There are currently 1011 clinical trials in Birmingham, Alabama looking for participants to engage in research studies. Trials are conducted at various facilities, including University of Alabama at Birmingham, University of Alabama, University of Alabama at Birmingham Cancer Center and University of Alabama Birmingham. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Safety, Tolerability and Pharmacokinetics of a Monoclonal Antibody Specific to B-and T-Lymphocyte Attenuator (BTLA) as Monotherapy and in Combination With an Anti-PD1 Monoclonal Antibody for Injection in Subjects With Advanced Malignancies
NCT04137900
Recruiting
The primary objective is to assess the safety and tolerability of TAB004 as monotherapy and in combination with toripalimab in subjects with selected advanced solid malignancies, including lymphoma, and to evaluate the recommended Phase 2 dose. The secondary objectives are to: 1) describe the pharmacokinetic (PK) profile of TAB004 monotherapy and in combination with toripalimab and to describe the PK profile of toripalimab when administered with TAB004, 2) evaluate antitumor activity of TAB004... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/01/2024
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Advanced Unresectable Solid Tumor, Metastatic Solid Tumor
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An Accessible and Inclusive Artificial Intelligence Assisted Chronic Disease Self-Management Telehealth Platform
NCT05481593
Recruiting
The purpose of this study to pilot test an accessible and inclusive artificial intelligence (AI)-assisted, individualized, family-focused lifestyle modification intervention (AI4CHRON) for health-related quality of life for adults with impaired mobility and chronic medical conditions.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/01/2024
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Disability Physical, Chronic Condition, Chronic Conditions, Multiple
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A Study to Evaluate the Efficacy of Amniotic Suspension Allograft in Patients With Osteoarthritis of the Knee
NCT06000410
Recruiting
This study is being conducted to evaluate the efficacy and safety of ASA compared to placebo in the management of osteoarthritis (OA) symptoms of the knee.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/01/2024
Locations: Central Research Associates, Inc., Birmingham, Alabama +1 locations
Conditions: Knee Osteoarthritis
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Gene Correction in Autologous CD34+ Hematopoietic Stem Cells (HbS to HbA) to Treat Severe Sickle Cell Disease
NCT04819841
Recruiting
This study is a first-in-human, single-arm, open-label Phase I/II study of nula-cel in approximately 15 participants, diagnosed with severe Sickle Cell Disease. The primary objective is to evaluate safety of the treatment in this patient population, as well as preliminary efficacy and pharmacodynamic data.
Gender:
All
Ages:
Between 12 years and 40 years
Trial Updated:
01/31/2024
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Sickle Cell Disease
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Pompe Disease Registry Protocol
NCT00231400
Recruiting
The Pompe Registry is a global, multicenter, international, longitudinal, observational, and voluntary program for patients with Pompe disease, designed to track the disease's natural history and outcomes in patients, both treated and not. Data from the Registry are also used to fulfill various global regulatory commitments, to support product development/reimbursement, and for other research and non-research related purposes. The objectives of the Registry are: To enhance understanding of the... Read More
Gender:
All
Ages:
All
Trial Updated:
01/31/2024
Locations: University Alabama at Birmingham Site Number : 840106, Birmingham, Alabama
Conditions: Glycogen Storage Disease Type II, Pompe Disease
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Video Telehealth Exercise Training in Cystic Fibrosis
NCT04680403
Recruiting
The purpose of this research study is to begin an exercise program for patients with a cystic fibrosis (CF) exacerbation.
Gender:
All
Ages:
19 years and above
Trial Updated:
01/30/2024
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Cystic Fibrosis
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Safety and Efficacy of Carbon Dioxide Gas for Endoscopy
NCT06134154
Recruiting
The goal of this clinical trial is to compare the efficacy and safety of air versus carbon dioxide gas insufflation for endoscopy in children. The main question[s] it aims to answer are: •to determine safety of CO2 Assess patient comfort (abdominal pain, flatulence and bloating) with CO2 use when compared to air.
Gender:
All
Ages:
Between 6 months and 18 years
Trial Updated:
01/30/2024
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Abdominal Pain
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Collecting and Storing Tissue From Young Patients With Cancer
NCT00898755
Recruiting
This laboratory study is collecting and storing tissue, blood, and bone marrow samples from young patients with cancer. Collecting and storing samples of tissue, blood, and bone marrow from patients with cancer to study in the laboratory may help doctors learn more about changes that may occur in DNA and identify biomarkers related to cancer.
Gender:
All
Ages:
21 years and below
Trial Updated:
01/29/2024
Locations: Children's Hospital of Alabama, Birmingham, Alabama +1 locations
Conditions: Acute Lymphoblastic Leukemia, Rhabdomyosarcoma, Acute Myeloid Leukemia, Central Nervous System Neoplasm, Ewing Sarcoma, Germ Cell Tumor, Leukemia, Lymphoma, Malignant Neoplasm, Neuroblastoma, Osteosarcoma, Retinoblastoma, Rhabdoid Tumor, Soft Tissue Sarcoma
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Impella Real-World Surveillance of Patients Using Sodium Bicarbonate
NCT05820451
Recruiting
The population enrolled in this study are all subjects who received an Impella in which a bicarbonate-based purge solution was used.
Gender:
All
Ages:
All
Trial Updated:
01/29/2024
Locations: University of Alabama, Birmingham, Alabama
Conditions: Cardiogenic Shock, High Risk PCI
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The Impact of Hip Exercises on Pelvic Floor Muscle Strength and Function in Older Women With Urinary Incontinence
NCT04631926
Recruiting
This is a prospective cohort study of 30 older women ages 65 and older with urinary incontinence (UI) who will under go a standardized 12-week hip muscle exercises (isometric strengthening of hip external rotators with progressive resistance training).
Gender:
Female
Ages:
65 years and above
Trial Updated:
01/29/2024
Locations: The Kirklin Clinic of Uab Hospital, Birmingham, Alabama
Conditions: Urinary Incontinence, Geriatric Syndrome
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Hearty Meals for Mom- Pilot Study of Meal Delivery for Cardiometabolic Health During Pregnancy
NCT05512247
Recruiting
This study is being done to assess the feasibility, acceptability, and preliminary impact of a meal delivery intervention designed to improve diet quality and promote appropriate gestational weight gain among predominantly Black and low-income pregnant women with overweight or obesity. This will be done by 1) assessing the feasibility and acceptability of the meal delivery intervention; 2) investigating changes in patient-reported diet quality, barriers to healthy eating, and food security; and... Read More
Gender:
Female
Ages:
18 years and above
Trial Updated:
01/26/2024
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Diet, Healthy, Pregnancy
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Validation of Early Prognostic Data for Recovery Outcome After Stroke for Future, Higher Yield Trials
NCT05338697
Recruiting
VERIFY will validate biomarkers of upper extremity (UE) motor outcome in the acute ischemic stroke window for immediate use in clinical trials, and explore these biomarkers in acute intracerebral hemorrhage. VERIFY will create the first multicenter, large-scale, prospective dataset of clinical, transmagnetic stimulation (TMS), and MRI measures in the acute stroke time window.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/24/2024
Locations: University of Alabama, Birmingham, Alabama
Conditions: Stroke, Stroke, Acute, Stroke, Ischemic, Stroke Hemorrhagic
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