There are currently 1011 clinical trials in Birmingham, Alabama looking for participants to engage in research studies. Trials are conducted at various facilities, including University of Alabama at Birmingham, University of Alabama, University of Alabama at Birmingham Cancer Center and University of Alabama Birmingham. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Gain of Keratinized Mucosa Around Teeth and Dental Implants Using a Combination of Strip Gingival Graft and Acellular Dermal Matrix
NCT04920136
Recruiting
This study is to compare the two techniques to achieve change in the tissue quality at areas of lack of Keratinized Tissue (KT) using soft tissue grafting with autogenous graft material (Free Gingival Graft)(FGG) vs Strip gingival graft with acellular dermal matrix (ADM) (SGG+ADM).
Gender:
All
Ages:
Between 18 years and 99 years
Trial Updated:
10/17/2023
Locations: Unversity of Alabama at Birmingham, School of Dentistry, Birmingham, Alabama
Conditions: Gingival Recession, Lack of Keratinized Attached Peri-implant Mucosa, Thin Gingiva
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Tigulixostat, Phase 3 Study, Allopurinol Controlled in Gout Patients
NCT05586971
Recruiting
The aim of this 12-month randomized multi-regional double-blind parallel group allopurinol and placebo-controlled phase 3 study is to assess the efficacy and safety of three different doses of Tigulixostat in gout patients with hyperuricemia.
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
10/17/2023
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Gout, Hyperuricemia, Gout Flare, Tophi
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Quadriceps Tendon Versus Bone Patellar Tendon Bone Autograft ACL Reconstruction RCT
NCT05461326
Recruiting
The choice of autograft for ACL reconstruction continues to be debated. To date, there has only be one completed randomized controlled trial with quad tendon to BTB and the tendon included a bone plug. There has been no study to date comparing an all soft tissue quad tendon to patellar tendon in a randomized controlled trial for ACL reconstruction.
Gender:
All
Ages:
Between 14 years and 65 years
Trial Updated:
10/15/2023
Locations: UAB Hospital Highlands, Birmingham, Alabama
Conditions: Orthopedic Disorder, Anterior Cruciate Ligament Injuries
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Exploratory Study of Low Dose Psilocybin
NCT05227742
Recruiting
The purpose of the present study is to evaluate the feasibility, initial signals of efficacy, and potential mechanisms of action of "microdoses" of psilocybin (i.e., low doses of psilocybin that are not believed to produce mystical-type, transcendent, hallucinogenic, or other overtly salient subjective effects that limit functionality) in the treatment of moderate to severe demoralization (feelings of hopelessness and meaningless that frequently accompany medical illness and other life hardship)... Read More
Gender:
All
Ages:
Between 25 years and 65 years
Trial Updated:
10/13/2023
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Demoralization
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A Phase II Study of Nivolumab + Ipilimumab in Advanced HCC Patients Who Have Progressed on First Line Atezolizumab + Bevacizumab
NCT05199285
Recruiting
This phase II trial tests whether nivolumab and ipilimumab works to shrink tumors in patients with liver cancer that has spread to nearby tissue or lymph nodes (locally advanced), has spread to other places in the body (metastatic), or cannot be removed by surgery (unresectable). Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Nivolumab and ipilim... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
10/13/2023
Locations: University of Alabama- Birmingham, Birmingham, Alabama
Conditions: BCLC Stage B Hepatocellular Carcinoma, BCLC Stage C Hepatocellular Carcinoma, Locally Advanced Hepatocellular Carcinoma, Metastatic Hepatocellular Carcinoma, Stage III Hepatocellular Carcinoma AJCC v8, Stage IIIA Hepatocellular Carcinoma AJCC v8, Stage IIIB Hepatocellular Carcinoma AJCC v8, Stage IV Hepatocellular Carcinoma AJCC v8, Stage IVA Hepatocellular Carcinoma AJCC v8, Stage IVB Hepatocellular Carcinoma AJCC v8, Unresectable Hepatocellular Carcinoma
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Saroglitazar Magnesium 4 mg for NASH in People Living With HIV in the US
NCT05211284
Recruiting
Saroglitazar Magnesium 4 mg for NASH in People Living with HIV in the US
Gender:
All
Ages:
18 years and above
Trial Updated:
10/06/2023
Locations: Zydus research site 4, Birmingham, Alabama
Conditions: Nonalcoholic Steatohepatitis
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Combination Study With Eftilagimod Alpha (a Soluble LAG-3 Fusion Protein) and Pembrolizumab in Patients With Recurrent or Metastatic HNSCC
NCT04811027
Recruiting
Evaluate the safety and efficacy of eftilagimod alpha in combination with pembrolizumab against pembrolizumab alone in 1st line metastatic or recurrent HNSCC with PD-L1 positive (CPS ≥1) tumors, and determine the efficacy and safety of efti plus pembrolizumab in patients with PD-L1 negative tumors.
Gender:
All
Ages:
18 years and above
Trial Updated:
10/06/2023
Locations: University of Alabama at Birmingham (UAB) - O'Neal Cancer Center, Birmingham, Alabama
Conditions: HNSCC
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NEUROMARK Registry Study
NCT05937308
Recruiting
The NEUROMARK Registry Study is a prospective, multicenter, single-arm, post-market, interventional registry study to collect real-world evidence of the NEUROMARK System in subjects with chronic rhinitis.
Gender:
All
Ages:
18 years and above
Trial Updated:
10/05/2023
Locations: Alabama Nasal & Sinus Center, Birmingham, Alabama
Conditions: Chronic Rhinitis
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EF-36/Keynote B36: A Pilot, Randomized, Open-label Study of Tumor Treating Fields (TTFields, 150 kHz) Concomitant With Pembrolizumab for First Line Treatment of Advanced or Metastatic Non-small Cell Lung Cancer
NCT04892472
Recruiting
This is a multicenter, randomized, open-label study of Tumor Treating Fields (TTFields) at 150 kHz to the thorax using the NovoTTF-200T System with IV pembrolizumab in subjects previously untreated for advanced or metastatic, PD-L1 positive non-small cell lung cancer (NSCLC). The primary objective is to evaluate the progression-free survival (PFS) by RECIST 1.1 in subjects with TPS ≥1 percent, 1L metastatic/current advanced NSCLC treated with TTFields concomitant with pembrolizumab compared to t... Read More
Gender:
All
Ages:
22 years and above
Trial Updated:
10/04/2023
Locations: Central Alabama Research, Birmingham, Alabama
Conditions: Non-small Cell Lung Cancer
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Making Intergenerational Connections Through Arts
NCT05986149
Recruiting
The purpose of the study is to evaluate the impact on older adults' wellbeing of participating in a 10-week conversation about arts and culture with an international university student whose native language is not English.
Gender:
All
Ages:
60 years and above
Trial Updated:
10/04/2023
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Older Adults
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Achieving Understanding of the Natural History of Sickle Cell Trait (AUNT)
NCT06071377
Recruiting
The main purpose of this study is to create a longitudinal cohort of those with Sickle Cell Trait (SCT) to better understand the hematologic phenotype for those that carry HbS, assess for differences in those with varying quantities of HbS and assess for potential clinical complications of SCT.
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
10/04/2023
Locations: University of Alabama, Birmingham, Alabama
Conditions: Sickle Cell Trait
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The Biosonographic Index
NCT04144894
Recruiting
In this exploratory study we explore the use of Shear Wave Elastography to differentiate between Acute Kidney Injury after vascular surgery and among the healthy population.
Gender:
All
Ages:
19 years and above
Trial Updated:
10/04/2023
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Acute Kidney Injury
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