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Cyclophosphamide Treatment Options in Canada
A collection of 300 research studies where Cyclophosphamide is the interventional treatment. These studies are located in the Canada . Cyclophosphamide is used for conditions such as Breast Cancer, Lymphoma and Leukemia.
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A Study to Compare the Efficacy and Safety of Golcadomide in Combination With Rituximab (Golca + R) vs Investigator's Choice in Participants With Relapsed/Refractory Follicular Lymphoma (GOLSEEK-4)
Recruiting
The study is designed as a multicenter, randomized, open label Phase 3 study to compare the efficacy and safety of golcadomide in combination with rituximab vs investigator's choice in participants with relapsed/refractory follicular lymphoma who have received at least one line of prior systemic therapy.
The study is designed as a multicenter, randomized, open label Phase 3 study to compare the efficacy and safety of golcadomide in combination with rituximab vs investigator's choice in participants with relapsed/refractory follicular lymphoma who have received at least one line of prior systemic therapy. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/21/2025
Locations: Local Institution - 0225, Birmingham, Alabama +153 locations
Local Institution - 0225, Birmingham, Alabama
Local Institution - 0014, Mobile, Alabama
Alaska Oncology and Hematology, Anchorage, Alaska
Local Institution - 0215, Little Rock, Arkansas
Local Institution - 0072, Duarte, California
Local Institution - 0119, San Francisco, California
Local Institution - 0008, Jacksonville, Florida
Local Institution - 0214, Tampa, Florida
Local Institution - 0217, Tampa, Florida
Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital, Marietta, Georgia
Local Institution - 0245, Newnan, Georgia
Local Institution - 0240, Arlington Heights, Illinois
Local Institution - 0253, Iowa City, Iowa
Local Institution - 0243, Waukee, Iowa
Local Institution - 0216, Westwood, Kansas
Local Institution - 0218, Lexington, Kentucky
Local Institution - 0023, Baltimore, Maryland
Greater Baltimore Medical Center, Towson, Maryland
Local Institution - 0145, Boston, Massachusetts
Local Institution - 0244, Boston, Massachusetts
Local Institution - 0247, Boston, Massachusetts
Hattiesburg Clinic Hematology/Oncology, Hattiesburg, Mississippi
Local Institution - 0144, Providence, Rhode Island
Local Institution - 0237, Austin, Texas
Local Institution - 0212, Fort Worth, Texas
Local Institution - 0230, San Antonio, Texas
Local Institution - 0236, Tyler, Texas
Local Institution - 0238, Fairfax, Virginia
Hematology Oncology Associates of Fredericksburg, Fredericksburg, Virginia
Local Institution - 0146, Roanoke, Virginia
Local Institution - 0143, Vancouver, Washington
Local Institution - 0134, Westmead, New South Wales
Local Institution - 0132, Adelaide, South Australia
Local Institution - 0131, Hobart, Tasmania
Local Institution - 0128, Heidelberg, Victoria
Local Institution - 0198, Malvern, Victoria
Local Institution - 0127, Perth, Western Australia
Local Institution - 0224, Perth, Western Australia
Local Institution - 0159, Vitoria, Espírito Santo
Local Institution - 0088, Niterói, Rio De Janeiro
Local Institution - 0087, Porto Alegre, Rio Grande Do Sul
Local Institution - 0079, Sao Paulo, São Paulo
Local Institution - 0089, Rio de Janeiro, Not set
Local Institution - 0066, São Paulo, Not set
Local Institution - 0092, São Paulo, Not set
Local Institution - 0200, Victoria, British Columbia
Princess Margaret Cancer Centre, Toronto, Ontario
Local Institution - 0250, Québec, Quebec
Local Institution - 0192, Sherbrooke, Quebec
Local Institution - 0226, Sherbrooke, Quebec
Local Institution - 0154, Santiago, Región Metropolitana De Santiago
Local Institution - 0155, Santiago, Región Metropolitana De Santiago
Local Institution - 0153, Santiago, Región Metropolitana De Santiago
Local Institution - 0246, Beijing, Beijing
Local Institution - 0171, Beijing, Beijing
Local Institution - 0172, Fuzhou Fujian, Fujian
Local Institution - 0173, Guangzhou, Guangdong
Local Institution - 0241, Harbin, Heilongjiang
Local Institution - 0176, Wuhan, Hubei
Local Institution - 0175, Changsha, Hunan
Local Institution - 0235, Hohhot, Inner Mongolia
Local Institution - 0233, Suzhou, Jiangsu
Local Institution - 0178, Nanchang, Jiangxi
Local Institution - 0239, Changchun, Jilin
Local Institution - 0177, Changchun, Jilin
Local Institution - 0179, Shenyang, Liaoning
Local Institution - 0242, Shenyang, Liaoning
Local Institution - 0180, Jinan, Shandong
Local Institution - 0181, Shanghai, Shanghai
Local Institution - 0249, Shanghai, Shanghai
Local Institution - 0234, Sichuan, Sichuan
Local Institution - 0182, Tianjin, Tianjin
Local Institution - 0227, Tianjin, Tianjin
Local Institution - 0248, Kunming, Yunnan
Local Institution - 0184, Hangzhou, Zhejiang
Local Institution - 0174, Zhengzhou, Not set
Local Institution - 0151, Oulu, Pohjois-Pohjanmaa
Local Institution - 0152, Turku, Varsinais-Suomi
Local Institution - 0150, Helsinki, Not set
Local Institution - 0100, Pessac, Aquitaine
Local Institution - 0044, Saint-Cloud, Hauts-de-Seine
Local Institution - 0047, Montpellier, Languedoc-Roussillon
Local Institution - 0120, Nantes, Loire-Atlantique
Local Institution - 0048, Lille, Nord
Local Institution - 0042, Pierre-Bénite, Rhône
Local Institution - 0191, Paris, Not set
Local Institution - 0121, Toulouse, Not set
Local Institution - 0163, Ulm, Baden-Württemberg
Local Institution - 0161, Augsburg, Bayern
Local Institution - 0220, Göttingen, Niedersachsen
Local Institution - 0166, Dortmund, Nordrhein-Westfalen
Local Institution - 0193, Düsseldorf, Nordrhein-Westfalen
Local Institution - 0231, Münster, Nordrhein-Westfalen
Local Institution - 0232, Münster, Nordrhein-Westfalen
Local Institution - 0164, Homburg, Saarland
Local Institution - 0165, Chemnitz, Sachsen
Local Institution - 0222, Erfurt, Thüringen
Local Institution - 0167, Jena, Thüringen
Local Institution - 0187, Dresden, Not set
Local Institution - 0162, München, Not set
Local Institution - 0221, Wuerzburg, Not set
Local Institution - 0109, Athens, Attikí
Local Institution - 0107, Αthens, Attikí
Local Institution - 0110, Thessaloniki, Thessaloníki
Local Institution - 0197, Thessaloniki, Thessaloníki
Local Institution - 0111, Alexandroupolis, Not set
Local Institution - 0108, Ioannina, Ípeiros
Local Institution - 0142, New Delhi, Delhi
Local Institution - 0139, Bengaluru, Karnataka
Local Institution - 0141, Mumbai, Maharashtra
Local Institution - 0140, Hyderabad, Telangana
Local Institution - 0138, Hyderabad, Telangana
Local Institution - 0104, Bologna, Emilia-Romagna
Local Institution - 0101, Meldola, Emilia-Romagna
Local Institution - 0103, Rozzano, Milano
Local Institution - 0106, Pisa, Toscana
Local Institution - 0102, Alessandria, Not set
Local Institution - 0105, Napoli, Not set
Local Institution - 0157, Torino, Not set
Aiiku Hospital, Sapporo, Hokkaido
Japanease Red Cross Society Himeji Hospital, Himeji, Hyogo
Local Institution - 0201, Morioka, Iwate
University of Yamanashi Hospital, Chuo, Yamanashi
Local Institution - 0059, Seoul, Seoul-teukbyeolsi [Seoul]
Local Institution - 0060, Seoul, Seoul-teukbyeolsi [Seoul]
Local Institution - 0061, Seoul, Seoul-teukbyeolsi [Seoul]
Local Institution - 0058, Seoul, Not set
Local Institution - 0050, Amsterdam, Noord-Holland
Local Institution - 0046, Groningen, Not set
Local Institution - 0053, Utrecht, Not set
Local Institution - 0188, Warszawa, Mazowieckie
Local Institution - 0186, Kraków, Małopolskie
Local Institution - 0190, Gdynia, Pomorskie
Local Institution - 0185, Skórzewo, Wielkopolskie
Local Institution - 0189, Łódź, Łódzkie
Local Institution - 0099, Dammam, Ash Sharqīyah
Local Institution - 0054, Riyadh, Not set
Local Institution - 0052, Riyadh, Not set
Local Institution - 0158, Sabadell, Barcelona [Barcelona]
Local Institution - 0122, Santander, Cantabria
Local Institution - 0124, Madrid, Madrid, Comunidad De
Local Institution - 0125, Valencia, Valenciana, Comunitat
Local Institution - 0126, Granada, Not set
Local Institution - 0123, Madrid, Not set
Local Institution - 0195, Istanbul- Fatih, İstanbul
Local Institution - 0194, Ankara, Not set
Local Institution - 0196, Antalya, Not set
Local Institution - 0223, Mersin, Not set
Local Institution - 0251, Abu Dhabi, Abū Z̧aby
Local Institution - 0252, Abu Dhabi, Abū Z̧aby
Norfolk and Norwich University Hospitals NHS Foundation Trust, Cringleford, England
Kent and Canterbury Hospital, Canterbury, Kent
Local Institution - 0213, London, London, City Of
Local Institution - 0149, Manchester, Not set
Conditions: Follicular Lymphoma
Study to Compare Axicabtagene Ciloleucel With Standard of Care Therapy as First-line Treatment in Participants With High-risk Large B-cell Lymphoma
Recruiting
The goal of this clinical study is to compare the study drug, axicabtagene ciloleucel, versus standard of care (SOC) in first-line therapy in participants with high-risk large B-cell lymphoma.
The goal of this clinical study is to compare the study drug, axicabtagene ciloleucel, versus standard of care (SOC) in first-line therapy in participants with high-risk large B-cell lymphoma. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/20/2025
Locations: University of Alabama Hospital, Birmingham, Alabama +89 locations
University of Alabama Hospital, Birmingham, Alabama
Banner MD Anderson Cancer Center, Gilbert, Arizona
Mayo Clinic, Phoenix, Arizona
UC San Diego Moores Cancer Center, La Jolla, California
University of California Los Angeles (UCLA), Los Angeles, California
Stanford Cancer Institute, Palo Alto, California
Colorado Blood Cancer Institute, Denver, Colorado
Moffitt Cancer Center, Tampa, Florida
Georgia Cancer Center at Augusta University, Augusta, Georgia
Northwestern Memorial Hospital, Chicago, Illinois
University of Chicago Medical Center, Chicago, Illinois
University of Iowa, Iowa City, Iowa
The University of Kansas Hospital, Westwood, Kansas
Norton Cancer Institute, St. Matthews Campus, Shelbyville, Kentucky
Ochsner Clinic Foundation, New Orleans, Louisiana
University of MD Greenebaum Comprehensive Cancer Center, Baltimore, Maryland
Dana-Farber Cancer Institute, Boston, Massachusetts
University of Michigan, Ann Arbor, Michigan
Mayo Clinic Cancer Center Outpatient Pharmacy, Rochester, Minnesota
John Theurer Cancer Center at Hackensack University Medical Center, Hackensack, New Jersey
Montefiore Medical Center, Bronx, New York
Roswell Park Cancer Institute, Buffalo, New York
Weill Cornell Medical College - NewYork Presbyterian Hospital, New York, New York
Columbia University Medical Center, New York, New York
University of Rochester Medical Center, Rochester, New York
Novant Health Cancer Institute- Hematology, Charlotte, North Carolina
Oncology Hematology Care Clinical Trials, LLC, Cincinnati, Ohio
UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania
Prisma Health Cancer Institute, Greenville, South Carolina
Avera Cancer Institute, Sioux Falls, South Dakota
Tennessee Oncology, PLLC, Nashville, Tennessee
Henry-Joyce Cancer Center, Nashville, Tennessee
University of Texas Southwestern Medical Center, Dallas, Texas
The University of Texas, MD Anderson Cancer Center, Houston, Texas
Intermountain LDS Hospital/Blood and Marrow Transplant/ Acute Leukemia Program, Salt Lake City, Utah
Virginia Commonwealth University, Richmond, Virginia
Fred Hutchinson Cancer Center, Seattle, Washington
Royal Prince Alfred Hospital, Camperdown, New South Wales
Royal Brisbane and Women's Hospital, South Brisbane, Queensland
Peter MacCallum Cancer Center, Melbourne, Victoria
Medizinische Universität Innsbruck, Innsbruck, Not set
Zuniklinikum Salzburg, Landeskrankenhaus, Universitatsklinik fur Innere Medizin III der PMU, Salzburg, Not set
Universitätsklinikum St. Pölten, St. Poelten, Not set
Medizinische Universität Wien (AKH Wien, Medical University Vienna and General Hospital Vienna), Vienna, Not set
Jewish General Hospital, Montreal, Not set
The Ottowa Hospital- General Campus, Ottawa, Not set
Princess Margaret Cancer Centre, Toronto, Not set
CHU Bordeaux-Hopital Haut-Leveque, Bordeaux, Not set
Centre Leon Berard, Cedex Lyon 08, Not set
CHU Dijon, Dijon, Not set
Hopital Claude Huriez CHU Lille, Service Maladies du sang, Lille cedex, Not set
Hopital Saint Eloi, Montpellier CEDEX 05, Not set
Centre Hospitalier Universitaire de Nice, Nice, Not set
Hopital Henri MONDOR, APHP, Paris, Not set
CHU Pontchaillou, Rennes CEDEX, Not set
Centre Hospitalier Universitaire(CHU) de Toulouse, Toulouse, Not set
Helios Klinikum Berlin-Buch, Berlin, Not set
Charite Universitaetsmedizin Berlin, Berlin, Not set
Universitätsklinikum bonn, medizinische klinik III, Bonn, Not set
Uniklinikum Duesseldorf, Klinik fuer Haematologie, Onkologie und klinische Immunologie, Duesseldorf, Not set
Universitätsklinik Erlangen, Erlangen, Not set
IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Not set
ASST Degli Spedali Civili di Brescia, Brescia, Not set
Ospedale San Raffaele, Milano, Not set
Azienda Ospedaliera di Perugia - Ospedale S. Maria della Misericordia, Perugia, Not set
Grande Ospedale Metropolitano Bianchi Melacrino Morelli, Reggio Calabria, Not set
Universita Cattolica del Sacro Cuore, Rome, Not set
IRCCS Istituto Clinico Humanitas, Rozzano, Not set
University Hospital, Kyoto Prefectural University of Medicine, Kyoto, Not set
Tohoku University Hospital, Miyagi, Not set
Osaka University Hospital, Osaka, Not set
Juntendo University Hospital, Tokyo, Not set
Tokyo Metropolitan Komagome Hospital, Tokyo, Not set
Academisch Medisch Centrum, Amsterdam, Not set
University Medical Center Groningen, Groningen, Not set
Leiden University Medical Center, Leiden, Not set
Maastricht Universitair Medisch Centrum, Maastricht, Not set
Universitair Medisch Centrum Utrecht, Utrecht, Not set
Centro Hospitalar Universitario Lisboa Norte, E.P.E. - Hospital de Santa Maria, Lisbon, Not set
Instituto Portugues de Oncologia de Lisboa Francisco Gentil - E.P.E., Lisbon, Not set
Instituto Portugues de Oncologia do Porto Francisco Gentil, E.P.E., Porto, Not set
Institut Catala d'Oncologia, Barcelona, Not set
Hospital Universitari Vall D'Hebron, Barcelona, Not set
Hospital Universitario 12 de Octubre, Madrid, Not set
Hospital Universitario de Salamanca, Salamanca, Not set
Hospital Universitario Marqués de Valdecilla, Santander, Not set
Hospital Universitario Virgen del Rocio, Sevilla, Not set
Hospital Clínico Universitario de Valencia, Valencia, Not set
Addenbrookes Hospital (Cambridge University Hospitals NHS Foundation Trust), Birmingham, Not set
University Hospitals Southampton, Southampton, Not set
Conditions: High-risk Large B-cell Lymphoma (LBCL)
A Study to Investigate Blinatumomab in Combination With Chemotherapy in Patients With Newly Diagnosed B-Lymphoblastic Leukemia
Active Not Recruiting
This phase III trial studies how well blinatumomab works in combination with chemotherapy in treating patients with newly diagnosed, standard risk B-lymphoblastic leukemia or B-lymphoblastic lymphoma with or without Down syndrome. Monoclonal antibodies, such as blinatumomab, may induce changes in the body's immune system and may interfere with the ability of cancer cells to grow and spread. Chemotherapy drugs, such as vincristine, dexamethasone, prednisone, prednisolone, pegaspargase, methotrexa... Read More
This phase III trial studies how well blinatumomab works in combination with chemotherapy in treating patients with newly diagnosed, standard risk B-lymphoblastic leukemia or B-lymphoblastic lymphoma with or without Down syndrome. Monoclonal antibodies, such as blinatumomab, may induce changes in the body's immune system and may interfere with the ability of cancer cells to grow and spread. Chemotherapy drugs, such as vincristine, dexamethasone, prednisone, prednisolone, pegaspargase, methotrexate, cytarabine, mercaptopurine, doxorubicin, cyclophosphamide, and thioguanine, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Leucovorin decreases the toxic effects of methotrexate. Giving monoclonal antibody therapy with chemotherapy may kill more cancer cells. Giving blinatumomab and combination chemotherapy may work better than combination chemotherapy alone in treating patients with B-ALL. This trial also assigns patients into different chemotherapy treatment regimens based on risk (the chance of cancer returning after treatment). Treating patients with chemotherapy based on risk may help doctors decide which patients can best benefit from which chemotherapy treatment regimens. Read Less
Gender:
ALL
Ages:
Between 365 days and 31 years
Trial Updated:
08/20/2025
Locations: Children's Hospital of Alabama, Birmingham, Alabama +227 locations
Children's Hospital of Alabama, Birmingham, Alabama
USA Health Strada Patient Care Center, Mobile, Alabama
Providence Alaska Medical Center, Anchorage, Alaska
Banner Children's at Desert, Mesa, Arizona
Phoenix Childrens Hospital, Phoenix, Arizona
Banner University Medical Center - Tucson, Tucson, Arizona
Arkansas Children's Hospital, Little Rock, Arkansas
Kaiser Permanente Downey Medical Center, Downey, California
City of Hope Comprehensive Cancer Center, Duarte, California
Loma Linda University Medical Center, Loma Linda, California
Miller Children's and Women's Hospital Long Beach, Long Beach, California
Children's Hospital Los Angeles, Los Angeles, California
Cedars Sinai Medical Center, Los Angeles, California
Mattel Children's Hospital UCLA, Los Angeles, California
Valley Children's Hospital, Madera, California
UCSF Benioff Children's Hospital Oakland, Oakland, California
Kaiser Permanente-Oakland, Oakland, California
Children's Hospital of Orange County, Orange, California
Lucile Packard Children's Hospital Stanford University, Palo Alto, California
Sutter Medical Center Sacramento, Sacramento, California
University of California Davis Comprehensive Cancer Center, Sacramento, California
Rady Children's Hospital - San Diego, San Diego, California
Naval Medical Center -San Diego, San Diego, California
UCSF Medical Center-Mission Bay, San Francisco, California
Santa Barbara Cottage Hospital, Santa Barbara, California
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California
Children's Hospital Colorado, Aurora, Colorado
Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center, Denver, Colorado
Connecticut Children's Medical Center, Hartford, Connecticut
Yale University, New Haven, Connecticut
Alfred I duPont Hospital for Children, Wilmington, Delaware
MedStar Georgetown University Hospital, Washington, District of Columbia
Children's National Medical Center, Washington, District of Columbia
Broward Health Medical Center, Fort Lauderdale, Florida
Golisano Children's Hospital of Southwest Florida, Fort Myers, Florida
University of Florida Health Science Center - Gainesville, Gainesville, Florida
Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood, Florida
Nemours Children's Clinic-Jacksonville, Jacksonville, Florida
Palms West Radiation Therapy, Loxahatchee Groves, Florida
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida
Nicklaus Children's Hospital, Miami, Florida
Miami Cancer Institute, Miami, Florida
AdventHealth Orlando, Orlando, Florida
Arnold Palmer Hospital for Children, Orlando, Florida
Nemours Children's Hospital, Orlando, Florida
Sacred Heart Hospital, Pensacola, Florida
Johns Hopkins All Children's Hospital, Saint Petersburg, Florida
Tampa General Hospital, Tampa, Florida
Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa, Florida
Saint Mary's Medical Center, West Palm Beach, Florida
Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta, Georgia
Augusta University Medical Center, Augusta, Georgia
Atrium Health Navicent, Macon, Georgia
Memorial Health University Medical Center, Savannah, Georgia
Kapiolani Medical Center for Women and Children, Honolulu, Hawaii
Tripler Army Medical Center, Honolulu, Hawaii
Saint Luke's Cancer Institute - Boise, Boise, Idaho
Lurie Children's Hospital-Chicago, Chicago, Illinois
University of Illinois, Chicago, Illinois
University of Chicago Comprehensive Cancer Center, Chicago, Illinois
Loyola University Medical Center, Maywood, Illinois
Advocate Children's Hospital-Oak Lawn, Oak Lawn, Illinois
Advocate Children's Hospital-Park Ridge, Park Ridge, Illinois
Saint Jude Midwest Affiliate, Peoria, Illinois
Southern Illinois University School of Medicine, Springfield, Illinois
Northwestern Medicine Central DuPage Hospital, Winfield, Illinois
Riley Hospital for Children, Indianapolis, Indiana
Ascension Saint Vincent Indianapolis Hospital, Indianapolis, Indiana
Blank Children's Hospital, Des Moines, Iowa
University of Iowa/Holden Comprehensive Cancer Center, Iowa City, Iowa
University of Kentucky/Markey Cancer Center, Lexington, Kentucky
Norton Children's Hospital, Louisville, Kentucky
Children's Hospital New Orleans, New Orleans, Louisiana
Ochsner Medical Center Jefferson, New Orleans, Louisiana
Eastern Maine Medical Center, Bangor, Maine
Maine Children's Cancer Program, Scarborough, Maine
University of Maryland/Greenebaum Cancer Center, Baltimore, Maryland
Sinai Hospital of Baltimore, Baltimore, Maryland
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland
Walter Reed National Military Medical Center, Bethesda, Maryland
Tufts Children's Hospital, Boston, Massachusetts
Massachusetts General Hospital Cancer Center, Boston, Massachusetts
Dana-Farber Cancer Institute, Boston, Massachusetts
Baystate Medical Center, Springfield, Massachusetts
UMass Memorial Medical Center - University Campus, Worcester, Massachusetts
C S Mott Children's Hospital, Ann Arbor, Michigan
Children's Hospital of Michigan, Detroit, Michigan
Henry Ford Health Saint John Hospital, Detroit, Michigan
Michigan State University, East Lansing, Michigan
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids, Michigan
Bronson Methodist Hospital, Kalamazoo, Michigan
Corewell Health Children's, Royal Oak, Michigan
Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis, Minnesota
University of Minnesota/Masonic Cancer Center, Minneapolis, Minnesota
Mayo Clinic in Rochester, Rochester, Minnesota
University of Mississippi Medical Center, Jackson, Mississippi
University of Missouri Children's Hospital, Columbia, Missouri
Children's Mercy Hospitals and Clinics, Kansas City, Missouri
Cardinal Glennon Children's Medical Center, Saint Louis, Missouri
Washington University School of Medicine, Saint Louis, Missouri
Mercy Hospital Saint Louis, Saint Louis, Missouri
Children's Hospital and Medical Center of Omaha, Omaha, Nebraska
University of Nebraska Medical Center, Omaha, Nebraska
University Medical Center of Southern Nevada, Las Vegas, Nevada
Sunrise Hospital and Medical Center, Las Vegas, Nevada
Alliance for Childhood Diseases/Cure 4 the Kids Foundation, Las Vegas, Nevada
Summerlin Hospital Medical Center, Las Vegas, Nevada
Renown Regional Medical Center, Reno, Nevada
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon, New Hampshire
Hackensack University Medical Center, Hackensack, New Jersey
Morristown Medical Center, Morristown, New Jersey
Jersey Shore Medical Center, Neptune, New Jersey
Saint Peter's University Hospital, New Brunswick, New Jersey
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick, New Jersey
Newark Beth Israel Medical Center, Newark, New Jersey
Saint Joseph's Regional Medical Center, Paterson, New Jersey
Presbyterian Hospital, Albuquerque, New Mexico
University of New Mexico Cancer Center, Albuquerque, New Mexico
Albany Medical Center, Albany, New York
Montefiore Medical Center - Moses Campus, Bronx, New York
Maimonides Medical Center, Brooklyn, New York
NYU Langone Hospital - Long Island, Mineola, New York
The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park, New York
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York, New York
Mount Sinai Hospital, New York, New York
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York, New York
Memorial Sloan Kettering Cancer Center, New York, New York
NYP/Weill Cornell Medical Center, New York, New York
University of Rochester, Rochester, New York
Stony Brook University Medical Center, Stony Brook, New York
State University of New York Upstate Medical University, Syracuse, New York
New York Medical College, Valhalla, New York
Mission Hospital, Asheville, North Carolina
UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina
Carolinas Medical Center/Levine Cancer Institute, Charlotte, North Carolina
Novant Health Presbyterian Medical Center, Charlotte, North Carolina
Duke University Medical Center, Durham, North Carolina
East Carolina University, Greenville, North Carolina
Wake Forest University Health Sciences, Winston-Salem, North Carolina
Sanford Broadway Medical Center, Fargo, North Dakota
Children's Hospital Medical Center of Akron, Akron, Ohio
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Rainbow Babies and Childrens Hospital, Cleveland, Ohio
Cleveland Clinic Foundation, Cleveland, Ohio
Nationwide Children's Hospital, Columbus, Ohio
Dayton Children's Hospital, Dayton, Ohio
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo, Ohio
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Natalie Warren Bryant Cancer Center at Saint Francis, Tulsa, Oklahoma
Legacy Emanuel Children's Hospital, Portland, Oregon
Oregon Health and Science University, Portland, Oregon
Lehigh Valley Hospital-Cedar Crest, Allentown, Pennsylvania
Geisinger Medical Center, Danville, Pennsylvania
Penn State Children's Hospital, Hershey, Pennsylvania
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Saint Christopher's Hospital for Children, Philadelphia, Pennsylvania
Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania
Rhode Island Hospital, Providence, Rhode Island
Medical University of South Carolina, Charleston, South Carolina
Prisma Health Richland Hospital, Columbia, South Carolina
BI-LO Charities Children's Cancer Center, Greenville, South Carolina
Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota
T C Thompson Children's Hospital, Chattanooga, Tennessee
East Tennessee Childrens Hospital, Knoxville, Tennessee
The Children's Hospital at TriStar Centennial, Nashville, Tennessee
Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee
Texas Tech University Health Sciences Center-Amarillo, Amarillo, Texas
Dell Children's Medical Center of Central Texas, Austin, Texas
Driscoll Children's Hospital, Corpus Christi, Texas
Medical City Dallas Hospital, Dallas, Texas
UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas
El Paso Children's Hospital, El Paso, Texas
Cook Children's Medical Center, Fort Worth, Texas
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston, Texas
M D Anderson Cancer Center, Houston, Texas
Covenant Children's Hospital, Lubbock, Texas
UMC Cancer Center / UMC Health System, Lubbock, Texas
Vannie Cook Children's Clinic, McAllen, Texas
Children's Hospital of San Antonio, San Antonio, Texas
Methodist Children's Hospital of South Texas, San Antonio, Texas
University of Texas Health Science Center at San Antonio, San Antonio, Texas
Scott and White Memorial Hospital, Temple, Texas
Primary Children's Hospital, Salt Lake City, Utah
University of Vermont and State Agricultural College, Burlington, Vermont
University of Virginia Cancer Center, Charlottesville, Virginia
Inova Fairfax Hospital, Falls Church, Virginia
Children's Hospital of The King's Daughters, Norfolk, Virginia
Naval Medical Center - Portsmouth, Portsmouth, Virginia
VCU Massey Comprehensive Cancer Center, Richmond, Virginia
Carilion Children's, Roanoke, Virginia
Seattle Children's Hospital, Seattle, Washington
Providence Sacred Heart Medical Center and Children's Hospital, Spokane, Washington
Mary Bridge Children's Hospital and Health Center, Tacoma, Washington
Madigan Army Medical Center, Tacoma, Washington
West Virginia University Charleston Division, Charleston, West Virginia
Edwards Comprehensive Cancer Center, Huntington, West Virginia
West Virginia University Healthcare, Morgantown, West Virginia
Saint Vincent Hospital Cancer Center Green Bay, Green Bay, Wisconsin
University of Wisconsin Carbone Cancer Center - University Hospital, Madison, Wisconsin
Marshfield Medical Center-Marshfield, Marshfield, Wisconsin
Children's Hospital of Wisconsin, Milwaukee, Wisconsin
John Hunter Children's Hospital, Hunter Regional Mail Centre, New South Wales
The Children's Hospital at Westmead, Westmead, New South Wales
Queensland Children's Hospital, South Brisbane, Queensland
Women's and Children's Hospital-Adelaide, North Adelaide, South Australia
Monash Medical Center-Clayton Campus, Clayton, Victoria
Royal Children's Hospital, Parkville, Victoria
Perth Children's Hospital, Perth, Western Australia
Alberta Children's Hospital, Calgary, Alberta
University of Alberta Hospital, Edmonton, Alberta
British Columbia Children's Hospital, Vancouver, British Columbia
CancerCare Manitoba, Winnipeg, Manitoba
Janeway Child Health Centre, Saint John's, Newfoundland and Labrador
IWK Health Centre, Halifax, Nova Scotia
McMaster Children's Hospital at Hamilton Health Sciences, Hamilton, Ontario
Kingston Health Sciences Centre, Kingston, Ontario
Children's Hospital, London, Ontario
Children's Hospital of Eastern Ontario, Ottawa, Ontario
Hospital for Sick Children, Toronto, Ontario
The Montreal Children's Hospital of the MUHC, Montreal, Quebec
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont, Sherbrooke, Quebec
Jim Pattison Children's Hospital, Saskatoon, Saskatchewan
Saskatoon Cancer Centre, Saskatoon, Saskatchewan
CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL), Quebec, Not set
Starship Children's Hospital, Grafton, Auckland
Christchurch Hospital, Christchurch, Not set
HIMA San Pablo Oncologic Hospital, Caguas, Not set
University Pediatric Hospital, San Juan, Not set
Conditions: B Acute Lymphoblastic Leukemia, B Lymphoblastic Lymphoma, Down Syndrome
Combination Chemotherapy in Treating Young Patients With Newly Diagnosed High-Risk B Acute Lymphoblastic Leukemia and Ph-Like TKI Sensitive Mutations
Active Not Recruiting
This randomized phase III trial studies how well combination chemotherapy works in treating young patients with newly diagnosed B acute lymphoblastic leukemia that is likely to come back or spread, and in patients with Philadelphia chromosome (Ph)-like tyrosine kinase inhibitor (TKI) sensitive mutations. Chemotherapy drugs, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving more than o... Read More
This randomized phase III trial studies how well combination chemotherapy works in treating young patients with newly diagnosed B acute lymphoblastic leukemia that is likely to come back or spread, and in patients with Philadelphia chromosome (Ph)-like tyrosine kinase inhibitor (TKI) sensitive mutations. Chemotherapy drugs, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving more than one drug (combination chemotherapy) and giving the drugs in different doses and in different combinations may kill more cancer cells. Read Less
Gender:
ALL
Ages:
Between 1 year and 31 years
Trial Updated:
08/20/2025
Locations: Children's Hospital of Alabama, Birmingham, Alabama +238 locations
Children's Hospital of Alabama, Birmingham, Alabama
University of Alabama at Birmingham Cancer Center, Birmingham, Alabama
USA Health Strada Patient Care Center, Mobile, Alabama
Providence Alaska Medical Center, Anchorage, Alaska
Banner Children's at Desert, Mesa, Arizona
Phoenix Childrens Hospital, Phoenix, Arizona
Banner University Medical Center - Tucson, Tucson, Arizona
Arkansas Children's Hospital, Little Rock, Arkansas
University of Arkansas for Medical Sciences, Little Rock, Arkansas
Kaiser Permanente Downey Medical Center, Downey, California
City of Hope Comprehensive Cancer Center, Duarte, California
Loma Linda University Medical Center, Loma Linda, California
Miller Children's and Women's Hospital Long Beach, Long Beach, California
Children's Hospital Los Angeles, Los Angeles, California
Cedars Sinai Medical Center, Los Angeles, California
Mattel Children's Hospital UCLA, Los Angeles, California
Valley Children's Hospital, Madera, California
UCSF Benioff Children's Hospital Oakland, Oakland, California
Kaiser Permanente-Oakland, Oakland, California
Children's Hospital of Orange County, Orange, California
Lucile Packard Children's Hospital Stanford University, Palo Alto, California
Sutter Medical Center Sacramento, Sacramento, California
University of California Davis Comprehensive Cancer Center, Sacramento, California
Rady Children's Hospital - San Diego, San Diego, California
Naval Medical Center -San Diego, San Diego, California
UCSF Medical Center-Parnassus, San Francisco, California
UCSF Medical Center-Mission Bay, San Francisco, California
Santa Barbara Cottage Hospital, Santa Barbara, California
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California
Children's Hospital Colorado, Aurora, Colorado
Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center, Denver, Colorado
Connecticut Children's Medical Center, Hartford, Connecticut
Yale University, New Haven, Connecticut
Alfred I duPont Hospital for Children, Wilmington, Delaware
MedStar Georgetown University Hospital, Washington, District of Columbia
Children's National Medical Center, Washington, District of Columbia
Broward Health Medical Center, Fort Lauderdale, Florida
Lee Memorial Health System, Fort Myers, Florida
Golisano Children's Hospital of Southwest Florida, Fort Myers, Florida
University of Florida Health Science Center - Gainesville, Gainesville, Florida
Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood, Florida
Nemours Children's Clinic-Jacksonville, Jacksonville, Florida
Palms West Radiation Therapy, Loxahatchee Groves, Florida
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida
Nicklaus Children's Hospital, Miami, Florida
Miami Cancer Institute, Miami, Florida
AdventHealth Orlando, Orlando, Florida
Arnold Palmer Hospital for Children, Orlando, Florida
Nemours Children's Clinic - Orlando, Orlando, Florida
Orlando Health Cancer Institute, Orlando, Florida
Nemours Children's Hospital, Orlando, Florida
Nemours Children's Clinic - Pensacola, Pensacola, Florida
Johns Hopkins All Children's Hospital, Saint Petersburg, Florida
Tampa General Hospital, Tampa, Florida
Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa, Florida
Saint Mary's Medical Center, West Palm Beach, Florida
Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta, Georgia
Augusta University Medical Center, Augusta, Georgia
Memorial Health University Medical Center, Savannah, Georgia
University of Hawaii Cancer Center, Honolulu, Hawaii
Kapiolani Medical Center for Women and Children, Honolulu, Hawaii
Tripler Army Medical Center, Honolulu, Hawaii
Saint Luke's Cancer Institute - Boise, Boise, Idaho
Lurie Children's Hospital-Chicago, Chicago, Illinois
University of Illinois, Chicago, Illinois
University of Chicago Comprehensive Cancer Center, Chicago, Illinois
Loyola University Medical Center, Maywood, Illinois
Advocate Children's Hospital-Oak Lawn, Oak Lawn, Illinois
Advocate Children's Hospital-Park Ridge, Park Ridge, Illinois
Advocate Lutheran General Hospital, Park Ridge, Illinois
Saint Jude Midwest Affiliate, Peoria, Illinois
Southern Illinois University School of Medicine, Springfield, Illinois
Riley Hospital for Children, Indianapolis, Indiana
Ascension Saint Vincent Indianapolis Hospital, Indianapolis, Indiana
Blank Children's Hospital, Des Moines, Iowa
University of Iowa/Holden Comprehensive Cancer Center, Iowa City, Iowa
University of Kentucky/Markey Cancer Center, Lexington, Kentucky
Norton Children's Hospital, Louisville, Kentucky
Tulane University School of Medicine, New Orleans, Louisiana
Children's Hospital New Orleans, New Orleans, Louisiana
Ochsner Medical Center Jefferson, New Orleans, Louisiana
Eastern Maine Medical Center, Bangor, Maine
Maine Children's Cancer Program, Scarborough, Maine
University of Maryland/Greenebaum Cancer Center, Baltimore, Maryland
Sinai Hospital of Baltimore, Baltimore, Maryland
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland
Walter Reed National Military Medical Center, Bethesda, Maryland
Tufts Children's Hospital, Boston, Massachusetts
Massachusetts General Hospital Cancer Center, Boston, Massachusetts
Baystate Medical Center, Springfield, Massachusetts
UMass Memorial Medical Center - University Campus, Worcester, Massachusetts
C S Mott Children's Hospital, Ann Arbor, Michigan
Wayne State University/Karmanos Cancer Institute, Detroit, Michigan
Henry Ford Health Saint John Hospital, Detroit, Michigan
Michigan State University, East Lansing, Michigan
Hurley Medical Center, Flint, Michigan
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids, Michigan
Bronson Methodist Hospital, Kalamazoo, Michigan
Corewell Health Children's, Royal Oak, Michigan
Corewell Health William Beaumont University Hospital, Royal Oak, Michigan
Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis, Minnesota
University of Minnesota/Masonic Cancer Center, Minneapolis, Minnesota
Mayo Clinic in Rochester, Rochester, Minnesota
University of Mississippi Medical Center, Jackson, Mississippi
University of Missouri Children's Hospital, Columbia, Missouri
Children's Mercy Hospitals and Clinics, Kansas City, Missouri
Cardinal Glennon Children's Medical Center, Saint Louis, Missouri
Washington University School of Medicine, Saint Louis, Missouri
Mercy Hospital Saint Louis, Saint Louis, Missouri
Children's Hospital and Medical Center of Omaha, Omaha, Nebraska
University of Nebraska Medical Center, Omaha, Nebraska
University Medical Center of Southern Nevada, Las Vegas, Nevada
Sunrise Hospital and Medical Center, Las Vegas, Nevada
Alliance for Childhood Diseases/Cure 4 the Kids Foundation, Las Vegas, Nevada
Summerlin Hospital Medical Center, Las Vegas, Nevada
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon, New Hampshire
Hackensack University Medical Center, Hackensack, New Jersey
Saint Barnabas Medical Center, Livingston, New Jersey
Morristown Medical Center, Morristown, New Jersey
Saint Peter's University Hospital, New Brunswick, New Jersey
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick, New Jersey
Newark Beth Israel Medical Center, Newark, New Jersey
Saint Joseph's Regional Medical Center, Paterson, New Jersey
Overlook Hospital, Summit, New Jersey
University of New Mexico Cancer Center, Albuquerque, New Mexico
Albany Medical Center, Albany, New York
Montefiore Medical Center - Moses Campus, Bronx, New York
Roswell Park Cancer Institute, Buffalo, New York
NYU Langone Hospital - Long Island, Mineola, New York
The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park, New York
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York, New York
Mount Sinai Hospital, New York, New York
NYP/Weill Cornell Medical Center, New York, New York
University of Rochester, Rochester, New York
Stony Brook University Medical Center, Stony Brook, New York
State University of New York Upstate Medical University, Syracuse, New York
New York Medical College, Valhalla, New York
Mission Hospital, Asheville, North Carolina
UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina
Carolinas Medical Center/Levine Cancer Institute, Charlotte, North Carolina
Novant Health Presbyterian Medical Center, Charlotte, North Carolina
Duke University Medical Center, Durham, North Carolina
East Carolina University, Greenville, North Carolina
Wake Forest University Health Sciences, Winston-Salem, North Carolina
Sanford Broadway Medical Center, Fargo, North Dakota
Children's Hospital Medical Center of Akron, Akron, Ohio
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Rainbow Babies and Childrens Hospital, Cleveland, Ohio
Cleveland Clinic Foundation, Cleveland, Ohio
Nationwide Children's Hospital, Columbus, Ohio
Dayton Children's Hospital, Dayton, Ohio
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo, Ohio
Mercy Children's Hospital, Toledo, Ohio
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Natalie Warren Bryant Cancer Center at Saint Francis, Tulsa, Oklahoma
Legacy Emanuel Children's Hospital, Portland, Oregon
Oregon Health and Science University, Portland, Oregon
Lehigh Valley Hospital-Cedar Crest, Allentown, Pennsylvania
Lehigh Valley Hospital - Muhlenberg, Bethlehem, Pennsylvania
Geisinger Medical Center, Danville, Pennsylvania
Penn State Children's Hospital, Hershey, Pennsylvania
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Saint Christopher's Hospital for Children, Philadelphia, Pennsylvania
Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania
Rhode Island Hospital, Providence, Rhode Island
Medical University of South Carolina, Charleston, South Carolina
Prisma Health Richland Hospital, Columbia, South Carolina
BI-LO Charities Children's Cancer Center, Greenville, South Carolina
Greenville Cancer Treatment Center, Greenville, South Carolina
Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota
T C Thompson Children's Hospital, Chattanooga, Tennessee
East Tennessee Childrens Hospital, Knoxville, Tennessee
Saint Jude Children's Research Hospital, Memphis, Tennessee
The Children's Hospital at TriStar Centennial, Nashville, Tennessee
Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee
Texas Tech University Health Sciences Center-Amarillo, Amarillo, Texas
Dell Children's Medical Center of Central Texas, Austin, Texas
Driscoll Children's Hospital, Corpus Christi, Texas
Medical City Dallas Hospital, Dallas, Texas
UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas
El Paso Children's Hospital, El Paso, Texas
Cook Children's Medical Center, Fort Worth, Texas
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston, Texas
M D Anderson Cancer Center, Houston, Texas
Covenant Children's Hospital, Lubbock, Texas
UMC Cancer Center / UMC Health System, Lubbock, Texas
Vannie Cook Children's Clinic, McAllen, Texas
Children's Hospital of San Antonio, San Antonio, Texas
Methodist Children's Hospital of South Texas, San Antonio, Texas
University of Texas Health Science Center at San Antonio, San Antonio, Texas
Scott and White Memorial Hospital, Temple, Texas
Primary Children's Hospital, Salt Lake City, Utah
University of Vermont and State Agricultural College, Burlington, Vermont
University of Virginia Cancer Center, Charlottesville, Virginia
Inova Fairfax Hospital, Falls Church, Virginia
Children's Hospital of The King's Daughters, Norfolk, Virginia
Naval Medical Center - Portsmouth, Portsmouth, Virginia
VCU Massey Comprehensive Cancer Center, Richmond, Virginia
Carilion Children's, Roanoke, Virginia
Seattle Children's Hospital, Seattle, Washington
Providence Sacred Heart Medical Center and Children's Hospital, Spokane, Washington
Mary Bridge Children's Hospital and Health Center, Tacoma, Washington
Madigan Army Medical Center, Tacoma, Washington
West Virginia University Charleston Division, Charleston, West Virginia
West Virginia University Healthcare, Morgantown, West Virginia
Saint Vincent Hospital Cancer Center Green Bay, Green Bay, Wisconsin
University of Wisconsin Carbone Cancer Center - University Hospital, Madison, Wisconsin
Marshfield Medical Center-Marshfield, Marshfield, Wisconsin
Children's Hospital of Wisconsin, Milwaukee, Wisconsin
John Hunter Children's Hospital, Hunter Regional Mail Centre, New South Wales
Royal Brisbane and Women's Hospital, Herston, Queensland
Royal Children's Hospital-Brisbane, Herston, Queensland
Queensland Children's Hospital, South Brisbane, Queensland
Women's and Children's Hospital-Adelaide, North Adelaide, South Australia
Monash Medical Center-Clayton Campus, Clayton, Victoria
Royal Children's Hospital, Parkville, Victoria
Princess Margaret Hospital for Children, Perth, Western Australia
Perth Children's Hospital, Perth, Western Australia
Alberta Children's Hospital, Calgary, Alberta
University of Alberta Hospital, Edmonton, Alberta
British Columbia Children's Hospital, Vancouver, British Columbia
CancerCare Manitoba, Winnipeg, Manitoba
Janeway Child Health Centre, Saint John's, Newfoundland and Labrador
IWK Health Centre, Halifax, Nova Scotia
McMaster Children's Hospital at Hamilton Health Sciences, Hamilton, Ontario
Kingston Health Sciences Centre, Kingston, Ontario
Children's Hospital, London, Ontario
Children's Hospital of Eastern Ontario, Ottawa, Ontario
Hospital for Sick Children, Toronto, Ontario
The Montreal Children's Hospital of the MUHC, Montreal, Quebec
Allan Blair Cancer Centre, Regina, Saskatchewan
Saskatoon Cancer Centre, Saskatoon, Saskatchewan
Our Lady's Children's Hospital, Dublin, Co Dublin
Starship Children's Hospital, Grafton, Auckland
Christchurch Hospital, Christchurch, Not set
San Jorge Children's Hospital, San Juan, Not set
University Pediatric Hospital, San Juan, Not set
Swiss Pediatric Oncology Group - Geneva, Geneva, Not set
Swiss Pediatric Oncology Group - Lausanne, Lausanne, Not set
Conditions: B Acute Lymphoblastic Leukemia, Central Nervous System Leukemia, Testicular Leukemia, B Acute Lymphoblastic Leukemia, BCR-ABL1-Like
Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma
Recruiting
This phase III trial tests how well the addition of dinutuximab to Induction chemotherapy along with standard of care surgical resection of the primary tumor, radiation, stem cell transplantation, and immunotherapy works for treating children with newly diagnosed high-risk neuroblastoma. Dinutuximab is a monoclonal antibody that binds to a molecule called GD2, which is found on the surface of neuroblastoma cells, but is not present on many healthy or normal cells in the body. When dinutuximab bi... Read More
This phase III trial tests how well the addition of dinutuximab to Induction chemotherapy along with standard of care surgical resection of the primary tumor, radiation, stem cell transplantation, and immunotherapy works for treating children with newly diagnosed high-risk neuroblastoma. Dinutuximab is a monoclonal antibody that binds to a molecule called GD2, which is found on the surface of neuroblastoma cells, but is not present on many healthy or normal cells in the body. When dinutuximab binds to the neuroblastoma cells, it helps signal the immune system to kill the tumor cells. This helps the cells of the immune system kill the cancer cells, this is a type of immunotherapy. When chemotherapy and immunotherapy are given together, during the same treatment cycle, it is called chemoimmunotherapy. This clinical trial randomly assigns patients to receive either standard chemotherapy and surgery or chemoimmunotherapy (chemotherapy plus dinutuximab) and surgery during Induction therapy. Chemotherapy drugs administered during Induction include, cyclophosphamide, topotecan, cisplatin, etoposide, vincristine, and doxorubicin. These drugs work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing or by stopping them from spreading. Upon completion of 5 cycles of Induction therapy, a disease evaluation is completed to determine how well the treatment worked. If the tumor responds to therapy, patients receive a tandem transplantation with stem cell rescue. If the tumor has little improvement or worsens, patients receive chemoimmunotherapy on Extended Induction. During Extended Induction, dinutuximab is given with irinotecan, temozolomide. Patients with a good response to therapy move on to Consolidation therapy, when very high doses of chemotherapy are given at two separate points to kill any remaining cancer cells. Following, transplant, radiation therapy is given to the site where the cancer originated (primary site) and to any other areas that are still active at the end of Induction. The final stage of therapy is Post-Consolidation. During Post-Consolidation, dinutuximab is given with isotretinoin, with the goal of maintaining the response achieved with the previous therapy. Adding dinutuximab to Induction chemotherapy along with standard of care surgical resection of the primary tumor, radiation, stem cell transplantation, and immunotherapy may be better at treating children with newly diagnosed high-risk neuroblastoma. Read Less
Gender:
ALL
Ages:
30 years and below
Trial Updated:
08/19/2025
Locations: Children's Hospital of Alabama, Birmingham, Alabama +161 locations
Children's Hospital of Alabama, Birmingham, Alabama
USA Health Strada Patient Care Center, Mobile, Alabama
Banner Children's at Desert, Mesa, Arizona
Phoenix Childrens Hospital, Phoenix, Arizona
Banner University Medical Center - Tucson, Tucson, Arizona
Arkansas Children's Hospital, Little Rock, Arkansas
Kaiser Permanente Downey Medical Center, Downey, California
City of Hope Comprehensive Cancer Center, Duarte, California
Loma Linda University Medical Center, Loma Linda, California
Miller Children's and Women's Hospital Long Beach, Long Beach, California
Children's Hospital Los Angeles, Los Angeles, California
Cedars Sinai Medical Center, Los Angeles, California
Mattel Children's Hospital UCLA, Los Angeles, California
Valley Children's Hospital, Madera, California
UCSF Benioff Children's Hospital Oakland, Oakland, California
Kaiser Permanente-Oakland, Oakland, California
Children's Hospital of Orange County, Orange, California
Lucile Packard Children's Hospital Stanford University, Palo Alto, California
University of California Davis Comprehensive Cancer Center, Sacramento, California
UCSF Medical Center-Mission Bay, San Francisco, California
Children's Hospital Colorado, Aurora, Colorado
Connecticut Children's Medical Center, Hartford, Connecticut
Yale University, New Haven, Connecticut
Alfred I duPont Hospital for Children, Wilmington, Delaware
Children's National Medical Center, Washington, District of Columbia
Broward Health Medical Center, Fort Lauderdale, Florida
Golisano Children's Hospital of Southwest Florida, Fort Myers, Florida
University of Florida Health Science Center - Gainesville, Gainesville, Florida
Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood, Florida
Nemours Children's Clinic-Jacksonville, Jacksonville, Florida
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida
Nicklaus Children's Hospital, Miami, Florida
AdventHealth Orlando, Orlando, Florida
Arnold Palmer Hospital for Children, Orlando, Florida
Nemours Children's Hospital, Orlando, Florida
Johns Hopkins All Children's Hospital, Saint Petersburg, Florida
Saint Mary's Medical Center, West Palm Beach, Florida
Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta, Georgia
Lurie Children's Hospital-Chicago, Chicago, Illinois
University of Illinois, Chicago, Illinois
University of Chicago Comprehensive Cancer Center, Chicago, Illinois
Advocate Children's Hospital-Oak Lawn, Oak Lawn, Illinois
Advocate Children's Hospital-Park Ridge, Park Ridge, Illinois
Saint Jude Midwest Affiliate, Peoria, Illinois
Southern Illinois University School of Medicine, Springfield, Illinois
Riley Hospital for Children, Indianapolis, Indiana
Blank Children's Hospital, Des Moines, Iowa
University of Iowa/Holden Comprehensive Cancer Center, Iowa City, Iowa
Wesley Medical Center, Wichita, Kansas
University of Kentucky/Markey Cancer Center, Lexington, Kentucky
Children's Hospital New Orleans, New Orleans, Louisiana
Eastern Maine Medical Center, Bangor, Maine
Maine Children's Cancer Program, Scarborough, Maine
University of Maryland/Greenebaum Cancer Center, Baltimore, Maryland
Sinai Hospital of Baltimore, Baltimore, Maryland
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland
Massachusetts General Hospital Cancer Center, Boston, Massachusetts
Dana-Farber Cancer Institute, Boston, Massachusetts
C S Mott Children's Hospital, Ann Arbor, Michigan
Children's Hospital of Michigan, Detroit, Michigan
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids, Michigan
Bronson Methodist Hospital, Kalamazoo, Michigan
Corewell Health Children's, Royal Oak, Michigan
Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis, Minnesota
University of Minnesota/Masonic Cancer Center, Minneapolis, Minnesota
Mayo Clinic in Rochester, Rochester, Minnesota
University of Mississippi Medical Center, Jackson, Mississippi
Children's Mercy Hospitals and Clinics, Kansas City, Missouri
Washington University School of Medicine, Saint Louis, Missouri
Mercy Hospital Saint Louis, Saint Louis, Missouri
Children's Hospital and Medical Center of Omaha, Omaha, Nebraska
University of Nebraska Medical Center, Omaha, Nebraska
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon, New Hampshire
Hackensack University Medical Center, Hackensack, New Jersey
Morristown Medical Center, Morristown, New Jersey
Saint Peter's University Hospital, New Brunswick, New Jersey
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick, New Jersey
Saint Joseph's Regional Medical Center, Paterson, New Jersey
University of New Mexico Cancer Center, Albuquerque, New Mexico
Albany Medical Center, Albany, New York
Montefiore Medical Center - Moses Campus, Bronx, New York
Roswell Park Cancer Institute, Buffalo, New York
NYU Langone Hospital - Long Island, Mineola, New York
The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park, New York
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York, New York
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York, New York
University of Rochester, Rochester, New York
New York Medical College, Valhalla, New York
Mission Hospital, Asheville, North Carolina
UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina
Carolinas Medical Center/Levine Cancer Institute, Charlotte, North Carolina
Novant Health Presbyterian Medical Center, Charlotte, North Carolina
Duke University Medical Center, Durham, North Carolina
East Carolina University, Greenville, North Carolina
Wake Forest University Health Sciences, Winston-Salem, North Carolina
Sanford Broadway Medical Center, Fargo, North Dakota
Children's Hospital Medical Center of Akron, Akron, Ohio
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Rainbow Babies and Childrens Hospital, Cleveland, Ohio
Cleveland Clinic Foundation, Cleveland, Ohio
Nationwide Children's Hospital, Columbus, Ohio
Dayton Children's Hospital, Dayton, Ohio
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo, Ohio
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Natalie Warren Bryant Cancer Center at Saint Francis, Tulsa, Oklahoma
Legacy Emanuel Children's Hospital, Portland, Oregon
Oregon Health and Science University, Portland, Oregon
Geisinger Medical Center, Danville, Pennsylvania
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Saint Christopher's Hospital for Children, Philadelphia, Pennsylvania
Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania
Rhode Island Hospital, Providence, Rhode Island
Medical University of South Carolina, Charleston, South Carolina
Prisma Health Richland Hospital, Columbia, South Carolina
BI-LO Charities Children's Cancer Center, Greenville, South Carolina
Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota
East Tennessee Childrens Hospital, Knoxville, Tennessee
Saint Jude Children's Research Hospital, Memphis, Tennessee
The Children's Hospital at TriStar Centennial, Nashville, Tennessee
Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee
Dell Children's Medical Center of Central Texas, Austin, Texas
Driscoll Children's Hospital, Corpus Christi, Texas
Medical City Dallas Hospital, Dallas, Texas
UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas
El Paso Children's Hospital, El Paso, Texas
Cook Children's Medical Center, Fort Worth, Texas
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston, Texas
M D Anderson Cancer Center, Houston, Texas
Covenant Children's Hospital, Lubbock, Texas
UMC Cancer Center / UMC Health System, Lubbock, Texas
Children's Hospital of San Antonio, San Antonio, Texas
Methodist Children's Hospital of South Texas, San Antonio, Texas
University of Texas Health Science Center at San Antonio, San Antonio, Texas
Primary Children's Hospital, Salt Lake City, Utah
University of Virginia Cancer Center, Charlottesville, Virginia
Naval Medical Center - Portsmouth, Portsmouth, Virginia
Seattle Children's Hospital, Seattle, Washington
Providence Sacred Heart Medical Center and Children's Hospital, Spokane, Washington
Mary Bridge Children's Hospital and Health Center, Tacoma, Washington
University of Wisconsin Carbone Cancer Center - University Hospital, Madison, Wisconsin
Marshfield Medical Center-Marshfield, Marshfield, Wisconsin
Children's Hospital of Wisconsin, Milwaukee, Wisconsin
Sydney Children's Hospital, Randwick, New South Wales
The Children's Hospital at Westmead, Westmead, New South Wales
Queensland Children's Hospital, South Brisbane, Queensland
Royal Children's Hospital, Parkville, Victoria
Perth Children's Hospital, Perth, Western Australia
Alberta Children's Hospital, Calgary, Alberta
University of Alberta Hospital, Edmonton, Alberta
British Columbia Children's Hospital, Vancouver, British Columbia
CancerCare Manitoba, Winnipeg, Manitoba
IWK Health Centre, Halifax, Nova Scotia
McMaster Children's Hospital at Hamilton Health Sciences, Hamilton, Ontario
Children's Hospital, London, Ontario
Children's Hospital of Eastern Ontario, Ottawa, Ontario
Hospital for Sick Children, Toronto, Ontario
The Montreal Children's Hospital of the MUHC, Montreal, Quebec
Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont, Sherbrooke, Quebec
Jim Pattison Children's Hospital, Saskatoon, Saskatchewan
CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL), Quebec, Not set
Starship Children's Hospital, Grafton, Auckland
Conditions: Neuroblastoma, Ganglioneuroblastoma, Nodular
A Study to Evaluate the Efficacy and Safety of JCAR017 in Adult Subjects With Relapsed or Refractory Indolent B-cell Non-Hodgkin Lymphoma (NHL)
Recruiting
This is a global Phase 2, open-label, single-arm, multicohort, multicenter study to evaluate efficacy and safety of JCAR017 in adult subjects with r/r FL or MZL.
The study will be conducted in compliance with the International Council on Harmonisation (ICH) of Technical Requirements for Registration of Pharmaceuticals for Human Use/Good Clinical Practice (GCP) and applicable regulatory requirements.
This study is divided into three periods:
* Pretreatment, which consists of screening assessme... Read More
This is a global Phase 2, open-label, single-arm, multicohort, multicenter study to evaluate efficacy and safety of JCAR017 in adult subjects with r/r FL or MZL.
The study will be conducted in compliance with the International Council on Harmonisation (ICH) of Technical Requirements for Registration of Pharmaceuticals for Human Use/Good Clinical Practice (GCP) and applicable regulatory requirements.
This study is divided into three periods:
* Pretreatment, which consists of screening assessments, leukapheresis and the Pretreatment evaluation;
* Treatment, which starts with the administration of lymphodepleting (LD) chemotherapy and continues through JCAR017 administration at Day 1 with follow-up through Day 29;
* Posttreatment, which includes follow-up assessments for disease status and safety for 5 years. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/19/2025
Locations: UCLA Medical Centre-Santa Monica, Santa Monica, California +58 locations
UCLA Medical Centre-Santa Monica, Santa Monica, California
University Of Colorado Cancer Center, Aurora, Colorado
Yale Cancer Center, New Haven, Connecticut
Local Institution - 0601, Hollywood, Florida
Washington University School Of Medicine, Miami, Florida
Northwestern University, Chicago, Illinois
Local Institution - 109, Niles, Illinois
University Of Iowa, Iowa City, Iowa
Cancer Center of Kansas, Wichita, Kansas
University of Maryland - Greenebaum Comprehensive Cancer Center, Baltimore, Maryland
Massachusetts General Hospital - Dana-Farber Cancer Institute, Boston, Massachusetts
Beth Israel Deaconess Medical Center, Boston, Massachusetts
Karmanos Cancer Center, Detroit, Michigan
Local Institution - 118, Detroit, Michigan
Atlantic Health System Morristown Medical Center, Morristown, New Jersey
Memorial Sloan Kettering Cancer Center, New York, New York
Novant Health Presbyterian Medical Center, Charlotte, North Carolina
Local Institution - 120, Fargo, North Dakota
Cleveland Clinic Foundation, Cleveland, Ohio
Providence Cancer Center/Earle A. Chiles Res. Inst., Portland, Oregon
University of Pennsylvania - Perelman Center for Advanced Medicine, Philadelphia, Pennsylvania
Local Institution - 126, Pittsburgh, Pennsylvania
Local Institution - 113, Sioux Falls, South Dakota
Local Institution - 125, Knoxville, Tennessee
Texas Oncology, Dallas, Texas
Houston Methodist Hospital, Houston, Texas
The University of Texas - MD Anderson Cancer Center, Houston, Texas
University Of Virginia Health System, Charlottesville, Virginia
Fred Hutchinson Cancer Center, Seattle, Washington
Allgemeinen Krankenhaus (AKH) Wien - Medizinische Universitaet Wien, Wien, Not set
Princess Margaret Cancer Centre, Toronto, Ontario
Hopital Maisonneuve - Rosemont, Montreal, Quebec
CHRU-Hopital Claude Huriez, Lille, Not set
CHU Montpellier - Hôpital Saint Eloi, Montpellier CEDEX 5, Not set
Hopital Saint Louis, Paris Cedex 10, Not set
Centre Hospitalier Lyon-Sud, Pierre-Benite CEDEX, Not set
Centre Hospitalier Universitaire de Rennes - Hopital Pontchaillou, Rennes Cedex 02, Not set
Institut Universitaire du Cancer Toulouse - Oncopole - CHU de TOULOUSE, Toulouse, Not set
Universitaetsklinikum Ulm, Ulm, Baden-Wurttemberg
Universitätsklinikum Regensburg, Regensburg, Bayern
Local Institution - 506, Berlin, Not set
Local Institution - 503, Karlsruhe, Not set
Local Institution - 505, Kiel, Not set
University Hospital Cologne, Köln, Not set
LMU Klinikum der Universitat Munchen, Munich, Not set
Azienda Ospedaliera Papa Giovanni Xxiii, Bergamo, Not set
Local Institution - 302, Bologna, Not set
Istituto Nazionale Per Lo Studio E La Cura Dei Tumori Fondazione Giovanni Pascale, Naples, Not set
Local Institution - 553, Sapporo-shi, Hokkaido
Local Institution - 550, Chuo-ku, Tokyo
Local Institution - 551, Minato-ku, Tokyo
Local Institution - 552, Fukuoka, Not set
Local Institution - 352, Barcelona, Not set
Hospital General Universitario Gregorio Marañon, Madrid, Not set
Hospital Universitario de Salamanca - Complejo Asistencial Universitario de Salamanca, Salamanca, Not set
Hospital Virgen Del Rocio, Sevilla, Not set
Karolinska Hospital, Stockholm, Not set
University College London Hospitals NHS Foundation Trust - University College Hospital, London, Not set
The Christie NHS Foundation Trust, Manchester, Not set
Conditions: Lymphoma, Non-Hodgkin
A Study to Compare the Efficacy and Safety of BMS-986393 Versus Standard Regimens in Adult Participants With Relapsed or Refractory and Lenalidomide-exposed Multiple Myeloma (QUINTESSENTIAL-2)
Recruiting
The purpose of this study is to compare the efficacy and safety of arlo-cel (BMS-986393) versus standard regimens in adult participants with Relapsed or Refractory and Lenalidomide-exposed Multiple Myeloma.
The purpose of this study is to compare the efficacy and safety of arlo-cel (BMS-986393) versus standard regimens in adult participants with Relapsed or Refractory and Lenalidomide-exposed Multiple Myeloma. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/19/2025
Locations: Local Institution - 0071, Birmingham, Alabama +123 locations
Local Institution - 0071, Birmingham, Alabama
UCLA Hematology/Oncology - Santa Monica, Los Angeles, California
Local Institution - 0130, Miami, Florida
Winship Cancer Institute, Emory University, Atlanta, Georgia
Local Institution - 0218, Shreveport, Louisiana
Local Institution - 0196, Boston, Massachusetts
Local Institution - 0067, Charlotte, North Carolina
Local Institution - 0216, Winston-Salem, North Carolina
Local Institution - 0193, Cleveland, Ohio
Fox Chase Cancer Center, Philadelphia, Pennsylvania
Local Institution - 0044, Salt Lake City, Utah
Local Institution - 0195, Milwaukee, Wisconsin
Hospital Italiano de Buenos Aires, ABB, Ciudad Autónoma De Buenos Aires
Local Institution - 0214, ABB, Ciudad Autónoma De Buenos Aires
Hospital Aleman, Buenos Aires, Ciudad Autónoma De Buenos Aires
Royal Prince Alfred Hospital, Camperdown, New South Wales
Local Institution - 0190, Liverpool, New South Wales
Local Institution - 0140, Brisbane, Queensland
Royal Adelaide Hospital, Adelaide, South Australia
Monash Health, Clayton, Victoria
Peter MacCallum Cancer Centre, Melbourne, Victoria
Local Institution - 0191, Melbourne, Victoria
Fiona Stanley Hospital, Murdoch, Western Australia
Ordensklinikum Linz GmbH Elisabethinen, Linz, Oberösterreich
Hanusch-Krankenhaus, Vienna, Not set
Local Institution - 0220, Edegem, Antwerpen
Local Institution - 0217, Brussels, Bruxelles-Capitale, Région De
Université Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant-Godinne - Site Godinne, Yvoir, Namur
UZ Gent, Gent, Oost-Vlaanderen
Local Institution - 0012, Nova Lima, Minas Gerais
Local Institution - 0103, São Paulo, SAO Paulo
Local Institution - 0013, Sao Paulo, São Paulo
Local Institution - 0031, São Paulo, Not set
Local Institution - 0069, Calgary, Alberta
Vancouver General Hospital, Vancouver, British Columbia
QEII Health Sciences Centre - Victoria General Site, Halifax, Nova Scotia
Local Institution - 0192, Hamilton, Ontario
CIUSSS de l'Est-de-l'Île-de-Montréal, Montreal, Quebec
Fakultní nemocnice Brno Bohunice, Brno, Brno-město
Local Institution - 0093, Hradec Kralove, Hradec Králové
Vseobecna fakultni nemocnice v Praze, Praha 2, Not set
Rigshospitalet, Copenhagen, Hovedstaden
Aarhus Universitetshospital, Skejby, Aarhus, Midtjylland
Local Institution - 0208, Roskilde, Sjælland
Odense Universitetshospital, Odense, Syddanmark
Helsinki University Hospital - Comprehensive Cancer Center (HYKS - Syöpäkeskus), Helsinki, Uusimaa
Hopital Claude Huriez - CHU de Lille, Lille, Nord
Local Institution - 0194, Nantes, Pays-de-la-Loire
Centre Hospitalier Lyon Sud, Pierre-Bénite, Rhône
Henri Mondor Hospital, Creteil, Val-de-Marne
Local Institution - 0210, Paris, Not set
TUM Universitätsklinikum, Technische Universität München, Munich, Bayern
Medizinische Hochschule Hannover, Hannover, Niedersachsen
Local Institution - 0211, Magdeburg, Sachsen-Anhalt
Local Institution - 0204, Chemnitz, Sachsen
Universitätsklinikum Leipzig, Leipzig, Sachsen
Local Institution - 0212, Kiel, Schleswig-Holstein
Local Institution - 0213, Berlin, Not set
Universitaetsklinikum Hamburg-Eppendorf, Hamburg, Not set
Universitaetsklinikum Heidelberg, Heidelberg, Not set
Klinikum Nuernberg Nord, Nuremberg, Not set
Universitaetsklinikum Wuerzburg, Wuerzburg, Not set
University Hospital of Patras, Patras, Achaḯa
Evangelismos General Hospital of Athens, Athens, Attikí
Local Institution - 0115, Chaidari, Attikí
Local Institution - 0125, Budapest, Not set
Sheba Medical Center, Ramat Gan, HaMerkaz
Sourasky Medical Center, Tel Aviv, Tell Abīb
Hadassah Medical Center, Jerusalem, Yerushalayim
Local Institution - 0107, Milan, Lombardia
Istituto Clinico Humanitas, Rozzano, Milano
Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Torino, Piemonte
IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola, Bologna, Not set
Local Institution - 0119, Genova, Not set
Local Institution - 0106, Udine, Not set
Nagoya City University Hospital, Nagoya, Aichi
Local Institution - 0105, Kashiwa, Chiba
Hyogo Medical University Hospital, Nishinomiya, Hyogo
Kanazawa University Hospital, Kanazawa, Ishikawa
Kyushu University Hospital, Fukuoka, Not set
Kumamoto University Hospital, Kumamoto, Not set
National Hospital Organization Okayama Medical Center, Okayama, Not set
Osaka Red Cross Hospital, Osaka, Not set
Japanese Red Cross Medical Center, Tokyo, Not set
Yamagata University Hospital, Yamagata, Not set
Local Institution - 0147, Seoul, Seoul-teukbyeolsi [Seoul]
Local Institution - 0146, Seoul, Seoul-teukbyeolsi [Seoul]
Local Institution - 0148, Seoul, Seoul-teukbyeolsi [Seoul]
Local Institution - 0149, Seoul, Seoul-teukbyeolsi [Seoul]
Local Institution - 0176, Nijmegen, Gelderland
Maastricht UMC+, Maastricht, Limburg
Local Institution - 0179, Amsterdam, Noord-Holland
Universitair Medisch Centrum Utrecht, Utrecht, Not set
Oslo Universitetssykehus Ullevål, Oslo, Not set
Centrum Onkologii Ziemi Lubelskiej, Lublin, Lubelskie
Uniwersyteckie Centrum Kliniczne, Gdańsk, Pomorskie
Local Institution - 0084, Katowice, Not set
Local Institution - 0183, Łódź, Łódzkie
Instituto Português de Oncologia do Porto Francisco Gentil, EPE, Porto, Not set
Fundeni Clinical Institute, Bucuresti, București
Institutul Regional de Oncologie, Iași, Not set
Local Institution - 0178, Riyadh, Not set
Local Institution - 0180, Singapore, Central Singapore
Local Institution - 0181, Singapore, Central Singapore
CHUS - Hospital Clinico Universitario, Santiago de Compostela, A Coruña [La Coruña]
Local Institution - 0203, Palma, Balears [Baleares]
Local Institution - 0201, Badalona, Barcelona [Barcelona]
Clinica Universidad de Navarra, Pamplona, Navarra
Local Institution - 0202, Granada, Not set
Hospital Universitario de Salamanca - Complejo Asistencial Universitario de Salamanca, Salamanca, Not set
Local Institution - 0023, Lund, Skåne Län [se-12]
Karolinska Universitetssjukhuset Huddinge, Huddinge, Not set
Inselspital Bern, Bern, Berne
Cantonal Hospital St.Gallen, st.Gallen, Sankt Gallen
Local Institution - 0150, Taipei City, Taipei
Local Institution - 0151, Taichung, Not set
Local Institution - 0152, Taipei, Not set
Local Institution - 0200, Taipei, Not set
Local Institution - 0170, Ankara, Not set
Addenbrooke's Hospital, Cambridge, Cambridgeshire
Local Institution - 0155, London, London, City Of
Local Institution - 0157, Oxford, Oxfordshire
The Christie NHS Foundation Trust, Manchester, Not set
Freeman Hospital, Newcastle upon Tyne, Not set
Conditions: Relapsed or Refractory Multiple Myeloma (RRMM)
A Phase III Trial Comparing Tisagenlecleucel to Standard of Care (SoC) in Adult Participants With r/r Follicular Lymphoma
Recruiting
This trial will compare tisagenlecleucel to standard of care in adult participants with relapsed or refractory (r/r) follicular lymphoma.
This trial will compare tisagenlecleucel to standard of care in adult participants with relapsed or refractory (r/r) follicular lymphoma. Read Less
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
08/18/2025
Locations: TRIHEALTH Good Samarithan Hospital, Cincinnati, Ohio +35 locations
TRIHEALTH Good Samarithan Hospital, Cincinnati, Ohio
VA Tennessee Valley Healthcare System, Nashville, Tennessee
Novartis Investigative Site, Camperdown, New South Wales
Novartis Investigative Site, Clayton, Victoria
Novartis Investigative Site, Melbourne, Victoria
Novartis Investigative Site, Nedlands, Western Australia
Novartis Investigative Site, Linz, Not set
Novartis Investigative Site, Salzburg, Not set
Novartis Investigative Site, Toronto, Ontario
Novartis Investigative Site, Montreal, Quebec
Novartis Investigative Site, Ostrava, Poruba
Novartis Investigative Site, Budapest, Not set
Novartis Investigative Site, Seoul, Not set
Novartis Investigative Site, Seoul, Not set
Novartis Investigative Site, Seoul, Not set
Novartis Investigative Site, Seoul, Not set
Novartis Investigative Site, Seoul, Not set
Novartis Investigative Site, Gliwice, Slaskie
Novartis Investigative Site, Poznan, Wielkopolskie
Novartis Investigative Site, Gdansk, Not set
Novartis Investigative Site, Lodz, Not set
Novartis Investigative Site, Bucharest, Not set
Novartis Investigative Site, Singapore, Not set
Novartis Investigative Site, Bratislava, Not set
Novartis Investigative Site, Hospitalet de LLobregat, Barcelona
Novartis Investigative Site, Santander, Cantabria
Novartis Investigative Site, Salamanca, Castilla Y Leon
Novartis Investigative Site, Barcelona, Catalunya
Novartis Investigative Site, Santiago De Compostela, Galicia
Novartis Investigative Site, El Palmar, Murcia
Novartis Investigative Site, Barcelona, Not set
Novartis Investigative Site, Cordoba, Not set
Novartis Investigative Site, Madrid, Not set
Novartis Investigative Site, Kaohsiung, Not set
Novartis Investigative Site, Taichung, Not set
Novartis Investigative Site, Taipei, Not set
Conditions: Follicular Lymphoma (FL)
A Study to Compare Standard Therapy to Treat Hodgkin Lymphoma to the Use of Two Drugs, Brentuximab Vedotin and Nivolumab
Recruiting
This phase III trial compares the effect of adding immunotherapy (brentuximab vedotin and nivolumab) to standard treatment (chemotherapy with or without radiation) to the standard treatment alone in improving survival in patients with stage I and II classical Hodgkin lymphoma. Brentuximab vedotin is in a class of medications called antibody-drug conjugates. It is made of a monoclonal antibody called brentuximab that is linked to a cytotoxic agent called vedotin. Brentuximab attaches to CD30 posi... Read More
This phase III trial compares the effect of adding immunotherapy (brentuximab vedotin and nivolumab) to standard treatment (chemotherapy with or without radiation) to the standard treatment alone in improving survival in patients with stage I and II classical Hodgkin lymphoma. Brentuximab vedotin is in a class of medications called antibody-drug conjugates. It is made of a monoclonal antibody called brentuximab that is linked to a cytotoxic agent called vedotin. Brentuximab attaches to CD30 positive lymphoma cells in a targeted way and delivers vedotin to kill them. A monoclonal antibody is a type of protein that can bind to certain targets in the body, such as molecules that cause the body to make an immune response (antigens). Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Chemotherapy drugs such as doxorubicin hydrochloride, bleomycin sulfate, vinblastine sulfate, dacarbazine, and procarbazine hydrochloride work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Cyclophosphamide is in a class of medications called alkylating agents. It works by damaging the cell's deoxyribonucleic acid (DNA) and may kill cancer cells. It may also lower the body's immune response. Etoposide is in a class of medications known as podophyllotoxin derivatives. It blocks a certain enzyme needed for cell division and DNA repair and may kill cancer cells. Vincristine is in a class of medications called vinca alkaloids. It works by stopping cancer cells from growing and dividing and may kill them. Prednisone is in a class of medications called corticosteroids. It is used to reduce inflammation and lower the body's immune response to help lessen the side effects of chemotherapy drugs. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Adding immunotherapy to the standard treatment of chemotherapy with or without radiation may increase survival and/or fewer short-term or long-term side effects in patients with classical Hodgkin lymphoma compared to the standard treatment alone. Read Less
Gender:
ALL
Ages:
Between 5 years and 60 years
Trial Updated:
08/16/2025
Locations: Children's Hospital of Alabama, Birmingham, Alabama +352 locations
Children's Hospital of Alabama, Birmingham, Alabama
USA Health Strada Patient Care Center, Mobile, Alabama
Providence Alaska Medical Center, Anchorage, Alaska
CTCA at Western Regional Medical Center, Goodyear, Arizona
Phoenix Childrens Hospital, Phoenix, Arizona
Arkansas Children's Hospital, Little Rock, Arkansas
City of Hope Corona, Corona, California
Kaiser Permanente Downey Medical Center, Downey, California
City of Hope Comprehensive Cancer Center, Duarte, California
Kaiser Permanente Dublin, Dublin, California
Kaiser Permanente-Fremont, Fremont, California
Kaiser Permanente-Fresno, Fresno, California
City of Hope Seacliff, Huntington Beach, California
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine, California
City of Hope at Irvine Lennar, Irvine, California
City of Hope Antelope Valley, Lancaster, California
Loma Linda University Medical Center, Loma Linda, California
Miller Children's and Women's Hospital Long Beach, Long Beach, California
City of Hope at Long Beach Elm, Long Beach, California
Children's Hospital Los Angeles, Los Angeles, California
Cedars Sinai Medical Center, Los Angeles, California
Kaiser Permanente-Modesto, Modesto, California
City of Hope Newport Beach, Newport Beach, California
Kaiser Permanente-Oakland, Oakland, California
Children's Hospital of Orange County, Orange, California
UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange, California
Kaiser Permanente Downtown Commons, Sacramento, California
Kaiser Permanente-South Sacramento, Sacramento, California
Rady Children's Hospital - San Diego, San Diego, California
Naval Medical Center -San Diego, San Diego, California
Kaiser Permanente-San Francisco, San Francisco, California
Kaiser Permanente-Santa Teresa-San Jose, San Jose, California
Kaiser Permanente San Leandro, San Leandro, California
Kaiser San Rafael-Gallinas, San Rafael, California
Kaiser Permanente-Santa Rosa, Santa Rosa, California
City of Hope South Pasadena, South Pasadena, California
Kaiser Permanente-South San Francisco, South San Francisco, California
City of Hope South Bay, Torrance, California
City of Hope Upland, Upland, California
Kaiser Permanente-Vallejo, Vallejo, California
Kaiser Permanente-Walnut Creek, Walnut Creek, California
Children's Hospital Colorado, Aurora, Colorado
Smilow Cancer Hospital-Derby Care Center, Derby, Connecticut
Smilow Cancer Hospital Care Center-Fairfield, Fairfield, Connecticut
Smilow Cancer Hospital Care Center at Glastonbury, Glastonbury, Connecticut
Smilow Cancer Hospital Care Center at Greenwich, Greenwich, Connecticut
Smilow Cancer Hospital Care Center - Guilford, Guilford, Connecticut
Smilow Cancer Hospital Care Center at Saint Francis, Hartford, Connecticut
Connecticut Children's Medical Center, Hartford, Connecticut
Yale University, New Haven, Connecticut
Yale-New Haven Hospital North Haven Medical Center, North Haven, Connecticut
Smilow Cancer Hospital Care Center at Long Ridge, Stamford, Connecticut
Smilow Cancer Hospital-Torrington Care Center, Torrington, Connecticut
Smilow Cancer Hospital Care Center-Trumbull, Trumbull, Connecticut
Smilow Cancer Hospital-Waterbury Care Center, Waterbury, Connecticut
Smilow Cancer Hospital Care Center - Waterford, Waterford, Connecticut
Alfred I duPont Hospital for Children, Wilmington, Delaware
MedStar Georgetown University Hospital, Washington, District of Columbia
Children's National Medical Center, Washington, District of Columbia
Broward Health Medical Center, Fort Lauderdale, Florida
Golisano Children's Hospital of Southwest Florida, Fort Myers, Florida
University of Florida Health Science Center - Gainesville, Gainesville, Florida
Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood, Florida
Nemours Children's Clinic-Jacksonville, Jacksonville, Florida
Nicklaus Children's Hospital, Miami, Florida
AdventHealth Orlando, Orlando, Florida
Arnold Palmer Hospital for Children, Orlando, Florida
Nemours Children's Hospital, Orlando, Florida
Nemours Children's Clinic - Pensacola, Pensacola, Florida
Sacred Heart Hospital, Pensacola, Florida
Johns Hopkins All Children's Hospital, Saint Petersburg, Florida
Tampa General Hospital, Tampa, Florida
Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa, Florida
Saint Mary's Medical Center, West Palm Beach, Florida
Grady Health System, Atlanta, Georgia
Emory Proton Therapy Center, Atlanta, Georgia
Emory University Hospital Midtown, Atlanta, Georgia
Emory University Hospital/Winship Cancer Institute, Atlanta, Georgia
Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta, Georgia
Emory Saint Joseph's Hospital, Atlanta, Georgia
Augusta University Medical Center, Augusta, Georgia
Atrium Health Navicent, Macon, Georgia
Kapiolani Medical Center for Women and Children, Honolulu, Hawaii
Saint Luke's Cancer Institute - Boise, Boise, Idaho
Saint Luke's Cancer Institute - Fruitland, Fruitland, Idaho
Saint Luke's Cancer Institute - Meridian, Meridian, Idaho
Saint Luke's Cancer Institute - Nampa, Nampa, Idaho
Saint Luke's Cancer Institute - Twin Falls, Twin Falls, Idaho
Rush-Copley Medical Center, Aurora, Illinois
Advocate Good Shepherd Hospital, Barrington, Illinois
Mount Sinai Hospital Medical Center, Chicago, Illinois
Lurie Children's Hospital-Chicago, Chicago, Illinois
Northwestern University, Chicago, Illinois
University of Illinois, Chicago, Illinois
University of Chicago Comprehensive Cancer Center, Chicago, Illinois
Advocate Illinois Masonic Medical Center, Chicago, Illinois
AMG Crystal Lake - Oncology, Crystal Lake, Illinois
Carle at The Riverfront, Danville, Illinois
Decatur Memorial Hospital, Decatur, Illinois
Northwestern Medicine Cancer Center Kishwaukee, DeKalb, Illinois
Advocate Good Samaritan Hospital, Downers Grove, Illinois
Carle Physician Group-Effingham, Effingham, Illinois
Crossroads Cancer Center, Effingham, Illinois
Advocate Sherman Hospital, Elgin, Illinois
Elmhurst Memorial Hospital, Elmhurst, Illinois
Northwestern Medicine Cancer Center Delnor, Geneva, Illinois
Northwestern Medicine Glenview Outpatient Center, Glenview, Illinois
Northwestern Medicine Grayslake Outpatient Center, Grayslake, Illinois
Advocate South Suburban Hospital, Hazel Crest, Illinois
Northwestern Medicine Lake Forest Hospital, Lake Forest, Illinois
AMG Libertyville - Oncology, Libertyville, Illinois
Condell Memorial Hospital, Libertyville, Illinois
Carle Physician Group-Mattoon/Charleston, Mattoon, Illinois
Loyola University Medical Center, Maywood, Illinois
Edward Hospital/Cancer Center, Naperville, Illinois
HSHS Saint Elizabeth's Hospital, O'Fallon, Illinois
Advocate Christ Medical Center, Oak Lawn, Illinois
Advocate Children's Hospital-Oak Lawn, Oak Lawn, Illinois
Northwestern Medicine Orland Park, Orland Park, Illinois
Advocate Children's Hospital-Park Ridge, Park Ridge, Illinois
Advocate Lutheran General Hospital, Park Ridge, Illinois
Saint Jude Midwest Affiliate, Peoria, Illinois
Edward Hospital/Cancer Center?Plainfield, Plainfield, Illinois
UW Health Carbone Cancer Center Rockford, Rockford, Illinois
Memorial Hospital East, Shiloh, Illinois
Southern Illinois University School of Medicine, Springfield, Illinois
Carle Cancer Center, Urbana, Illinois
Northwestern Medicine Cancer Center Warrenville, Warrenville, Illinois
Rush-Copley Healthcare Center, Yorkville, Illinois
Riley Hospital for Children, Indianapolis, Indiana
Ascension Saint Vincent Indianapolis Hospital, Indianapolis, Indiana
UI Health Care Mission Cancer and Blood - Ankeny Clinic, Ankeny, Iowa
UI Health Care Mission Cancer and Blood - West Des Moines Clinic, Clive, Iowa
Blank Children's Hospital, Des Moines, Iowa
Iowa Methodist Medical Center, Des Moines, Iowa
UI Health Care Mission Cancer and Blood - Des Moines Clinic, Des Moines, Iowa
UI Health Care Mission Cancer and Blood - Laurel Clinic, Des Moines, Iowa
University of Iowa/Holden Comprehensive Cancer Center, Iowa City, Iowa
UI Health Care Mission Cancer and Blood - Waukee Clinic, Waukee, Iowa
Wesley Medical Center, Wichita, Kansas
University of Kentucky/Markey Cancer Center, Lexington, Kentucky
Norton Children's Hospital, Louisville, Kentucky
The James Graham Brown Cancer Center at University of Louisville, Louisville, Kentucky
UofL Health Medical Center Northeast, Louisville, Kentucky
Children's Hospital New Orleans, New Orleans, Louisiana
Ochsner Medical Center Jefferson, New Orleans, Louisiana
Eastern Maine Medical Center, Bangor, Maine
Maine Children's Cancer Program, Scarborough, Maine
University of Maryland/Greenebaum Cancer Center, Baltimore, Maryland
Sinai Hospital of Baltimore, Baltimore, Maryland
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland
Dana-Farber Cancer Institute, Boston, Massachusetts
UMass Memorial Medical Center - University Campus, Worcester, Massachusetts
Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor, Michigan
C S Mott Children's Hospital, Ann Arbor, Michigan
Bronson Battle Creek, Battle Creek, Michigan
Trinity Health IHA Medical Group Hematology Oncology - Brighton, Brighton, Michigan
Trinity Health IHA Medical Group Hematology Oncology - Canton, Canton, Michigan
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital, Chelsea, Michigan
Corewell Health Dearborn Hospital, Dearborn, Michigan
Children's Hospital of Michigan, Detroit, Michigan
Wayne State University/Karmanos Cancer Institute, Detroit, Michigan
Henry Ford Hospital, Detroit, Michigan
Michigan State University, East Lansing, Michigan
Weisberg Cancer Treatment Center, Farmington Hills, Michigan
Corewell Health Farmington Hills Hospital, Farmington Hills, Michigan
Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids, Michigan
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids, Michigan
Trinity Health Grand Rapids Hospital, Grand Rapids, Michigan
Bronson Methodist Hospital, Kalamazoo, Michigan
West Michigan Cancer Center, Kalamazoo, Michigan
Beacon Kalamazoo Cancer Center, Kalamazoo, Michigan
Trinity Health Saint Mary Mercy Livonia Hospital, Livonia, Michigan
Trinity Health Muskegon Hospital, Muskegon, Michigan
Cancer and Hematology Centers of Western Michigan - Norton Shores, Norton Shores, Michigan
Henry Ford Medical Center-Columbus, Novi, Michigan
Corewell Health Reed City Hospital, Reed City, Michigan
Corewell Health Children's, Royal Oak, Michigan
Corewell Health William Beaumont University Hospital, Royal Oak, Michigan
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center, Saint Joseph, Michigan
Munson Medical Center, Traverse City, Michigan
Corewell Health Beaumont Troy Hospital, Troy, Michigan
University of Michigan Health - West, Wyoming, Michigan
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus, Ypsilanti, Michigan
Mercy Hospital, Coon Rapids, Minnesota
Fairview Southdale Hospital, Edina, Minnesota
Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis, Minnesota
Abbott-Northwestern Hospital, Minneapolis, Minnesota
University of Minnesota/Masonic Cancer Center, Minneapolis, Minnesota
Mayo Clinic in Rochester, Rochester, Minnesota
Park Nicollet Clinic - Saint Louis Park, Saint Louis Park, Minnesota
Regions Hospital, Saint Paul, Minnesota
United Hospital, Saint Paul, Minnesota
University of Mississippi Medical Center, Jackson, Mississippi
Saint Luke's Hospital, Chesterfield, Missouri
Siteman Cancer Center at West County Hospital, Creve Coeur, Missouri
Children's Mercy Hospitals and Clinics, Kansas City, Missouri
Cardinal Glennon Children's Medical Center, Saint Louis, Missouri
Washington University School of Medicine, Saint Louis, Missouri
Siteman Cancer Center-South County, Saint Louis, Missouri
Siteman Cancer Center at Christian Hospital, Saint Louis, Missouri
Mercy Hospital Saint Louis, Saint Louis, Missouri
Siteman Cancer Center at Saint Peters Hospital, Saint Peters, Missouri
Nebraska Medicine-Bellevue, Bellevue, Nebraska
Children's Hospital and Medical Center of Omaha, Omaha, Nebraska
Nebraska Medicine-Village Pointe, Omaha, Nebraska
University of Nebraska Medical Center, Omaha, Nebraska
Alliance for Childhood Diseases/Cure 4 the Kids Foundation, Las Vegas, Nevada
Renown Regional Medical Center, Reno, Nevada
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon, New Hampshire
Cooper Hospital University Medical Center, Camden, New Jersey
Trinitas Hospital and Comprehensive Cancer Center - Williamson Street Campus, Elizabeth, New Jersey
Hackensack University Medical Center, Hackensack, New Jersey
Jersey City Medical Center, Jersey City, New Jersey
Saint Barnabas Medical Center, Livingston, New Jersey
Monmouth Medical Center, Long Branch, New Jersey
Morristown Medical Center, Morristown, New Jersey
Jersey Shore Medical Center, Neptune, New Jersey
Saint Peter's University Hospital, New Brunswick, New Jersey
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick, New Jersey
Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey
Newark Beth Israel Medical Center, Newark, New Jersey
Saint Joseph's Regional Medical Center, Paterson, New Jersey
Community Medical Center, Toms River, New Jersey
Presbyterian Hospital, Albuquerque, New Mexico
University of New Mexico Cancer Center, Albuquerque, New Mexico
Albany Medical Center, Albany, New York
Montefiore Medical Center - Moses Campus, Bronx, New York
Roswell Park Cancer Institute, Buffalo, New York
Hematology Oncology Associates of CNY at Camillus, Camillus, New York
Hematology Oncology Associates of Central New York-East Syracuse, East Syracuse, New York
Glens Falls Hospital, Glens Falls, New York
NYU Langone Hospital - Long Island, Mineola, New York
The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park, New York
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York, New York
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York, New York
Memorial Sloan Kettering Cancer Center, New York, New York
NYP/Weill Cornell Medical Center, New York, New York
University of Rochester, Rochester, New York
Stony Brook University Medical Center, Stony Brook, New York
State University of New York Upstate Medical University, Syracuse, New York
Wilmot Cancer Institute at Webster, Webster, New York
Mission Hospital, Asheville, North Carolina
UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina
Carolinas Medical Center/Levine Cancer Institute, Charlotte, North Carolina
Duke University Medical Center, Durham, North Carolina
East Carolina University, Greenville, North Carolina
Wake Forest University Health Sciences, Winston-Salem, North Carolina
Sanford Broadway Medical Center, Fargo, North Dakota
Children's Hospital Medical Center of Akron, Akron, Ohio
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Rainbow Babies and Childrens Hospital, Cleveland, Ohio
Cleveland Clinic Foundation, Cleveland, Ohio
Nationwide Children's Hospital, Columbus, Ohio
Dayton Children's Hospital, Dayton, Ohio
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo, Ohio
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Providence Willamette Falls Medical Center, Oregon City, Oregon
Providence Portland Medical Center, Portland, Oregon
Providence Saint Vincent Medical Center, Portland, Oregon
Legacy Emanuel Children's Hospital, Portland, Oregon
Oregon Health and Science University, Portland, Oregon
Lehigh Valley Hospital-Cedar Crest, Allentown, Pennsylvania
Geisinger Medical Center, Danville, Pennsylvania
Penn State Children's Hospital, Hershey, Pennsylvania
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Saint Christopher's Hospital for Children, Philadelphia, Pennsylvania
Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania
Rhode Island Hospital, Providence, Rhode Island
Smilow Cancer Hospital Care Center - Westerly, Westerly, Rhode Island
Prisma Health Cancer Institute - Spartanburg, Boiling Springs, South Carolina
Medical University of South Carolina, Charleston, South Carolina
Prisma Health Richland Hospital, Columbia, South Carolina
Saint Francis Hospital, Greenville, South Carolina
BI-LO Charities Children's Cancer Center, Greenville, South Carolina
Saint Francis Cancer Center, Greenville, South Carolina
Prisma Health Cancer Institute - Eastside, Greenville, South Carolina
Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota
T C Thompson Children's Hospital, Chattanooga, Tennessee
East Tennessee Childrens Hospital, Knoxville, Tennessee
The Children's Hospital at TriStar Centennial, Nashville, Tennessee
Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee
Dell Children's Medical Center of Central Texas, Austin, Texas
Driscoll Children's Hospital, Corpus Christi, Texas
Medical City Dallas Hospital, Dallas, Texas
UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas
El Paso Children's Hospital, El Paso, Texas
Cook Children's Medical Center, Fort Worth, Texas
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston, Texas
M D Anderson Cancer Center, Houston, Texas
Covenant Children's Hospital, Lubbock, Texas
UMC Cancer Center / UMC Health System, Lubbock, Texas
Children's Hospital of San Antonio, San Antonio, Texas
Methodist Children's Hospital of South Texas, San Antonio, Texas
University of Texas Health Science Center at San Antonio, San Antonio, Texas
Scott and White Memorial Hospital, Temple, Texas
Huntsman Cancer Institute/University of Utah, Salt Lake City, Utah
Primary Children's Hospital, Salt Lake City, Utah
University of Vermont and State Agricultural College, Burlington, Vermont
University of Virginia Cancer Center, Charlottesville, Virginia
Inova Fairfax Hospital, Falls Church, Virginia
Children's Hospital of The King's Daughters, Norfolk, Virginia
Naval Medical Center - Portsmouth, Portsmouth, Virginia
VCU Massey Comprehensive Cancer Center, Richmond, Virginia
Carilion Children's, Roanoke, Virginia
Valley Medical Center, Renton, Washington
Seattle Children's Hospital, Seattle, Washington
Providence Sacred Heart Medical Center and Children's Hospital, Spokane, Washington
Mary Bridge Children's Hospital and Health Center, Tacoma, Washington
West Virginia University Charleston Division, Charleston, West Virginia
Edwards Comprehensive Cancer Center, Huntington, West Virginia
Aurora Cancer Care-Southern Lakes VLCC, Burlington, Wisconsin
Aurora Saint Luke's South Shore, Cudahy, Wisconsin
Aurora Health Care Germantown Health Center, Germantown, Wisconsin
Aurora Cancer Care-Grafton, Grafton, Wisconsin
Saint Vincent Hospital Cancer Center Green Bay, Green Bay, Wisconsin
Aurora BayCare Medical Center, Green Bay, Wisconsin
Aurora Cancer Care-Kenosha South, Kenosha, Wisconsin
Gundersen Lutheran Medical Center, La Crosse, Wisconsin
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center, Madison, Wisconsin
University of Wisconsin Carbone Cancer Center - University Hospital, Madison, Wisconsin
Aurora Bay Area Medical Group-Marinette, Marinette, Wisconsin
Marshfield Medical Center-Marshfield, Marshfield, Wisconsin
Aurora Cancer Care-Milwaukee, Milwaukee, Wisconsin
Aurora Saint Luke's Medical Center, Milwaukee, Wisconsin
Children's Hospital of Wisconsin, Milwaukee, Wisconsin
Aurora Sinai Medical Center, Milwaukee, Wisconsin
ProHealth D N Greenwald Center, Mukwonago, Wisconsin
ProHealth Oconomowoc Memorial Hospital, Oconomowoc, Wisconsin
Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh, Wisconsin
Aurora Cancer Care-Racine, Racine, Wisconsin
Saint Vincent Hospital Cancer Center at Sheboygan, Sheboygan, Wisconsin
Vince Lombardi Cancer Clinic-Sheboygan, Sheboygan, Wisconsin
Saint Vincent Hospital Cancer Center at Sturgeon Bay, Sturgeon Bay, Wisconsin
Aurora Medical Center in Summit, Summit, Wisconsin
Vince Lombardi Cancer Clinic-Two Rivers, Two Rivers, Wisconsin
UW Cancer Center at ProHealth Care, Waukesha, Wisconsin
Aurora Cancer Care-Milwaukee West, Wauwatosa, Wisconsin
Aurora West Allis Medical Center, West Allis, Wisconsin
Alberta Children's Hospital, Calgary, Alberta
University of Alberta Hospital, Edmonton, Alberta
CancerCare Manitoba, Winnipeg, Manitoba
IWK Health Centre, Halifax, Nova Scotia
McMaster Children's Hospital at Hamilton Health Sciences, Hamilton, Ontario
Children's Hospital, London, Ontario
Children's Hospital of Eastern Ontario, Ottawa, Ontario
Hospital for Sick Children, Toronto, Ontario
The Montreal Children's Hospital of the MUHC, Montreal, Quebec
Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont, Sherbrooke, Quebec
Jim Pattison Children's Hospital, Saskatoon, Saskatchewan
CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL), Quebec, Not set
University Pediatric Hospital, San Juan, Not set
Conditions: Lugano Classification Limited Stage Hodgkin Lymphoma AJCC v8
Nivolumab in Combination With Chemo-Immunotherapy for the Treatment of Newly Diagnosed Primary Mediastinal B-Cell Lymphoma
Active Not Recruiting
This phase III trial compares the effects of nivolumab with chemo-immunotherapy versus chemo-immunotherapy alone in treating patients with newly diagnosed primary mediastinal B-cell lymphoma (PMBCL). Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of cancer cells to grow and spread. Treatment for PMBCL involves chemotherapy combined with an immunotherapy called rituximab. Chemotherapy drugs work... Read More
This phase III trial compares the effects of nivolumab with chemo-immunotherapy versus chemo-immunotherapy alone in treating patients with newly diagnosed primary mediastinal B-cell lymphoma (PMBCL). Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of cancer cells to grow and spread. Treatment for PMBCL involves chemotherapy combined with an immunotherapy called rituximab. Chemotherapy drugs work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Rituximab is a monoclonal antibody. It binds to a protein called CD20, which is found on B cells (a type of white blood cell) and some types of cancer cells. This may help the immune system kill cancer cells. Giving nivolumab with chemo-immunotherapy may help treat patients with PMBCL. Read Less
Gender:
ALL
Ages:
2 years and above
Trial Updated:
08/15/2025
Locations: Children's Hospital of Alabama, Birmingham, Alabama +233 locations
Children's Hospital of Alabama, Birmingham, Alabama
USA Health Strada Patient Care Center, Mobile, Alabama
Providence Alaska Medical Center, Anchorage, Alaska
Banner Children's at Desert, Mesa, Arizona
Banner University Medical Center - Tucson, Tucson, Arizona
Arkansas Children's Hospital, Little Rock, Arkansas
UC Irvine Health Cancer Center-Newport, Costa Mesa, California
Kaiser Permanente Downey Medical Center, Downey, California
City of Hope Comprehensive Cancer Center, Duarte, California
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine, California
City of Hope at Irvine Lennar, Irvine, California
Loma Linda University Medical Center, Loma Linda, California
Miller Children's and Women's Hospital Long Beach, Long Beach, California
Children's Hospital Los Angeles, Los Angeles, California
Cedars Sinai Medical Center, Los Angeles, California
Mattel Children's Hospital UCLA, Los Angeles, California
Valley Children's Hospital, Madera, California
Kaiser Permanente-Oakland, Oakland, California
Children's Hospital of Orange County, Orange, California
UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange, California
Lucile Packard Children's Hospital Stanford University, Palo Alto, California
University of California Davis Comprehensive Cancer Center, Sacramento, California
Rady Children's Hospital - San Diego, San Diego, California
Children's Hospital Colorado, Aurora, Colorado
Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center, Denver, Colorado
Connecticut Children's Medical Center, Hartford, Connecticut
Alfred I duPont Hospital for Children, Wilmington, Delaware
MedStar Georgetown University Hospital, Washington, District of Columbia
Children's National Medical Center, Washington, District of Columbia
Broward Health Medical Center, Fort Lauderdale, Florida
Golisano Children's Hospital of Southwest Florida, Fort Myers, Florida
University of Florida Health Science Center - Gainesville, Gainesville, Florida
Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood, Florida
Nemours Children's Clinic-Jacksonville, Jacksonville, Florida
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida
Arnold Palmer Hospital for Children, Orlando, Florida
Nemours Children's Hospital, Orlando, Florida
Johns Hopkins All Children's Hospital, Saint Petersburg, Florida
Tampa General Hospital, Tampa, Florida
Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa, Florida
Emory Proton Therapy Center, Atlanta, Georgia
Emory University Hospital Midtown, Atlanta, Georgia
Emory University Hospital/Winship Cancer Institute, Atlanta, Georgia
Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta, Georgia
Emory Saint Joseph's Hospital, Atlanta, Georgia
Memorial Health University Medical Center, Savannah, Georgia
Kapiolani Medical Center for Women and Children, Honolulu, Hawaii
Saint Luke's Cancer Institute - Boise, Boise, Idaho
Rush-Copley Medical Center, Aurora, Illinois
Lurie Children's Hospital-Chicago, Chicago, Illinois
Northwestern University, Chicago, Illinois
University of Illinois, Chicago, Illinois
University of Chicago Comprehensive Cancer Center, Chicago, Illinois
Carle at The Riverfront, Danville, Illinois
Decatur Memorial Hospital, Decatur, Illinois
Northwestern Medicine Cancer Center Kishwaukee, DeKalb, Illinois
Carle Physician Group-Effingham, Effingham, Illinois
Northwestern Medicine Cancer Center Delnor, Geneva, Illinois
Northwestern Medicine Lake Forest Hospital, Lake Forest, Illinois
Carle Physician Group-Mattoon/Charleston, Mattoon, Illinois
Loyola University Medical Center, Maywood, Illinois
HSHS Saint Elizabeth's Hospital, O'Fallon, Illinois
Advocate Children's Hospital-Oak Lawn, Oak Lawn, Illinois
Advocate Children's Hospital-Park Ridge, Park Ridge, Illinois
Saint Jude Midwest Affiliate, Peoria, Illinois
Southern Illinois University School of Medicine, Springfield, Illinois
Springfield Clinic, Springfield, Illinois
Springfield Memorial Hospital, Springfield, Illinois
Carle Cancer Center, Urbana, Illinois
Northwestern Medicine Cancer Center Warrenville, Warrenville, Illinois
Riley Hospital for Children, Indianapolis, Indiana
Reid Health, Richmond, Indiana
UI Health Care Mission Cancer and Blood - Ankeny Clinic, Ankeny, Iowa
UI Health Care Mission Cancer and Blood - West Des Moines Clinic, Clive, Iowa
Blank Children's Hospital, Des Moines, Iowa
Mercy Medical Center - Des Moines, Des Moines, Iowa
UI Health Care Mission Cancer and Blood - Laurel Clinic, Des Moines, Iowa
University of Iowa/Holden Comprehensive Cancer Center, Iowa City, Iowa
Siouxland Regional Cancer Center, Sioux City, Iowa
UI Health Care Mission Cancer and Blood - Waukee Clinic, Waukee, Iowa
Wesley Medical Center, Wichita, Kansas
University of Kentucky/Markey Cancer Center, Lexington, Kentucky
Norton Children's Hospital, Louisville, Kentucky
Children's Hospital New Orleans, New Orleans, Louisiana
Ochsner Medical Center Jefferson, New Orleans, Louisiana
Eastern Maine Medical Center, Bangor, Maine
Maine Children's Cancer Program, Scarborough, Maine
University of Maryland/Greenebaum Cancer Center, Baltimore, Maryland
Greater Baltimore Medical Center, Baltimore, Maryland
Sinai Hospital of Baltimore, Baltimore, Maryland
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland
Walter Reed National Military Medical Center, Bethesda, Maryland
Tufts Medical Center, Boston, Massachusetts
Dana-Farber Cancer Institute, Boston, Massachusetts
C S Mott Children's Hospital, Ann Arbor, Michigan
Children's Hospital of Michigan, Detroit, Michigan
Henry Ford Hospital, Detroit, Michigan
Michigan State University, East Lansing, Michigan
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids, Michigan
Bronson Methodist Hospital, Kalamazoo, Michigan
Corewell Health Lakeland Hospitals - Niles Hospital, Niles, Michigan
Corewell Health Children's, Royal Oak, Michigan
Minnesota Oncology - Burnsville, Burnsville, Minnesota
Mercy Hospital, Coon Rapids, Minnesota
Fairview Southdale Hospital, Edina, Minnesota
Unity Hospital, Fridley, Minnesota
Minnesota Oncology Hematology PA-Maplewood, Maplewood, Minnesota
Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis, Minnesota
Abbott-Northwestern Hospital, Minneapolis, Minnesota
Park Nicollet Clinic - Saint Louis Park, Saint Louis Park, Minnesota
United Hospital, Saint Paul, Minnesota
University of Mississippi Medical Center, Jackson, Mississippi
Saint Luke's Hospital, Chesterfield, Missouri
Siteman Cancer Center at West County Hospital, Creve Coeur, Missouri
Children's Mercy Hospitals and Clinics, Kansas City, Missouri
Washington University School of Medicine, Saint Louis, Missouri
Siteman Cancer Center-South County, Saint Louis, Missouri
Siteman Cancer Center at Christian Hospital, Saint Louis, Missouri
Mercy Hospital Saint Louis, Saint Louis, Missouri
Siteman Cancer Center at Saint Peters Hospital, Saint Peters, Missouri
Children's Hospital and Medical Center of Omaha, Omaha, Nebraska
University of Nebraska Medical Center, Omaha, Nebraska
Alliance for Childhood Diseases/Cure 4 the Kids Foundation, Las Vegas, Nevada
Renown Regional Medical Center, Reno, Nevada
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon, New Hampshire
Memorial Sloan Kettering Basking Ridge, Basking Ridge, New Jersey
Hackensack University Medical Center, Hackensack, New Jersey
Memorial Sloan Kettering Monmouth, Middletown, New Jersey
Memorial Sloan Kettering Bergen, Montvale, New Jersey
Morristown Medical Center, Morristown, New Jersey
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick, New Jersey
Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey
Saint Joseph's Regional Medical Center, Paterson, New Jersey
Presbyterian Hospital, Albuquerque, New Mexico
Albany Medical Center, Albany, New York
Montefiore Medical Center - Moses Campus, Bronx, New York
Roswell Park Cancer Institute, Buffalo, New York
Memorial Sloan Kettering Commack, Commack, New York
Memorial Sloan Kettering Westchester, Harrison, New York
The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park, New York
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York, New York
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York, New York
Memorial Sloan Kettering Cancer Center, New York, New York
NYP/Weill Cornell Medical Center, New York, New York
University of Rochester, Rochester, New York
Stony Brook University Medical Center, Stony Brook, New York
State University of New York Upstate Medical University, Syracuse, New York
Memorial Sloan Kettering Nassau, Uniondale, New York
New York Medical College, Valhalla, New York
Wilmot Cancer Institute at Webster, Webster, New York
Mission Hospital, Asheville, North Carolina
AdventHealth Infusion Center Asheville, Asheville, North Carolina
Carolinas Medical Center/Levine Cancer Institute, Charlotte, North Carolina
Novant Health Presbyterian Medical Center, Charlotte, North Carolina
East Carolina University, Greenville, North Carolina
AdventHealth Hendersonville, Hendersonville, North Carolina
Wake Forest University Health Sciences, Winston-Salem, North Carolina
Sanford Broadway Medical Center, Fargo, North Dakota
Children's Hospital Medical Center of Akron, Akron, Ohio
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Rainbow Babies and Childrens Hospital, Cleveland, Ohio
Cleveland Clinic Foundation, Cleveland, Ohio
Nationwide Children's Hospital, Columbus, Ohio
Dayton Children's Hospital, Dayton, Ohio
Dayton Physician LLC - Englewood, Dayton, Ohio
Greater Dayton Cancer Center, Kettering, Ohio
Kettering Medical Center, Kettering, Ohio
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo, Ohio
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Legacy Emanuel Children's Hospital, Portland, Oregon
Oregon Health and Science University, Portland, Oregon
Lehigh Valley Hospital-Cedar Crest, Allentown, Pennsylvania
Geisinger Medical Center, Danville, Pennsylvania
Penn State Children's Hospital, Hershey, Pennsylvania
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Saint Christopher's Hospital for Children, Philadelphia, Pennsylvania
Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania
Rhode Island Hospital, Providence, Rhode Island
Prisma Health Richland Hospital, Columbia, South Carolina
Saint Francis Hospital, Greenville, South Carolina
BI-LO Charities Children's Cancer Center, Greenville, South Carolina
Saint Francis Cancer Center, Greenville, South Carolina
Prisma Health Cancer Institute - Eastside, Greenville, South Carolina
Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota
East Tennessee Childrens Hospital, Knoxville, Tennessee
Saint Jude Children's Research Hospital, Memphis, Tennessee
The Children's Hospital at TriStar Centennial, Nashville, Tennessee
Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee
Texas Tech University Health Sciences Center-Amarillo, Amarillo, Texas
Dell Children's Medical Center of Central Texas, Austin, Texas
Driscoll Children's Hospital, Corpus Christi, Texas
Medical City Dallas Hospital, Dallas, Texas
UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas
El Paso Children's Hospital, El Paso, Texas
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston, Texas
Houston Methodist Hospital, Houston, Texas
M D Anderson Cancer Center, Houston, Texas
Covenant Children's Hospital, Lubbock, Texas
UMC Cancer Center / UMC Health System, Lubbock, Texas
Children's Hospital of San Antonio, San Antonio, Texas
Methodist Children's Hospital of South Texas, San Antonio, Texas
University of Texas Health Science Center at San Antonio, San Antonio, Texas
Primary Children's Hospital, Salt Lake City, Utah
University of Virginia Cancer Center, Charlottesville, Virginia
Inova Fairfax Hospital, Falls Church, Virginia
Children's Hospital of The King's Daughters, Norfolk, Virginia
VCU Massey Comprehensive Cancer Center, Richmond, Virginia
Carilion Children's, Roanoke, Virginia
Valley Medical Center, Renton, Washington
Seattle Children's Hospital, Seattle, Washington
Providence Sacred Heart Medical Center and Children's Hospital, Spokane, Washington
Mary Bridge Children's Hospital and Health Center, Tacoma, Washington
Madigan Army Medical Center, Tacoma, Washington
West Virginia University Charleston Division, Charleston, West Virginia
University of Wisconsin Carbone Cancer Center - University Hospital, Madison, Wisconsin
Marshfield Medical Center-Marshfield, Marshfield, Wisconsin
John Hunter Children's Hospital, Hunter Regional Mail Centre, New South Wales
The Children's Hospital at Westmead, Westmead, New South Wales
Queensland Children's Hospital, South Brisbane, Queensland
Royal Children's Hospital, Parkville, Victoria
Perth Children's Hospital, Perth, Western Australia
University of Alberta Hospital, Edmonton, Alberta
CancerCare Manitoba, Winnipeg, Manitoba
Janeway Child Health Centre, Saint John's, Newfoundland and Labrador
IWK Health Centre, Halifax, Nova Scotia
McMaster Children's Hospital at Hamilton Health Sciences, Hamilton, Ontario
Children's Hospital, London, Ontario
Children's Hospital of Eastern Ontario, Ottawa, Ontario
Hospital for Sick Children, Toronto, Ontario
The Montreal Children's Hospital of the MUHC, Montreal, Quebec
Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont, Sherbrooke, Quebec
CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL), Quebec, Not set
HIMA San Pablo Oncologic Hospital, Caguas, Not set
Conditions: Primary Mediastinal Large B-Cell Lymphoma
A Study of CC-97540 (BMS-986353), CD19-Targeted NEX-T CAR T Cells, in Participants With Active SLE Despite Immunosuppressants (Breakfree-SLE)
Recruiting
The purpose of this study is to evaluate the efficacy, safety and drug levels of CC-97540 in participants with active systemic lupus erythematosus (SLE) including lupus nephritis with inadequate response to glucocorticoids and at least 2 immunosuppressants.
The purpose of this study is to evaluate the efficacy, safety and drug levels of CC-97540 in participants with active systemic lupus erythematosus (SLE) including lupus nephritis with inadequate response to glucocorticoids and at least 2 immunosuppressants. Read Less
Gender:
ALL
Ages:
16 years and above
Trial Updated:
08/14/2025
Locations: Local Institution - 0009, Birmingham, Alabama +70 locations
Local Institution - 0009, Birmingham, Alabama
Local Institution - 0038, Los Angeles, California
Local Institution - 0051, Los Angeles, California
Local Institution - 0035, Palo Alto, California
University of Colorado Anschutz Medical Campus, Aurora, Colorado
Mayo Clinic in Florida, Jacksonville, Florida
Local Institution - 0002, Miami, Florida
Local Institution - 0008, Tampa, Florida
Local Institution - 0036, Tampa, Florida
Local Institution - 0062, Zephyrhills, Florida
Local Institution - 0052, Boston, Massachusetts
Local Institution - 0011, Rochester, Minnesota
Atlantic Health System Overlook Medical Center, Summit, New Jersey
Local Institution - 0040, New York, New York
Icahn School of Medicine at Mount Sinai, New York, New York
Local Institution - 0005, New York, New York
Local Institution - 0039, New York, New York
Local Institution - 0010, Chapel Hill, North Carolina
Local Institution - 0065, Charlotte, North Carolina
Local Institution - 0012, Cincinnati, Ohio
Local Institution - 0003, Cleveland, Ohio
Local Institution - 0041, Oklahoma City, Oklahoma
Baylor Scott and White Research Institute, Dallas, Texas
Local Institution - 0007, Seattle, Washington
Local Institution - 0016, ABB, Ciudad Autónoma De Buenos Aires
Local Institution - 0017, ABB, Ciudad Autónoma De Buenos Aires
Local Institution - 0023, Buenos Aires, Ciudad Autónoma De Buenos Aires
Local Institution - 0037, Vienna, Wien
Local Institution - 0031, Salzburg, Not set
Local Institution - 0020, Leuven, Vlaams-Brabant
Local Institution - 0058, Sao Paulo, São Paulo
Local Institution - 0021, São Paulo, Not set
Local Institution - 0022, São Paulo, Not set
Local Institution - 0048, Vancouver, British Columbia
Local Institution - 0045, Toronto, Ontario
Local Institution - 0056, Odense, Syddanmark
Local Institution - 0047, Copenhagen, Not set
Local Institution - 0018, Montpellier, Hérault
Local Institution - 0019, Rennes, Not set
Local Institution - 0064, Paris, Île-de-France
Local Institution - 0029, Köln, Nordrhein-Westfalen
Local Institution - 0030, Magdeburg, Sachsen-Anhalt
Local Institution - 0028, Leipzig, Sachsen
Local Institution - 0026, Berlin, Not set
Local Institution - 0027, Erlangen, Not set
Local Institution - 0043, Ramat Gan, HaMerkaz
Local Institution - 0042, Jerusalem, Not set
Local Institution - 0025, Roma, Lazio
Local Institution - 0032, Milan, Milano
Local Institution - 0044, Rome, Roma
Local Institution - 0070, Pisa, Toscana
Local Institution - 0055, Sapporo, Hokkaido
Local Institution - 0072, Yokohama, Kanagawa
Local Institution - 0068, Bunkyo-ku, Tokyo
Local Institution - 0069, Shinjuku-ku, Tokyo
Local Institution - 0067, Chiba, Not set
Local Institution - 0054, Fukuoka, Not set
Local Institution - 0063, Okayama, Not set
Local Institution - 0053, Osaka, Not set
Local Institution - 0046, Amsterdam, Noord-Holland
Local Institution - 0034, Łódź, Łódzkie
Local Institution - 0024, Bytom, Śląskie
Local Institution - 0049, Gliwice, Śląskie
Local Institution - 0013, Lisbon, Lisboa
Local Institution - 0015, Barcelona, Barcelona [Barcelona]
Local Institution - 0071, Esplugues de Llobregat, Barcelona [Barcelona]
Local Institution - 0014, Málaga, Not set
Local Institution - 0060, London, London, City Of
Local Institution - 0061, London, London, City Of
Local Institution - 0050, London, London, City Of
Local Institution - 0057, London, London, City Of
Conditions: Lupus Erythematosus, Systemic, Lupus Nephritis
A Study of Daratumumab-Based Therapies in Participants With Amyloid Light Chain (AL) Amyloidosis
Active Not Recruiting
The purpose of this study is to characterize cardiac safety of Daratumumab, Cyclophosphamide, Bortezomib, and Dexamethasone (D-VCd) treatment regimens (Arm A: daratumumab + immediate VCd treatment and Arm B: daratumumab + deferred VCd) in newly diagnosed systemic amyloid light chain (AL) amyloidosis with cardiac involvement and to identify potential mitigation strategies for cardiac toxicity (cohort 1); to characterize the pharmacokinetics of subcutaneous (SC) daratumumab, among racial and ethni... Read More
The purpose of this study is to characterize cardiac safety of Daratumumab, Cyclophosphamide, Bortezomib, and Dexamethasone (D-VCd) treatment regimens (Arm A: daratumumab + immediate VCd treatment and Arm B: daratumumab + deferred VCd) in newly diagnosed systemic amyloid light chain (AL) amyloidosis with cardiac involvement and to identify potential mitigation strategies for cardiac toxicity (cohort 1); to characterize the pharmacokinetics of subcutaneous (SC) daratumumab, among racial and ethnic minorities, including Black or African American, with newly diagnosed AL amyloidosis treated with D-VCd (cohort 2). Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/14/2025
Locations: City of Hope, Duarte, California +45 locations
City of Hope, Duarte, California
Smilow Cancer Hospital/Yale Cancer Center, New Haven, Connecticut
Moffitt Cancer Center, Tampa, Florida
Winship Cancer Institute Emory University, Atlanta, Georgia
Tufts Medical Center, Boston, Massachusetts
Boston University Medical Center, Boston, Massachusetts
Barbara Ann Karmanos Cancer Institute, Detroit, Michigan
Memorial Sloan Kettering, New York, New York
Levine Cancer Institute, Charlotte, North Carolina
Wake Forest University - Baptist Medical Center, Winston-Salem, North Carolina
University Hospital of Cleveland, Cleveland, Ohio
Ohio Health Research Institute, Columbus, Ohio
West Penn Hospital, Pittsburgh, Pennsylvania
UT Southwestern Medical Center, Dallas, Texas
VCU Medical Center, Richmond, Virginia
University of Washington, Seattle, Washington
Tom Baker Cancer Center, Calgary, Alberta
Cross Cancer Institute, Edmonton, Alberta
University Health Network UHN Princess Margaret Cancer Centre, Toronto, Ontario
Peking University First Hospital, Beijing, Not set
Peking University People s Hospital, Beijing, Not set
West China Hospital Si Chuan University, Chengdu, Not set
First affiliated Hospital of Zhejiang University, Hangzhou, Not set
Ruijin Hospital Shanghai Jiao Tong University, Shanghai, Not set
CHU de Limoges, Limoges Cedex, Not set
Centre hospitalier Lyon-Sud, Pierre Benite cedex, Not set
CHU De Poitiers, Poitiers, Not set
CHU Rangueil, Toulouse, Not set
Charite Campus Benjamin Franklin, Berlin, Not set
Universitatsklinikum Essen, Essen, Not set
Universitaetsklinikum Heidelberg Medizinische Klinik V, Heidelberg, Not set
Alexandra General Hospital of Athens, Athens, Not set
Università Degli Studi Di Napoli Federico Ii, Napoli, Not set
Fondazione IRCCS Policlinico San Matteo, Pavia, Not set
DIPARTIMENTO DI BIOTECNOLOGIE CELLULARI ED EMATOLOGIA - UNIVERSITà ''LA SAPIENZA'', Roma, Not set
University Medical Center Groningen, Groningen, Not set
Hospital Maastricht University Medical Center, Maastricht, Not set
UMC Utrecht, Utrecht, Not set
Hosp. Univ. Germans Trias I Pujol, Badalona, Not set
Hosp Univ Vall D Hebron, Barcelona, Not set
Hosp Clinic de Barcelona, Barcelona, Not set
Clinica Univ. de Navarra, Madrid, Not set
Clinica Univ. de Navarra, Pamplona, Not set
Hosp Clinico Univ de Salamanca, Salamanca, Not set
Leicester Royal Infirmary - Haematology, Leicester, Not set
University College Hospital, London, Not set
Conditions: Amyloidosis
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