruiting
The overall objective of this project is to develop and obtain preliminary data on acceptability, feasibility, and initial efficacy of Native PATHS. This work is guided by the stage model guidelines for treatment development and adaptation 25. Stage 1a will occur in two sequential steps. First, the investigators will recruit youth who are in 5th - 8th grade and their family members (N=24, 12 youth, 12 adults 18+) to participate in three talking circle sessions to obtain feedback on the cultural... Read More
Gender:
ALL
Ages:
Between 10 years and 14 years
Trial Updated:
06/04/2024
Locations: University of Rhode Island, Kingston, Rhode Island
Conditions: Alcohol Drinking, Tobacco Use, Drug Use
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Effects of Semaglutide on Intracranial Blood Flow and Brain-Barrier Permeability in Type-2 Diabetes
NCT05780905
Recruiting
A human subjects research study, the primary purpose of which is to assess the EFFECTS OF SEMAGLUTIDE ON INTRACRANIAL BLOOD FLOW AND BLOOD-BRAIN BARRIER PERMEABILITY IN TYPE-2 DIABETES (T2D) through testing of the intervention on patients in a clinical setting. The study will randomize subjects with diabetes to either semaglutide or matching placebo. Magnetic resonance images will be primary endpoint measured at baseline and at one year to assess effect of this FDA approved medication. Given th... Read More
Gender:
ALL
Ages:
Between 40 years and 65 years
Trial Updated:
06/04/2024
Locations: University of Washington - Harborview Medical Center, Seattle, Washington
Conditions: Diabetes Mellitus, Type 2, Stroke (CVA) or Transient Ischemic Attack
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Motor and Neurophysiological Changes After Ischemic Conditioning in Individuals With Stroke
NCT05906602
Recruiting
The goal of this clinical trial is to test ischemic conditioning (blood flow restriction) as a neuromodulatory technique to improve gait function in stroke. Neuromodulation is emerging as a promising adjunct strategy to facilitate changes in brain activity and improve motor behavior following a neurological injury such as stroke. The main questions this trial aims to answer are: * Can ischemic conditioning produce neuromodulatory changes in the lower limb primary motor cortex? * Can ischemic c... Read More
Gender:
ALL
Ages:
21 years and above
Trial Updated:
06/04/2024
Locations: University of Illinois Chicago, Chicago, Illinois
Conditions: Stroke
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A Pilot RCT to Improve Cognitive Processing Speed in Acute SCI
NCT06238492
Recruiting
This study seeks conduct a pilot study to test whether a cognitive training program can improve processing speed abilities in individuals with acute traumatic spinal cord injury.
Gender:
ALL
Ages:
Between 18 years and 59 years
Trial Updated:
06/04/2024
Locations: Craig Hospital, Englewood, Colorado +2 locations
Conditions: Spinal Cord Injuries, Cognitive Dysfunction, Cognitive Impairment, Acute Spinal Cord Injury
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Tai Chi as a Novel Strategy to Increase Physical Activity Among Adults Pursuing Metabolic and Bariatric Surgery
NCT06445413
Recruiting
The goal of this clinical trial is to evaluate the feasibility and acceptability of a 10-wk hybrid Tai Chi (TC) program with in-person classes and online TC videos among 24 physically inactive adults who are seeking metabolic and bariatric surgery (MBS) in a single-arm trial. The aims are: Aim 1: Feasibility: To evaluate whether TC is feasible, defined as a mean attendance rate of ≥70% in-person TC classes attended. Aim 2: Acceptability: To evaluate whether TC is acceptable, defined as a mean... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
06/04/2024
Locations: Hartford Hospital, Hartford, Connecticut
Conditions: Obesity
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Evaluation of a Decision Aid for Deep Brain Stimulation Surgery for Parkinson's Disease
NCT06446505
Recruiting
The goal of this clinical trial is to learn if a Decision Aid can help patients with Parkinson's disease make a decision about undergoing Deep Brain Stimulation surgery. The main questions it aims to answer are: * Is the Decision Aid acceptable to patients with Parkinson's disease considering Deep Brain Stimulation surgery? * Does the decision aid improve decision quality (informed, value-based decision) and uncertainty about the decision? Researchers will compare immediate use of the decision... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/04/2024
Locations: University of Colorado Anschutz, Aurora, Colorado
Conditions: Parkinson Disease
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Robot-assisted Training in Children With CP
NCT06450158
Recruiting
Cerebral palsy (CP) is the most common physical disability in early childhood causing serious motor and sensory impairments. Effective interventions for the recovery of motor functions are of profound significance to children with CP, their families, caregivers, and health professionals. Robot-assisted rehabilitation represents a frontier with potential to improve motor functions and induce brain reorganization in children with CP.
Gender:
ALL
Ages:
Between 7 years and 18 years
Trial Updated:
06/04/2024
Locations: Cook Children's Medical Center, Fort Worth, Texas
Conditions: Cerebral Palsy
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Mitral Valve Screening Survey
NCT04736667
Recruiting
This study aims to examine the clinical profile/anatomical characteristics and natural history of patients who subsequently fail screening for transcatheter mitral valve intervention (TMVI).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/03/2024
Locations: Phoenix Cardiovascular Research Group, Phoenix, Arizona +15 locations
Conditions: Mitral Valve Disease
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Eliminating Monitor Overuse Trial (EMO Trial)
NCT05132322
Recruiting
The purpose of this study is to identify the optimal deimplementation strategies for an overused practice: continuous pulse oximetry monitoring of children hospitalized with bronchiolitis who are not receiving supplemental oxygen.
Gender:
ALL
Ages:
2 months and above
Trial Updated:
06/03/2024
Locations: Children's of Alabama, Birmingham, Alabama +57 locations
Conditions: Bronchiolitis Acute Viral
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Evaluating the Feasibility of VR for Pediatric Renal Biopsies
NCT05267704
Recruiting
The purpose of this study is to assess the use of virtual reality (VR) as an adjunct or alternative to pharmacologic sedation in pediatric patients undergoing renal biopsy.
Gender:
ALL
Ages:
Between 5 years and 17 years
Trial Updated:
06/03/2024
Locations: UCSF Benioff Children's Hospital, San Francisco, California
Conditions: Pain, Procedural, Procedural Anxiety, Sedation Complication
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Rescue Pharmacotherapy for OSA
NCT05293600
Recruiting
Persistent obstructive sleep apnea (OSA) is common in people treated with mandibular advancement device (MAD) or hypoglossal nerve stimulation (HGNS). For most patients, these treatments are the last line of defense. If MAD or HGNS do not work, then patients are left to suffer the consequences of undertreated OSA. In this study, the investigators want to test the addition of a drug treatment to their regimen. Endotypes will be targeted pharmacologically with one of the following drugs: acetazola... Read More
Gender:
ALL
Ages:
Between 21 years and 70 years
Trial Updated:
06/03/2024
Locations: Sleep Disorders Research Program Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Obstructive Sleep Apnea
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Liver Cancer Disparities in American Indian and Alaska Native Persons
NCT05304234
Recruiting
We are performing a pilot and feasibility randomized controlled trial (RCT) of HCC screening by US + AFP every 6 months (n=100), the current standard-of-care, versus aMRI + AFP every 6 months (n=100) for 12 months (i.e. at time 0, 6 and 12 months) among AI/AN patients with cirrhosis or HBV.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
06/03/2024
Locations: Cherokee Nation Health Service, Tahlequah, Oklahoma
Conditions: Hepatocellular Carcinoma, Cirrhosis, Liver, Hepatitis B
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