PHESGO Maintenance After T-DXd Short Induction for HER2+ Unresectable Locally Recurrent or Metastatic Breast Cancer
NCT06172127
Recruiting
DEMETHER is a phase II trial exploring the maintenance of trastuzumab and pertuzumab fixed dose combination (FDC) for subcutaneous administration (SC, PHESGO) following trastuzumab deruxtecan (T-DXd) as induction treatment for HER2-positive unresectable locally recurrent or metastatic breast cancer (MBC) patients.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/20/2025
Locations: Northwell Health, New York, New York +22 locations
Conditions: HER2-positive Breast Cancer
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One Week Clinical Study in Subjects With Menopausal Symptoms
NCT06794021
Recruiting
The goal of this clinical trial is to Examine the Benefits of an Oral Product in Subjects With Menopausal Symptoms. The main questions it aims to answer are: 1. To assess the efficacy for improvement of menopausal vasomotor symptoms within 24 hours compared to placebo through Daily Diary and Mobile Application 2. To assess the efficacy for improvement of menopausal vasomotor symptoms hours compared to placebo through days 2-6 Daily Diary and Mobile Application 3. To assess the efficacy of the i... Read More
Gender:
FEMALE
Ages:
Between 40 years and 65 years
Trial Updated:
01/20/2025
Locations: San Francisco Research Institute, San Francisco, California
Conditions: Healthy, Menopause
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Personalized Feedback Intervention for Alcohol and Opioid Use Among Adults with Chronic Pain
NCT04592978
Recruiting
Over one-quarter of American adults engage in hazardous drinking (i.e., a pattern of alcohol consumption that increases risk for harmful consequences), which is the third leading cause of preventable death in the U.S. Rates of hazardous drinking are significantly higher among individuals with (vs. without) chronic pain. Moreover, 20% of individuals prescribed opioids endorse concurrent alcohol and opioid use, which may interfere with chronic pain treatment and lead to dangerous/potentially fatal... Read More
Gender:
ALL
Ages:
21 years and above
Trial Updated:
01/20/2025
Locations: Syracuse University, Syracuse, New York
Conditions: Alcohol Drinking, Pain, Opioid Use, Feedback, Psychological
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Switch Maintenance in Pancreatic
NCT05419479
Recruiting
This study is being done to test the safety and effectiveness of combining domvanalimab (AB154), zimberelimab (AB122), and APX005M with pancreatic cancer that has spread to other parts of body. This research study involves immunotherapy. Immunotherapy triggers the body's immune system to fight cancer cells. The names of the study drugs involved in this study are: * Domvanalimab (also known as AB154) * Zimberelimab (also known as AB122) * APX005M
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/20/2025
Locations: Dana Farber Cancer Institute, Boston, Massachusetts
Conditions: Pancreatic Cancer, Adenocarcinoma of the Pancreas, Squamous Cell Carcinoma of Pancreas, Adenosquamous Carcinoma of the Pancreas
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The STOP-MED CTRCD Trial
NCT06183437
Recruiting
Cancer therapy-related cardiac dysfunction (CTRCD) is when the heart's ability to pump oxygenated blood to the body is compromised. It is a side effect of cancer therapy which can occur as commonly as in 1 in 5 patients. When this occurs, heart failure medications are started to protect the heart from progressing to heart failure. With early detection and treatment, heart function recovers to normal in \>80% of patients. Unfortunately, heart failure medications are associated with an undesirable... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/20/2025
Locations: Brigham and Women's Hospital, Boston, Massachusetts +9 locations
Conditions: Heart Failure, Cardiotoxicity, Cardiac Toxicity, Antineoplastics Toxicity, Cancer
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Tocilizumab and Atezolizumab in Adults With Locally Advanced or Metastatic Non-Small Cell Lung Cancer Refractory to 1st Line Immune Checkpoint Inhibitor-Based Therapy
NCT04691817
Recruiting
This is a research study to evaluate the safety and effectiveness of tocilizumab in combination with atezolizumab to treat non-small cell lung cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/20/2025
Locations: Abramson Cancer Center of the University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Lung Cancer, Nonsmall Cell
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Coconut Oil to Prevent Mouth Sores in Pediatric Patients Receiving High Dose Chemotherapy
NCT05441813
Recruiting
The purpose of this study is to learn if virgin coconut oil (VCO) mouth rinse can help prevent oral mucositis. The Study Investigator will compare standard of care mucositis prevention rinses with the VCO mouth rinse added to the standard of care mucositis prevention rinses. The severity of oral mucositis between the 2 groups will be evaluated. Some of the standard of care rinses that can be used to prevent mucositis are normal saline, Benadryl (diphenhydramine), Mylanta, lidocaine, or other com... Read More
Gender:
ALL
Ages:
Between 7 years and 26 years
Trial Updated:
01/20/2025
Locations: Atrium Health Levine Children's Hospital, Charlotte, North Carolina
Conditions: Oral Mucositis
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WATD and Cancer-Related Fatigue: A Study For Patients Undergoing Anti-Cancer Treatment
NCT06291324
Recruiting
The purpose of this study is to evaluate the feasibility of using a commercial WATD (Wearable Activity Tracker Device) to collect HRV (Heart Rate Variability) data from pancreatic and breast cancer patients.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/20/2025
Locations: Levine Cancer Institute, Charlotte, North Carolina
Conditions: Pancreatic Cancer, Breast Cancer
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The Pericapsular Nerve Block in Total Hip Arthroplasty
NCT04729686
Recruiting
In order to continue progressing towards outpatient total hip arthroplasty (THA), methods to adequately manage postoperative pain is of paramount importance. The purpose of this study is to quantify the effectiveness of the pericapsular nerve block in total hip arthroplasty in comparison to the fascia iliaca nerve block.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
01/20/2025
Locations: Sinai Hospital of Baltimore, Baltimore, Maryland
Conditions: Hip Osteoarthritis, Hip Arthropathy
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Intravesical BCG vs GEMDOCE in NMIBC
NCT05538663
Recruiting
The study hypothesis is that BCG naïve non-muscle invasive bladder cancer (NMIBC) patients treated with intravesical Gemcitabine + Docetaxel (GEMDOCE) will result in a non-inferior event-free survival (EFS) compared to standard treatment with intravesical BCG. The purpose of this study is to test whether Gemcitabine + Docetaxel is a better or worse treatment than the usual BCG therapy approach. The primary objective of this study is to determine the event free survival (EFS) of BCG-naïve high gr... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/20/2025
Locations: University of Alabama at Birmingham Cancer Center, Birmingham, Alabama +228 locations
Conditions: Non-muscle-invasive Bladder Cancer
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3D Printed Personalized Ostomy Appliance
NCT06310070
Recruiting
The goal of this clinical trial is to learn about the effectiveness of using a 3D scan for a personal ostomy appliance. The main question it aims to answer is: • Whether or not a 3D scan of a stoma reduces leakages and improves patient quality of life in regard to using a personalized ostomy appliance. Participants will * Spend 2 weeks with their standard of care ostomy appliance * Spend 2 weeks with their personalized ostomy appliance made from a 3D scan * Participate in daily surveys and we... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
01/20/2025
Locations: Carilion Clinic, Roanoke, Virginia
Conditions: 3D Printing, Ostomy, Leakage
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Testicular Tissue Cryopreservation in Children
NCT02872532
Recruiting
This protocol is being designed to offer testicular tissue cryopreservation to male pediatric patients (0-17 years of age) with fertility threatening medical diagnoses or facing surgery, chemotherapy or radiation therapy that may cause loss of reproductive potential.
Gender:
MALE
Ages:
Between 0 years and 17 years
Trial Updated:
01/19/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Cancer, Cancer-Related Condition, Infertility
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