Cyclophosphamide Treatment Options in Canada

A collection of 300 research studies where Cyclophosphamide is the interventional treatment. These studies are located in the Canada . Cyclophosphamide is used for conditions such as Breast Cancer, Lymphoma and Leukemia.

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A Study to Evaluate the Efficacy and Safety of CAEL-101 in Patients With Mayo Stage IIIa AL Amyloidosis (CARES)

NCT04512235

Active Not Recruiting

AL (or light chain) amyloidosis begins in the bone marrow where abnormal proteins misfold and create free light chains that cannot be broken down. These free light chains bind together to form amyloid fibrils that build up in the extracellular space of organs, affecting the kidneys, heart, liver, spleen, nervous system and digestive tract. The primary purpose of this study is to determine whether CAEL-101, a monoclonal antibody that removes AL amyloid deposits from tissues and organs, improves... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

05/22/2025

Locations: Research Site, Scottsdale, Arizona +109 locations

Research Site, Scottsdale, Arizona

Research Site, Duarte, California

Research Site, Palo Alto, California

Research Site, San Francisco, California

Research Site, Jacksonville, Florida

Research Site, Weston, Florida

Research Site, Indianapolis, Indiana

Research Site, New Orleans, Louisiana

Research Site, Baltimore, Maryland

Research Site, Boston, Massachusetts

Research Site, Detroit, Michigan

Research Site, Rochester, Minnesota

Research Site, Saint Louis, Missouri

Research Site, New York, New York

Research Site, Rochester, New York

Research Site, Chapel Hill, North Carolina

Research Site, Durham, North Carolina

Research Site, Winston-Salem, North Carolina

Research Site, Cleveland, Ohio

Research Site, Columbus, Ohio

Research Site, Portland, Oregon

Research Site, Philadelphia, Pennsylvania

Research Site, Nashville, Tennessee

Research Site, Dallas, Texas

Research Site, Houston, Texas

Research Site, Salt Lake City, Utah

Research Site, Seattle, Washington

Research Site, Madison, Wisconsin

Research Site, Milwaukee, Wisconsin

Research Site, Box Hill, Not set

Research Site, Murdoch, Not set

Research Site, Westmead, Not set

Research Site, Woolloongabba, Not set

Research Site, Linz, Not set

Research Site, Vienna, Not set

Research Site, Anderlecht, Not set

Research Site, Leuven, Not set

Research Site, Porto Alegre, Not set

Research Site, Ribeirão Preto, Not set

Research Site, Salvador, Not set

Research Site, Calgary, Alberta

Research Site, Toronto, Ontario

Research Site, Beijing, Not set

Research Site, Guangzhou, Not set

Research Site, Hangzhou, Not set

Research Site, Shanghai, Not set

Research Site, Suzhou, Not set

Research Site, Wenzhou, Not set

Research Site, Wuhan, Not set

Research Site, Ostrava Poruba, Not set

Research Site, Prague, Not set

Research Site, Caen, Not set

Research Site, Creteil, Not set

Research Site, Dijon, Not set

Research Site, Lille, Not set

Research Site, Limoges, Not set

Research Site, Marseille, Not set

Research Site, Paris, Not set

Research Site, Pessac, Not set

Research Site, Pierre Benite, Not set

Research Site, Poitiers, Not set

Research Site, Rennes, Not set

Research Site, Toulouse, Not set

Research Site, Tours, Not set

Research Site, Berlin, Not set

Research Site, Düsseldorf, Not set

Research Site, Essen, Not set

Research Site, Hamburg, Not set

Research Site, Heidelberg, Not set

Research Site, Wuerzburg, Not set

Research Site, Athens, Not set

Research Site, Rio, Not set

Research Site, Thessaloniki, Not set

Research Site, Haifa, Not set

Research Site, Jerusalem, Not set

Research Site, Petah Tikva, Not set

Research Site, Tel Aviv, Not set

Research Site, Tel Hashomer, Not set

Research Site, Brescia, Not set

Research Site, Fukushima-shi, Not set

Research Site, Kanazawa-shi, Not set

Research Site, Kashiwa-shi, Not set

Research Site, Kita-ku, Not set

Research Site, Kumamoto-shi, Not set

Research Site, Matsumoto-shi, Not set

Research Site, Nagoya-shi, Not set

Research Site, Shibuya-ku, Not set

Research Site, Seoul, Not set

Research Site, Gdańsk, Not set

Research Site, Warszawa, Not set

Research Site, St. Petersburg, Not set

Research Site, Barcelona, Not set

Research Site, Gijón, Not set

Research Site, Granada, Not set

Research Site, Madrid, Not set

Research Site, Majadahonda, Not set

Research Site, Pamplona, Not set

Research Site, Salamanca, Not set

Research Site, Sevilla, Not set

Research Site, Valencia, Not set

Research Site, Glasgow, Not set

Research Site, London, Not set

Conditions: AL Amyloidosis

Learn More ›

Study to Compare Axicabtagene Ciloleucel With Standard of Care Therapy as First-line Treatment in Participants With High-risk Large B-cell Lymphoma

NCT05605899

Recruiting

The goal of this clinical study is to compare the study drug, axicabtagene ciloleucel, versus standard of care (SOC) in first-line therapy in participants with high-risk large B-cell lymphoma.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

05/16/2025

Locations: University of Alabama Hospital, Birmingham, Alabama +89 locations

University of Alabama Hospital, Birmingham, Alabama

Banner MD Anderson Cancer Center, Gilbert, Arizona

Mayo Clinic, Phoenix, Arizona

UC San Diego Moores Cancer Center, La Jolla, California

University of California Los Angeles (UCLA), Los Angeles, California

Stanford Cancer Institute, Palo Alto, California

Colorado Blood Cancer Institute, Denver, Colorado

Moffitt Cancer Center, Tampa, Florida

Georgia Cancer Center at Augusta University, Augusta, Georgia

Northwestern Memorial Hospital, Chicago, Illinois

University of Chicago Medical Center, Chicago, Illinois

University of Iowa, Iowa City, Iowa

The University of Kansas Hospital, Westwood, Kansas

Norton Cancer Institute, St. Matthews Campus, Shelbyville, Kentucky

Ochsner Clinic Foundation, New Orleans, Louisiana

University of MD Greenebaum Comprehensive Cancer Center, Baltimore, Maryland

Dana-Farber Cancer Institute, Boston, Massachusetts

University of Michigan, Ann Arbor, Michigan

Mayo Clinic Cancer Center Outpatient Pharmacy, Rochester, Minnesota

John Theurer Cancer Center at Hackensack University Medical Center, Hackensack, New Jersey

Montefiore Medical Center, Bronx, New York

Roswell Park Cancer Institute, Buffalo, New York

Weill Cornell Medical College - NewYork Presbyterian Hospital, New York, New York

Columbia University Medical Center, New York, New York

University of Rochester Medical Center, Rochester, New York

Novant Health Cancer Institute- Hematology, Charlotte, North Carolina

Oncology Hematology Care Clinical Trials, LLC, Cincinnati, Ohio

UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania

Prisma Health Cancer Institute, Greenville, South Carolina

Avera Cancer Institute, Sioux Falls, South Dakota

Tennessee Oncology, PLLC, Nashville, Tennessee

Henry-Joyce Cancer Center, Nashville, Tennessee

University of Texas Southwestern Medical Center, Dallas, Texas

The University of Texas, MD Anderson Cancer Center, Houston, Texas

Intermountain LDS Hospital/Blood and Marrow Transplant/ Acute Leukemia Program, Salt Lake City, Utah

Virginia Commonwealth University, Richmond, Virginia

Fred Hutchinson Cancer Center, Seattle, Washington

Royal Prince Alfred Hospital, Camperdown, New South Wales

Royal Brisbane and Women's Hospital, South Brisbane, Queensland

Peter MacCallum Cancer Center, Melbourne, Victoria

Medizinische Universität Innsbruck, Innsbruck, Not set

Zuniklinikum Salzburg, Landeskrankenhaus, Universitatsklinik fur Innere Medizin III der PMU, Salzburg, Not set

Universitätsklinikum St. Pölten, St. Poelten, Not set

Medizinische Universität Wien (AKH Wien, Medical University Vienna and General Hospital Vienna), Vienna, Not set

Jewish General Hospital, Montreal, Not set

The Ottowa Hospital- General Campus, Ottawa, Not set

Princess Margaret Cancer Centre, Toronto, Not set

CHU Bordeaux-Hopital Haut-Leveque, Bordeaux, Not set

Centre Leon Berard, Cedex Lyon 08, Not set

CHU Dijon, Dijon, Not set

Hopital Claude Huriez CHU Lille, Service Maladies du sang, Lille cedex, Not set

Hopital Saint Eloi, Montpellier CEDEX 05, Not set

Centre Hospitalier Universitaire de Nice, Nice, Not set

Hopital Henri MONDOR, APHP, Paris, Not set

CHU Pontchaillou, Rennes CEDEX, Not set

Centre Hospitalier Universitaire(CHU) de Toulouse, Toulouse, Not set

Helios Klinikum Berlin-Buch, Berlin, Not set

Charite Universitaetsmedizin Berlin, Berlin, Not set

Universitätsklinikum bonn, medizinische klinik III, Bonn, Not set

Uniklinikum Duesseldorf, Klinik fuer Haematologie, Onkologie und klinische Immunologie, Duesseldorf, Not set

Universitätsklinik Erlangen, Erlangen, Not set

IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Not set

ASST Degli Spedali Civili di Brescia, Brescia, Not set

Ospedale San Raffaele, Milano, Not set

Azienda Ospedaliera di Perugia - Ospedale S. Maria della Misericordia, Perugia, Not set

Grande Ospedale Metropolitano Bianchi Melacrino Morelli, Reggio Calabria, Not set

Universita Cattolica del Sacro Cuore, Rome, Not set

IRCCS Istituto Clinico Humanitas, Rozzano, Not set

University Hospital, Kyoto Prefectural University of Medicine, Kyoto, Not set

Tohoku University Hospital, Miyagi, Not set

Osaka University Hospital, Osaka, Not set

Juntendo University Hospital, Tokyo, Not set

Tokyo Metropolitan Komagome Hospital, Tokyo, Not set

Academisch Medisch Centrum, Amsterdam, Not set

University Medical Center Groningen, Groningen, Not set

Leiden University Medical Center, Leiden, Not set

Maastricht Universitair Medisch Centrum, Maastricht, Not set

Universitair Medisch Centrum Utrecht, Utrecht, Not set

Centro Hospitalar Universitario Lisboa Norte, E.P.E. - Hospital de Santa Maria, Lisbon, Not set

Instituto Portugues de Oncologia de Lisboa Francisco Gentil - E.P.E., Lisbon, Not set

Instituto Portugues de Oncologia do Porto Francisco Gentil, E.P.E., Porto, Not set

Institut Catala d'Oncologia, Barcelona, Not set

Hospital Universitari Vall D'Hebron, Barcelona, Not set

Hospital Universitario 12 de Octubre, Madrid, Not set

Hospital Universitario de Salamanca, Salamanca, Not set

Hospital Universitario Marqués de Valdecilla, Santander, Not set

Hospital Universitario Virgen del Rocio, Sevilla, Not set

Hospital Clínico Universitario de Valencia, Valencia, Not set

Addenbrookes Hospital (Cambridge University Hospitals NHS Foundation Trust), Birmingham, Not set

University Hospitals Southampton, Southampton, Not set

Conditions: High-risk Large B-cell Lymphoma (LBCL)

Learn More ›

Study of Carfilzomib in Combination With Induction Chemotherapy in Children With Relapsed or Refractory Acute Lymphoblastic Leukemia

NCT02303821

Completed

The purpose of Phase 1b of this study is to: * Asses the safety, tolerability and activity of carfilzomib, alone and in combination with induction chemotherapy, in children with relapsed or refractory acute lymphoblastic leukemia (ALL). * Determine the maximum tolerated dose (MTD) and to recommend a phase 2 dose of carfilzomib in combination with induction chemotherapy. The purpose of Phase 2 of this study is to compare the rate of complete remission (CR) of carfilzomib in combination with vin... Read More

Gender:

ALL

Ages:

Between 1 month and 21 years

Trial Updated:

05/16/2025

Locations: University of California San Francisco Benioff Childrens Hospital Oakland, Oakland, California +121 locations

University of California San Francisco Benioff Childrens Hospital Oakland, Oakland, California

Childrens Hospital of Orange County, Orange, California

Childrens Hospital Colorado, Aurora, Colorado

Childrens Healthcare of Atlanta, Egleston, Atlanta, Georgia

Lurie Childrens Hospital of Chicago, Chicago, Illinois

The Sidney Kimmel Comprehensive Cancer Center at John Hopkins, Baltimore, Maryland

Childrens Hospital and Clinics of Minnesota, Minneapolis, Minnesota

Childrens Mercy Hospital, Kansas City, Missouri

Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey

Childrens Hospital of New York Presbyterian, New York, New York

Levine Childrens Hospital at Carolinas Medical Center d/b/a Atrium Health, Charlotte, North Carolina

Cincinnati Childrens Hospital Medical Center, Cincinnati, Ohio

The Cleveland Clinic Foundation, Cleveland, Ohio

Nationwide Childrens Hospital, Columbus, Ohio

Childrens Hospital of Philadelphia, Philadelphia, Pennsylvania

Saint Judes Childrens Research Hospital, Memphis, Tennessee

Childrens Medical Center, Dallas, Texas

Texas Childrens Hospital West Tower, Houston, Texas

University of Texas Health Science Center at San Antonio, San Antonio, Texas

University of Utah Medical Center Primary Childrens Medical Center, Salt Lake City, Utah

West Virginia University Medicine Childrens, Morgantown, West Virginia

Medical College of Wisconsin, Milwaukee, Wisconsin

Hospital Aleman, Ciudad Autonoma de Buenos Aires, Buenos Aires

Hospital Italiano de Buenos Aires, Ciudad Autonoma de Buenos Aires, Buenos Aires

Hospital Universitario Austral, Pilar, Buenos Aires

Sydney Childrens Hospital, Randwick, New South Wales

The Childrens Hospital at Westmead, Westmead, New South Wales

Queensland Childrens Hospital, South Brisbane, Queensland

The Royal Childrens Hospital, Parkville, Victoria

Perth Childrens Hospital, Nedlands, Western Australia

St Anna Kinderspital, Wien, Not set

Hospital São Rafael - IDOR, Salvador, Bahia

Hospital da Crianca de Brasília, Brasília, Distrito Federal

Liga Paranaense do Combate ao Cancer - Hospital Erasto Gaertner, Curitba, Paraná

Hospital Pequeno Principe, Curitiba, Paraná

Instituto de Medicina Integral Professor Fernando Figueira, Recife, Pernambuco

Hospital de Clinicas de Porto Alegre, Porto Alegre, Rio Grande Do Sul

Hospital da Crianca Santo Antonio Irmandade Santa Casa de Misericordia de Porto Alegre, Porto Alegre, Rio Grande Do Sul

Fundacao Pio 12 Hospital de Amor de Barretos, Barretos, São Paulo

Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo, Ribeirao Preto, São Paulo

Itaci Instituto de Tratamento do Cancer Infantil, Sao Paulo, São Paulo

Beneficencia Portuguesa de Sao Paulo, São Paulo, Not set

University Multiprofile Hospital for Active Treatment Tsaritsa Yoanna-ISUL EAD, Sofia, Not set

Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec

Hospital Luis Calvo Mackenna, Santiago de Chile, Not set

Hospital Roberto del Rio, Santiago, Not set

Sociedad de Oncologia y Hematologia del Cesar, Valledupar, Cesar

Clinica Imbanaco S.A.S, Cali, Valle Del Cauca

Fakultni nemocnice Brno, Brno, Not set

University Hospital Rigshospitalet, Kobenhavn O, Not set

Centre Hospitalier Universitaire de Bordeaux - Hopital Pellegrin, Bordeaux Cedex, Not set

Centre Hospitalier Regional Universitaire de Lille, Lille, Not set

Hopital Armand Trousseau, Paris, Not set

Hopital Robert Debre, Paris, Not set

Centre Hospitalier Universitaire de Toulouse - Hopital des enfants, Toulouse Cedex 9, Not set

Centre Hospitalier Universitaire de Nancy - Hopital Enfants de Brabois, Vandoeuvre les Nancy Cedex, Not set

Agia Sofia Children Hospital, Athens, Not set

Agia Sofia Children Hospital, Goudi, Not set

General Children Hospital Panagioti and Aglaias Kyriakou, Goudi, Not set

General University Hospital of Patras Panagia i Voithia, Patra, Not set

Ippokrateio General Hospital of Thessaloniki, Thessaloniki, Not set

Hong Kong Childrens Hospital, Kowloon Bay, Not set

Sheba Medical Center, Tel Hashomer, Not set

Azienda Ospedaliera Universitaria Consorziale Policlinico di Bari, Bari, Not set

Azienda Ospedaliera Universitaria Policlinico Vittorio Emanuele Presidio Ospedaliero G Rodolico, Catania, Not set

IRCCS Istituto Giannina Gaslini, Genova, Not set

Fondazione IRCCS San Gerardo dei Tintori, Monza (MB), Not set

Azienda Ospedaliera di Rilievo Nazionale Santobono Pausilipon, Napoli, Not set

Azienda Ospedaliera di Padova, Padova, Not set

Fondazione IRCCS Policlinico San Matteo, Pavia, Not set

IRCCS Ospedale Pediatrico Bambino Gesu, Roma, Not set

Azienda Ospedaliera Citta della Salute e della Scienza Torino Ospedale Infantile Regina Margherita, Torino, Not set

Seoul National University Hospital, Seoul, Not set

Asan Medical Center, Seoul, Not set

Samsung Medical Center, Seoul, Not set

Pusan National University Yangsan Hospital, Yangsan-si, Gyeongsangnam-do, Not set

BRCR Global Mexico, Mexico, Distrito Federal

Instituto Nacional de Pediatria, Mexico, Distrito Federal

BRCR Global Mexico, Guadalajara, Jalisco

BRCR Global Mexico, Puebla, Not set

Prinses Maxima Centrum voor Kinderoncologie, Utrecht, Not set

Oslo Universitetssykehus Rikshospitalet, Oslo, Not set

Uniwersytecki Szpital Dzieciecy w Krakowie, Krakow, Not set

CSK Uniwersytetu Medycznego w Lodzi Uniwersyteckie Centrum Pediatrii im Marii Konopnickiej, Lodz, Not set

Uniwersytecki szpital dzieciecy, Lublin, Not set

Uck wum dzieciecy szpital kliniczny im jozefa polikarpa brudzinskiego, Warszawa, Not set

Uniwersytecki Szpital Kliniczny im Jana Mikulicza-Radeckiego we Wroclawiu, Wroclaw, Not set

SPSK nr 1 im Prof Stanislawa Szyszko Slaskiego Uniwersytetu Medycznego w Katowicach, Zabrze, Not set

Centro Hospitalar Universitario de Coimbra, Coimbra, Not set

Instituto Portugues de Oncologia de Lisboa Francisco Gentil, EPE, Lisboa, Not set

Instituto Portugues de Oncologia do Porto Francisco Gentil, EPE, Porto, Not set

Institutul Clinic Fundeni, Bucharest, Not set

Institutul Oncologic Prof Dr Ion Chiricuta Cluj-Napoca, Cluj Napoca, Not set

Spitalul Clinic de Urgenta pentru Copii Louis Turcanu Timisoara, Timisoara, Not set

FSBI N N Blokhin Russian Oncology Research Center Ministry of Health of Russian Federation, Moscow, Not set

FSBI FSCC of pediatric hematology, oncology and immunology n a Dmitry Rogachev, Moscow, Not set

SBEI of HPE Saint Petersburg State Medical University na academic I P Pavlov of MoH of RF, Saint Petersburg, Not set

King Fahad Medical City, Riyadh, Not set

National University Hospital, Singapore, Not set

KK Womens and Childrens Hospital, Singapore, Not set

Chris Hani Baragwanath Hospital, Johannesburg, Not set

Hospital Sant Joan de Deu, Esplugues de Llobregat, Cataluña

Hospital Universitario Infantil Niño Jesus, Madrid, Not set

Hospital Universitario La Paz, Madrid, Not set

Karolinska Universitetssjukhuset Solna, Solna, Not set

National Taiwan University Hospital, Taipei, Not set

Mackay Memorial Hospital Taipei Branch, Taipei, Not set

Linkou Chang Gung Memorial Hospital, Taoyuan, Not set

King Chulalongkorn Memorial Hospital, Bangkok, Not set

Phramongkutklao Hospital, Bangkok, Not set

Ramathibodi Hospital, Bangkok, Not set

Siriraj Hospital, Bangkok, Not set

Acibadem Adana Hastanesi, Adana, Not set

Ankara Universitesi Tip Fakultesi Hastanesi, Ankara, Not set

Ankara Bilkent Sehir Hastanesi, Ankara, Not set

Medical Park Antalya Hastanesi, Antalya, Not set

Bursa Uludag Universitesi Tip Fakultesi, Bursa, Not set

Medical Park Bahcelievler Hastanesi, Istanbul, Not set

Medipol Mega Universite Hastanesi, Istanbul, Not set

Ege Universitesi Tip Fakultesi, Izmir, Not set

Erciyes Universitesi Tip Fakultesi Mustafa Eraslan ve Fevzi Mercan Cocuk Hastanesi, Kayseri, Not set

The Royal Marsden NHS Foundation Trust, Sutton, Not set

Conditions: Acute Lymphoblastic Leukemia (ALL)

Learn More ›

ATG Plus PTCy vs ATG for CGVHD Prophylaxis

NCT04202835

Active Not Recruiting

A Randomized Pilot Trial to test the feasibility of comparing anti-thymocyte globulin plus post transplant cyclophosphamide with anti-thymocyte globulin alone to prevent chronic graft versus host disease.

Gender:

ALL

Ages:

Between 16 years and 70 years

Trial Updated:

05/07/2025

Locations: Kinghorn Cancer Centre, St Vincent's Health Network, Darlinghurst, New South Wales +8 locations

Conditions: Acute Leukemia, Myelodysplasia, Chronic Graft-versus-host-disease

Learn More ›

Mismatched Related Donor Versus Matched Unrelated Donor Stem Cell Transplantation for Children, Adolescents, and Young Adults With Acute Leukemia or Myelodysplastic Syndrome

NCT05457556

Active Not Recruiting

This phase III trial compares hematopoietic (stem) cell transplantation (HCT) using mismatched related donors (haploidentical \[haplo\]) versus matched unrelated donors (MUD) in treating children, adolescents, and young adults with acute leukemia or myelodysplastic syndrome (MDS). HCT is considered standard of care treatment for patients with high-risk acute leukemia and MDS. In HCT, patients are given very high doses of chemotherapy and/or radiation therapy, which is intended to kill cancer cel... Read More

Gender:

ALL

Ages:

Between 6 months and 21 years

Trial Updated:

05/06/2025

Locations: Children's Hospital of Alabama, Birmingham, Alabama +62 locations

Children's Hospital of Alabama, Birmingham, Alabama

Phoenix Childrens Hospital, Phoenix, Arizona

Arkansas Children's Hospital, Little Rock, Arkansas

City of Hope Comprehensive Cancer Center, Duarte, California

Loma Linda University Medical Center, Loma Linda, California

Children's Hospital Los Angeles, Los Angeles, California

UCSF Benioff Children's Hospital Oakland, Oakland, California

Lucile Packard Children's Hospital Stanford University, Palo Alto, California

UCSF Medical Center-Mission Bay, San Francisco, California

Children's Hospital Colorado, Aurora, Colorado

Yale University, New Haven, Connecticut

Alfred I duPont Hospital for Children, Wilmington, Delaware

Children's National Medical Center, Washington, District of Columbia

University of Florida Health Science Center - Gainesville, Gainesville, Florida

Nemours Children's Clinic-Jacksonville, Jacksonville, Florida

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida

Nicklaus Children's Hospital, Miami, Florida

AdventHealth Orlando, Orlando, Florida

Johns Hopkins All Children's Hospital, Saint Petersburg, Florida

Lurie Children's Hospital-Chicago, Chicago, Illinois

University of Chicago Comprehensive Cancer Center, Chicago, Illinois

Riley Hospital for Children, Indianapolis, Indiana

University of Iowa/Holden Comprehensive Cancer Center, Iowa City, Iowa

Norton Children's Hospital, Louisville, Kentucky

Children's Hospital New Orleans, New Orleans, Louisiana

Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland

C S Mott Children's Hospital, Ann Arbor, Michigan

Children's Hospital of Michigan, Detroit, Michigan

Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids, Michigan

Mayo Clinic in Rochester, Rochester, Minnesota

University of Mississippi Medical Center, Jackson, Mississippi

Children's Mercy Hospitals and Clinics, Kansas City, Missouri

Washington University School of Medicine, Saint Louis, Missouri

Hackensack University Medical Center, Hackensack, New Jersey

Montefiore Medical Center - Moses Campus, Bronx, New York

Roswell Park Cancer Institute, Buffalo, New York

The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park, New York

Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York, New York

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York, New York

University of Rochester, Rochester, New York

New York Medical College, Valhalla, New York

Carolinas Medical Center/Levine Cancer Institute, Charlotte, North Carolina

Duke University Medical Center, Durham, North Carolina

Cleveland Clinic Foundation, Cleveland, Ohio

University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma

Penn State Children's Hospital, Hershey, Pennsylvania

Medical University of South Carolina, Charleston, South Carolina

The Children's Hospital at TriStar Centennial, Nashville, Tennessee

Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee

Medical City Dallas Hospital, Dallas, Texas

UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas

Cook Children's Medical Center, Fort Worth, Texas

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston, Texas

Methodist Children's Hospital of South Texas, San Antonio, Texas

Primary Children's Hospital, Salt Lake City, Utah

Virginia Commonwealth University/Massey Cancer Center, Richmond, Virginia

University of Wisconsin Carbone Cancer Center - University Hospital, Madison, Wisconsin

The Children's Hospital at Westmead, Westmead, New South Wales

Alberta Children's Hospital, Calgary, Alberta

British Columbia Children's Hospital, Vancouver, British Columbia

CancerCare Manitoba, Winnipeg, Manitoba

Hospital for Sick Children, Toronto, Ontario

Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec

Conditions: Myelodysplastic Syndrome, Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Mixed Phenotype Acute Leukemia

Learn More ›

Trastuzumab Deruxtecan (T-DXd) Alone or in Sequence With THP, Versus Standard Treatment (ddAC-THP), in HER2-positive Early Breast Cancer

NCT05113251

Active Not Recruiting

This study will look at the efficacy and safety of trastuzumab deruxtecan (T-DXd) in a neoadjuvant setting, in high-risk, HER2-positive early non-metastatic breast cancer.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

05/05/2025

Locations: Research Site, Springdale, Arkansas +145 locations

Research Site, Springdale, Arkansas

Research Site, Beverly Hills, California

Research Site, Glendale, California

Research Site, Los Alamitos, California

Research Site, Orange, California

Research Site, New Haven, Connecticut

Research Site, Fort Wayne, Indiana

Research Site, Lexington, Kentucky

Research Site, Louisville, Kentucky

Research Site, Shreveport, Louisiana

Research Site, Minneapolis, Minnesota

Research Site, Las Vegas, Nevada

Research Site, East Brunswick, New Jersey

Research Site, Summit, New Jersey

Research Site, Commack, New York

Research Site, Durham, North Carolina

Research Site, Greenville, South Carolina

Research Site, Germantown, Tennessee

Research Site, Nashville, Tennessee

Research Site, Fort Worth, Texas

Research Site, Ogden, Utah

Research Site, Tacoma, Washington

Research Site, Goiânia, Not set

Research Site, Ijuí, Not set

Research Site, Natal, Not set

Research Site, Porto Alegre, Not set

Research Site, São Paulo, Not set

Research Site, Panagyurishte, Not set

Research Site, Sofia, Not set

Research Site, Edmonton, Alberta

Research Site, Toronto, Ontario

Research Site, Montreal, Quebec

Research Site, Quebec City, Quebec

Research Site, Sherbrooke, Quebec

Research Site, Montreal, Not set

Research Site, Beijing, Not set

Research Site, Changsha, Not set

Research Site, Chongqing, Not set

Research Site, Guangzhou, Not set

Research Site, Kunming, Not set

Research Site, Nanning, Not set

Research Site, Qingdao, Not set

Research Site, Shanghai, Not set

Research Site, Shenyang, Not set

Research Site, Tianjin, Not set

Research Site, Wuhan, Not set

Research Site, Zhengzhou, Not set

Research Site, Augsburg, Not set

Research Site, Berlin, Not set

Research Site, Erlangen, Not set

Research Site, Hamburg, Not set

Research Site, Heidelberg, Not set

Research Site, Kiel, Not set

Research Site, Leipzig, Not set

Research Site, Muenster, Not set

Research Site, Mönchengladbach, Not set

Research Site, München, Not set

Research Site, Paderborn, Not set

Research Site, Tübingen, Not set

Research Site, Gurgaon, Not set

Research Site, Howrah, Not set

Research Site, Nagpur, Not set

Research Site, Nashik, Not set

Research Site, New Delhi, Not set

Research Site, Raipur, Not set

Research Site, Rishikesh, Not set

Research Site, Surat, Not set

Research Site, Thiruvananthapuram, Not set

Research Site, Bologna, Not set

Research Site, Candiolo, Not set

Research Site, Livorno, Not set

Research Site, Milano, Not set

Research Site, Naples, Not set

Research Site, Napoli, Not set

Research Site, Negrar, Not set

Research Site, Padova, Not set

Research Site, Roma, Not set

Research Site, Rozzano, Not set

Research Site, Chuo-ku, Not set

Research Site, Hidaka-shi, Not set

Research Site, Hiroshima-shi, Not set

Research Site, Kawasaki-shi, Not set

Research Site, Koto-ku, Not set

Research Site, Nagoya-shi, Not set

Research Site, Ota-shi, Not set

Research Site, Shinjuku-ku, Not set

Research Site, Goyang-si, Not set

Research Site, Seoul, Not set

Research Site, Lima, Not set

Research Site, Bacolod, Not set

Research Site, Cebu City, Not set

Research Site, Davao City, Not set

Research Site, Iloilo, Not set

Research Site, Quezon City, Not set

Research Site, San Juan, Not set

Research Site, Biała Podlaska, Not set

Research Site, Białystok, Not set

Research Site, Bydgoszcz, Not set

Research Site, Koszalin, Not set

Research Site, Lublin, Not set

Research Site, Rzeszów, Not set

Research Site, Warszawa, Not set

Research Site, Moscow, Not set

Research Site, Saint Petersburg, Not set

Research Site, Ar Riyāḑ, Not set

Research Site, Dammam, Not set

Research Site, Jeddah, Not set

Research Site, Riyadh, Not set

Research Site, Barcelona, Not set

Research Site, Madrid, Not set

Research Site, Sevilla, Not set

Research Site, Vigo, Not set

Research Site, Kaohsiung, Not set

Research Site, Taichung, Not set

Research Site, Tainan, Not set

Research Site, Taipei City, Not set

Research Site, Taipei, Not set

Research Site, Taoyuan, Not set

Research Site, Bangkok, Not set

Research Site, Chiang Mai, Not set

Research Site, Hat Yai, Not set

Research Site, Khon Kaen, Not set

Conditions: Breast Neoplasms, Breast Cancer, HER2-positive Early Breast Cancer

Learn More ›

A Trial Comparing Unrelated Donor BMT With IST for Pediatric and Young Adult Patients With Severe Aplastic Anemia (TransIT, BMT CTN 2202)

NCT05600426

Recruiting

Severe Aplastic Anemia (SAA) is a rare condition in which the body stops producing enough new blood cells. SAA can be cured with immune suppressive therapy or a bone marrow transplant. Regular treatment for patients with aplastic anemia who have a matched sibling (brother or sister), or family donor is a bone marrow transplant. Patients without a matched family donor normally are treated with immune suppressive therapy (IST). Match unrelated donor (URD) bone marrow transplant (BMT) is used as a... Read More

Gender:

ALL

Ages:

Between 0 years and 25 years

Trial Updated:

05/05/2025

Locations: University of Alabama at Birmingham, Birmingham, Alabama +49 locations

University of Alabama at Birmingham, Birmingham, Alabama

Phoenix Children's Hospital, Phoenix, Arizona

Arkansas, Little Rock, Arkansas

Loma Linda, Loma Linda, California

Children's Hospital Los Angeles, Los Angeles, California

UCLA, Los Angeles, California

Children's Hospital & Research Center Oakland, Oakland, California

Children's Hospital of Orange County, Orange, California

Stanford, Palo Alto, California

Rady Children's Hospital San Diego, San Diego, California

University of California San Francisco, San Francisco, California

Children's Hospital Colorado, Aurora, Colorado

Yale University, New Haven, Connecticut

Nemours Children's Hospital, Delaware, Wilmington, Delaware

Children's National Hospital, Washington, District of Columbia

University of Florida, Gainesville, Florida

University of Miami, Miami, Florida

Nicklaus Children's Hospital, Miami, Florida

Johns Hopkins All Children's Hospital, Saint Petersburg, Florida

Children's Hospital of Atlanta/Emory, Atlanta, Georgia

Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois

University of Chicago, Chicago, Illinois

Indiana University Hospital/Riley Hospital for Children, Indianapolis, Indiana

Children's Hospital NOLA, New Orleans, Louisiana

Maine Health, Scarborough, Maine

Boston Children's Hospital, Boston, Massachusetts

University of Michigan, Ann Arbor, Michigan

Helen DeVos Children's Hospital, Grand Rapids, Michigan

Mayo Clinic Rochestser, Rochester, Minnesota

University of Mississippi Medical Center, Jackson, Mississippi

Washington University in St. Louis, Saint Louis, Missouri

Hackensack University Medical Center, Hackensack, New Jersey

Roswell Park Comprehensive Cancer Center, Buffalo, New York

Cohen Children's Medical Center of New York, New Hyde Park, New York

Columbia University Medical Center, New York, New York

University of North Carolina, Chapel Hill, North Carolina

Levine Children's Hospital, Charlotte, North Carolina

Duke University, Durham, North Carolina

Nationwide Children's Hospital, Columbus, Ohio

Oregon Health & Science University, Portland, Oregon

Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

St. Jude Children's Research Hospital, Memphis, Tennessee

Vanderbilt University Medical Center, Nashville, Tennessee

Children's Medical Center Dallas, Dallas, Texas

Texas Children's Hospital, Houston, Texas

University of Utah/Primary Children's Hospital, Salt Lake City, Utah

Children's Hospital of the King's Daughter, Norfolk, Virginia

Fred Hutchinson Cancer Center, Seattle, Washington

University of Wisconsin, Madison, Wisconsin

Winnipeg CancerCare Manitoba, Winnipeg, Manitoba

Conditions: Severe Aplastic Anemia

Learn More ›

A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma

NCT01878617

Active Not Recruiting

Historically, medulloblastoma treatment has been determined by the amount of leftover disease present after surgery, also known as clinical risk (standard vs. high risk). Recent studies have shown that medulloblastoma is made up of distinct molecular subgroups which respond differently to treatment. This suggests that clinical risk alone is not adequate to identify actual risk of recurrence. In order to address this, we will stratify medulloblastoma treatment in this phase II clinical trial based on both clinical risk (low, standard, intermediate, or high risk) and molecular subtype (WNT, SHH, or Non-WNT Non-SHH). This stratified clinical and molecular treatment approach will be used to evaluate the following: * To find out if participants with low-risk WNT tumors can be treated with a lower dose of radiation to the brain and spine, and a lower dose of the chemotherapy drug cyclophosphamide while still achieving the same survival rate as past St. Jude studies with fewer side effects. * To find out if adding targeted chemotherapy after standard chemotherapy will benefit participants with SHH positive tumors. * To find out if adding new chemotherapy agents to the standard chemotherapy will improve the outcome for intermediate and high risk Non-WNT Non-SHH tumors. * To define the cure rate for standard risk Non-WNT Non-SHH tumors treated with reduced dose cyclophosphamide and compare this to participants from the past St. Jude study. All participants on this study will have surgery to remove as much of the primary tumor as safely possible, radiation therapy, and chemotherapy. The amount of radiation therapy and type of chemotherapy received will be determined by the participant's treatment stratum. Treatment stratum assignment will be based on the tumor's molecular subgroup assignment and clinical risk. The participant will be assigned to one of three medulloblastoma subgroups determined by analysis of the tumor tissue for tumor biomarkers: * WNT (Strata W): positive for WNT biomarkers * SHH (Strata S): positive for SHH biomarkers * Non-WNT Non-SHH, Failed, or Indeterminate (Strata N): negative for WNT and SHH biomarkers or results are indeterminable Participants will then be assigned to a clinical risk group (low, standard, intermediate, or high) based on assessment of: * How much tumor is left after surgery * If the cancer has spread to other sites outside the brain \[i.e., to the spinal cord or within the fluid surrounding the spinal cord, called cerebrospinal fluid (CSF)\] * The appearance of the tumor cells under the microscope * Whether or not there are chromosomal abnormalities in the tumor, and if present, what type (also called cytogenetics analysis) Read Less

Gender:

ALL

Ages:

Between 3 years and 39 years

Trial Updated:

05/01/2025

Locations: Lucille Packard Children's Hospital at Stanford University Medical Center, Palo Alto, California +22 locations

Conditions: Medulloblastoma

Learn More ›

A Phase 2 Study of Ruxolitinib With Chemotherapy in Children With Acute Lymphoblastic Leukemia

NCT02723994

Active Not Recruiting

This is a nonrandomized study of ruxolitinib in combination with a standard multi-agent chemotherapy regimen for the treatment of B-cell acute lymphoblastic leukemia. Part 1 of the study will optimize the dose of study drug (ruxolitinib) in combination with the chemotherapy regimen. Part 2 will evaluate the efficacy of combination chemotherapy and ruxolitinib at the recommended dose determined in Part 1.

Gender:

ALL

Ages:

Between 1 year and 21 years

Trial Updated:

04/30/2025

Locations: The Childrens Hospital of Alabama, Birmingham, Alabama +110 locations

The Childrens Hospital of Alabama, Birmingham, Alabama

Phoenix Children'S Hospital, Phoenix, Arizona

Arkansas Childrens Hospital, Little Rock, Arkansas

Kaiser Permanente, Fontana, California

Loma Linda University Cancer Center, Loma Linda, California

Miller Childrens Hospital Pharmacy, Long Beach, California

Children'S Hospital Los Angeles, Los Angeles, California

Kaiser Foundation Health Plan, Los Angeles, California

Southern California Permanente Medical Group, Los Angeles, California

Valley Childrens Hospital, Madera, California

Choc Children Hospital, Orange, California

Lucille Packard Childrens Hospital, Palo Alto, California

Kaiser Permanente, San Diego, California

Rady Children'S Hospital - San Diego, San Diego, California

Ucsf Pediatric Oncology, San Francisco, California

Kaiser Permanente Downey, Santa Fe Springs, California

Children'S Hospital Colorado, Aurora, Colorado

Connecticut Children'S Medical Ctr, Hartford, Connecticut

Smilow Cancer Center - Yale, New Haven, Connecticut

Alfred I. Dupont Hospital For Children, Wilmington, Delaware

Childrens Hospital of Southwest Florida, Fort Myers, Florida

Joe Dimaggio Children Hospital, Hollywood, Florida

Nemours Childrens Clinic, Jacksonville, Florida

University of Florida Health Shands Hospital, Jacksonville, Florida

Florida Hospital Orlando, Orlando, Florida

Arnold Palmer Hospital For Children, Orlando, Florida

Nemours Childrens Clinic, Pensacola, Florida

All Childrens Hospital, Saint Petersburg, Florida

St Josephs Childrens Hospital Tampa, Tampa, Florida

Saint Marys Medical Center, West Palm Beach, Florida

Egleston Children'S Health, Atlanta, Georgia

Kapiolani Medical Center For Women and Children, Honolulu, Hawaii

Ann & Robert H. Lurie Children'S Hospital, Chicago, Illinois

Loyola University Medical Center, Maywood, Illinois

Southern Illinois University School of Medicine, Springfield, Illinois

Riley Hospital For Children, Indianapolis, Indiana

St Vincent Hospital, Indianapolis, Indiana

Blank Childrens Hospital, Des Moines, Iowa

University of Iowa Hospital and Clinics, Iowa City, Iowa

University of Kentucky, Lexington, Kentucky

Kosair Childrens Hospital, Louisville, Kentucky

Ochsner Clinic, New Orleans, Louisiana

Maine Center For Cancer Medicine, Scarborough, Maine

Sinai Hospital of Baltimore, Baltimore, Maryland

Johns Hopkins University, Baltimore, Maryland

Dana Farber Boston Children'S, Boston, Massachusetts

Cs Mott Childrens Hospital, Ann Arbor, Michigan

Helen Devos Childrens Hosp, Grand Rapids, Michigan

Michigan State University, Lansing, Michigan

Children'S Hospitals and Clinics of Minnesota, Minneapolis, Minnesota

University of Minnesota, Minneapolis, Minnesota

University of Mississippi Medical Center, Jackson, Mississippi

The Children'S Mercy Hospital Outpatient, Kansas City, Missouri

Washington University, Saint Louis, Missouri

Children'S Hospital & Medical Center, Omaha, Nebraska

Alliance For Childhood Diseases, Las Vegas, Nevada

Children'S Center For Cancer & Blood Dis, Las Vegas, Nevada

Hackensack University Medical Center, Hackensack, New Jersey

Morristown Medical Center, Morristown, New Jersey

Rutgers Cancer Institute of Nj, New Brunswick, New Jersey

Newark Beth Israel Medical Center, Newark, New Jersey

St Josephs Regional Medical Center, Paterson, New Jersey

University of New Mexico Hospital, Albuquerque, New Mexico

Albany Medical College, Albany, New York

Roswell Park Comprehensive Cancer Center, Buffalo, New York

Cohen Children'S Medical Center, New Hyde Park, New York

Weill Cornell Medical College, New York, New York

Nyu Clinical Cancer Center, New York, New York

University of Rochester Medical Center, Rochester, New York

Suny Upstate Medical University, Syracuse, New York

New York Medical College, Valhalla, New York

University of North Carolina At Chapel Hill, Chapel Hill, North Carolina

Carolinas Medical Center, Charlotte, North Carolina

Wake Forest University, Winston-Salem, North Carolina

Akron Children'S Hospital, Akron, Ohio

Cincinnati Childrens Hospital Medical Center, Cincinnati, Ohio

Rainbow Babies & Children Hosp, Cleveland, Ohio

Cleveland Clinic Foundation, Cleveland, Ohio

Nationwide Children'S Hospital, Columbus, Ohio

Dayton Children'S Hospital, Dayton, Ohio

Toledo Hospital, Toledo, Ohio

University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma

Legacy Emanuel Hospital and Health Center, Portland, Oregon

Doernbecher Childrens Hospital, Portland, Oregon

Penn State Hershey Medical Center, Hershey, Pennsylvania

Children'S Hospital of Philadelphia, Philadelphia, Pennsylvania

Childrens Hospital of Pittsburgh, Pittsburgh, Pennsylvania

Hasbro Childrens Hospital, Providence, Rhode Island

Medical University of South Carolina, Charleston, South Carolina

Vanderbilt University Medical Center, Nashville, Tennessee

Dell Childrens Medical Center of Central Texas, Austin, Texas

Driscoll Children'S Hospital, Corpus Christi, Texas

Medical City Dallas Hospital, Dallas, Texas

University of Texas Southwestern Medical Center, Dallas, Texas

El Paso Children'S Hospital Corporation, El Paso, Texas

Texas Childrens Hospital, Houston, Texas

University of Texas Health Science Cente, San Antonio, Texas

Primary Children'S Hospital, Salt Lake City, Utah

Children'S Hospital of the, Norfolk, Virginia

Seattle Children'S Hospital, Seattle, Washington

Providence Sacred Heart Medical Center & Children'S Hospital, Spokane, Washington

St Vincent Hospital, Green Bay, Wisconsin

Medical College of Wisconsin, Milwaukee, Wisconsin

Alberta'S Children Hospital, Calgary, Alberta

Bc Children'S Hospital, Vancouver, British Columbia

The Hospital For Sick Children, Toronto, Ontario

Chu Sainte-Justine, Montreal, Quebec

McGill University Health Centre/Glen Site/Cedars Cancer Centre, Montreal, Quebec

McMaster University Medical Centre, Hamilton, Not set

San Jorge Childrens Hospital, San Juan, Not set

University Pediatric Hospital, San Juan, Not set

Conditions: Leukemia

Learn More ›

Combination Chemotherapy With or Without Radiation Therapy in Treating Young Patients With Newly Diagnosed Stage III or Stage IV Wilms' Tumor

NCT00379340

Active Not Recruiting

This phase III trial is studying how well combination chemotherapy with or without radiation therapy works in treating young patients with newly diagnosed stage III or stage IV Wilms' tumor. Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays to kill tumor cells. Giving more than one drug (combination chemotherapy) with or without radiation therapy may kill mo... Read More

Gender:

ALL

Ages:

29 years and below

Trial Updated:

04/30/2025

Locations: Children's Hospital of Alabama, Birmingham, Alabama +226 locations

Children's Hospital of Alabama, Birmingham, Alabama

University of Alabama at Birmingham Cancer Center, Birmingham, Alabama

USA Health Strada Patient Care Center, Mobile, Alabama

Phoenix Childrens Hospital, Phoenix, Arizona

Banner University Medical Center - Tucson, Tucson, Arizona

Arkansas Children's Hospital, Little Rock, Arkansas

University of Arkansas for Medical Sciences, Little Rock, Arkansas

Kaiser Permanente Downey Medical Center, Downey, California

Loma Linda University Medical Center, Loma Linda, California

Miller Children's and Women's Hospital Long Beach, Long Beach, California

Children's Hospital Los Angeles, Los Angeles, California

Cedars Sinai Medical Center, Los Angeles, California

Valley Children's Hospital, Madera, California

UCSF Benioff Children's Hospital Oakland, Oakland, California

Kaiser Permanente-Oakland, Oakland, California

Children's Hospital of Orange County, Orange, California

Lucile Packard Children's Hospital Stanford University, Palo Alto, California

Sutter Medical Center Sacramento, Sacramento, California

University of California Davis Comprehensive Cancer Center, Sacramento, California

Rady Children's Hospital - San Diego, San Diego, California

UCSF Medical Center-Parnassus, San Francisco, California

UCSF Medical Center-Mission Bay, San Francisco, California

Children's Hospital Colorado, Aurora, Colorado

Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center, Denver, Colorado

University of Connecticut, Farmington, Connecticut

Connecticut Children's Medical Center, Hartford, Connecticut

Yale University, New Haven, Connecticut

Alfred I duPont Hospital for Children, Wilmington, Delaware

MedStar Georgetown University Hospital, Washington, District of Columbia

Children's National Medical Center, Washington, District of Columbia

Broward Health Medical Center, Fort Lauderdale, Florida

Lee Memorial Health System, Fort Myers, Florida

Golisano Children's Hospital of Southwest Florida, Fort Myers, Florida

University of Florida Health Science Center - Gainesville, Gainesville, Florida

Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood, Florida

Nemours Children's Clinic-Jacksonville, Jacksonville, Florida

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida

Nicklaus Children's Hospital, Miami, Florida

Miami Cancer Institute, Miami, Florida

AdventHealth Orlando, Orlando, Florida

Arnold Palmer Hospital for Children, Orlando, Florida

Nemours Children's Clinic - Orlando, Orlando, Florida

Orlando Health Cancer Institute, Orlando, Florida

Nemours Children's Clinic - Pensacola, Pensacola, Florida

Sacred Heart Hospital, Pensacola, Florida

Johns Hopkins All Children's Hospital, Saint Petersburg, Florida

Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa, Florida

Saint Mary's Medical Center, West Palm Beach, Florida

Emory University Hospital/Winship Cancer Institute, Atlanta, Georgia

Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta, Georgia

Memorial Health University Medical Center, Savannah, Georgia

University of Hawaii Cancer Center, Honolulu, Hawaii

Tripler Army Medical Center, Honolulu, Hawaii

Saint Luke's Cancer Institute - Boise, Boise, Idaho

Lurie Children's Hospital-Chicago, Chicago, Illinois

University of Illinois, Chicago, Illinois

University of Chicago Comprehensive Cancer Center, Chicago, Illinois

Loyola University Medical Center, Maywood, Illinois

Advocate Children's Hospital-Oak Lawn, Oak Lawn, Illinois

Advocate Children's Hospital-Park Ridge, Park Ridge, Illinois

Advocate Lutheran General Hospital, Park Ridge, Illinois

Saint Jude Midwest Affiliate, Peoria, Illinois

Southern Illinois University School of Medicine, Springfield, Illinois

Indiana University/Melvin and Bren Simon Cancer Center, Indianapolis, Indiana

Riley Hospital for Children, Indianapolis, Indiana

Ascension Saint Vincent Indianapolis Hospital, Indianapolis, Indiana

Blank Children's Hospital, Des Moines, Iowa

University of Iowa/Holden Comprehensive Cancer Center, Iowa City, Iowa

University of Kansas Cancer Center, Kansas City, Kansas

University of Kentucky/Markey Cancer Center, Lexington, Kentucky

Norton Children's Hospital, Louisville, Kentucky

Tulane University School of Medicine, New Orleans, Louisiana

Children's Hospital New Orleans, New Orleans, Louisiana

Ochsner Medical Center Jefferson, New Orleans, Louisiana

Eastern Maine Medical Center, Bangor, Maine

University of Maryland/Greenebaum Cancer Center, Baltimore, Maryland

Sinai Hospital of Baltimore, Baltimore, Maryland

Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland

Walter Reed National Military Medical Center, Bethesda, Maryland

Tufts Children's Hospital, Boston, Massachusetts

Massachusetts General Hospital Cancer Center, Boston, Massachusetts

Dana-Farber Cancer Institute, Boston, Massachusetts

Baystate Medical Center, Springfield, Massachusetts

UMass Memorial Medical Center - University Campus, Worcester, Massachusetts

C S Mott Children's Hospital, Ann Arbor, Michigan

Wayne State University/Karmanos Cancer Institute, Detroit, Michigan

Henry Ford Health Saint John Hospital, Detroit, Michigan

Michigan State University Clinical Center, East Lansing, Michigan

Hurley Medical Center, Flint, Michigan

Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids, Michigan

Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids, Michigan

Bronson Methodist Hospital, Kalamazoo, Michigan

Kalamazoo Center for Medical Studies, Kalamazoo, Michigan

Corewell Health Children's, Royal Oak, Michigan

Corewell Health William Beaumont University Hospital, Royal Oak, Michigan

Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis, Minnesota

University of Minnesota/Masonic Cancer Center, Minneapolis, Minnesota

Mayo Clinic in Rochester, Rochester, Minnesota

University of Mississippi Medical Center, Jackson, Mississippi

MU Health - University Hospital/Ellis Fischel Cancer Center, Columbia, Missouri

University of Missouri Children's Hospital, Columbia, Missouri

Children's Mercy Hospitals and Clinics, Kansas City, Missouri

Cardinal Glennon Children's Medical Center, Saint Louis, Missouri

Washington University School of Medicine, Saint Louis, Missouri

Mercy Hospital Saint Louis, Saint Louis, Missouri

Children's Hospital and Medical Center of Omaha, Omaha, Nebraska

University of Nebraska Medical Center, Omaha, Nebraska

Alliance for Childhood Diseases/Cure 4 the Kids Foundation, Las Vegas, Nevada

Nevada Cancer Research Foundation NCORP, Las Vegas, Nevada

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon, New Hampshire

Hackensack University Medical Center, Hackensack, New Jersey

Morristown Medical Center, Morristown, New Jersey

Saint Peter's University Hospital, New Brunswick, New Jersey

Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick, New Jersey

Newark Beth Israel Medical Center, Newark, New Jersey

Saint Joseph's Regional Medical Center, Paterson, New Jersey

Overlook Hospital, Summit, New Jersey

University of New Mexico Cancer Center, Albuquerque, New Mexico

Albany Medical Center, Albany, New York

Montefiore Medical Center - Moses Campus, Bronx, New York

Brooklyn Hospital Center, Brooklyn, New York

Roswell Park Cancer Institute, Buffalo, New York

NYU Langone Hospital - Long Island, Mineola, New York

The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park, New York

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York, New York

Memorial Sloan Kettering Cancer Center, New York, New York

NYP/Weill Cornell Medical Center, New York, New York

University of Rochester, Rochester, New York

Stony Brook University Medical Center, Stony Brook, New York

State University of New York Upstate Medical University, Syracuse, New York

New York Medical College, Valhalla, New York

Mission Hospital, Asheville, North Carolina

UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina

Carolinas Medical Center/Levine Cancer Institute, Charlotte, North Carolina

Novant Health Presbyterian Medical Center, Charlotte, North Carolina

Duke University Medical Center, Durham, North Carolina

East Carolina University, Greenville, North Carolina

Wake Forest University Health Sciences, Winston-Salem, North Carolina

Sanford Broadway Medical Center, Fargo, North Dakota

Children's Hospital Medical Center of Akron, Akron, Ohio

Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio

Rainbow Babies and Childrens Hospital, Cleveland, Ohio

Cleveland Clinic Foundation, Cleveland, Ohio

Nationwide Children's Hospital, Columbus, Ohio

Dayton Children's Hospital, Dayton, Ohio

ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo, Ohio

Mercy Children's Hospital, Toledo, Ohio

University of Toledo, Toledo, Ohio

University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma

Natalie Warren Bryant Cancer Center at Saint Francis, Tulsa, Oklahoma

Legacy Emanuel Children's Hospital, Portland, Oregon

Legacy Emanuel Hospital and Health Center, Portland, Oregon

Oregon Health and Science University, Portland, Oregon

Lehigh Valley Hospital - Muhlenberg, Bethlehem, Pennsylvania

Geisinger Medical Center, Danville, Pennsylvania

Penn State Milton S Hershey Medical Center, Hershey, Pennsylvania

Penn State Children's Hospital, Hershey, Pennsylvania

Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

Children's Oncology Group, Philadelphia, Pennsylvania

Saint Christopher's Hospital for Children, Philadelphia, Pennsylvania

Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania

Rhode Island Hospital, Providence, Rhode Island

Medical University of South Carolina, Charleston, South Carolina

Prisma Health Richland Hospital, Columbia, South Carolina

BI-LO Charities Children's Cancer Center, Greenville, South Carolina

Greenville Cancer Treatment Center, Greenville, South Carolina

Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota

T C Thompson Children's Hospital, Chattanooga, Tennessee

East Tennessee Childrens Hospital, Knoxville, Tennessee

Saint Jude Children's Research Hospital, Memphis, Tennessee

Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee

Texas Tech University Health Sciences Center-Amarillo, Amarillo, Texas

Dell Children's Medical Center of Central Texas, Austin, Texas

Driscoll Children's Hospital, Corpus Christi, Texas

Medical City Dallas Hospital, Dallas, Texas

UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas

Brooke Army Medical Center, Fort Sam Houston, Texas

Cook Children's Medical Center, Fort Worth, Texas

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston, Texas

Covenant Children's Hospital, Lubbock, Texas

Methodist Children's Hospital of South Texas, San Antonio, Texas

University of Texas Health Science Center at San Antonio, San Antonio, Texas

Scott and White Memorial Hospital, Temple, Texas

Primary Children's Hospital, Salt Lake City, Utah

University of Vermont and State Agricultural College, Burlington, Vermont

University of Virginia Cancer Center, Charlottesville, Virginia

Inova Fairfax Hospital, Falls Church, Virginia

Children's Hospital of The King's Daughters, Norfolk, Virginia

Virginia Commonwealth University/Massey Cancer Center, Richmond, Virginia

Carilion Children's, Roanoke, Virginia

Seattle Children's Hospital, Seattle, Washington

Providence Sacred Heart Medical Center and Children's Hospital, Spokane, Washington

Mary Bridge Children's Hospital and Health Center, Tacoma, Washington

Madigan Army Medical Center, Tacoma, Washington

West Virginia University Charleston Division, Charleston, West Virginia

Cabell-Huntington Hospital, Huntington, West Virginia

University of Wisconsin Carbone Cancer Center - University Hospital, Madison, Wisconsin

Marshfield Medical Center-Marshfield, Marshfield, Wisconsin

Children's Hospital of Wisconsin, Milwaukee, Wisconsin

Sydney Children's Hospital, Randwick, New South Wales

The Children's Hospital at Westmead, Westmead, New South Wales

Royal Brisbane and Women's Hospital, Herston, Queensland

Royal Children's Hospital-Brisbane, Herston, Queensland

Queensland Children's Hospital, South Brisbane, Queensland

Women's and Children's Hospital-Adelaide, North Adelaide, South Australia

Royal Children's Hospital, Parkville, Victoria

Princess Margaret Hospital for Children, Perth, Western Australia

Alberta Children's Hospital, Calgary, Alberta

University of Alberta Hospital, Edmonton, Alberta

British Columbia Children's Hospital, Vancouver, British Columbia

CancerCare Manitoba, Winnipeg, Manitoba

Janeway Child Health Centre, Saint John's, Newfoundland and Labrador

IWK Health Centre, Halifax, Nova Scotia

McMaster Children's Hospital at Hamilton Health Sciences, Hamilton, Ontario

Kingston Health Sciences Centre, Kingston, Ontario

Children's Hospital, London, Ontario

Victoria Hospital, London, Ontario

Children's Hospital of Eastern Ontario, Ottawa, Ontario

Hospital for Sick Children, Toronto, Ontario

The Montreal Children's Hospital of the MUHC, Montreal, Quebec

Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec

Saskatoon Cancer Centre, Saskatoon, Saskatchewan

CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL), Quebec, Not set

Schneider Children's Medical Center of Israel, Petah Tikua, Not set

Starship Children's Hospital, Grafton, Auckland

San Jorge Children's Hospital, San Juan, Not set

Swiss Pediatric Oncology Group - Bern, Bern, Not set

Conditions: Stage III Kidney Wilms Tumor, Stage IV Kidney Wilms Tumor

Learn More ›

DALY II USA/ MB-CART2019.1 for DLBCL

NCT04792489

Recruiting

DALY II USA is a phase II, multi-center, single arm study to evaluate the efficacy, safety, and pharmacokinetics of zamtocabtagene autoleucel (MB-CART2019.1) in patients with relapsed and/or refractory diffuse large B cell lymphoma (DLBCL) after receiving at least two lines of therapy. Additional cohorts include subjects with B-cell primary or secondary central nervous system (CNS) lymphoma (PCNSL) and (SCNSL), mantle cell lymphoma (MCL) and Richter's transformation (RT) after receiving at least... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

04/21/2025

Locations: Banner MD Anderson Cancer Center, Gilbert, Arizona +24 locations

Banner MD Anderson Cancer Center, Gilbert, Arizona

Mayo Clinic, Phoenix, Arizona

UC San Diego Health, La Jolla, California

Stanford University, Stanford, California

Yale University, New Haven, Connecticut

Baptist Health Miami Cancer Institute, Miami, Florida

Winship Cancer Institute of Emory University, Atlanta, Georgia

Georgia Cancer Center at Augusta University, Augusta, Georgia

Robert H Lurie Cancer Center, Chicago, Illinois

University of Kansas Cancer Center, Westwood, Kansas

University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, Maryland

Dana Farber Cancer Institute, Boston, Massachusetts

University of Michigan, Ann Arbor, Michigan

Mayo Clinic, Rochester, Minnesota

University of Nebraska Medical Center, Omaha, Nebraska

Memorial Sloan Kettering Cancer Center, New York, New York

Duke University Medical Center - Division of Hematologic Malignancies, Durham, North Carolina

The Ohio State University Wexner Medical Center James Cancer, Columbus, Ohio

Oregon Health and Science University Knight Cancer Institute, Portland, Oregon

University of Pittsburgh - Hillman Cancer Center, Pittsburgh, Pennsylvania

Allegheny Health Network Cancer Institute, Pittsburg, Pennsylvania

UT Southwestern Medical Center, Dallas, Texas

Froedtert Hospital and the Medical College of Wisconsin, Milwaukee, Wisconsin

University of Alberta Cross Cancer Institute, Edmonton, Alberta

Princess Margaret Cancer Centre, Toronto, Ontario

Conditions: Refractory Diffuse Large B Cell Lymphoma (DLBCL), Relapsed Diffuse Large B Cell Lymphoma, High Grade B-cell Lymphoma (HGBCL), Primary Mediastinal B-cell Lymphoma (PMBCL), Transformed Lymphoma, Central Nervous System Lymphoma, Mantle Cell Lymphoma (MCL), Richter Transformation

Learn More ›

Novel Combination Therapy in the Treatment of Relapsed and Refractory Aggressive B-Cell Lymphoma

NCT02436707

Active Not Recruiting

The purpose of this study is to find out what effects new combinations of treatment will have this disease. New promising treatment strategies will be added to this study as they are available to be compared against the standard treatment.

Gender:

ALL

Ages:

Between 16 years and 65 years

Trial Updated:

04/14/2025

Locations: Arthur J.E. Child Comprehensive Cancer Centre, Calgary, Alberta +12 locations

Conditions: Lymphoma

Learn More ›