Long-term Safety and Efficacy of ESK-001 in Moderate to Severe Plaque Psoriasis
NCT06846541
Recruiting
The objective of the ESK-001-018 long term extension is to evaluate the safety and efficacy of ESK-001 over time. The scientific questions it aims to answer are: * How safe is taking ESK-001 long-term in people with moderate to severe plaque psoriasis? * Does taking ESK-001 long-term reduce the severity of people's plaque psoriasis? Patients will enter the long-term extension study following completion of one of the parent studies (ESK-001-016 or ESK-001-017) and will receive open-label ESK-00... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/23/2025
Locations: Total Dermatology, Birmingham, Alabama +59 locations
Conditions: Plaque Psoriasis, Psoriasis (PsO), Psoriasis, Moderate Psoriasis, Severe Psoriasis
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Affect-based Impulsivity in Borderline Personality Disorder
NCT06880640
Recruiting
The purpose of this research study is to investigate how personality traits and neuroendocrine systems relate to decision-making patterns in individuals 18-45 years old. The main question it aims to answer is how neuroendocrine activity impacts decision-making. Participants will complete online behavioral tasks, a stress induction procedure, self-report surveys, and a cognitive assessment. During the session, psychophysiological measures will be collected, including electrocardiogram (ECG) and... Read More
Gender:
ALL
Ages:
Between 18 years and 45 years
Trial Updated:
04/23/2025
Locations: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Conditions: Borderline Personality Disorder (BPD), Healthy Controls Group - Age and Sex-matched
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Long-term Follow-up of a Cochlear Implant With Dexamethasone Eluting Electrode Array
NCT06936449
Recruiting
A long-term follow-up of Cochlear's cochlear implant electrode array which passively elutes dexamethasone for a defined period of time to help reduce inflammatory responses.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/23/2025
Locations: Rocky Mountain Ear Center, Englewood, Colorado
Conditions: Sensorineural Hearing Loss, Bilateral Hearing Loss
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Efficacy and Safety of Topical Clascoterone (WINLEVI) Cream 1% in Patients With Facial Acneiform Rosacea: A Phase 2 Clinical Trial
NCT06952517
Recruiting
To demonstrate the efficacy of Clascoterone cream 1% in reducing the size of sebaceous glands in study participants with acneiform rosacea.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/23/2025
Locations: New York Harbor VA Brooklyn Campus, Brooklyn, New York
Conditions: Papular-pustular Rosacea, Papulopustular Rosacea (PPR), Papulopustular Rosacea
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Study of Chediak-Higashi Syndrome
NCT00005917
Recruiting
Chediak-Higashi syndrome (CHS) is a rare autosomal recessive disorder characterized in its classical form by oculocutaneous albinism, a bleeding diathesis, recurrent infection due to abnormal neutrophil and natural killer cell function, and eventual progression to a lymphohistiocytic infiltration known as the accelerated phase . Death often occurs within the first decade as a result of infection or the development of the accelerated phase; bone marrow transplantation is curative except for the l... Read More
Gender:
ALL
Ages:
Between 1 month and 70 years
Trial Updated:
04/23/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Chediak-Higashi Syndrome
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Neoadjuvant Weekly Paclitaxel and Biomarkers of Therapy Response
NCT03096418
Recruiting
The hypothesis of this study is that paclitaxel levels increase chromosomal instability (CIN) in tumors and this is lethal to tumors that have pre-existing CIN. Treatment will be administered on an outpatient basis. Paclitaxel will be initiated as standard infusions on days 1, 8, and 15 of a 21-day cycle. Participants will continue with paclitaxel for cycles 2-4 prior to surgery.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
04/23/2025
Locations: University of Wisconsin Carbone Cancer Center, Madison, Wisconsin
Conditions: Breast Neoplasm Female
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Creation of a Biospecimen Repository From Patients With Interstitial Lung Diseases (ILD)
NCT03478826
Recruiting
To develop a repository of blood samples from patients with ILD to support future studies into the development of such biomarkers. Patients with pneumonia and healthy patients will also be recruited as a control group.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/23/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Interstitial Lung Disease
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CPX-351 in Treating Patients With Relapsed or Refractory High Risk Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia
NCT03896269
Recruiting
This phase I trial studies best dose and side effects of liposome-encapsulated daunorubicin-cytarabine (CPX-351) and how well it works in treating patients with high risk myelodysplastic syndrome or chronic myelomonocytic leukemia that has come back or has not responded to treatment. Drugs used in chemotherapy, such as liposome-encapsulated daunorubicin-cytarabine, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stoppi... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/23/2025
Locations: M D Anderson Cancer Center, Houston, Texas
Conditions: Blasts 10-19 Percent of Bone Marrow Nucleated Cells, Blasts More Than 5 Percent of Bone Marrow Nucleated Cells, High Risk Chronic Myelomonocytic Leukemia, Recurrent Chronic Myelomonocytic Leukemia, Recurrent High Risk Myelodysplastic Syndrome, Refractory Chronic Myelomonocytic Leukemia, Refractory High Risk Myelodysplastic Syndrome
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CYTO Reductive Surgery in Kidney Cancer Plus Immunotherapy and Targeted Kinase Inhibition
NCT04322955
Recruiting
The purpose of this study is to determine if the use of immunotherapy nivolumab and the targeted therapy cabozantinib prior to removal of the kidney, will increase the number subjects who are without any visible kidney cancer in their body at some point during the course of treatment.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/23/2025
Locations: The Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey +3 locations
Conditions: Kidney Cancer, Renal Cell Carcinoma
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FNS (FEMORAL NECK SYSTEM) Study
NCT04577261
Recruiting
A post-market, prospective study to evaluate the reoperation rate of displaced and nondisplaced femoral neck fractures treated with the Femoral Neck System (FNS)™
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/23/2025
Locations: Wake Forest Health Sciences, Winston-Salem, North Carolina
Conditions: Femoral Neck Fractures
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Neural Correlates of Real World Spatial Navigation in Humans
NCT04874220
Recruiting
The purpose of this study is to understand the neural mechanisms that support real world spatial navigation in humans using deep brain recordings and stimulation during virtual reality (VR), augmented reality, and real world memory tasks. We will determine the cognitive (i.e., memory) and behavioral (i.e., body, head, eye position and movement) factors that modulate deep brain activity and the consequent effects of memory-enhancing deep brain stimulation.
Gender:
ALL
Ages:
Between 12 years and 70 years
Trial Updated:
04/23/2025
Locations: University of California Los Angeles, Los Angeles, California
Conditions: Memory, Delayed
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Patient-Centered Outcomes in the Surgical Treatment of Uterovaginal Prolapse
NCT05063331
Recruiting
The purpose of this study is to compare two types of surgery for the treatment of uterovaginal prolapse to determine which surgery works best from a patient's perspective and has the lowest number of short-term and long-term complications.
Gender:
FEMALE
Ages:
Between 18 years and 80 years
Trial Updated:
04/23/2025
Locations: Mayo Clinic, Jacksonville, Florida +6 locations
Conditions: Uterine Prolapse
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