There are currently 1011 clinical trials in Birmingham, Alabama looking for participants to engage in research studies. Trials are conducted at various facilities, including University of Alabama at Birmingham, University of Alabama, University of Alabama at Birmingham Cancer Center and University of Alabama Birmingham. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Colonoscopy vs Stool Testing for Older Adults With Colon Polyps
NCT05612347
Recruiting
This is a multi-site comparative effectiveness randomized controlled trial (RCT) comparing annual fecal immunochemical testing (FIT) and colonoscopy for post-polypectomy surveillance among adults aged 65-82 with a history of colorectal polyps who are due for surveillance colonoscopy.
Gender:
All
Ages:
Between 65 years and 82 years
Trial Updated:
02/26/2024
Locations: University of Alabama Birmingham, Birmingham, Alabama
Conditions: Colorectal Polyp, Colorectal Neoplasms, Colorectal Adenoma, Colorectal Cancer, Digestive System Disease
Register for Updates
Enroll -HD: A Prospective Registry Study in a Global Huntington's Disease Cohort
NCT01574053
Recruiting
Enroll-HD is a longitudinal, observational, multinational study that integrates two former Huntington's disease (HD) registries-REGISTRY in Europe, and COHORT in North America and Australasia-while also expanding to include sites in Latin America. More than 30,000 participants have now enrolled into the study. With annual assessments and no end date, Enroll-HD has built a large and rich database of longitudinal clinical data and biospecimens that form the basis for studies developing tools and b... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/26/2024
Locations: University of Alabama, Birmingham, Alabama
Conditions: Huntington's Disease
Register for Updates
A Study to Evaluate Safety, Drug Levels and Effectiveness of CC-92480 (BMS-986348) in Combination With Other Treatments in Participants With Relapsed or Refractory Multiple Myeloma
NCT05372354
Recruiting
The purpose of this study is to assess the safety, tolerability and preliminary effectiveness of CC-92480 (BMS-986348) in novel therapeutic combinations for the treatment of Relapsed or Refractory Multiple Myeloma (RRMM).
Gender:
All
Ages:
18 years and above
Trial Updated:
02/26/2024
Locations: UAB Comprehensive Cancer Center, Birmingham, Alabama
Conditions: Multiple Myeloma
Register for Updates
A Study of Cabozantinib as a Maintenance Agent to Prevent Progression or Recurrence in High-Risk Pediatric Solid Tumors
NCT05135975
Recruiting
This study will expand the types of pediatric cancers being evaluated for response to cabozantinib. The current COG study is restricted to Ewing sarcoma, osteosarcoma, rhabdomyosarcoma, Wilms tumor, and a handful of uncommon tumors. The proposed study will extend this evaluation to tumors that have been shown to either express known targets of cabozantinib or with preclinical evidence of efficacy, including specifically neuroblastomas. These tumors have high morbidity and mortality, particularly... Read More
Gender:
All
Ages:
Between 18 months and 40 years
Trial Updated:
02/26/2024
Locations: Children's Hospital of Alabama/UAB, Birmingham, Alabama
Conditions: Neuroblastoma, Sarcoma
Register for Updates
Molecular Transducers of Physical Activity Consortium
NCT03960827
Recruiting
The goal of the Molecular Transducers of Physical Activity Consortium (MoTrPAC) is to assess molecular changes that occur in response to physical activity (PA). To achieve this aim, a mechanistic randomized controlled trial (RCT) is conducted, in which adult study participants are randomized to endurance exercise (EE) training, resistance exercise (RE) training, or no exercise Control for a period of approximately 12 weeks. The overarching hypothesis is that there are discoverable molecular tran... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/23/2024
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Physical Activity
Register for Updates
A Study to Evaluate Sapablursen (Formerly ISIS 702843, IONIS-TMPRSS6-LRx) in Patients With Polycythemia Vera
NCT05143957
Recruiting
The main purpose of this study is to evaluate the efficacy of sapablursen in reducing the frequency of phlebotomy and in improving quality of life assessments in participants with polycythemia vera.
Gender:
All
Ages:
Between 18 years and 90 years
Trial Updated:
02/23/2024
Locations: O'Neal Comprehensive Cancer Center University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Phlebotomy Dependent Polycythemia Vera
Register for Updates
Oral Pyridoxal 5'-Phosphate for the Treatment of Patients With PNPO Deficiency
NCT04706013
Recruiting
The proposed clinical study is intended to evaluate oral P5P for the treatment of patients confirmed to have Pyridox(am)ine 5'-Phosphate Oxidase (PNPO) deficiency via genetic analysis. There is an unmet clinical need for pharmaceutical grade P5P, as to date none has been made commercially available. Patients will receive pharmaceutical grade P5P according to their normal oral P5P dosing regimen, as previously established by their physicians.
Gender:
All
Ages:
All
Trial Updated:
02/22/2024
Locations: Children's Hospital of Alabama, Birmingham, Alabama
Conditions: Pyridox(am)Ine 5'-Phosphate Oxidase Deficiency
Register for Updates
Promoting Resilience in Women With Breast Cancer
NCT06133348
Recruiting
The PRISM (Promoting Resilience in Stress Management) intervention is an evidence-based program that builds resilience. This program was developed in adolescent and young adult oncology and utilizes centrally administered skills-based coaching to bolster positive psychological tools known as resilience resources. These resources include stress management, goal-setting, and positive reframing. Previous studies using this intervention have found PRISM to be successfully administered remotely and i... Read More
Gender:
Female
Ages:
18 years and above
Trial Updated:
02/22/2024
Locations: The University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Breast Cancer
Register for Updates
A Study to Investigate Safety and Effect of Sparsentan in Combination With SGLT2 Inhibition in Participants With IgAN
NCT05856760
Recruiting
This is a 28-week, open-label, multicenter, single-group Phase 2 exploratory study to determine the safety and effect of sparsentan in participants with IgAN who are at risk of disease progression to kidney failure despite being on both stable RAASi and SGLT2 inhibitor treatment for at least 12 weeks prior to study entry
Gender:
All
Ages:
18 years and above
Trial Updated:
02/22/2024
Locations: Travere Investigational Site, Birmingham, Alabama
Conditions: Immunoglobulin A Nephropathy
Register for Updates
Factors in Learning And Plasticity: Healthy Vision
NCT05439759
Recruiting
A greater understanding of plasticity after central vision loss can inform new therapies for treating low vision and has the potential to benefit millions of individuals suffering from low vision. The treatment of low vision is particularly relevant to the mission of the National Eye Institute (NEI) to support research on visual disorders, mechanisms of visual function, and preservation of sight. The comparison of different training and outcome factors is in line with the National Institute of M... Read More
Gender:
All
Ages:
Between 18 years and 30 years
Trial Updated:
02/21/2024
Locations: UAB, Birmingham, Alabama
Conditions: Central Visual Impairment, Macular Degeneration
Register for Updates
Factors in Learning And Plasticity: Macular Degeneration
NCT05454124
Recruiting
A greater understanding of plasticity after central vision loss can inform new therapies for treating low vision and has the potential to benefit millions of individuals suffering from low vision. The treatment of low vision is particularly relevant to the mission of the NEI to support research on visual disorders, mechanisms of visual function, and preservation of sight. The comparison of different training and outcome factors is in line with the NIMH RDOC framework and studies in an aging popu... Read More
Gender:
All
Ages:
Between 18 years and 89 years
Trial Updated:
02/21/2024
Locations: UAB, Birmingham, Alabama
Conditions: Central Visual Impairment, Macular Degeneration
Register for Updates
Deep Functional Phenotyping of the ALA Lung Health Cohort
NCT06177717
Recruiting
The goal of this observational study is to learn about lung structure and function in a group of 1000 healthy people aged 25 to 35. The main questions it aims to answer are whether people's bodies, environment, and general lung health are associated with: the structure of the participants lungs' airways, the structure of blood vessels in the participants lungs and heart, and the participants lungs' ability to exchange gases. Participants will take four different lung function tests to measure... Read More
Gender:
All
Ages:
Between 25 years and 35 years
Trial Updated:
02/21/2024
Locations: University of Alabama, Birmingham, Alabama
Conditions: Lung Diseases
Register for Updates