There are currently 1011 clinical trials in Birmingham, Alabama looking for participants to engage in research studies. Trials are conducted at various facilities, including University of Alabama at Birmingham, University of Alabama, University of Alabama at Birmingham Cancer Center and University of Alabama Birmingham. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
A Trial of Pessary and Progesterone for Preterm Prevention in Twin Gestation With a Short Cervix
NCT02518594
Recruiting
This protocol outlines a randomized trial of 630 women evaluating the use of micronized vaginal progesterone or pessary versus control (placebo) to prevent early preterm birth in women carrying twins and with a cervical length of less than 30 millimeters.
Gender:
Female
Ages:
All
Trial Updated:
03/06/2024
Locations: University of Alabama - Birmingham, Birmingham, Alabama
Conditions: Short Cervical Length
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Acceptance and Commitment Therapy for Depressed Individuals Living With Spinal Cord Injury Sustained Within 5 Years
NCT05725161
Recruiting
This randomized controlled trial aims to assess effects of videoconferencing acceptance and commitment therapy (ACT) on mental health outcomes in individuals living with spinal cord injuries (SCI). A total of 40 individuals living with SCI sustained within 5 years and experiencing depressive symptoms will be recruited and randomly assigned to either the ACT group or the wait-list control group. The ACT group will receive 8 weekly individual ACT sessions guided by a coach through videoconferencin... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/05/2024
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Depression, Spinal Cord Injuries
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Safety and Effectiveness of the Globe® Pulsed Field System for Treating Patients With Symptomatic Paroxysmal or Persistent Atrial Fibrillation
NCT05462145
Recruiting
This study will evaluate the safety and effectiveness of the Globe® Pulsed Field System for treating patients with symptomatic paroxysmal or persistent atrial fibrillation (AF).
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
03/05/2024
Locations: University of Alabama Heersink School of Medicine, Birmingham, Alabama +1 locations
Conditions: Paroxysmal Atrial Fibrillation, Persistent Atrial Fibrillation
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CARBON: UAB Cardiovascular Research Biobank
NCT05067231
Recruiting
The UAB Cardiovascular Research Biobank (CARBON) will be a resource that contains biological materials, such as DNA samples, in addition to health and personal information on a large number of people over time. It will be set up so that it can be used in the future as a resource for researchers undertaking a wide range of medical research.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/05/2024
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Natriuretic Peptides, Cardiovascular Diseases, Hypertension, Diabetes, Obesity
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Transcranial Direct Current Stimulation for Post-stroke Motor Recovery
NCT03826030
Recruiting
This research study is to find out if brain stimulation at different dosage level combined with an efficacy-proven rehabilitation therapy can improve arm function. The stimulation technique is called transcranial direct current stimulation (tDCS). The treatment uses direct currents to stimulate specific parts of the brain affected by stroke. The adjunctive rehabilitation therapy is called "modified Constraint-Induced Movement Therapy" (mCIMT). During this therapy the subject will wear a mitt on... Read More
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
03/05/2024
Locations: University of Alabama, Birmingham, Alabama
Conditions: Stroke, Ischemic, Motor Activity, Upper Extremity Paralysis
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Longitudinal Study of the Porphyrias
NCT01561157
Recruiting
The objective of this protocol is to conduct a longitudinal multidisciplinary investigation of the human porphyrias including the natural history, morbidity, pregnancy outcomes, and mortality in people with these disorders.
Gender:
All
Ages:
1 minute and above
Trial Updated:
03/05/2024
Locations: University of Alabama, Birmingham, Birmingham, Alabama
Conditions: Acute Porphyrias, Cutaneous Porphyrias
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Effect of Weight Loss on Urinary Oxalate Excretion in Obese Calcium Oxalate Kidney Stone Formers
NCT04633811
Recruiting
This protocol seeks to determine if weight reduction with the Optifast VLCD program leads to reduced contribution of endogenous oxalate synthesis to the urinary oxalate pool in obese calcium oxalate stone formers.
Gender:
All
Ages:
Between 19 years and 65 years
Trial Updated:
03/05/2024
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Kidney Stone
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DCSZ11 as a Monotherapy and in Combination in Patients With Advanced or Metastatic Solid Tumors
NCT05785754
Recruiting
This is a multicenter, open-label, Phase 1 study to assess the effects of DCSZ11, an anti-CD93 monoclonal antibody, as a monotherapy and in combination in patients with advanced or metastatic solid tumors.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/04/2024
Locations: University of Alabama, Birmingham, Alabama
Conditions: Advanced or Metastatic Solid Tumors
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Understanding the Long-term Impact of COVID on Children and Families
NCT05172011
Recruiting
This is a combined retrospective and prospective, longitudinal, observational meta-cohort of individuals age 0-25 years who will enter the cohort with and without SARS-CoV-2 infection at varying stages before and after infection. Individuals with and without SARS-CoV-2 infection and with or without PASC symptoms will be followed to identify risk factors and occurrence of PASC. This study will be conducted in the United States and participants will be recruited through inpatient, outpatient, and... Read More
Gender:
All
Ages:
25 years and below
Trial Updated:
03/04/2024
Locations: University of Alabama at Birmingham (Pregnancy Cohort), Birmingham, Alabama
Conditions: SARS-CoV-2 Infection
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A Study to Evaluate the Safety of mRNA-0184 in Participants With Heart Failure
NCT05659264
Recruiting
The primary objective of this study is to evaluate the safety and tolerability of single and multiple doses at escalating dose levels of mRNA-0184.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/29/2024
Locations: Cardiology PC, Birmingham, Alabama +1 locations
Conditions: Chronic Heart Failure
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Usage of Spirometry in Managing IgG Therapy in CVID With Airway Disease
NCT05193552
Recruiting
Although there is evidence in the literature that gammaglobulin replacement therapy can lead to a reduction in the prevalence of pulmonary infection and improved lung function, there is no published study to guide immunologists regarding the use of spirometry in titrating IG therapy to assist in the management of immunodeficiency patients with regards to gammaglobulin replacement therapy. The investigators propose to study the use of spirometry to identify patients that could potentially benefi... Read More
Gender:
All
Ages:
21 years and above
Trial Updated:
02/29/2024
Locations: Community Health 20, Birmingham, Alabama
Conditions: Common Variable Immunodeficiency
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Trauma Resuscitation With Low-Titer Group O Whole Blood or Products
NCT05638581
Recruiting
The goal of this clinical trial is to compare the effectiveness of unseparated whole blood (referred to as Low-Titer Group O Whole Blood) and the separate components of whole blood (including red cells, plasma, platelets, and cryoprecipitate) in critically injured patients who require large-volume blood transfusions.
Gender:
All
Ages:
15 years and above
Trial Updated:
02/29/2024
Locations: University of Alabama at Birmingham, UAB Hospital, Birmingham, Alabama
Conditions: Wounds and Injuries, Shock, Hemorrhagic
Register for Updates