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Cyclophosphamide Treatment Options in Canada
A collection of 300 research studies where Cyclophosphamide is the interventional treatment. These studies are located in the Canada . Cyclophosphamide is used for conditions such as Breast Cancer, Lymphoma and Leukemia.
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Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma
Recruiting
This phase III trial tests how well the addition of dinutuximab to Induction chemotherapy along with standard of care surgical resection of the primary tumor, radiation, stem cell transplantation, and immunotherapy works for treating children with newly diagnosed high-risk neuroblastoma. Dinutuximab is a monoclonal antibody that binds to a molecule called GD2, which is found on the surface of neuroblastoma cells, but is not present on many healthy or normal cells in the body. When dinutuximab bi... Read More
This phase III trial tests how well the addition of dinutuximab to Induction chemotherapy along with standard of care surgical resection of the primary tumor, radiation, stem cell transplantation, and immunotherapy works for treating children with newly diagnosed high-risk neuroblastoma. Dinutuximab is a monoclonal antibody that binds to a molecule called GD2, which is found on the surface of neuroblastoma cells, but is not present on many healthy or normal cells in the body. When dinutuximab binds to the neuroblastoma cells, it helps signal the immune system to kill the tumor cells. This helps the cells of the immune system kill the cancer cells, this is a type of immunotherapy. When chemotherapy and immunotherapy are given together, during the same treatment cycle, it is called chemoimmunotherapy. This clinical trial randomly assigns patients to receive either standard chemotherapy and surgery or chemoimmunotherapy (chemotherapy plus dinutuximab) and surgery during Induction therapy. Chemotherapy drugs administered during Induction include, cyclophosphamide, topotecan, cisplatin, etoposide, vincristine, and doxorubicin. These drugs work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing or by stopping them from spreading. Upon completion of 5 cycles of Induction therapy, a disease evaluation is completed to determine how well the treatment worked. If the tumor responds to therapy, patients receive a tandem transplantation with stem cell rescue. If the tumor has little improvement or worsens, patients receive chemoimmunotherapy on Extended Induction. During Extended Induction, dinutuximab is given with irinotecan, temozolomide. Patients with a good response to therapy move on to Consolidation therapy, when very high doses of chemotherapy are given at two separate points to kill any remaining cancer cells. Following, transplant, radiation therapy is given to the site where the cancer originated (primary site) and to any other areas that are still active at the end of Induction. The final stage of therapy is Post-Consolidation. During Post-Consolidation, dinutuximab is given with isotretinoin, with the goal of maintaining the response achieved with the previous therapy. Adding dinutuximab to Induction chemotherapy along with standard of care surgical resection of the primary tumor, radiation, stem cell transplantation, and immunotherapy may be better at treating children with newly diagnosed high-risk neuroblastoma. Read Less
Gender:
ALL
Ages:
30 years and below
Trial Updated:
07/31/2025
Locations: Children's Hospital of Alabama, Birmingham, Alabama +158 locations
Children's Hospital of Alabama, Birmingham, Alabama
USA Health Strada Patient Care Center, Mobile, Alabama
Banner Children's at Desert, Mesa, Arizona
Phoenix Childrens Hospital, Phoenix, Arizona
Banner University Medical Center - Tucson, Tucson, Arizona
Arkansas Children's Hospital, Little Rock, Arkansas
Kaiser Permanente Downey Medical Center, Downey, California
City of Hope Comprehensive Cancer Center, Duarte, California
Loma Linda University Medical Center, Loma Linda, California
Miller Children's and Women's Hospital Long Beach, Long Beach, California
Children's Hospital Los Angeles, Los Angeles, California
Cedars Sinai Medical Center, Los Angeles, California
Mattel Children's Hospital UCLA, Los Angeles, California
Valley Children's Hospital, Madera, California
UCSF Benioff Children's Hospital Oakland, Oakland, California
Kaiser Permanente-Oakland, Oakland, California
Children's Hospital of Orange County, Orange, California
Lucile Packard Children's Hospital Stanford University, Palo Alto, California
University of California Davis Comprehensive Cancer Center, Sacramento, California
UCSF Medical Center-Mission Bay, San Francisco, California
Children's Hospital Colorado, Aurora, Colorado
Connecticut Children's Medical Center, Hartford, Connecticut
Yale University, New Haven, Connecticut
Alfred I duPont Hospital for Children, Wilmington, Delaware
Children's National Medical Center, Washington, District of Columbia
Broward Health Medical Center, Fort Lauderdale, Florida
Golisano Children's Hospital of Southwest Florida, Fort Myers, Florida
University of Florida Health Science Center - Gainesville, Gainesville, Florida
Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood, Florida
Nemours Children's Clinic-Jacksonville, Jacksonville, Florida
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida
Nicklaus Children's Hospital, Miami, Florida
AdventHealth Orlando, Orlando, Florida
Arnold Palmer Hospital for Children, Orlando, Florida
Nemours Children's Hospital, Orlando, Florida
Johns Hopkins All Children's Hospital, Saint Petersburg, Florida
Saint Mary's Medical Center, West Palm Beach, Florida
Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta, Georgia
Lurie Children's Hospital-Chicago, Chicago, Illinois
University of Illinois, Chicago, Illinois
University of Chicago Comprehensive Cancer Center, Chicago, Illinois
Advocate Children's Hospital-Oak Lawn, Oak Lawn, Illinois
Advocate Children's Hospital-Park Ridge, Park Ridge, Illinois
Saint Jude Midwest Affiliate, Peoria, Illinois
Southern Illinois University School of Medicine, Springfield, Illinois
Riley Hospital for Children, Indianapolis, Indiana
Blank Children's Hospital, Des Moines, Iowa
University of Iowa/Holden Comprehensive Cancer Center, Iowa City, Iowa
Wesley Medical Center, Wichita, Kansas
University of Kentucky/Markey Cancer Center, Lexington, Kentucky
Children's Hospital New Orleans, New Orleans, Louisiana
Eastern Maine Medical Center, Bangor, Maine
Maine Children's Cancer Program, Scarborough, Maine
University of Maryland/Greenebaum Cancer Center, Baltimore, Maryland
Sinai Hospital of Baltimore, Baltimore, Maryland
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland
Dana-Farber Cancer Institute, Boston, Massachusetts
C S Mott Children's Hospital, Ann Arbor, Michigan
Children's Hospital of Michigan, Detroit, Michigan
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids, Michigan
Bronson Methodist Hospital, Kalamazoo, Michigan
Corewell Health Children's, Royal Oak, Michigan
Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis, Minnesota
University of Minnesota/Masonic Cancer Center, Minneapolis, Minnesota
Mayo Clinic in Rochester, Rochester, Minnesota
University of Mississippi Medical Center, Jackson, Mississippi
Children's Mercy Hospitals and Clinics, Kansas City, Missouri
Washington University School of Medicine, Saint Louis, Missouri
Mercy Hospital Saint Louis, Saint Louis, Missouri
Children's Hospital and Medical Center of Omaha, Omaha, Nebraska
University of Nebraska Medical Center, Omaha, Nebraska
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon, New Hampshire
Hackensack University Medical Center, Hackensack, New Jersey
Morristown Medical Center, Morristown, New Jersey
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick, New Jersey
Saint Joseph's Regional Medical Center, Paterson, New Jersey
University of New Mexico Cancer Center, Albuquerque, New Mexico
Albany Medical Center, Albany, New York
Montefiore Medical Center - Moses Campus, Bronx, New York
Roswell Park Cancer Institute, Buffalo, New York
NYU Langone Hospital - Long Island, Mineola, New York
The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park, New York
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York, New York
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York, New York
University of Rochester, Rochester, New York
New York Medical College, Valhalla, New York
Mission Hospital, Asheville, North Carolina
UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina
Carolinas Medical Center/Levine Cancer Institute, Charlotte, North Carolina
Novant Health Presbyterian Medical Center, Charlotte, North Carolina
Duke University Medical Center, Durham, North Carolina
East Carolina University, Greenville, North Carolina
Wake Forest University Health Sciences, Winston-Salem, North Carolina
Sanford Broadway Medical Center, Fargo, North Dakota
Children's Hospital Medical Center of Akron, Akron, Ohio
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Rainbow Babies and Childrens Hospital, Cleveland, Ohio
Cleveland Clinic Foundation, Cleveland, Ohio
Nationwide Children's Hospital, Columbus, Ohio
Dayton Children's Hospital, Dayton, Ohio
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo, Ohio
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Legacy Emanuel Children's Hospital, Portland, Oregon
Oregon Health and Science University, Portland, Oregon
Geisinger Medical Center, Danville, Pennsylvania
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Saint Christopher's Hospital for Children, Philadelphia, Pennsylvania
Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania
Rhode Island Hospital, Providence, Rhode Island
Medical University of South Carolina, Charleston, South Carolina
Prisma Health Richland Hospital, Columbia, South Carolina
BI-LO Charities Children's Cancer Center, Greenville, South Carolina
Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota
East Tennessee Childrens Hospital, Knoxville, Tennessee
Saint Jude Children's Research Hospital, Memphis, Tennessee
The Children's Hospital at TriStar Centennial, Nashville, Tennessee
Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee
Dell Children's Medical Center of Central Texas, Austin, Texas
Driscoll Children's Hospital, Corpus Christi, Texas
Medical City Dallas Hospital, Dallas, Texas
UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas
El Paso Children's Hospital, El Paso, Texas
Cook Children's Medical Center, Fort Worth, Texas
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston, Texas
M D Anderson Cancer Center, Houston, Texas
Covenant Children's Hospital, Lubbock, Texas
UMC Cancer Center / UMC Health System, Lubbock, Texas
Children's Hospital of San Antonio, San Antonio, Texas
Methodist Children's Hospital of South Texas, San Antonio, Texas
University of Texas Health Science Center at San Antonio, San Antonio, Texas
Primary Children's Hospital, Salt Lake City, Utah
University of Virginia Cancer Center, Charlottesville, Virginia
Naval Medical Center - Portsmouth, Portsmouth, Virginia
Seattle Children's Hospital, Seattle, Washington
Providence Sacred Heart Medical Center and Children's Hospital, Spokane, Washington
Mary Bridge Children's Hospital and Health Center, Tacoma, Washington
University of Wisconsin Carbone Cancer Center - University Hospital, Madison, Wisconsin
Marshfield Medical Center-Marshfield, Marshfield, Wisconsin
Children's Hospital of Wisconsin, Milwaukee, Wisconsin
Sydney Children's Hospital, Randwick, New South Wales
The Children's Hospital at Westmead, Westmead, New South Wales
Queensland Children's Hospital, South Brisbane, Queensland
Royal Children's Hospital, Parkville, Victoria
Perth Children's Hospital, Perth, Western Australia
Alberta Children's Hospital, Calgary, Alberta
University of Alberta Hospital, Edmonton, Alberta
British Columbia Children's Hospital, Vancouver, British Columbia
CancerCare Manitoba, Winnipeg, Manitoba
IWK Health Centre, Halifax, Nova Scotia
McMaster Children's Hospital at Hamilton Health Sciences, Hamilton, Ontario
Children's Hospital, London, Ontario
Children's Hospital of Eastern Ontario, Ottawa, Ontario
Hospital for Sick Children, Toronto, Ontario
The Montreal Children's Hospital of the MUHC, Montreal, Quebec
Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont, Sherbrooke, Quebec
Jim Pattison Children's Hospital, Saskatoon, Saskatchewan
CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL), Quebec, Not set
Starship Children's Hospital, Grafton, Auckland
Conditions: Neuroblastoma, Ganglioneuroblastoma, Nodular
A Study to Compare Standard Therapy to Treat Hodgkin Lymphoma to the Use of Two Drugs, Brentuximab Vedotin and Nivolumab
Recruiting
This phase III trial compares the effect of adding immunotherapy (brentuximab vedotin and nivolumab) to standard treatment (chemotherapy with or without radiation) to the standard treatment alone in improving survival in patients with stage I and II classical Hodgkin lymphoma. Brentuximab vedotin is in a class of medications called antibody-drug conjugates. It is made of a monoclonal antibody called brentuximab that is linked to a cytotoxic agent called vedotin. Brentuximab attaches to CD30 posi... Read More
This phase III trial compares the effect of adding immunotherapy (brentuximab vedotin and nivolumab) to standard treatment (chemotherapy with or without radiation) to the standard treatment alone in improving survival in patients with stage I and II classical Hodgkin lymphoma. Brentuximab vedotin is in a class of medications called antibody-drug conjugates. It is made of a monoclonal antibody called brentuximab that is linked to a cytotoxic agent called vedotin. Brentuximab attaches to CD30 positive lymphoma cells in a targeted way and delivers vedotin to kill them. A monoclonal antibody is a type of protein that can bind to certain targets in the body, such as molecules that cause the body to make an immune response (antigens). Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Chemotherapy drugs such as doxorubicin hydrochloride, bleomycin sulfate, vinblastine sulfate, dacarbazine, and procarbazine hydrochloride work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Cyclophosphamide is in a class of medications called alkylating agents. It works by damaging the cell's deoxyribonucleic acid (DNA) and may kill cancer cells. It may also lower the body's immune response. Etoposide is in a class of medications known as podophyllotoxin derivatives. It blocks a certain enzyme needed for cell division and DNA repair and may kill cancer cells. Vincristine is in a class of medications called vinca alkaloids. It works by stopping cancer cells from growing and dividing and may kill them. Prednisone is in a class of medications called corticosteroids. It is used to reduce inflammation and lower the body's immune response to help lessen the side effects of chemotherapy drugs. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Adding immunotherapy to the standard treatment of chemotherapy with or without radiation may increase survival and/or fewer short-term or long-term side effects in patients with classical Hodgkin lymphoma compared to the standard treatment alone. Read Less
Gender:
ALL
Ages:
Between 5 years and 60 years
Trial Updated:
07/29/2025
Locations: USA Health Strada Patient Care Center, Mobile, Alabama +351 locations
USA Health Strada Patient Care Center, Mobile, Alabama
Providence Alaska Medical Center, Anchorage, Alaska
CTCA at Western Regional Medical Center, Goodyear, Arizona
Phoenix Childrens Hospital, Phoenix, Arizona
Arkansas Children's Hospital, Little Rock, Arkansas
City of Hope Corona, Corona, California
Kaiser Permanente Downey Medical Center, Downey, California
City of Hope Comprehensive Cancer Center, Duarte, California
Kaiser Permanente Dublin, Dublin, California
Kaiser Permanente-Fremont, Fremont, California
Kaiser Permanente-Fresno, Fresno, California
City of Hope Seacliff, Huntington Beach, California
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine, California
City of Hope at Irvine Lennar, Irvine, California
City of Hope Antelope Valley, Lancaster, California
Loma Linda University Medical Center, Loma Linda, California
Miller Children's and Women's Hospital Long Beach, Long Beach, California
City of Hope at Long Beach Elm, Long Beach, California
Children's Hospital Los Angeles, Los Angeles, California
Cedars Sinai Medical Center, Los Angeles, California
Kaiser Permanente-Modesto, Modesto, California
City of Hope Newport Beach, Newport Beach, California
Kaiser Permanente-Oakland, Oakland, California
Children's Hospital of Orange County, Orange, California
UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange, California
Kaiser Permanente Downtown Commons, Sacramento, California
Kaiser Permanente-South Sacramento, Sacramento, California
Rady Children's Hospital - San Diego, San Diego, California
Naval Medical Center -San Diego, San Diego, California
Kaiser Permanente-San Francisco, San Francisco, California
Kaiser Permanente-Santa Teresa-San Jose, San Jose, California
Kaiser Permanente San Leandro, San Leandro, California
Kaiser San Rafael-Gallinas, San Rafael, California
Kaiser Permanente-Santa Rosa, Santa Rosa, California
City of Hope South Pasadena, South Pasadena, California
Kaiser Permanente-South San Francisco, South San Francisco, California
City of Hope South Bay, Torrance, California
City of Hope Upland, Upland, California
Kaiser Permanente-Vallejo, Vallejo, California
Kaiser Permanente-Walnut Creek, Walnut Creek, California
Children's Hospital Colorado, Aurora, Colorado
Smilow Cancer Hospital-Derby Care Center, Derby, Connecticut
Smilow Cancer Hospital Care Center-Fairfield, Fairfield, Connecticut
Smilow Cancer Hospital Care Center at Glastonbury, Glastonbury, Connecticut
Smilow Cancer Hospital Care Center at Greenwich, Greenwich, Connecticut
Smilow Cancer Hospital Care Center - Guilford, Guilford, Connecticut
Smilow Cancer Hospital Care Center at Saint Francis, Hartford, Connecticut
Connecticut Children's Medical Center, Hartford, Connecticut
Yale University, New Haven, Connecticut
Yale-New Haven Hospital North Haven Medical Center, North Haven, Connecticut
Smilow Cancer Hospital Care Center at Long Ridge, Stamford, Connecticut
Smilow Cancer Hospital-Torrington Care Center, Torrington, Connecticut
Smilow Cancer Hospital Care Center-Trumbull, Trumbull, Connecticut
Smilow Cancer Hospital-Waterbury Care Center, Waterbury, Connecticut
Smilow Cancer Hospital Care Center - Waterford, Waterford, Connecticut
Alfred I duPont Hospital for Children, Wilmington, Delaware
MedStar Georgetown University Hospital, Washington, District of Columbia
Children's National Medical Center, Washington, District of Columbia
Broward Health Medical Center, Fort Lauderdale, Florida
Golisano Children's Hospital of Southwest Florida, Fort Myers, Florida
University of Florida Health Science Center - Gainesville, Gainesville, Florida
Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood, Florida
Nemours Children's Clinic-Jacksonville, Jacksonville, Florida
Nicklaus Children's Hospital, Miami, Florida
AdventHealth Orlando, Orlando, Florida
Arnold Palmer Hospital for Children, Orlando, Florida
Nemours Children's Hospital, Orlando, Florida
Nemours Children's Clinic - Pensacola, Pensacola, Florida
Sacred Heart Hospital, Pensacola, Florida
Johns Hopkins All Children's Hospital, Saint Petersburg, Florida
Tampa General Hospital, Tampa, Florida
Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa, Florida
Saint Mary's Medical Center, West Palm Beach, Florida
Grady Health System, Atlanta, Georgia
Emory Proton Therapy Center, Atlanta, Georgia
Emory University Hospital Midtown, Atlanta, Georgia
Emory University Hospital/Winship Cancer Institute, Atlanta, Georgia
Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta, Georgia
Emory Saint Joseph's Hospital, Atlanta, Georgia
Augusta University Medical Center, Augusta, Georgia
Atrium Health Navicent, Macon, Georgia
Kapiolani Medical Center for Women and Children, Honolulu, Hawaii
Saint Luke's Cancer Institute - Boise, Boise, Idaho
Saint Luke's Cancer Institute - Fruitland, Fruitland, Idaho
Saint Luke's Cancer Institute - Meridian, Meridian, Idaho
Saint Luke's Cancer Institute - Nampa, Nampa, Idaho
Saint Luke's Cancer Institute - Twin Falls, Twin Falls, Idaho
Rush-Copley Medical Center, Aurora, Illinois
Advocate Good Shepherd Hospital, Barrington, Illinois
Mount Sinai Hospital Medical Center, Chicago, Illinois
Lurie Children's Hospital-Chicago, Chicago, Illinois
Northwestern University, Chicago, Illinois
University of Illinois, Chicago, Illinois
University of Chicago Comprehensive Cancer Center, Chicago, Illinois
Advocate Illinois Masonic Medical Center, Chicago, Illinois
AMG Crystal Lake - Oncology, Crystal Lake, Illinois
Carle at The Riverfront, Danville, Illinois
Decatur Memorial Hospital, Decatur, Illinois
Northwestern Medicine Cancer Center Kishwaukee, DeKalb, Illinois
Advocate Good Samaritan Hospital, Downers Grove, Illinois
Carle Physician Group-Effingham, Effingham, Illinois
Crossroads Cancer Center, Effingham, Illinois
Advocate Sherman Hospital, Elgin, Illinois
Elmhurst Memorial Hospital, Elmhurst, Illinois
Northwestern Medicine Cancer Center Delnor, Geneva, Illinois
Northwestern Medicine Glenview Outpatient Center, Glenview, Illinois
Northwestern Medicine Grayslake Outpatient Center, Grayslake, Illinois
Advocate South Suburban Hospital, Hazel Crest, Illinois
Northwestern Medicine Lake Forest Hospital, Lake Forest, Illinois
AMG Libertyville - Oncology, Libertyville, Illinois
Condell Memorial Hospital, Libertyville, Illinois
Carle Physician Group-Mattoon/Charleston, Mattoon, Illinois
Loyola University Medical Center, Maywood, Illinois
Edward Hospital/Cancer Center, Naperville, Illinois
HSHS Saint Elizabeth's Hospital, O'Fallon, Illinois
Advocate Christ Medical Center, Oak Lawn, Illinois
Advocate Children's Hospital-Oak Lawn, Oak Lawn, Illinois
Northwestern Medicine Orland Park, Orland Park, Illinois
Advocate Children's Hospital-Park Ridge, Park Ridge, Illinois
Advocate Lutheran General Hospital, Park Ridge, Illinois
Saint Jude Midwest Affiliate, Peoria, Illinois
Edward Hospital/Cancer Center?Plainfield, Plainfield, Illinois
UW Health Carbone Cancer Center Rockford, Rockford, Illinois
Memorial Hospital East, Shiloh, Illinois
Southern Illinois University School of Medicine, Springfield, Illinois
Carle Cancer Center, Urbana, Illinois
Northwestern Medicine Cancer Center Warrenville, Warrenville, Illinois
Rush-Copley Healthcare Center, Yorkville, Illinois
Riley Hospital for Children, Indianapolis, Indiana
Ascension Saint Vincent Indianapolis Hospital, Indianapolis, Indiana
UI Health Care Mission Cancer and Blood - Ankeny Clinic, Ankeny, Iowa
UI Health Care Mission Cancer and Blood - West Des Moines Clinic, Clive, Iowa
Blank Children's Hospital, Des Moines, Iowa
Iowa Methodist Medical Center, Des Moines, Iowa
UI Health Care Mission Cancer and Blood - Des Moines Clinic, Des Moines, Iowa
UI Health Care Mission Cancer and Blood - Laurel Clinic, Des Moines, Iowa
University of Iowa/Holden Comprehensive Cancer Center, Iowa City, Iowa
UI Health Care Mission Cancer and Blood - Waukee Clinic, Waukee, Iowa
Wesley Medical Center, Wichita, Kansas
University of Kentucky/Markey Cancer Center, Lexington, Kentucky
Norton Children's Hospital, Louisville, Kentucky
The James Graham Brown Cancer Center at University of Louisville, Louisville, Kentucky
UofL Health Medical Center Northeast, Louisville, Kentucky
Children's Hospital New Orleans, New Orleans, Louisiana
Ochsner Medical Center Jefferson, New Orleans, Louisiana
Eastern Maine Medical Center, Bangor, Maine
Maine Children's Cancer Program, Scarborough, Maine
University of Maryland/Greenebaum Cancer Center, Baltimore, Maryland
Sinai Hospital of Baltimore, Baltimore, Maryland
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland
Dana-Farber Cancer Institute, Boston, Massachusetts
UMass Memorial Medical Center - University Campus, Worcester, Massachusetts
Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor, Michigan
C S Mott Children's Hospital, Ann Arbor, Michigan
Bronson Battle Creek, Battle Creek, Michigan
Trinity Health IHA Medical Group Hematology Oncology - Brighton, Brighton, Michigan
Trinity Health IHA Medical Group Hematology Oncology - Canton, Canton, Michigan
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital, Chelsea, Michigan
Corewell Health Dearborn Hospital, Dearborn, Michigan
Children's Hospital of Michigan, Detroit, Michigan
Wayne State University/Karmanos Cancer Institute, Detroit, Michigan
Henry Ford Hospital, Detroit, Michigan
Michigan State University, East Lansing, Michigan
Weisberg Cancer Treatment Center, Farmington Hills, Michigan
Corewell Health Farmington Hills Hospital, Farmington Hills, Michigan
Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids, Michigan
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids, Michigan
Trinity Health Grand Rapids Hospital, Grand Rapids, Michigan
Bronson Methodist Hospital, Kalamazoo, Michigan
West Michigan Cancer Center, Kalamazoo, Michigan
Ascension Borgess Cancer Center, Kalamazoo, Michigan
Trinity Health Saint Mary Mercy Livonia Hospital, Livonia, Michigan
Trinity Health Muskegon Hospital, Muskegon, Michigan
Cancer and Hematology Centers of Western Michigan - Norton Shores, Norton Shores, Michigan
Henry Ford Medical Center-Columbus, Novi, Michigan
Corewell Health Reed City Hospital, Reed City, Michigan
Corewell Health Children's, Royal Oak, Michigan
Corewell Health William Beaumont University Hospital, Royal Oak, Michigan
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center, Saint Joseph, Michigan
Munson Medical Center, Traverse City, Michigan
Corewell Health Beaumont Troy Hospital, Troy, Michigan
University of Michigan Health - West, Wyoming, Michigan
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus, Ypsilanti, Michigan
Mercy Hospital, Coon Rapids, Minnesota
Fairview Southdale Hospital, Edina, Minnesota
Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis, Minnesota
Abbott-Northwestern Hospital, Minneapolis, Minnesota
University of Minnesota/Masonic Cancer Center, Minneapolis, Minnesota
Mayo Clinic in Rochester, Rochester, Minnesota
Park Nicollet Clinic - Saint Louis Park, Saint Louis Park, Minnesota
Regions Hospital, Saint Paul, Minnesota
United Hospital, Saint Paul, Minnesota
University of Mississippi Medical Center, Jackson, Mississippi
Saint Luke's Hospital, Chesterfield, Missouri
Siteman Cancer Center at West County Hospital, Creve Coeur, Missouri
Children's Mercy Hospitals and Clinics, Kansas City, Missouri
Cardinal Glennon Children's Medical Center, Saint Louis, Missouri
Washington University School of Medicine, Saint Louis, Missouri
Siteman Cancer Center-South County, Saint Louis, Missouri
Siteman Cancer Center at Christian Hospital, Saint Louis, Missouri
Mercy Hospital Saint Louis, Saint Louis, Missouri
Siteman Cancer Center at Saint Peters Hospital, Saint Peters, Missouri
Nebraska Medicine-Bellevue, Bellevue, Nebraska
Children's Hospital and Medical Center of Omaha, Omaha, Nebraska
Nebraska Medicine-Village Pointe, Omaha, Nebraska
University of Nebraska Medical Center, Omaha, Nebraska
Alliance for Childhood Diseases/Cure 4 the Kids Foundation, Las Vegas, Nevada
Renown Regional Medical Center, Reno, Nevada
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon, New Hampshire
Cooper Hospital University Medical Center, Camden, New Jersey
Trinitas Hospital and Comprehensive Cancer Center - Williamson Street Campus, Elizabeth, New Jersey
Hackensack University Medical Center, Hackensack, New Jersey
Jersey City Medical Center, Jersey City, New Jersey
Saint Barnabas Medical Center, Livingston, New Jersey
Monmouth Medical Center, Long Branch, New Jersey
Morristown Medical Center, Morristown, New Jersey
Jersey Shore Medical Center, Neptune, New Jersey
Saint Peter's University Hospital, New Brunswick, New Jersey
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick, New Jersey
Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey
Newark Beth Israel Medical Center, Newark, New Jersey
Saint Joseph's Regional Medical Center, Paterson, New Jersey
Community Medical Center, Toms River, New Jersey
Presbyterian Hospital, Albuquerque, New Mexico
University of New Mexico Cancer Center, Albuquerque, New Mexico
Albany Medical Center, Albany, New York
Montefiore Medical Center - Moses Campus, Bronx, New York
Roswell Park Cancer Institute, Buffalo, New York
Hematology Oncology Associates of CNY at Camillus, Camillus, New York
Hematology Oncology Associates of Central New York-East Syracuse, East Syracuse, New York
Glens Falls Hospital, Glens Falls, New York
NYU Langone Hospital - Long Island, Mineola, New York
The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park, New York
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York, New York
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York, New York
Memorial Sloan Kettering Cancer Center, New York, New York
NYP/Weill Cornell Medical Center, New York, New York
University of Rochester, Rochester, New York
Stony Brook University Medical Center, Stony Brook, New York
State University of New York Upstate Medical University, Syracuse, New York
Wilmot Cancer Institute at Webster, Webster, New York
Mission Hospital, Asheville, North Carolina
UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina
Carolinas Medical Center/Levine Cancer Institute, Charlotte, North Carolina
Duke University Medical Center, Durham, North Carolina
East Carolina University, Greenville, North Carolina
Wake Forest University Health Sciences, Winston-Salem, North Carolina
Sanford Broadway Medical Center, Fargo, North Dakota
Children's Hospital Medical Center of Akron, Akron, Ohio
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Rainbow Babies and Childrens Hospital, Cleveland, Ohio
Cleveland Clinic Foundation, Cleveland, Ohio
Nationwide Children's Hospital, Columbus, Ohio
Dayton Children's Hospital, Dayton, Ohio
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo, Ohio
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Providence Willamette Falls Medical Center, Oregon City, Oregon
Providence Portland Medical Center, Portland, Oregon
Providence Saint Vincent Medical Center, Portland, Oregon
Legacy Emanuel Children's Hospital, Portland, Oregon
Oregon Health and Science University, Portland, Oregon
Lehigh Valley Hospital-Cedar Crest, Allentown, Pennsylvania
Geisinger Medical Center, Danville, Pennsylvania
Penn State Children's Hospital, Hershey, Pennsylvania
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Saint Christopher's Hospital for Children, Philadelphia, Pennsylvania
Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania
Rhode Island Hospital, Providence, Rhode Island
Smilow Cancer Hospital Care Center - Westerly, Westerly, Rhode Island
Prisma Health Cancer Institute - Spartanburg, Boiling Springs, South Carolina
Medical University of South Carolina, Charleston, South Carolina
Prisma Health Richland Hospital, Columbia, South Carolina
Saint Francis Hospital, Greenville, South Carolina
BI-LO Charities Children's Cancer Center, Greenville, South Carolina
Saint Francis Cancer Center, Greenville, South Carolina
Prisma Health Cancer Institute - Eastside, Greenville, South Carolina
Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota
T C Thompson Children's Hospital, Chattanooga, Tennessee
East Tennessee Childrens Hospital, Knoxville, Tennessee
The Children's Hospital at TriStar Centennial, Nashville, Tennessee
Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee
Dell Children's Medical Center of Central Texas, Austin, Texas
Driscoll Children's Hospital, Corpus Christi, Texas
Medical City Dallas Hospital, Dallas, Texas
UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas
El Paso Children's Hospital, El Paso, Texas
Cook Children's Medical Center, Fort Worth, Texas
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston, Texas
M D Anderson Cancer Center, Houston, Texas
Covenant Children's Hospital, Lubbock, Texas
UMC Cancer Center / UMC Health System, Lubbock, Texas
Children's Hospital of San Antonio, San Antonio, Texas
Methodist Children's Hospital of South Texas, San Antonio, Texas
University of Texas Health Science Center at San Antonio, San Antonio, Texas
Scott and White Memorial Hospital, Temple, Texas
Huntsman Cancer Institute/University of Utah, Salt Lake City, Utah
Primary Children's Hospital, Salt Lake City, Utah
University of Vermont and State Agricultural College, Burlington, Vermont
University of Virginia Cancer Center, Charlottesville, Virginia
Inova Fairfax Hospital, Falls Church, Virginia
Children's Hospital of The King's Daughters, Norfolk, Virginia
Naval Medical Center - Portsmouth, Portsmouth, Virginia
VCU Massey Comprehensive Cancer Center, Richmond, Virginia
Carilion Children's, Roanoke, Virginia
Valley Medical Center, Renton, Washington
Seattle Children's Hospital, Seattle, Washington
Providence Sacred Heart Medical Center and Children's Hospital, Spokane, Washington
Mary Bridge Children's Hospital and Health Center, Tacoma, Washington
West Virginia University Charleston Division, Charleston, West Virginia
Edwards Comprehensive Cancer Center, Huntington, West Virginia
Aurora Cancer Care-Southern Lakes VLCC, Burlington, Wisconsin
Aurora Saint Luke's South Shore, Cudahy, Wisconsin
Aurora Health Care Germantown Health Center, Germantown, Wisconsin
Aurora Cancer Care-Grafton, Grafton, Wisconsin
Saint Vincent Hospital Cancer Center Green Bay, Green Bay, Wisconsin
Aurora BayCare Medical Center, Green Bay, Wisconsin
Aurora Cancer Care-Kenosha South, Kenosha, Wisconsin
Gundersen Lutheran Medical Center, La Crosse, Wisconsin
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center, Madison, Wisconsin
University of Wisconsin Carbone Cancer Center - University Hospital, Madison, Wisconsin
Aurora Bay Area Medical Group-Marinette, Marinette, Wisconsin
Marshfield Medical Center-Marshfield, Marshfield, Wisconsin
Aurora Cancer Care-Milwaukee, Milwaukee, Wisconsin
Aurora Saint Luke's Medical Center, Milwaukee, Wisconsin
Children's Hospital of Wisconsin, Milwaukee, Wisconsin
Aurora Sinai Medical Center, Milwaukee, Wisconsin
ProHealth D N Greenwald Center, Mukwonago, Wisconsin
ProHealth Oconomowoc Memorial Hospital, Oconomowoc, Wisconsin
Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh, Wisconsin
Aurora Cancer Care-Racine, Racine, Wisconsin
Saint Vincent Hospital Cancer Center at Sheboygan, Sheboygan, Wisconsin
Vince Lombardi Cancer Clinic-Sheboygan, Sheboygan, Wisconsin
Saint Vincent Hospital Cancer Center at Sturgeon Bay, Sturgeon Bay, Wisconsin
Aurora Medical Center in Summit, Summit, Wisconsin
Vince Lombardi Cancer Clinic-Two Rivers, Two Rivers, Wisconsin
UW Cancer Center at ProHealth Care, Waukesha, Wisconsin
Aurora Cancer Care-Milwaukee West, Wauwatosa, Wisconsin
Aurora West Allis Medical Center, West Allis, Wisconsin
Alberta Children's Hospital, Calgary, Alberta
University of Alberta Hospital, Edmonton, Alberta
CancerCare Manitoba, Winnipeg, Manitoba
IWK Health Centre, Halifax, Nova Scotia
McMaster Children's Hospital at Hamilton Health Sciences, Hamilton, Ontario
Children's Hospital, London, Ontario
Children's Hospital of Eastern Ontario, Ottawa, Ontario
Hospital for Sick Children, Toronto, Ontario
The Montreal Children's Hospital of the MUHC, Montreal, Quebec
Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont, Sherbrooke, Quebec
Jim Pattison Children's Hospital, Saskatoon, Saskatchewan
CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL), Quebec, Not set
University Pediatric Hospital, San Juan, Not set
Conditions: Lugano Classification Limited Stage Hodgkin Lymphoma AJCC v8
A Study to Evaluate the Efficacy and Safety of JCAR017 in Adult Subjects With Relapsed or Refractory Indolent B-cell Non-Hodgkin Lymphoma (NHL)
Recruiting
This is a global Phase 2, open-label, single-arm, multicohort, multicenter study to evaluate efficacy and safety of JCAR017 in adult subjects with r/r FL or MZL.
The study will be conducted in compliance with the International Council on Harmonisation (ICH) of Technical Requirements for Registration of Pharmaceuticals for Human Use/Good Clinical Practice (GCP) and applicable regulatory requirements.
This study is divided into three periods:
* Pretreatment, which consists of screening assessme... Read More
This is a global Phase 2, open-label, single-arm, multicohort, multicenter study to evaluate efficacy and safety of JCAR017 in adult subjects with r/r FL or MZL.
The study will be conducted in compliance with the International Council on Harmonisation (ICH) of Technical Requirements for Registration of Pharmaceuticals for Human Use/Good Clinical Practice (GCP) and applicable regulatory requirements.
This study is divided into three periods:
* Pretreatment, which consists of screening assessments, leukapheresis and the Pretreatment evaluation;
* Treatment, which starts with the administration of lymphodepleting (LD) chemotherapy and continues through JCAR017 administration at Day 1 with follow-up through Day 29;
* Posttreatment, which includes follow-up assessments for disease status and safety for 5 years. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/29/2025
Locations: UCLA Medical Centre-Santa Monica, Santa Monica, California +58 locations
UCLA Medical Centre-Santa Monica, Santa Monica, California
University Of Colorado Cancer Center, Aurora, Colorado
Yale Cancer Center, New Haven, Connecticut
Local Institution - 0601, Hollywood, Florida
Washington University School Of Medicine, Miami, Florida
Northwestern University, Chicago, Illinois
Local Institution - 109, Niles, Illinois
University Of Iowa, Iowa City, Iowa
Cancer Center of Kansas, Wichita, Kansas
University of Maryland - Greenebaum Comprehensive Cancer Center, Baltimore, Maryland
Massachusetts General Hospital - Dana-Farber Cancer Institute, Boston, Massachusetts
Beth Israel Deaconess Medical Center, Boston, Massachusetts
Karmanos Cancer Center, Detroit, Michigan
Local Institution - 118, Detroit, Michigan
Atlantic Health System Morristown Medical Center, Morristown, New Jersey
Memorial Sloan Kettering Cancer Center, New York, New York
Novant Health Presbyterian Medical Center, Charlotte, North Carolina
Local Institution - 120, Fargo, North Dakota
Cleveland Clinic Foundation, Cleveland, Ohio
Providence Cancer Center/Earle A. Chiles Res. Inst., Portland, Oregon
University of Pennsylvania - Perelman Center for Advanced Medicine, Philadelphia, Pennsylvania
Local Institution - 126, Pittsburgh, Pennsylvania
Local Institution - 113, Sioux Falls, South Dakota
Local Institution - 125, Knoxville, Tennessee
Texas Oncology, Dallas, Texas
Houston Methodist Hospital, Houston, Texas
The University of Texas - MD Anderson Cancer Center, Houston, Texas
University Of Virginia Health System, Charlottesville, Virginia
Fred Hutchinson Cancer Center, Seattle, Washington
Allgemeinen Krankenhaus (AKH) Wien - Medizinische Universitaet Wien, Wien, Not set
Princess Margaret Cancer Centre, Toronto, Ontario
Hopital Maisonneuve - Rosemont, Montreal, Quebec
CHRU-Hopital Claude Huriez, Lille, Not set
CHU Montpellier - Hôpital Saint Eloi, Montpellier CEDEX 5, Not set
Hopital Saint Louis, Paris Cedex 10, Not set
Centre Hospitalier Lyon-Sud, Pierre-Benite CEDEX, Not set
Centre Hospitalier Universitaire de Rennes - Hopital Pontchaillou, Rennes Cedex 02, Not set
Institut Universitaire du Cancer Toulouse - Oncopole - CHU de TOULOUSE, Toulouse, Not set
Universitaetsklinikum Ulm, Ulm, Baden-Wurttemberg
Local Institution - 504, Regensburg, Bayern
Local Institution - 506, Berlin, Not set
Local Institution - 503, Karlsruhe, Not set
Local Institution - 505, Kiel, Not set
University Hospital Cologne, Köln, Not set
LMU Klinikum der Universitat Munchen, Munich, Not set
Azienda Ospedaliera Papa Giovanni Xxiii, Bergamo, Not set
Local Institution - 302, Bologna, Not set
Istituto Nazionale Per Lo Studio E La Cura Dei Tumori Fondazione Giovanni Pascale, Naples, Not set
Local Institution - 553, Sapporo-shi, Hokkaido
Local Institution - 550, Chuo-ku, Tokyo
Local Institution - 551, Minato-ku, Tokyo
Local Institution - 552, Fukuoka, Not set
Local Institution - 352, Barcelona, Not set
Hospital General Universitario Gregorio Marañon, Madrid, Not set
Hospital Universitario de Salamanca - Complejo Asistencial Universitario de Salamanca, Salamanca, Not set
Hospital Virgen Del Rocio, Sevilla, Not set
Karolinska Hospital, Stockholm, Not set
University College London Hospitals NHS Foundation Trust - University College Hospital, London, Not set
The Christie NHS Foundation Trust, Manchester, Not set
Conditions: Lymphoma, Non-Hodgkin
S0221 Adjuvant Doxorubicin, Cyclophosphamide, and Paclitaxel in Treating Patients With Breast Cancer
Active Not Recruiting
RATIONALE: Drugs used in chemotherapy, such as doxorubicin, cyclophosphamide, and paclitaxel, use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug and giving them after surgery may kill any remaining tumor cells. It is not yet known which combination chemotherapy regimen is more effective in treating resected breast cancer.
PURPOSE: This randomized phase III trial is comparing 2 different regimens of combination chemotherapy to see how w... Read More
RATIONALE: Drugs used in chemotherapy, such as doxorubicin, cyclophosphamide, and paclitaxel, use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug and giving them after surgery may kill any remaining tumor cells. It is not yet known which combination chemotherapy regimen is more effective in treating resected breast cancer.
PURPOSE: This randomized phase III trial is comparing 2 different regimens of combination chemotherapy to see how well they work in treating patients who have undergone surgery for stage I, stage II, or stage III breast cancer. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/29/2025
Locations: Regional Medical Center, Anniston, Alabama +541 locations
Regional Medical Center, Anniston, Alabama
UAB Comprehensive Cancer Center, Birmingham, Alabama
Providence Cancer Center at Providence Hospital, Mobile, Alabama
Providence Cancer Center, Anchorage, Alaska
Mayo Clinic Scottsdale, Scottsdale, Arizona
Arizona Cancer Center at University of Arizona Health Sciences Center, Tucson, Arizona
Hembree Mercy Cancer Center at St. Edward Mercy Medical Center, Fort Smith, Arkansas
Arkansas Cancer Research Center at University of Arkansas for Medical Sciences, Little Rock, Arkansas
Alta Bates Summit Comprehensive Cancer Center, Berkeley, California
Peninsula Medical Center, Burlingame, California
East Bay Radiation Oncology Center, Castro Valley, California
Valley Medical Oncology Consultants - Castro Valley, Castro Valley, California
Valley Medical Oncology, Fremont, California
California Cancer Center - Woodward Park Office, Fresno, California
Todd Cancer Institute at Long Beach Memorial Medical Center, Long Beach, California
USC/Norris Comprehensive Cancer Center and Hospital, Los Angeles, California
Contra Costa Regional Medical Center, Martinez, California
Tibotec Therapeutics - Division of Ortho Biotech Products, LP, Marysville, California
Memorial Medical Center, Modesto, California
El Camino Hospital Cancer Center, Mountain View, California
Sutter Health - Western Division Cancer Research Group, Novato, California
Highland General Hospital, Oakland, California
Alta Bates Summit Medical Center - Summit Campus, Oakland, California
Bay Area Breast Surgeons, Incorporated, Oakland, California
CCOP - Bay Area Tumor Institute, Oakland, California
Larry G Strieff MD Medical Corporation, Oakland, California
Tom K Lee, Incorporated, Oakland, California
St. Joseph Hospital Regional Cancer Center - Orange, Orange, California
Desert Regional Medical Center Comprehensive Cancer Center, Palm Springs, California
Valley Medical Oncology Consultants - Pleasanton, Pleasanton, California
Sutter Cancer Center at Roseville Medical Center, Roseville, California
Sutter Cancer Center, Sacramento, California
University of California Davis Cancer Center, Sacramento, California
UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California
California Pacific Medical Center - California Campus, San Francisco, California
Doctors Medical Center - San Pablo Campus, San Pablo, California
Sutter Solano Medical Center, Vallejo, California
San Luis Valley Regional Medical Center, Alamosa, Colorado
University of Colorado Cancer Center at UC Health Sciences Center, Aurora, Colorado
Memorial Hospital Cancer Center - Colorado Springs, Colorado Springs, Colorado
Denver Health Medical Center, Denver, Colorado
Veterans Affairs Medical Center - Denver, Denver, Colorado
Shaw Regional Cancer Center, Edwards, Colorado
Valley View Hospital Cancer Center, Glenwood Springs, Colorado
Montrose Memorial Hospital Cancer Center, Montrose, Colorado
Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center, Hartford, Connecticut
Yale Cancer Center, New Haven, Connecticut
Washington Cancer Institute at Washington Hospital Center, Washington, District of Columbia
Herbert D. Kerman Regional Oncology Center - Daytona Beach, Daytona Beach, Florida
Florida Hospital Memorial Medical Center, Daytona Beach, Florida
Michael and Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital, Fort Lauderdale, Florida
Mayo Clinic - Jacksonville, Jacksonville, Florida
Ella Milbank Foshay Cancer Center at Jupiter Medical Center, Jupiter, Florida
CCOP - Mount Sinai Medical Center, Miami Beach, Florida
Piedmont Hospital, Atlanta, Georgia
Northside Hospital Cancer Center, Atlanta, Georgia
Saint Joseph's Hospital of Atlanta, Atlanta, Georgia
CCOP - Atlanta Regional, Atlanta, Georgia
WellStar Cobb Hospital, Austell, Georgia
John B. Amos Cancer Center, Columbus, Georgia
Charles B. Eberhart Cancer Center at DeKalb Medical Center, Decatur, Georgia
Piedmont Fayette Hospital, Fayetteville, Georgia
Dwight David Eisenhower Army Medical Center, Fort Gordon, Georgia
Gwinnett Medical Center, Lawrenceville, Georgia
Kennestone Cancer Center at Wellstar Kennestone Hospital, Marietta, Georgia
Southern Regional Medical Center, Riverdale, Georgia
Harbin Clinic Cancer Center - Medical Oncology, Rome, Georgia
Pearlman Comprehensive Cancer Center at South Georgia Medical Center, Valdosta, Georgia
Kapiolani Medical Center at Pali Momi, 'Aiea, Hawaii
Cancer Research Center of Hawaii, Honolulu, Hawaii
OnCare Hawaii, Incorporated - Lusitana, Honolulu, Hawaii
Queen's Cancer Institute at Queen's Medical Center, Honolulu, Hawaii
Straub Clinic and Hospital, Incorporated, Honolulu, Hawaii
Hawaii Medical Center - East, Honolulu, Hawaii
OnCare Hawaii, Incorporated - Kuakini, Honolulu, Hawaii
Kapiolani Medical Center for Women and Children, Honolulu, Hawaii
Tripler Army Medical Center, Honolulu, Hawaii
Castle Medical Center, Kailua, Hawaii
Kauai Medical Clinic, Lihue, Hawaii
Maui Memorial Medical Center, Wailuku, Hawaii
Pacific Cancer Institute - Maui, Wailuku, Hawaii
Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center, Boise, Idaho
Mountain States Tumor Institute at St. Luke's Regional Medical Center, Boise, Idaho
Kootenai Cancer Center - Coeur d'Alene, Coeur d'Alene, Idaho
Saint Anthony's Hospital at Saint Anthony's Health Center, Alton, Illinois
Rush-Copley Cancer Care Center, Aurora, Illinois
Illinois CancerCare - Bloomington, Bloomington, Illinois
St. Joseph Medical Center, Bloomington, Illinois
Graham Hospital, Canton, Illinois
Illinois CancerCare - Canton, Canton, Illinois
Illinois CancerCare - Carthage, Carthage, Illinois
Memorial Hospital, Carthage, Illinois
Robert H. Lurie Comprehensive Cancer Center at Northwestern University, Chicago, Illinois
Hematology and Oncology Associates, Chicago, Illinois
Resurrection Medical Center, Chicago, Illinois
Saint Joseph Hospital, Chicago, Illinois
Decatur Memorial Hospital Cancer Care Institute, Decatur, Illinois
Sherman Hospital, Elgin, Illinois
Elmhurst Memorial Hospital, Elmhurst, Illinois
Eureka Community Hospital, Eureka, Illinois
Illinois CancerCare - Eureka, Eureka, Illinois
St. Francis Hospital, Evanston, Illinois
Galesburg Clinic, PC, Galesburg, Illinois
Illinois CancerCare - Galesburg, Galesburg, Illinois
Ingalls Cancer Care Center at Ingalls Memorial Hospital, Harvey, Illinois
Illinois CancerCare - Havana, Havana, Illinois
Mason District Hospital, Havana, Illinois
Kellogg Cancer Care Center, Highland Park, Illinois
Joliet Oncology-Hematology Associates, Limited - West, Joliet, Illinois
Provena St. Mary's Regional Cancer Center - Kankakee, Kankakee, Illinois
Illinois CancerCare - Kewanee Clinic, Kewanee, Illinois
North Shore Oncology and Hematology Associates, Limited - Libertyville, Libertyville, Illinois
Illinois CancerCare - Macomb, Macomb, Illinois
McDonough District Hospital, Macomb, Illinois
Cardinal Bernardin Cancer Center at Loyola University Medical Center, Maywood, Illinois
Illinois CancerCare - Monmouth, Monmouth, Illinois
OSF Holy Family Medical Center, Monmouth, Illinois
Good Samaritan Regional Health Center, Mount Vernon, Illinois
Edward Hospital Cancer Center, Naperville, Illinois
Hematology Oncology Consultants - Naperville, Naperville, Illinois
Cancer Care and Hematology Specialists of Chicagoland - Niles, Niles, Illinois
BroMenn Regional Medical Center, Normal, Illinois
Community Cancer Center, Normal, Illinois
Illinois CancerCare - Community Cancer Center, Normal, Illinois
Community Hospital of Ottawa, Ottawa, Illinois
Oncology Hematology Associates of Central Illinois, PC - Ottawa, Ottawa, Illinois
Cancer Treatment Center at Pekin Hospital, Pekin, Illinois
Illinois CancerCare - Pekin, Pekin, Illinois
Proctor Hospital, Peoria, Illinois
CCOP - Illinois Oncology Research Association, Peoria, Illinois
Oncology Hematology Associates of Central Illinois, PC - Peoria, Peoria, Illinois
Methodist Medical Center of Illinois, Peoria, Illinois
OSF St. Francis Medical Center, Peoria, Illinois
Illinois CancerCare - Peru, Peru, Illinois
Illinois Valley Community Hospital, Peru, Illinois
Illinois CancerCare - Princeton, Princeton, Illinois
Perry Memorial Hospital, Princeton, Illinois
Swedish-American Regional Cancer Center, Rockford, Illinois
Hematology Oncology Associates - Skokie, Skokie, Illinois
Illinois CancerCare - Spring Valley, Spring Valley, Illinois
Regional Cancer Center at Memorial Medical Center, Springfield, Illinois
CCOP - Carle Cancer Center, Urbana, Illinois
Central Dupage Cancer Center, Warrenville, Illinois
St. Francis Hospital and Health Centers - Beech Grove Campus, Beech Grove, Indiana
Elkhart Clinic, LLC, Elkhart, Indiana
Michiana Hematology-Oncology, PC - Elkhart, Elkhart, Indiana
Elkhart General Hospital, Elkhart, Indiana
Fort Wayne Medical Oncology and Hematology, Fort Wayne, Indiana
Howard Community Hospital, Kokomo, Indiana
Center for Cancer Therapy at LaPorte Hospital and Health Services, La Porte, Indiana
Saint Anthony Memorial Health Centers, Michigan City, Indiana
Michiana Hematology-Oncology, PC - South Bend, Mishawaka, Indiana
Saint Joseph Regional Medical Center, Mishawaka, Indiana
Michiana Hematology Oncology PC - Plymouth, Plymouth, Indiana
Reid Hospital & Health Care Services, Richmond, Indiana
CCOP - Northern Indiana CR Consortium, South Bend, Indiana
Memorial Hospital of South Bend, South Bend, Indiana
Michiana Hematology Oncology PC - La Porte, Westville, Indiana
McFarland Clinic, PC, Ames, Iowa
Hematology Oncology Associates of the Quad Cities, Bettendorf, Iowa
Cedar Rapids Oncology Associates, Cedar Rapids, Iowa
Mercy Regional Cancer Center at Mercy Medical Center, Cedar Rapids, Iowa
Medical Oncology and Hematology Associates - West Des Moines, Clive, Iowa
Heartland Oncology and Hematology, Council Bluffs, Iowa
Genesis Regional Cancer Center at Genesis Medical Center, Davenport, Iowa
CCOP - Iowa Oncology Research Association, Des Moines, Iowa
John Stoddard Cancer Center at Iowa Methodist Medical Center, Des Moines, Iowa
Medical Oncology and Hematology Associates at John Stoddard Cancer Center, Des Moines, Iowa
Medical Oncology and Hematology Associates at Mercy Cancer Center, Des Moines, Iowa
Mercy Cancer Center at Mercy Medical Center - Des Moines, Des Moines, Iowa
John Stoddard Cancer Center at Iowa Lutheran Hospital, Des Moines, Iowa
Mercy Cancer Center at Mercy Medical Center - North Iowa, Mason City, Iowa
McCreery Cancer Center at Ottumwa Regional, Ottumwa, Iowa
Siouxland Hematology-Oncology Associates, LLP, Sioux City, Iowa
Mercy Medical Center - Sioux City, Sioux City, Iowa
St. Luke's Regional Medical Center, Sioux City, Iowa
Cancer Center of Kansas, PA - Chanute, Chanute, Kansas
Cancer Center of Kansas, PA - Dodge City, Dodge City, Kansas
Cancer Center of Kansas, PA - El Dorado, El Dorado, Kansas
Cancer Center of Kansas - Fort Scott, Fort Scott, Kansas
Hays Medical Center, Hays, Kansas
Hutchinson Hospital Corporation, Hutchinson, Kansas
Cancer Center of Kansas-Independence, Independence, Kansas
Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center, Kansas City, Kansas
Cancer Center of Kansas, PA - Kingman, Kingman, Kansas
Lawrence Memorial Hospital, Lawrence, Kansas
Cancer Center of Kansas, PA - Liberal, Liberal, Kansas
Cancer Center of Kansas, PA - Newton, Newton, Kansas
Menorah Medical Center, Overland Park, Kansas
Saint Luke's Hospital - South, Overland Park, Kansas
Cancer Center of Kansas, PA - Parsons, Parsons, Kansas
Mount Carmel Regional Cancer Center, Pittsburg, Kansas
CCOP - Kansas City, Prairie Village, Kansas
Cancer Center of Kansas, PA - Pratt, Pratt, Kansas
Cancer Center of Kansas, PA - Salina, Salina, Kansas
Cotton-O'Neil Cancer Center, Topeka, Kansas
St. Francis Comprehensive Cancer Center, Topeka, Kansas
Cancer Center of Kansas, PA - Wellington, Wellington, Kansas
Associates in Womens Health, PA - North Review, Wichita, Kansas
Cancer Center of Kansas, PA - Medical Arts Tower, Wichita, Kansas
Cancer Center of Kansas, PA - Wichita, Wichita, Kansas
CCOP - Wichita, Wichita, Kansas
Via Christi Cancer Center at Via Christi Regional Medical Center, Wichita, Kansas
Cancer Center of Kansas, PA - Winfield, Winfield, Kansas
Tulane Cancer Center Office of Clinical Research, Alexandria, Louisiana
Ochsner Health Center - Bluebonnet, Baton Rouge, Louisiana
Ochsner Health Center - Covington, Covington, Louisiana
Louisiana State University Health Sciences Center - Monroe, Monroe, Louisiana
New Orleans Cancer Institute at Memorial Medical Center, New Orleans, Louisiana
CCOP - Ochsner, New Orleans, Louisiana
Ochsner Cancer Institute at Ochsner Clinic Foundation, New Orleans, Louisiana
Christus Schumpert Cancer Treatment Center, Shreveport, Louisiana
Feist-Weiller Cancer Center at Louisiana State University Health Sciences, Shreveport, Louisiana
Alvin and Lois Lapidus Cancer Institute at Sinai Hospital, Baltimore, Maryland
St. Agnes Hospital Cancer Center, Baltimore, Maryland
Regional Cancer Center at Western Maryland Health System - Sacred Heart Campus, Cumberland, Maryland
Peninsula Regional Medical Center, Salisbury, Maryland
Caritas St. Elizabeth's Medical Center, Brighton, Massachusetts
Addison Gilbert Hospital, Gloucester, Massachusetts
Hickman Cancer Center at Bixby Medical Center, Adrian, Michigan
Saint Joseph Mercy Cancer Center, Ann Arbor, Michigan
CCOP - Michigan Cancer Research Consortium, Ann Arbor, Michigan
University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan
Battle Creek Health System Cancer Care Center, Battle Creek, Michigan
Bay Regional Medical Center, Bay City, Michigan
Mecosta County Medical Center, Big Rapids, Michigan
Oakwood Cancer Center at Oakwood Hospital and Medical Center, Dearborn, Michigan
Barbara Ann Karmanos Cancer Institute, Detroit, Michigan
Genesys Hurley Cancer Institute, Flint, Michigan
Hurley Medical Center, Flint, Michigan
Butterworth Hospital at Spectrum Health, Grand Rapids, Michigan
CCOP - Grand Rapids, Grand Rapids, Michigan
Lacks Cancer Center at Saint Mary's Health Care, Grand Rapids, Michigan
Van Elslander Cancer Center at St. John Hospital and Medical Center, Grosse Pointe Woods, Michigan
Foote Memorial Hospital, Jackson, Michigan
Borgess Medical Center, Kalamazoo, Michigan
West Michigan Cancer Center, Kalamazoo, Michigan
Bronson Methodist Hospital, Kalamazoo, Michigan
Breslin Cancer Center at Ingham Regional Medical Center, Lansing, Michigan
Sparrow Regional Cancer Center, Lansing, Michigan
Lapeer Regional Hospital, Lapeer, Michigan
St. Mary Mercy Hospital, Livonia, Michigan
MidMichigan Medical Center - Midland, Midland, Michigan
Community Cancer Center of Monroe, Monroe, Michigan
Mercy Memorial Hospital - Monroe, Monroe, Michigan
Clemens Regional Medical Center, Mount Clemens, Michigan
Mercy General Health Partners, Muskegon, Michigan
Michiana Hematology Oncology PC - Niles, Niles, Michigan
Northern Michigan Hospital, Petoskey, Michigan
St. Joseph Mercy Oakland, Pontiac, Michigan
Mercy Regional Cancer Center at Mercy Hospital, Port Huron, Michigan
William Beaumont Hospital - Royal Oak Campus, Royal Oak, Michigan
Seton Cancer Institute at Saint Mary's - Saginaw, Saginaw, Michigan
Lakeland Regional Cancer Care Center - St. Joseph, Saint Joseph, Michigan
Lakeside Cancer Specialists, PLLC, Saint Joseph, Michigan
Providence Cancer Institute at Providence Hospital - Southfield Campus, Southfield, Michigan
Munson Medical Center, Traverse City, Michigan
St. John Macomb Hospital, Warren, Michigan
Metro Health Hospital, Wyoming, Michigan
Not set, Alexandria, Minnesota
Fairview Ridges Hospital, Burnsville, Minnesota
Mercy and Unity Cancer Center at Mercy Hospital, Coon Rapids, Minnesota
Fairview Southdale Hospital, Edina, Minnesota
Mercy and Unity Cancer Center at Unity Hospital, Fridley, Minnesota
Hutchinson Area Health Care, Hutchinson, Minnesota
HealthEast Cancer Care at St. John's Hospital, Maplewood, Minnesota
Minnesota Oncology Hematology, PA - Maplewood, Maplewood, Minnesota
Virginia Piper Cancer Institute at Abbott - Northwestern Hospital, Minneapolis, Minnesota
Hennepin County Medical Center - Minneapolis, Minneapolis, Minnesota
Humphrey Cancer Center at North Memorial Outpatient Center, Robbinsdale, Minnesota
Mayo Clinic Cancer Center, Rochester, Minnesota
CentraCare Clinic - River Campus, Saint Cloud, Minnesota
Coborn Cancer Center, Saint Cloud, Minnesota
CCOP - Metro-Minnesota, Saint Louis Park, Minnesota
Park Nicollet Cancer Center, Saint Louis Park, Minnesota
Regions Hospital Cancer Care Center, Saint Paul, Minnesota
United Hospital, Saint Paul, Minnesota
St. Francis Cancer Center at St. Francis Medical Center, Shakopee, Minnesota
Lakeview Hospital, Stillwater, Minnesota
Ridgeview Medical Center, Waconia, Minnesota
Willmar Cancer Center at Rice Memorial Hospital, Willmar, Minnesota
Minnesota Oncology Hematology, PA - Woodbury, Woodbury, Minnesota
Keesler Air Force Base Medical Center, Keesler Air Force Base, Mississippi
Regional Cancer Center at Singing River Hospital, Pascagoula, Mississippi
Saint Francis Medical Center, Cape Girardeau, Missouri
Southeast Cancer Center, Cape Girardeau, Missouri
Goldschmidt Cancer Center, Jefferson City, Missouri
Freeman Cancer Institute at Freeman Health System, Joplin, Missouri
St. John's Regional Medical Center, Joplin, Missouri
Truman Medical Center - Hospital Hill, Kansas City, Missouri
Saint Luke's Cancer Institute at Saint Luke's Hospital, Kansas City, Missouri
St. Joseph Medical Center, Kansas City, Missouri
North Kansas City Hospital, Kansas City, Missouri
Parvin Radiation Oncology, Kansas City, Missouri
Heartland Hematology Oncology Associates, Incorporated, Kansas City, Missouri
Research Medical Center, Kansas City, Missouri
Saint Luke's East - Lee's Summit, Lee's Summit, Missouri
Liberty Hospital, Liberty, Missouri
Heartland Regional Medical Center, Saint Joseph, Missouri
Saint Joseph Oncology, Incorporated, Saint Joseph, Missouri
Midwest Hematology Oncology Group, Incorporated, Saint Louis, Missouri
Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis, Saint Louis, Missouri
Missouri Baptist Cancer Center, Saint Louis, Missouri
CCOP - St. Louis-Cape Girardeau, Saint Louis, Missouri
Comprehensive Cancer Care, PC, Saint Louis, Missouri
David C. Pratt Cancer Center at St. John's Mercy, Saint Louis, Missouri
CCOP - Cancer Research for the Ozarks, Springfield, Missouri
St. John's Regional Health Center, Springfield, Missouri
Hulston Cancer Center at Cox Medical Center South, Springfield, Missouri
CCOP - Montana Cancer Consortium, Billings, Montana
St. Vincent Healthcare Cancer Care Services, Billings, Montana
Hematology-Oncology Centers of the Northern Rockies - Billings, Billings, Montana
Billings Clinic - Downtown, Billings, Montana
Bozeman Deaconess Cancer Center, Bozeman, Montana
St. James Healthcare Cancer Care, Butte, Montana
Big Sky Oncology, Great Falls, Montana
Great Falls Clinic - Main Facility, Great Falls, Montana
Sletten Cancer Institute at Benefis Healthcare, Great Falls, Montana
Northern Montana Hospital, Havre, Montana
St. Peter's Hospital, Helena, Montana
Glacier Oncology, PLLC, Kalispell, Montana
Kalispell Medical Oncology at KRMC, Kalispell, Montana
Kalispell Regional Medical Center, Kalispell, Montana
Montana Cancer Center at St. Patrick Hospital and Health Sciences Center, Missoula, Montana
Cancer Resource Center - Lincoln, Lincoln, Nebraska
CCOP - Missouri Valley Cancer Consortium, Omaha, Nebraska
Immanuel Medical Center, Omaha, Nebraska
Alegant Health Cancer Center at Bergan Mercy Medical Center, Omaha, Nebraska
Lakeside Hospital, Omaha, Nebraska
Creighton University Medical Center, Omaha, Nebraska
University Medical Center of Southern Nevada, Las Vegas, Nevada
CCOP - Nevada Cancer Research Foundation, Las Vegas, Nevada
New Hampshire Oncology - Hematology, PA at Payson Center for Cancer Care, Concord, New Hampshire
New Hampshire Oncology - Hematology, PA - Hooksett, Hooksett, New Hampshire
Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire
Dizzy Gillespie Cancer Institute at Englewood Hospital and Medical Center, Englewood, New Jersey
CCOP - Northern New Jersey, Hackensack, New Jersey
St. Barnabas Medical Center Cancer Center, Livingston, New Jersey
UMDNJ University Hospital, Newark, New Jersey
Somerset Medical Center, Somerville, New Jersey
Overlook Hospital, Summit, New Jersey
Franklin & Edith Scarpa Regional Cancer Center at South Jersey Healthcare, Vineland, New Jersey
Hematology Oncology Associates, PC, Albuquerque, New Mexico
Presbyterian Cancer Treatment Center at Presbyterian Kaseman Hospital, Albuquerque, New Mexico
University of New Mexico Cancer Center, Albuquerque, New Mexico
University of New Mexico Cancer Center - South, Las Cruces, New Mexico
Roswell Park Cancer Institute, Buffalo, New York
CCOP - Hematology-Oncology Associates of Central New York, East Syracuse, New York
Beth Israel Medical Center - Petrie Division, New York, New York
New York Weill Cornell Cancer Center at Cornell University, New York, New York
St. Luke's - Roosevelt Hospital Center - St.Luke's Division, New York, New York
Union State Bank Cancer Center at Nyack Hospital, Nyack, New York
Highland Hospital of Rochester, Rochester, New York
Lipson Cancer and Blood Center at Rochester General Hospital, Rochester, New York
James P. Wilmot Cancer Center at University of Rochester Medical Center, Rochester, New York
Hope A Women's Cancer Center, Asheville, North Carolina
Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill, Chapel Hill, North Carolina
Batte Cancer Center at Northeast Medical Center, Concord, North Carolina
Wayne Memorial Hospital, Incorporated, Goldsboro, North Carolina
Kinston Medical Specialists, Kinston, North Carolina
Bismarck Cancer Center, Bismarck, North Dakota
Medcenter One Hospital Cancer Care Center, Bismarck, North Dakota
Mid Dakota Clinic, PC, Bismarck, North Dakota
St. Alexius Medical Center Cancer Center, Bismarck, North Dakota
Altru Cancer Center at Altru Hospital, Grand Forks, North Dakota
McDowell Cancer Center at Akron General Medical Center, Akron, Ohio
Summa Center for Cancer Care at Akron City Hospital, Akron, Ohio
Barberton Citizens Hospital, Barberton, Ohio
Cleveland Clinic Beachwood Family Health and Surgery Center, Beachwood, Ohio
Mary Rutan Hospital, Bellefontaine, Ohio
Wood County Oncology Center, Bowling Green, Ohio
Mercy Cancer Center at Mercy Medical Center, Canton, Ohio
Adena Regional Medical Center, Chillicothe, Ohio
Good Samaritan Hospital Cancer Treatment Center, Cincinnati, Ohio
Bethesda North Hospital, Cincinnati, Ohio
Case Comprehensive Cancer Center, Cleveland, Ohio
Cleveland Clinic Cancer Center at Fairview Hospital, Cleveland, Ohio
Cleveland Clinic Taussig Cancer Center, Cleveland, Ohio
Riverside Methodist Hospital Cancer Care, Columbus, Ohio
CCOP - Columbus, Columbus, Ohio
Grant Medical Center Cancer Care, Columbus, Ohio
Mount Carmel Health - West Hospital, Columbus, Ohio
Doctors Hospital at Ohio Health, Columbus, Ohio
Grandview Hospital, Dayton, Ohio
Good Samaritan Hospital, Dayton, Ohio
David L. Rike Cancer Center at Miami Valley Hospital, Dayton, Ohio
Samaritan North Cancer Care Center, Dayton, Ohio
CCOP - Dayton, Dayton, Ohio
Grady Memorial Hospital, Delaware, Ohio
Community Cancer Center, Elyria, Ohio
Hematology Oncology Center, Elyria, Ohio
Blanchard Valley Medical Associates, Findlay, Ohio
Middletown Regional Hospital, Franklin, Ohio
Wayne Hospital, Greenville, Ohio
Cleveland Clinic Cancer Center, Independence, Ohio
Charles F. Kettering Memorial Hospital, Kettering, Ohio
Fairfield Medical Center, Lancaster, Ohio
St. Rita's Medical Center, Lima, Ohio
Lima Memorial Hospital, Lima, Ohio
MedCentral - Mansfield Hospital, Mansfield, Ohio
Strecker Cancer Center at Marietta Memorial Hospital, Marietta, Ohio
Northwest Ohio Oncology Center, Maumee, Ohio
Hillcrest Cancer Center at Hillcrest Hospital, Mayfield Heights, Ohio
Knox Community Hospital, Mount Vernon, Ohio
Licking Memorial Cancer Care Program at Licking Memorial Hospital, Newark, Ohio
Fisher-Titus Medical Center, Norwalk, Ohio
St. Charles Mercy Hospital, Oregon, Ohio
Toledo Clinic - Oregon, Oregon, Ohio
Parma Community General Hospital, Parma, Ohio
North Coast Cancer Care, Incorporated, Sandusky, Ohio
Community Hospital of Springfield and Clark County, Springfield, Ohio
Cleveland Clinic Foundation - Strongsville, Strongsville, Ohio
Flower Hospital Cancer Center, Sylvania, Ohio
Mercy Hospital of Tiffin, Tiffin, Ohio
Toledo Hospital, Toledo, Ohio
St. Vincent Mercy Medical Center, Toledo, Ohio
Medical University of Ohio Cancer Center, Toledo, Ohio
CCOP - Toledo Community Hospital, Toledo, Ohio
St. Anne Mercy Hospital, Toledo, Ohio
Toledo Clinic, Incorporated - Main Clinic, Toledo, Ohio
UVMC Cancer Care Center at Upper Valley Medical Center, Troy, Ohio
Fulton County Health Center, Wauseon, Ohio
Mount Carmel St. Ann's Cancer Center, Westerville, Ohio
Cleveland Clinic - Wooster, Wooster, Ohio
Ruth G. McMillan Cancer Center at Greene Memorial Hospital, Xenia, Ohio
Genesis - Good Samaritan Hospital, Zanesville, Ohio
Cleo Craig Cancer Research Clinic, Lawton, Oklahoma
Cancer Care Associates - Norman, Norman, Oklahoma
Cancer Care Associates - Mercy Campus, Oklahoma City, Oklahoma
Cancer Care Associates at Troy and Dollie Smith Cancer Center, Oklahoma City, Oklahoma
Clackamas Radiation Oncology Center, Clackamas, Oregon
Bay Area Hospital, Coos Bay, Oregon
Providence Milwaukie Hospital, Milwaukie, Oregon
Providence Newberg Medical Center, Newberg, Oregon
Willamette Falls Hospital, Oregon City, Oregon
Legacy Good Samaritan Hospital & Comprehensive Cancer Center, Portland, Oregon
Providence Cancer Center at Providence Portland Medical Center, Portland, Oregon
CCOP - Columbia River Oncology Program, Portland, Oregon
Providence St. Vincent Medical Center, Portland, Oregon
Knight Cancer Institute at Oregon Health and Science University, Portland, Oregon
Butler Memorial Hospital, Butler, Pennsylvania
Dale and Frances Hughes Cancer Center at Pocono Medical Center, East Stroudsburg, Pennsylvania
PinnacleHealth Regional Cancer Center at Polyclinic Hospital, Harrisburg, Pennsylvania
Penn State Hershey Cancer Institute at Milton S. Hershey Medical Center, Hershey, Pennsylvania
Lewistown Hospital, Lewistown, Pennsylvania
Kimmel Cancer Center at Thomas Jefferson University - Philadelphia, Philadelphia, Pennsylvania
Fox Chase Cancer Center - Philadelphia, Philadelphia, Pennsylvania
Pottstown Memorial Regional Cancer Center, Pottstown, Pennsylvania
Guthrie Cancer Center at Guthrie Clinic Sayre, Sayre, Pennsylvania
Mercy Hospital Cancer Center - Scranton, Scranton, Pennsylvania
Hematology and Oncology Associates of Northeastern Pennsylvania, Scranton, Pennsylvania
Mount Nittany Medical Center, State College, Pennsylvania
Associates in Hematology-Oncology, PC at Crozer Regional Cancer Center, Upland, Pennsylvania
Susquehanna Cancer Center at Divine Providence Hospital, Williamsport, Pennsylvania
South Carolina Oncology Associates, PA, Columbia, South Carolina
Cancer Centers of the Carolinas - Easley, Easley, South Carolina
McLeod Regional Medical Center, Florence, South Carolina
Cancer Centers of the Carolinas - Faris Road, Greenville, South Carolina
Cancer Centers of the Carolinas - Grove Commons, Greenville, South Carolina
Greenville Hospital Cancer Center, Greenville, South Carolina
CCOP - Greenville, Greenville, South Carolina
Self Regional Cancer Center at Self Regional Medical Center, Greenwood, South Carolina
Cancer Centers of the Carolinas - Greer Medical Oncology, Greer, South Carolina
Cancer Centers of the Carolinas - Seneca, Seneca, South Carolina
Cancer Centers of the Carolinas - Spartanburg, Spartanburg, South Carolina
Rapid City Regional Hospital, Rapid City, South Dakota
Medical X-Ray Center, PC, Sioux Falls, South Dakota
Sanford Cancer Center at Sanford USD Medical Center, Sioux Falls, South Dakota
University of Tennessee Cancer Institute - Memphis, Memphis, Tennessee
MBCCOP - Meharry Medical College - Nashville, Nashville, Tennessee
Texas Tech University Health Sciences Center School of Medicine - El Paso, El Paso, Texas
University of Texas Medical Branch, Galveston, Texas
UMC Southwest Cancer and Research Center, Lubbock, Texas
Veterans Affairs Medical Center - San Antonio (Murphy), San Antonio, Texas
University of Texas Health Science Center at San Antonio, San Antonio, Texas
University Hospital - San Antonio, San Antonio, Texas
American Fork Hospital, American Fork, Utah
Sandra L. Maxwell Cancer Center, Cedar City, Utah
Logan Regional Hospital, Logan, Utah
Jon and Karen Huntsman Cancer Center at Intermountain Medical Center, Murray, Utah
Val and Ann Browning Cancer Center at McKay-Dee Hospital Center, Ogden, Utah
Utah Valley Regional Medical Center - Provo, Provo, Utah
Dixie Regional Medical Center - East Campus, Saint George, Utah
Utah Cancer Specialists at UCS Cancer Center, Salt Lake City, Utah
LDS Hospital, Salt Lake City, Utah
Green Mountain Oncology Group, Bennington, Vermont
Fredericksburg Oncology, Incorporated, Fredericksburg, Virginia
Hematology-Oncology Associates of Fredericksburg, Incorporated, Fredericksburg, Virginia
Island Hospital Cancer Care Center at Island Hospital, Anacortes, Washington
St. Joseph Cancer Center, Bellingham, Washington
Olympic Hematology and Oncology, Bremerton, Washington
Highline Medical Center Cancer Center, Burien, Washington
Providence Centralia Hospital, Centralia, Washington
St. Francis Hospital, Federal Way, Washington
Columbia Basin Hematology, Kennewick, Washington
Skagit Valley Hospital Cancer Care Center, Mount Vernon, Washington
Providence St. Peter Hospital Regional Cancer Center, Olympia, Washington
Harrison Poulsbo Hematology and Onocology, Poulsbo, Washington
Good Samaritan Cancer Center, Puyallup, Washington
Harborview Medical Center, Seattle, Washington
Minor and James Medical, PLLC, Seattle, Washington
Fred Hutchinson Cancer Research Center, Seattle, Washington
Group Health Central Hospital, Seattle, Washington
Swedish Cancer Institute at Swedish Medical Center - First Hill Campus, Seattle, Washington
University Cancer Center at University of Washington Medical Center, Seattle, Washington
North Puget Oncology at United General Hospital, Sedro-Woolley, Washington
Cancer Care Northwest - Spokane South, Spokane, Washington
Providence Cancer Center at Sacred Heart Medical Center, Spokane, Washington
Evergreen Hematology and Oncology, PS, Spokane, Washington
Franciscan Cancer Center at St. Joseph Medical Center, Tacoma, Washington
Allenmore Hospital, Tacoma, Washington
CCOP - Northwest, Tacoma, Washington
MultiCare Regional Cancer Center at Tacoma General Hospital, Tacoma, Washington
Madigan Army Medical Center - Tacoma, Tacoma, Washington
St. Clare Hospital, Tacoma, Washington
Southwest Washington Medical Center Cancer Center, Vancouver, Washington
Northwest Cancer Specialists at Vancouver Cancer Center, Vancouver, Washington
Wenatchee Valley Medical Center, Wenatchee, Washington
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital, Yakima, Washington
Community Comprehensive Cancer Center at Camden-Clark Memorial Hospital, Parkersburg, West Virginia
Princeton Community Hospital, Princeton, West Virginia
Langlade Memorial Hospital, Antigo, Wisconsin
Fox Valley Hematology and Oncology - East Grant Street, Appleton, Wisconsin
Vince Lombardi Cancer Clinic - Green Bay at Aurora BayCare Medical Center, Green Bay, Wisconsin
UW Cancer Center Johnson Creek, Johnson Creek, Wisconsin
Franciscan Skemp Healthcare - La Crosse Campus, La Crosse, Wisconsin
Gundersen Lutheran Center for Cancer and Blood, La Crosse, Wisconsin
University of Wisconsin Paul P. Carbone Comprehensive Cancer Center, Madison, Wisconsin
Holy Family Memorial Medical Center Cancer Care Center, Manitowoc, Wisconsin
Vince Lombardi Cancer Clinic - Marinette, Marinette, Wisconsin
Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh, Wisconsin
All Saints Cancer Center at Wheaton Franciscan Healthcare, Racine, Wisconsin
Vince Lombardi Cancer Clinic - Sheboygan, Sheboygan, Wisconsin
Aurora Medical Center, Summit, Wisconsin
Vince Lombardi Cancer Clinic - Two Rivers, Two Rivers, Wisconsin
University of Wisconcin Cancer Center at Aspirus Wausau Hospital, Wausau, Wisconsin
Oncology Alliance, SC - Milwaukee - West, Wauwatosa, Wisconsin
Riverview UW Cancer Center at Riverview Hospital, Wisconsin Rapids, Wisconsin
Welch Cancer Center at Sheridan Memorial Hospital, Sheridan, Wyoming
Cancer Care Program at Thunder Bay Regional Health Sciences, Thunder Bay, Ontario
Allan Blair Cancer Centre at Pasqua Hospital, Regina, Saskatchewan
San Juan City Hospital, San Juan, Not set
Conditions: Breast Cancer
A Study to Compare the Efficacy and Safety of BMS-986393 Versus Standard Regimens in Adult Participants With Relapsed or Refractory and Lenalidomide-exposed Multiple Myeloma (QUINTESSENTIAL-2)
Recruiting
The purpose of this study is to compare the efficacy and safety of arlo-cel (BMS-986393) versus standard regimens in adult participants with Relapsed or Refractory and Lenalidomide-exposed Multiple Myeloma.
The purpose of this study is to compare the efficacy and safety of arlo-cel (BMS-986393) versus standard regimens in adult participants with Relapsed or Refractory and Lenalidomide-exposed Multiple Myeloma. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/29/2025
Locations: Local Institution - 0071, Birmingham, Alabama +125 locations
Local Institution - 0071, Birmingham, Alabama
UCLA Hematology/Oncology - Santa Monica, Los Angeles, California
Local Institution - 0130, Miami, Florida
Winship Cancer Institute, Emory University, Atlanta, Georgia
Local Institution - 0196, Boston, Massachusetts
Local Institution - 0067, Charlotte, North Carolina
Local Institution - 0216, Winston-Salem, North Carolina
Local Institution - 0193, Cleveland, Ohio
Fox Chase Cancer Center, Philadelphia, Pennsylvania
Local Institution - 0044, Salt Lake City, Utah
Local Institution - 0195, Milwaukee, Wisconsin
Hospital Italiano de Buenos Aires, ABB, Ciudad Autónoma De Buenos Aires
Local Institution - 0214, ABB, Ciudad Autónoma De Buenos Aires
Hospital Aleman, Buenos Aires, Ciudad Autónoma De Buenos Aires
Royal Prince Alfred Hospital, Camperdown, New South Wales
Local Institution - 0190, Liverpool, New South Wales
Local Institution - 0140, Brisbane, Queensland
Royal Adelaide Hospital, Adelaide, South Australia
Monash Health, Clayton, Victoria
Peter MacCallum Cancer Centre, Melbourne, Victoria
Local Institution - 0191, Melbourne, Victoria
Fiona Stanley Hospital, Murdoch, Western Australia
Ordensklinikum Linz GmbH Elisabethinen, Linz, Oberösterreich
Hanusch-Krankenhaus, Vienna, Not set
Local Institution - 0220, Edegem, Antwerpen
Local Institution - 0217, Brussels, Bruxelles-Capitale, Région De
Local Institution - 0162, Yvoir, Namur
UZ Gent, Gent, Oost-Vlaanderen
Local Institution - 0012, Nova Lima, Minas Gerais
Local Institution - 0103, São Paulo, SAO Paulo
Local Institution - 0013, Sao Paulo, São Paulo
Local Institution - 0031, São Paulo, Not set
Local Institution - 0069, Calgary, Alberta
Vancouver General Hospital, Vancouver, British Columbia
QEII Health Sciences Centre - Victoria General Site, Halifax, Nova Scotia
Local Institution - 0192, Hamilton, Ontario
CIUSSS de l'Est-de-l'Île-de-Montréal, Montreal, Quebec
Fakultní nemocnice Brno Bohunice, Brno, Brno-město
Local Institution - 0093, Hradec Kralove, Hradec Králové
Vseobecna fakultni nemocnice v Praze, Praha 2, Not set
Rigshospitalet, Copenhagen, Hovedstaden
Aarhus Universitetshospital, Skejby, Aarhus, Midtjylland
Local Institution - 0208, Roskilde, Sjælland
Odense Universitetshospital, Odense, Syddanmark
Helsinki University Hospital - Comprehensive Cancer Center (HYKS - Syöpäkeskus), Helsinki, Uusimaa
Hopital Claude Huriez - CHU de Lille, Lille, Nord
Local Institution - 0194, Nantes, Pays-de-la-Loire
Centre Hospitalier Lyon Sud, Pierre-Bénite, Rhône
Henri Mondor Hospital, Creteil, Val-de-Marne
Local Institution - 0210, Paris, Not set
TUM Universitätsklinikum, Technische Universität München, Munich, Bayern
Medizinische Hochschule Hannover, Hannover, Niedersachsen
Local Institution - 0211, Magdeburg, Sachsen-Anhalt
Local Institution - 0204, Chemnitz, Sachsen
Universitätsklinikum Leipzig, Leipzig, Sachsen
Local Institution - 0212, Kiel, Schleswig-Holstein
Local Institution - 0213, Berlin, Not set
Universitaetsklinikum Hamburg-Eppendorf, Hamburg, Not set
Universitaetsklinikum Heidelberg, Heidelberg, Not set
Klinikum Nuernberg Nord, Nuremberg, Not set
Universitaetsklinikum Wuerzburg, Wuerzburg, Not set
University Hospital of Patras, Patras, Achaḯa
Evangelismos General Hospital of Athens, Athens, Attikí
Local Institution - 0115, Chaidari, Attikí
Local Institution - 0125, Budapest, Not set
Local Institution - 0124, Debrecen, Not set
Sheba Medical Center, Ramat Gan, HaMerkaz
Sourasky Medical Center, Tel Aviv, Tell Abīb
Hadassah Medical Center, Jerusalem, Yerushalayim
Local Institution - 0107, Milan, Lombardia
Istituto Clinico Humanitas, Rozzano, Milano
Local Institution - 0128, Torino, Piemonte
Local Institution - 0108, Bologna, Not set
Local Institution - 0119, Genova, Not set
Local Institution - 0106, Udine, Not set
Nagoya City University Hospital, Nagoya, Aichi
Local Institution - 0105, Kashiwa, Chiba
Hyogo Medical University Hospital, Nishinomiya, Hyogo
Kanazawa University Hospital, Kanazawa, Ishikawa
Kyushu University Hospital, Fukuoka, Not set
Kumamoto University Hospital, Kumamoto, Not set
National Hospital Organization Okayama Medical Center, Okayama, Not set
Osaka Red Cross Hospital, Osaka, Not set
Japanese Red Cross Medical Center, Tokyo, Not set
Yamagata University Hospital, Yamagata, Not set
Local Institution - 0147, Seoul, Seoul-teukbyeolsi [Seoul]
Local Institution - 0146, Seoul, Seoul-teukbyeolsi [Seoul]
Local Institution - 0148, Seoul, Seoul-teukbyeolsi [Seoul]
Local Institution - 0149, Seoul, Seoul-teukbyeolsi [Seoul]
Local Institution - 0176, Nijmegen, Gelderland
Maastricht UMC+, Maastricht, Limburg
Local Institution - 0179, Amsterdam, Noord-Holland
Local Institution - 0161, Groningen, Not set
Local Institution - 0159, Utrecht, Not set
Universitair Medisch Centrum Utrecht, Utrecht, Not set
Oslo Universitetssykehus Ullevål, Oslo, Not set
Centrum Onkologii Ziemi Lubelskiej, Lublin, Lubelskie
Uniwersyteckie Centrum Kliniczne, Gdańsk, Pomorskie
Local Institution - 0084, Katowice, Not set
Local Institution - 0183, Łódź, Łódzkie
Instituto Português de Oncologia do Porto Francisco Gentil, EPE, Porto, Not set
Fundeni Clinical Institute, Bucuresti, București
Institutul Regional de Oncologie, Iași, Not set
Local Institution - 0178, Riyadh, Not set
Local Institution - 0180, Singapore, Central Singapore
Local Institution - 0181, Singapore, Central Singapore
CHUS - Hospital Clinico Universitario, Santiago de Compostela, A Coruña [La Coruña]
Local Institution - 0203, Palma, Balears [Baleares]
Local Institution - 0201, Badalona, Barcelona [Barcelona]
Clinica Universidad de Navarra, Pamplona, Navarra
Local Institution - 0202, Granada, Not set
Hospital Universitario de Salamanca - Complejo Asistencial Universitario de Salamanca, Salamanca, Not set
Local Institution - 0023, Lund, Skåne Län [se-12]
Karolinska Universitetssjukhuset Huddinge, Huddinge, Not set
Inselspital Bern, Bern, Berne
Cantonal Hospital St.Gallen, st.Gallen, Sankt Gallen
Local Institution - 0150, Taipei City, Taipei
Local Institution - 0151, Taichung, Not set
Local Institution - 0152, Taipei, Not set
Local Institution - 0200, Taipei, Not set
Local Institution - 0170, Ankara, Not set
Addenbrooke's Hospital, Cambridge, Cambridgeshire
Local Institution - 0155, London, London, City Of
Local Institution - 0157, Oxford, Oxfordshire
The Christie NHS Foundation Trust, Manchester, Not set
Local Institution - 0154, Newcastle upon Tyne, Not set
Conditions: Relapsed or Refractory Multiple Myeloma (RRMM)
A Study of CC-97540 (BMS-986353), CD19-Targeted NEX-T CAR T Cells, in Participants With Active SLE Despite Immunosuppressants (Breakfree-SLE)
Recruiting
The purpose of this study is to evaluate the efficacy, safety and drug levels of CC-97540 in participants with active systemic lupus erythematosus (SLE) including lupus nephritis with inadequate response to glucocorticoids and at least 2 immunosuppressants.
The purpose of this study is to evaluate the efficacy, safety and drug levels of CC-97540 in participants with active systemic lupus erythematosus (SLE) including lupus nephritis with inadequate response to glucocorticoids and at least 2 immunosuppressants. Read Less
Gender:
ALL
Ages:
16 years and above
Trial Updated:
07/28/2025
Locations: Local Institution - 0009, Birmingham, Alabama +70 locations
Local Institution - 0009, Birmingham, Alabama
Local Institution - 0038, Los Angeles, California
Local Institution - 0051, Los Angeles, California
Local Institution - 0035, Palo Alto, California
University of Colorado Anschutz Medical Campus, Aurora, Colorado
Local Institution - 0006, Jacksonville, Florida
Local Institution - 0002, Miami, Florida
Local Institution - 0008, Tampa, Florida
Local Institution - 0036, Tampa, Florida
Local Institution - 0062, Zephyrhills, Florida
Local Institution - 0052, Boston, Massachusetts
Local Institution - 0011, Rochester, Minnesota
Atlantic Health System Overlook Medical Center, Summit, New Jersey
Local Institution - 0040, New York, New York
Local Institution - 0004, New York, New York
Local Institution - 0005, New York, New York
Local Institution - 0039, New York, New York
Local Institution - 0010, Chapel Hill, North Carolina
Local Institution - 0065, Charlotte, North Carolina
Local Institution - 0012, Cincinnati, Ohio
Local Institution - 0003, Cleveland, Ohio
Local Institution - 0041, Oklahoma City, Oklahoma
Baylor Scott and White Research Institute, Dallas, Texas
Local Institution - 0007, Seattle, Washington
Local Institution - 0016, ABB, Ciudad Autónoma De Buenos Aires
Local Institution - 0017, ABB, Ciudad Autónoma De Buenos Aires
Local Institution - 0023, Buenos Aires, Ciudad Autónoma De Buenos Aires
Local Institution - 0037, Vienna, Wien
Local Institution - 0031, Salzburg, Not set
Local Institution - 0020, Leuven, Vlaams-Brabant
Local Institution - 0058, Sao Paulo, São Paulo
Local Institution - 0021, São Paulo, Not set
Local Institution - 0022, São Paulo, Not set
Local Institution - 0048, Vancouver, British Columbia
Local Institution - 0045, Toronto, Ontario
Local Institution - 0056, Odense, Syddanmark
Local Institution - 0047, Copenhagen, Not set
Local Institution - 0018, Montpellier, Hérault
Local Institution - 0019, Rennes, Not set
Local Institution - 0064, Paris, Île-de-France
Local Institution - 0029, Köln, Nordrhein-Westfalen
Local Institution - 0030, Magdeburg, Sachsen-Anhalt
Local Institution - 0028, Leipzig, Sachsen
Local Institution - 0026, Berlin, Not set
Local Institution - 0027, Erlangen, Not set
Local Institution - 0043, Ramat Gan, HaMerkaz
Local Institution - 0042, Jerusalem, Not set
Local Institution - 0025, Roma, Lazio
Local Institution - 0032, Milan, Milano
Local Institution - 0044, Rome, Roma
Local Institution - 0070, Pisa, Toscana
Local Institution - 0055, Sapporo, Hokkaido
Local Institution - 0072, Yokohama, Kanagawa
Local Institution - 0068, Bunkyo-ku, Tokyo
Local Institution - 0069, Shinjuku-ku, Tokyo
Local Institution - 0067, Chiba, Not set
Local Institution - 0054, Fukuoka, Not set
Local Institution - 0063, Okayama, Not set
Local Institution - 0053, Osaka, Not set
Local Institution - 0046, Amsterdam, Noord-Holland
Local Institution - 0034, Łódź, Łódzkie
Local Institution - 0024, Bytom, Śląskie
Local Institution - 0049, Gliwice, Śląskie
Local Institution - 0013, Lisbon, Lisboa
Local Institution - 0015, Barcelona, Barcelona [Barcelona]
Local Institution - 0071, Esplugues de Llobregat, Barcelona [Barcelona]
Local Institution - 0014, Málaga, Not set
Local Institution - 0060, London, London, City Of
Local Institution - 0061, London, London, City Of
Local Institution - 0050, London, London, City Of
Local Institution - 0057, London, London, City Of
Conditions: Lupus Erythematosus, Systemic, Lupus Nephritis
Safe Effective Therapy With Low-Dose Glucocorticoid in ANCA-Associated Vasculitis (SAFE-LOW)
Not Yet Recruiting
The purpose of this study is to determine the safety and efficacy of a therapeutic regimen consisting of 4 weeks of glucocorticoids given with a combination of the usual induction agents for ANCA-associated vasculitis. The trial will compare this regimen to the current standard of care treatment and glucocorticoid dosing for ANCA-associated vasculitis with severe kidney involvement. This trial will begin as a pilot to assess feasibility of recruitment and of adherence to the intervention.
The purpose of this study is to determine the safety and efficacy of a therapeutic regimen consisting of 4 weeks of glucocorticoids given with a combination of the usual induction agents for ANCA-associated vasculitis. The trial will compare this regimen to the current standard of care treatment and glucocorticoid dosing for ANCA-associated vasculitis with severe kidney involvement. This trial will begin as a pilot to assess feasibility of recruitment and of adherence to the intervention. Read Less
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/28/2025
Locations: St-Joseph's Hospital, Hamilton, Ontario +1 locations
St-Joseph's Hospital, Hamilton, Ontario
The Ottawa Hospital, Ottawa, Ontario
Conditions: Granulomatosis With Polyangiitis, Microscopic Polyangiitis (MPA)
Total Therapy for Infants With Acute Lymphoblastic Leukemia (ALL) I
Active Not Recruiting
The purpose of this study is to test the good and bad effects of the study drugs bortezomib and vorinostat when they are given in combination with chemotherapy commonly used to treat acute lymphoblastic leukemia (ALL) in infants. For example, adding these drugs could decrease the number of leukemia cells, but it could also cause additional side effects. Bortezomib and vorinostat have been approved by the US Food and Drug Administration (FDA) to treat other cancers in adults, but they have not be... Read More
The purpose of this study is to test the good and bad effects of the study drugs bortezomib and vorinostat when they are given in combination with chemotherapy commonly used to treat acute lymphoblastic leukemia (ALL) in infants. For example, adding these drugs could decrease the number of leukemia cells, but it could also cause additional side effects. Bortezomib and vorinostat have been approved by the US Food and Drug Administration (FDA) to treat other cancers in adults, but they have not been approved for treating children with leukemia. With this research, we plan to meet the following goals:
PRIMARY OBJECTIVE:
* Determine the tolerability of incorporating bortezomib and vorinostat into an ALL chemotherapy backbone for newly diagnosed infants with ALL.
SECONDARY OBJECTIVES:
* Estimate the event-free survival and overall survival of infants with ALL who are treated with bortezomib and vorinostat in combination with an ALL chemotherapy backbone.
* Measure minimal residual disease (MRD) positivity using both flow cytometry and PCR.
* Compare end of induction, end of consolidation, and end of reinduction MRD levels to Interfant99 (ClinicalTrials.gov registration ID number NCT00015873) participant outcomes. Read Less
Gender:
ALL
Ages:
365 days and below
Trial Updated:
07/28/2025
Locations: Children's Hospital Los Angeles, Los Angeles, California +16 locations
Children's Hospital Los Angeles, Los Angeles, California
Children's Hospital of Orange County, Orange, California
Lucile Packard Children's Hospital Stanford University, Palo Alto, California
Rady Children's Hospital and Health Center, San Diego, California
Children's Hospital and Clinics of Minnesota, Minneapolis, Minnesota
St. Jude Affiliate-Charlotte, Charlotte, North Carolina
Cincinnati Children's Hospital, Cincinnati, Ohio
Oregon Health and Science University, Portland, Oregon
St. Jude Children's Research Hospital, Memphis, Tennessee
Children's Hospital of the King's Daughters (CHKD), Norfolk, Virginia
Alberta Children's Hospital, Calgary, Alberta
Stollery Children's Hospital, Edmonton, Alberta
Children's & Women's Health Centre of British Columbia, Vancouver, British Columbia
McMaster Children's Hospital at Hamilton Health Sciences, Hamilton, Ontario
Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec
The Montreal Children's Hospital (MUHC-McGill), Montreal, Quebec
Centre Hospitalier Universitaire de Quebec, Québec, Quebec
Conditions: Acute Lymphoblastic Leukemia
Combination Chemotherapy With or Without Ganitumab in Treating Patients With Newly Diagnosed Metastatic Ewing Sarcoma
Active Not Recruiting
This randomized phase III trial studies how well combination chemotherapy with or without ganitumab works in treating patients with newly diagnosed Ewing sarcoma that has spread to other parts of the body. Treatment with drugs that block the IGF-1R pathway, such as ganitumab, may interfere with the ability of tumor cells to grow and spread. Drugs used in chemotherapy, such as vincristine, doxorubicin, cyclophosphamide, ifosfamide, and etoposide, work in different ways to stop the growth of tumor... Read More
This randomized phase III trial studies how well combination chemotherapy with or without ganitumab works in treating patients with newly diagnosed Ewing sarcoma that has spread to other parts of the body. Treatment with drugs that block the IGF-1R pathway, such as ganitumab, may interfere with the ability of tumor cells to grow and spread. Drugs used in chemotherapy, such as vincristine, doxorubicin, cyclophosphamide, ifosfamide, and etoposide, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether adding ganitumab to combination chemotherapy is more effective in treating patients with newly diagnosed metastatic Ewing sarcoma. Read Less
Gender:
ALL
Ages:
50 years and below
Trial Updated:
07/25/2025
Locations: Children's Hospital of Alabama, Birmingham, Alabama +314 locations
Children's Hospital of Alabama, Birmingham, Alabama
USA Health Strada Patient Care Center, Mobile, Alabama
Providence Alaska Medical Center, Anchorage, Alaska
Banner Children's at Desert, Mesa, Arizona
Phoenix Childrens Hospital, Phoenix, Arizona
Banner University Medical Center - Tucson, Tucson, Arizona
Onvida Health Yuma Medical Center, Yuma, Arizona
CHI Saint Vincent Cancer Center Hot Springs, Hot Springs, Arkansas
Arkansas Children's Hospital, Little Rock, Arkansas
Kaiser Permanente Downey Medical Center, Downey, California
City of Hope Comprehensive Cancer Center, Duarte, California
Loma Linda University Medical Center, Loma Linda, California
Miller Children's and Women's Hospital Long Beach, Long Beach, California
Children's Hospital Los Angeles, Los Angeles, California
Valley Children's Hospital, Madera, California
UCSF Benioff Children's Hospital Oakland, Oakland, California
Kaiser Permanente-Oakland, Oakland, California
Children's Hospital of Orange County, Orange, California
Lucile Packard Children's Hospital Stanford University, Palo Alto, California
Sutter Medical Center Sacramento, Sacramento, California
University of California Davis Comprehensive Cancer Center, Sacramento, California
Rady Children's Hospital - San Diego, San Diego, California
UCSF Medical Center-Parnassus, San Francisco, California
UCSF Medical Center-Mission Bay, San Francisco, California
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California
Children's Hospital Colorado, Aurora, Colorado
Penrose-Saint Francis Healthcare, Colorado Springs, Colorado
Rocky Mountain Cancer Centers-Penrose, Colorado Springs, Colorado
AdventHealth Porter, Denver, Colorado
Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center, Denver, Colorado
Mercy Medical Center, Durango, Colorado
Southwest Oncology PC, Durango, Colorado
Mountain Blue Cancer Care Center, Golden, Colorado
Rocky Mountain Cancer Centers-Lakewood, Lakewood, Colorado
Saint Anthony Hospital, Lakewood, Colorado
AdventHealth Littleton, Littleton, Colorado
Longmont United Hospital, Longmont, Colorado
Rocky Mountain Cancer Centers-Longmont, Longmont, Colorado
AdventHealth Parker, Parker, Colorado
Rocky Mountain Cancer Centers-Parker, Parker, Colorado
Saint Mary Corwin Medical Center, Pueblo, Colorado
Rocky Mountain Cancer Centers - Pueblo, Pueblo, Colorado
Rocky Mountain Cancer Centers-Thornton, Thornton, Colorado
Connecticut Children's Medical Center, Hartford, Connecticut
Yale University, New Haven, Connecticut
Alfred I duPont Hospital for Children, Wilmington, Delaware
MedStar Georgetown University Hospital, Washington, District of Columbia
Children's National Medical Center, Washington, District of Columbia
Golisano Children's Hospital of Southwest Florida, Fort Myers, Florida
University of Florida Health Science Center - Gainesville, Gainesville, Florida
Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood, Florida
Nemours Children's Clinic-Jacksonville, Jacksonville, Florida
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida
Nicklaus Children's Hospital, Miami, Florida
AdventHealth Orlando, Orlando, Florida
Arnold Palmer Hospital for Children, Orlando, Florida
Nemours Children's Hospital, Orlando, Florida
Nemours Children's Clinic - Pensacola, Pensacola, Florida
Johns Hopkins All Children's Hospital, Saint Petersburg, Florida
Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa, Florida
Saint Mary's Medical Center, West Palm Beach, Florida
Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta, Georgia
Augusta University Medical Center, Augusta, Georgia
Memorial Health University Medical Center, Savannah, Georgia
Straub Clinic and Hospital, Honolulu, Hawaii
Kaiser Permanente Moanalua Medical Center, Honolulu, Hawaii
Kapiolani Medical Center for Women and Children, Honolulu, Hawaii
Saint Luke's Cancer Institute - Boise, Boise, Idaho
Rush-Copley Medical Center, Aurora, Illinois
Lurie Children's Hospital-Chicago, Chicago, Illinois
University of Illinois, Chicago, Illinois
University of Chicago Comprehensive Cancer Center, Chicago, Illinois
Carle at The Riverfront, Danville, Illinois
Carle Physician Group-Effingham, Effingham, Illinois
Carle Physician Group-Mattoon/Charleston, Mattoon, Illinois
Loyola University Medical Center, Maywood, Illinois
SSM Health Good Samaritan, Mount Vernon, Illinois
Advocate Children's Hospital-Oak Lawn, Oak Lawn, Illinois
Advocate Children's Hospital-Park Ridge, Park Ridge, Illinois
Saint Jude Midwest Affiliate, Peoria, Illinois
Saint John's Hospital, Springfield, Illinois
Southern Illinois University School of Medicine, Springfield, Illinois
Springfield Memorial Hospital, Springfield, Illinois
Carle Cancer Center, Urbana, Illinois
The Carle Foundation Hospital, Urbana, Illinois
Rush-Copley Healthcare Center, Yorkville, Illinois
Deaconess Clinic Downtown, Evansville, Indiana
Riley Hospital for Children, Indianapolis, Indiana
Ascension Saint Vincent Indianapolis Hospital, Indianapolis, Indiana
Franciscan Saint Anthony Health-Michigan City, Michigan City, Indiana
Woodland Cancer Care Center, Michigan City, Indiana
Chancellor Center for Oncology, Newburgh, Indiana
Mercy Cancer Center-West Lakes, Clive, Iowa
UI Health Care Mission Cancer and Blood - West Des Moines Clinic, Clive, Iowa
Alegent Health Mercy Hospital, Council Bluffs, Iowa
Greater Regional Medical Center, Creston, Iowa
Blank Children's Hospital, Des Moines, Iowa
Mercy Medical Center - Des Moines, Des Moines, Iowa
UI Health Care Mission Cancer and Blood - Laurel Clinic, Des Moines, Iowa
University of Iowa/Holden Comprehensive Cancer Center, Iowa City, Iowa
Mercy Medical Center-West Lakes, West Des Moines, Iowa
Flaget Memorial Hospital, Bardstown, Kentucky
Commonwealth Cancer Center-Corbin, Corbin, Kentucky
Saint Joseph Radiation Oncology Resource Center, Lexington, Kentucky
Saint Joseph Hospital East, Lexington, Kentucky
University of Kentucky/Markey Cancer Center, Lexington, Kentucky
Saint Joseph London, London, Kentucky
Jewish Hospital, Louisville, Kentucky
Norton Children's Hospital, Louisville, Kentucky
Saints Mary and Elizabeth Hospital, Louisville, Kentucky
UofL Health Medical Center Northeast, Louisville, Kentucky
Jewish Hospital Medical Center South, Shepherdsville, Kentucky
Children's Hospital New Orleans, New Orleans, Louisiana
Ochsner Medical Center Jefferson, New Orleans, Louisiana
Eastern Maine Medical Center, Bangor, Maine
Maine Children's Cancer Program, Scarborough, Maine
University of Maryland/Greenebaum Cancer Center, Baltimore, Maryland
Sinai Hospital of Baltimore, Baltimore, Maryland
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland
Walter Reed National Military Medical Center, Bethesda, Maryland
Massachusetts General Hospital Cancer Center, Boston, Massachusetts
Dana-Farber Cancer Institute, Boston, Massachusetts
Baystate Medical Center, Springfield, Massachusetts
UMass Memorial Medical Center - University Campus, Worcester, Massachusetts
C S Mott Children's Hospital, Ann Arbor, Michigan
University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan
Bronson Battle Creek, Battle Creek, Michigan
Wayne State University/Karmanos Cancer Institute, Detroit, Michigan
Henry Ford Health Saint John Hospital, Detroit, Michigan
Hurley Medical Center, Flint, Michigan
Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids, Michigan
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids, Michigan
Trinity Health Grand Rapids Hospital, Grand Rapids, Michigan
Bronson Methodist Hospital, Kalamazoo, Michigan
West Michigan Cancer Center, Kalamazoo, Michigan
Ascension Borgess Hospital, Kalamazoo, Michigan
Trinity Health Muskegon Hospital, Muskegon, Michigan
Corewell Health Lakeland Hospitals - Niles Hospital, Niles, Michigan
Huron Medical Center PC, Port Huron, Michigan
Lake Huron Medical Center, Port Huron, Michigan
Corewell Health Reed City Hospital, Reed City, Michigan
Corewell Health Children's, Royal Oak, Michigan
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center, Saint Joseph, Michigan
Corewell Health Lakeland Hospitals - Saint Joseph Hospital, Saint Joseph, Michigan
Munson Medical Center, Traverse City, Michigan
Essentia Health Cancer Center, Duluth, Minnesota
Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis, Minnesota
University of Minnesota/Masonic Cancer Center, Minneapolis, Minnesota
Mayo Clinic in Rochester, Rochester, Minnesota
University of Mississippi Medical Center, Jackson, Mississippi
Central Care Cancer Center - Bolivar, Bolivar, Missouri
Cox Cancer Center Branson, Branson, Missouri
University of Missouri Children's Hospital, Columbia, Missouri
Freeman Health System, Joplin, Missouri
Mercy Hospital Joplin, Joplin, Missouri
Children's Mercy Hospitals and Clinics, Kansas City, Missouri
Mercy Clinic-Rolla-Cancer and Hematology, Rolla, Missouri
Phelps Health Delbert Day Cancer Institute, Rolla, Missouri
Heartland Regional Medical Center, Saint Joseph, Missouri
Cardinal Glennon Children's Medical Center, Saint Louis, Missouri
Mercy Infusion Center - Chippewa, Saint Louis, Missouri
Washington University School of Medicine, Saint Louis, Missouri
Mercy Hospital Saint Louis, Saint Louis, Missouri
Mercy Hospital Springfield, Springfield, Missouri
CoxHealth South Hospital, Springfield, Missouri
Nebraska Medicine-Bellevue, Bellevue, Nebraska
Nebraska Cancer Specialists/Oncology Hematology West PC, Grand Island, Nebraska
Fred and Pamela Buffett Cancer Center - Kearney, Kearney, Nebraska
CHI Health Good Samaritan, Kearney, Nebraska
Saint Elizabeth Regional Medical Center, Lincoln, Nebraska
Children's Hospital and Medical Center of Omaha, Omaha, Nebraska
Nebraska Medicine-Village Pointe, Omaha, Nebraska
Alegent Health Immanuel Medical Center, Omaha, Nebraska
Hematology and Oncology Consultants PC, Omaha, Nebraska
Alegent Health Bergan Mercy Medical Center, Omaha, Nebraska
Alegent Health Lakeside Hospital, Omaha, Nebraska
Creighton University Medical Center, Omaha, Nebraska
University of Nebraska Medical Center, Omaha, Nebraska
Midlands Community Hospital, Papillion, Nebraska
Carson Tahoe Regional Medical Center, Carson City, Nevada
Comprehensive Cancer Centers of Nevada-Horizon Ridge, Henderson, Nevada
University Medical Center of Southern Nevada, Las Vegas, Nevada
Sunrise Hospital and Medical Center, Las Vegas, Nevada
Ann M Wierman MD LTD, Las Vegas, Nevada
Alliance for Childhood Diseases/Cure 4 the Kids Foundation, Las Vegas, Nevada
Summerlin Hospital Medical Center, Las Vegas, Nevada
Hope Cancer Care of Nevada-Pahrump, Pahrump, Nevada
Renown Regional Medical Center, Reno, Nevada
Saint Mary's Regional Medical Center, Reno, Nevada
Radiation Oncology Associates, Reno, Nevada
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon, New Hampshire
Hackensack University Medical Center, Hackensack, New Jersey
Morristown Medical Center, Morristown, New Jersey
Saint Peter's University Hospital, New Brunswick, New Jersey
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick, New Jersey
Newark Beth Israel Medical Center, Newark, New Jersey
Saint Joseph's Regional Medical Center, Paterson, New Jersey
Albany Medical Center, Albany, New York
Montefiore Medical Center-Einstein Campus, Bronx, New York
Montefiore Medical Center-Weiler Hospital, Bronx, New York
Children's Hospital at Montefiore, Bronx, New York
Montefiore Medical Center - Moses Campus, Bronx, New York
Roswell Park Cancer Institute, Buffalo, New York
Glens Falls Hospital, Glens Falls, New York
NYU Langone Hospital - Long Island, Mineola, New York
The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park, New York
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York, New York
Mount Sinai Hospital, New York, New York
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York, New York
University of Rochester, Rochester, New York
Stony Brook University Medical Center, Stony Brook, New York
State University of New York Upstate Medical University, Syracuse, New York
New York Medical College, Valhalla, New York
Mission Hospital, Asheville, North Carolina
UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina
Carolinas Medical Center/Levine Cancer Institute, Charlotte, North Carolina
Duke University Medical Center, Durham, North Carolina
Wake Forest University Health Sciences, Winston-Salem, North Carolina
Sanford Broadway Medical Center, Fargo, North Dakota
Children's Hospital Medical Center of Akron, Akron, Ohio
Good Samaritan Hospital - Cincinnati, Cincinnati, Ohio
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Bethesda North Hospital, Cincinnati, Ohio
TriHealth Cancer Institute-Westside, Cincinnati, Ohio
TriHealth Cancer Institute-Anderson, Cincinnati, Ohio
Rainbow Babies and Childrens Hospital, Cleveland, Ohio
Cleveland Clinic Foundation, Cleveland, Ohio
Nationwide Children's Hospital, Columbus, Ohio
Dayton Children's Hospital, Dayton, Ohio
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo, Ohio
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Mercy Hospital Oklahoma City, Oklahoma City, Oklahoma
Legacy Emanuel Children's Hospital, Portland, Oregon
Oregon Health and Science University, Portland, Oregon
Lehigh Valley Hospital-Cedar Crest, Allentown, Pennsylvania
Lehigh Valley Hospital - Muhlenberg, Bethlehem, Pennsylvania
Geisinger Medical Center, Danville, Pennsylvania
Penn State Children's Hospital, Hershey, Pennsylvania
Drexel University School of Medicine, Philadelphia, Pennsylvania
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Saint Christopher's Hospital for Children, Philadelphia, Pennsylvania
Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania
Rhode Island Hospital, Providence, Rhode Island
Medical University of South Carolina, Charleston, South Carolina
Prisma Health Richland Hospital, Columbia, South Carolina
Saint Francis Hospital, Greenville, South Carolina
BI-LO Charities Children's Cancer Center, Greenville, South Carolina
Saint Francis Cancer Center, Greenville, South Carolina
Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota
T C Thompson Children's Hospital, Chattanooga, Tennessee
Memorial Hospital, Chattanooga, Tennessee
Pulmonary Medicine Center of Chattanooga-Hixson, Hixson, Tennessee
East Tennessee Childrens Hospital, Knoxville, Tennessee
Saint Jude Children's Research Hospital, Memphis, Tennessee
The Children's Hospital at TriStar Centennial, Nashville, Tennessee
Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee
Memorial GYN Plus, Ooltewah, Tennessee
Dell Children's Medical Center of Central Texas, Austin, Texas
Saint Joseph Regional Cancer Center, Bryan, Texas
Driscoll Children's Hospital, Corpus Christi, Texas
Medical City Dallas Hospital, Dallas, Texas
UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas
El Paso Children's Hospital, El Paso, Texas
Cook Children's Medical Center, Fort Worth, Texas
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston, Texas
M D Anderson Cancer Center, Houston, Texas
Covenant Children's Hospital, Lubbock, Texas
UMC Cancer Center / UMC Health System, Lubbock, Texas
Texas Tech University Health Sciences Center-Lubbock, Lubbock, Texas
Children's Hospital of San Antonio, San Antonio, Texas
Methodist Children's Hospital of South Texas, San Antonio, Texas
University of Texas Health Science Center at San Antonio, San Antonio, Texas
Scott and White Memorial Hospital, Temple, Texas
Primary Children's Hospital, Salt Lake City, Utah
Central Vermont Medical Center/National Life Cancer Treatment, Berlin, Vermont
University of Vermont Medical Center, Burlington, Vermont
University of Vermont and State Agricultural College, Burlington, Vermont
Inova Fairfax Hospital, Falls Church, Virginia
Children's Hospital of The King's Daughters, Norfolk, Virginia
Naval Medical Center - Portsmouth, Portsmouth, Virginia
VCU Massey Comprehensive Cancer Center, Richmond, Virginia
Carilion Children's, Roanoke, Virginia
Highline Medical Center-Main Campus, Burien, Washington
Saint Elizabeth Hospital, Enumclaw, Washington
Saint Francis Hospital, Federal Way, Washington
Saint Clare Hospital, Lakewood, Washington
Harrison HealthPartners Hematology and Oncology-Poulsbo, Poulsbo, Washington
Seattle Children's Hospital, Seattle, Washington
Saint Michael Cancer Center, Silverdale, Washington
Providence Sacred Heart Medical Center and Children's Hospital, Spokane, Washington
Franciscan Research Center-Northwest Medical Plaza, Tacoma, Washington
Mary Bridge Children's Hospital and Health Center, Tacoma, Washington
Northwest Medical Specialties PLLC, Tacoma, Washington
Madigan Army Medical Center, Tacoma, Washington
West Virginia University Healthcare, Morgantown, West Virginia
Saint Vincent Hospital Cancer Center Green Bay, Green Bay, Wisconsin
Saint Vincent Hospital Cancer Center at Marinette, Marinette, Wisconsin
Marshfield Medical Center-Marshfield, Marshfield, Wisconsin
Children's Hospital of Wisconsin, Milwaukee, Wisconsin
Alberta Children's Hospital, Calgary, Alberta
University of Alberta Hospital, Edmonton, Alberta
British Columbia Children's Hospital, Vancouver, British Columbia
CancerCare Manitoba, Winnipeg, Manitoba
Janeway Child Health Centre, Saint John's, Newfoundland and Labrador
IWK Health Centre, Halifax, Nova Scotia
McMaster Children's Hospital at Hamilton Health Sciences, Hamilton, Ontario
Kingston Health Sciences Centre, Kingston, Ontario
Children's Hospital, London, Ontario
Children's Hospital of Eastern Ontario, Ottawa, Ontario
Hospital for Sick Children, Toronto, Ontario
The Montreal Children's Hospital of the MUHC, Montreal, Quebec
Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec
CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL), Quebec, Not set
San Jorge Children's Hospital, San Juan, Not set
University Pediatric Hospital, San Juan, Not set
Conditions: Metastatic Ewing Sarcoma, Metastatic Malignant Neoplasm in the Bone, Metastatic Malignant Neoplasm in the Bone Marrow, Metastatic Malignant Neoplasm in the Lung, Metastatic Peripheral Primitive Neuroectodermal Tumor of Bone, Peripheral Primitive Neuroectodermal Tumor of Soft Tissues
Combination Chemotherapy With or Without Bortezomib in Treating Younger Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or Stage II-IV T-Cell Lymphoblastic Lymphoma
Active Not Recruiting
This randomized phase III trial compares how well combination chemotherapy works when given with or without bortezomib in treating patients with newly diagnosed T-cell acute lymphoblastic leukemia or stage II-IV T-cell lymphoblastic lymphoma. Bortezomib may help reduce the number of leukemia or lymphoma cells by blocking some of the enzymes needed for cell growth. It may also help chemotherapy work better by making cancer cells more sensitive to the drugs. It is not yet known if giving standard... Read More
This randomized phase III trial compares how well combination chemotherapy works when given with or without bortezomib in treating patients with newly diagnosed T-cell acute lymphoblastic leukemia or stage II-IV T-cell lymphoblastic lymphoma. Bortezomib may help reduce the number of leukemia or lymphoma cells by blocking some of the enzymes needed for cell growth. It may also help chemotherapy work better by making cancer cells more sensitive to the drugs. It is not yet known if giving standard chemotherapy with or without bortezomib is more effective in treating newly diagnosed T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma. Read Less
Gender:
ALL
Ages:
Between 1 year and 30 years
Trial Updated:
07/25/2025
Locations: Children's Hospital of Alabama, Birmingham, Alabama +211 locations
Children's Hospital of Alabama, Birmingham, Alabama
USA Health Strada Patient Care Center, Mobile, Alabama
Providence Alaska Medical Center, Anchorage, Alaska
Banner Children's at Desert, Mesa, Arizona
Phoenix Childrens Hospital, Phoenix, Arizona
Banner University Medical Center - Tucson, Tucson, Arizona
Arkansas Children's Hospital, Little Rock, Arkansas
Kaiser Permanente Downey Medical Center, Downey, California
City of Hope Comprehensive Cancer Center, Duarte, California
Loma Linda University Medical Center, Loma Linda, California
Miller Children's and Women's Hospital Long Beach, Long Beach, California
Children's Hospital Los Angeles, Los Angeles, California
Cedars Sinai Medical Center, Los Angeles, California
Valley Children's Hospital, Madera, California
UCSF Benioff Children's Hospital Oakland, Oakland, California
Kaiser Permanente-Oakland, Oakland, California
Children's Hospital of Orange County, Orange, California
Lucile Packard Children's Hospital Stanford University, Palo Alto, California
Sutter Medical Center Sacramento, Sacramento, California
University of California Davis Comprehensive Cancer Center, Sacramento, California
Rady Children's Hospital - San Diego, San Diego, California
Naval Medical Center -San Diego, San Diego, California
UCSF Medical Center-Mission Bay, San Francisco, California
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California
Children's Hospital Colorado, Aurora, Colorado
Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center, Denver, Colorado
Connecticut Children's Medical Center, Hartford, Connecticut
Yale University, New Haven, Connecticut
Alfred I duPont Hospital for Children, Wilmington, Delaware
MedStar Georgetown University Hospital, Washington, District of Columbia
Children's National Medical Center, Washington, District of Columbia
Broward Health Medical Center, Fort Lauderdale, Florida
Golisano Children's Hospital of Southwest Florida, Fort Myers, Florida
University of Florida Health Science Center - Gainesville, Gainesville, Florida
Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood, Florida
Nemours Children's Clinic-Jacksonville, Jacksonville, Florida
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida
Nicklaus Children's Hospital, Miami, Florida
Miami Cancer Institute, Miami, Florida
AdventHealth Orlando, Orlando, Florida
Arnold Palmer Hospital for Children, Orlando, Florida
Nemours Children's Hospital, Orlando, Florida
Nemours Children's Clinic - Pensacola, Pensacola, Florida
Johns Hopkins All Children's Hospital, Saint Petersburg, Florida
Tampa General Hospital, Tampa, Florida
Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa, Florida
Saint Mary's Medical Center, West Palm Beach, Florida
Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta, Georgia
Augusta University Medical Center, Augusta, Georgia
Memorial Health University Medical Center, Savannah, Georgia
Kapiolani Medical Center for Women and Children, Honolulu, Hawaii
Saint Luke's Cancer Institute - Boise, Boise, Idaho
Lurie Children's Hospital-Chicago, Chicago, Illinois
University of Illinois, Chicago, Illinois
University of Chicago Comprehensive Cancer Center, Chicago, Illinois
Loyola University Medical Center, Maywood, Illinois
Advocate Children's Hospital-Oak Lawn, Oak Lawn, Illinois
Advocate Children's Hospital-Park Ridge, Park Ridge, Illinois
Saint Jude Midwest Affiliate, Peoria, Illinois
Southern Illinois University School of Medicine, Springfield, Illinois
Riley Hospital for Children, Indianapolis, Indiana
Ascension Saint Vincent Indianapolis Hospital, Indianapolis, Indiana
Blank Children's Hospital, Des Moines, Iowa
University of Iowa/Holden Comprehensive Cancer Center, Iowa City, Iowa
University of Kentucky/Markey Cancer Center, Lexington, Kentucky
Norton Children's Hospital, Louisville, Kentucky
Children's Hospital New Orleans, New Orleans, Louisiana
Ochsner Medical Center Jefferson, New Orleans, Louisiana
Eastern Maine Medical Center, Bangor, Maine
Maine Children's Cancer Program, Scarborough, Maine
University of Maryland/Greenebaum Cancer Center, Baltimore, Maryland
Sinai Hospital of Baltimore, Baltimore, Maryland
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland
Walter Reed National Military Medical Center, Bethesda, Maryland
Tufts Children's Hospital, Boston, Massachusetts
Massachusetts General Hospital Cancer Center, Boston, Massachusetts
Baystate Medical Center, Springfield, Massachusetts
UMass Memorial Medical Center - University Campus, Worcester, Massachusetts
C S Mott Children's Hospital, Ann Arbor, Michigan
Wayne State University/Karmanos Cancer Institute, Detroit, Michigan
Henry Ford Health Saint John Hospital, Detroit, Michigan
Michigan State University, East Lansing, Michigan
Hurley Medical Center, Flint, Michigan
Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids, Michigan
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids, Michigan
Bronson Methodist Hospital, Kalamazoo, Michigan
West Michigan Cancer Center, Kalamazoo, Michigan
Corewell Health Children's, Royal Oak, Michigan
Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis, Minnesota
University of Minnesota/Masonic Cancer Center, Minneapolis, Minnesota
Mayo Clinic in Rochester, Rochester, Minnesota
University of Mississippi Medical Center, Jackson, Mississippi
University of Missouri Children's Hospital, Columbia, Missouri
Children's Mercy Hospitals and Clinics, Kansas City, Missouri
Cardinal Glennon Children's Medical Center, Saint Louis, Missouri
Washington University School of Medicine, Saint Louis, Missouri
Mercy Hospital Saint Louis, Saint Louis, Missouri
Children's Hospital and Medical Center of Omaha, Omaha, Nebraska
University of Nebraska Medical Center, Omaha, Nebraska
University Medical Center of Southern Nevada, Las Vegas, Nevada
Sunrise Hospital and Medical Center, Las Vegas, Nevada
Alliance for Childhood Diseases/Cure 4 the Kids Foundation, Las Vegas, Nevada
Summerlin Hospital Medical Center, Las Vegas, Nevada
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon, New Hampshire
Hackensack University Medical Center, Hackensack, New Jersey
Morristown Medical Center, Morristown, New Jersey
Saint Peter's University Hospital, New Brunswick, New Jersey
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick, New Jersey
Newark Beth Israel Medical Center, Newark, New Jersey
Saint Joseph's Regional Medical Center, Paterson, New Jersey
University of New Mexico Cancer Center, Albuquerque, New Mexico
Albany Medical Center, Albany, New York
Montefiore Medical Center - Moses Campus, Bronx, New York
Roswell Park Cancer Institute, Buffalo, New York
NYU Langone Hospital - Long Island, Mineola, New York
The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park, New York
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York, New York
Mount Sinai Hospital, New York, New York
NYP/Weill Cornell Medical Center, New York, New York
University of Rochester, Rochester, New York
Stony Brook University Medical Center, Stony Brook, New York
State University of New York Upstate Medical University, Syracuse, New York
New York Medical College, Valhalla, New York
Mission Hospital, Asheville, North Carolina
UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina
Carolinas Medical Center/Levine Cancer Institute, Charlotte, North Carolina
Novant Health Presbyterian Medical Center, Charlotte, North Carolina
Duke University Medical Center, Durham, North Carolina
East Carolina University, Greenville, North Carolina
Wake Forest University Health Sciences, Winston-Salem, North Carolina
Sanford Broadway Medical Center, Fargo, North Dakota
Children's Hospital Medical Center of Akron, Akron, Ohio
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Rainbow Babies and Childrens Hospital, Cleveland, Ohio
Cleveland Clinic Foundation, Cleveland, Ohio
Nationwide Children's Hospital, Columbus, Ohio
Dayton Children's Hospital, Dayton, Ohio
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo, Ohio
Mercy Children's Hospital, Toledo, Ohio
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Legacy Emanuel Children's Hospital, Portland, Oregon
Oregon Health and Science University, Portland, Oregon
Lehigh Valley Hospital-Cedar Crest, Allentown, Pennsylvania
Lehigh Valley Hospital - Muhlenberg, Bethlehem, Pennsylvania
Geisinger Medical Center, Danville, Pennsylvania
Penn State Children's Hospital, Hershey, Pennsylvania
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Saint Christopher's Hospital for Children, Philadelphia, Pennsylvania
Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania
Medical University of South Carolina, Charleston, South Carolina
Prisma Health Richland Hospital, Columbia, South Carolina
BI-LO Charities Children's Cancer Center, Greenville, South Carolina
Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota
T C Thompson Children's Hospital, Chattanooga, Tennessee
East Tennessee Childrens Hospital, Knoxville, Tennessee
The Children's Hospital at TriStar Centennial, Nashville, Tennessee
Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee
Dell Children's Medical Center of Central Texas, Austin, Texas
Driscoll Children's Hospital, Corpus Christi, Texas
Medical City Dallas Hospital, Dallas, Texas
UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas
El Paso Children's Hospital, El Paso, Texas
Cook Children's Medical Center, Fort Worth, Texas
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston, Texas
M D Anderson Cancer Center, Houston, Texas
Covenant Children's Hospital, Lubbock, Texas
UMC Cancer Center / UMC Health System, Lubbock, Texas
Children's Hospital of San Antonio, San Antonio, Texas
Methodist Children's Hospital of South Texas, San Antonio, Texas
University of Texas Health Science Center at San Antonio, San Antonio, Texas
Primary Children's Hospital, Salt Lake City, Utah
University of Vermont and State Agricultural College, Burlington, Vermont
University of Virginia Cancer Center, Charlottesville, Virginia
Inova Fairfax Hospital, Falls Church, Virginia
Children's Hospital of The King's Daughters, Norfolk, Virginia
Naval Medical Center - Portsmouth, Portsmouth, Virginia
VCU Massey Comprehensive Cancer Center, Richmond, Virginia
Carilion Children's, Roanoke, Virginia
Seattle Children's Hospital, Seattle, Washington
Providence Sacred Heart Medical Center and Children's Hospital, Spokane, Washington
Mary Bridge Children's Hospital and Health Center, Tacoma, Washington
Madigan Army Medical Center, Tacoma, Washington
West Virginia University Charleston Division, Charleston, West Virginia
West Virginia University Healthcare, Morgantown, West Virginia
Saint Vincent Hospital Cancer Center Green Bay, Green Bay, Wisconsin
University of Wisconsin Carbone Cancer Center - University Hospital, Madison, Wisconsin
Marshfield Medical Center-Marshfield, Marshfield, Wisconsin
Children's Hospital of Wisconsin, Milwaukee, Wisconsin
John Hunter Children's Hospital, Hunter Regional Mail Centre, New South Wales
The Children's Hospital at Westmead, Westmead, New South Wales
Queensland Children's Hospital, South Brisbane, Queensland
Women's and Children's Hospital-Adelaide, North Adelaide, South Australia
Monash Medical Center-Clayton Campus, Clayton, Victoria
Royal Children's Hospital, Parkville, Victoria
Princess Margaret Hospital for Children, Perth, Western Australia
Perth Children's Hospital, Perth, Western Australia
Alberta Children's Hospital, Calgary, Alberta
University of Alberta Hospital, Edmonton, Alberta
British Columbia Children's Hospital, Vancouver, British Columbia
CancerCare Manitoba, Winnipeg, Manitoba
Janeway Child Health Centre, Saint John's, Newfoundland and Labrador
IWK Health Centre, Halifax, Nova Scotia
McMaster Children's Hospital at Hamilton Health Sciences, Hamilton, Ontario
Kingston Health Sciences Centre, Kingston, Ontario
Children's Hospital, London, Ontario
Children's Hospital of Eastern Ontario, Ottawa, Ontario
Hospital for Sick Children, Toronto, Ontario
The Montreal Children's Hospital of the MUHC, Montreal, Quebec
Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec
Saskatoon Cancer Centre, Saskatoon, Saskatchewan
Starship Children's Hospital, Grafton, Auckland
Christchurch Hospital, Christchurch, Not set
Conditions: Adult T Acute Lymphoblastic Leukemia, Ann Arbor Stage II Adult Lymphoblastic Lymphoma, Ann Arbor Stage II Childhood Lymphoblastic Lymphoma, Ann Arbor Stage III Adult Lymphoblastic Lymphoma, Ann Arbor Stage III Childhood Lymphoblastic Lymphoma, Ann Arbor Stage IV Adult Lymphoblastic Lymphoma, Ann Arbor Stage IV Childhood Lymphoblastic Lymphoma, Childhood T Acute Lymphoblastic Leukemia
Nivolumab in Combination With Chemo-Immunotherapy for the Treatment of Newly Diagnosed Primary Mediastinal B-Cell Lymphoma
Active Not Recruiting
This phase III trial compares the effects of nivolumab with chemo-immunotherapy versus chemo-immunotherapy alone in treating patients with newly diagnosed primary mediastinal B-cell lymphoma (PMBCL). Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of cancer cells to grow and spread. Treatment for PMBCL involves chemotherapy combined with an immunotherapy called rituximab. Chemotherapy drugs work... Read More
This phase III trial compares the effects of nivolumab with chemo-immunotherapy versus chemo-immunotherapy alone in treating patients with newly diagnosed primary mediastinal B-cell lymphoma (PMBCL). Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of cancer cells to grow and spread. Treatment for PMBCL involves chemotherapy combined with an immunotherapy called rituximab. Chemotherapy drugs work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Rituximab is a monoclonal antibody. It binds to a protein called CD20, which is found on B cells (a type of white blood cell) and some types of cancer cells. This may help the immune system kill cancer cells. Giving nivolumab with chemo-immunotherapy may help treat patients with PMBCL. Read Less
Gender:
ALL
Ages:
2 years and above
Trial Updated:
07/25/2025
Locations: Children's Hospital of Alabama, Birmingham, Alabama +233 locations
Children's Hospital of Alabama, Birmingham, Alabama
USA Health Strada Patient Care Center, Mobile, Alabama
Providence Alaska Medical Center, Anchorage, Alaska
Banner Children's at Desert, Mesa, Arizona
Banner University Medical Center - Tucson, Tucson, Arizona
Arkansas Children's Hospital, Little Rock, Arkansas
UC Irvine Health Cancer Center-Newport, Costa Mesa, California
Kaiser Permanente Downey Medical Center, Downey, California
City of Hope Comprehensive Cancer Center, Duarte, California
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine, California
City of Hope at Irvine Lennar, Irvine, California
Loma Linda University Medical Center, Loma Linda, California
Miller Children's and Women's Hospital Long Beach, Long Beach, California
Children's Hospital Los Angeles, Los Angeles, California
Cedars Sinai Medical Center, Los Angeles, California
Mattel Children's Hospital UCLA, Los Angeles, California
Valley Children's Hospital, Madera, California
Kaiser Permanente-Oakland, Oakland, California
Children's Hospital of Orange County, Orange, California
UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange, California
Lucile Packard Children's Hospital Stanford University, Palo Alto, California
University of California Davis Comprehensive Cancer Center, Sacramento, California
Rady Children's Hospital - San Diego, San Diego, California
Children's Hospital Colorado, Aurora, Colorado
Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center, Denver, Colorado
Connecticut Children's Medical Center, Hartford, Connecticut
Alfred I duPont Hospital for Children, Wilmington, Delaware
MedStar Georgetown University Hospital, Washington, District of Columbia
Children's National Medical Center, Washington, District of Columbia
Broward Health Medical Center, Fort Lauderdale, Florida
Golisano Children's Hospital of Southwest Florida, Fort Myers, Florida
University of Florida Health Science Center - Gainesville, Gainesville, Florida
Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood, Florida
Nemours Children's Clinic-Jacksonville, Jacksonville, Florida
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida
Arnold Palmer Hospital for Children, Orlando, Florida
Nemours Children's Hospital, Orlando, Florida
Johns Hopkins All Children's Hospital, Saint Petersburg, Florida
Tampa General Hospital, Tampa, Florida
Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa, Florida
Emory Proton Therapy Center, Atlanta, Georgia
Emory University Hospital Midtown, Atlanta, Georgia
Emory University Hospital/Winship Cancer Institute, Atlanta, Georgia
Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta, Georgia
Emory Saint Joseph's Hospital, Atlanta, Georgia
Memorial Health University Medical Center, Savannah, Georgia
Kapiolani Medical Center for Women and Children, Honolulu, Hawaii
Saint Luke's Cancer Institute - Boise, Boise, Idaho
Rush-Copley Medical Center, Aurora, Illinois
Lurie Children's Hospital-Chicago, Chicago, Illinois
Northwestern University, Chicago, Illinois
University of Illinois, Chicago, Illinois
University of Chicago Comprehensive Cancer Center, Chicago, Illinois
Carle at The Riverfront, Danville, Illinois
Decatur Memorial Hospital, Decatur, Illinois
Northwestern Medicine Cancer Center Kishwaukee, DeKalb, Illinois
Carle Physician Group-Effingham, Effingham, Illinois
Northwestern Medicine Cancer Center Delnor, Geneva, Illinois
Northwestern Medicine Lake Forest Hospital, Lake Forest, Illinois
Carle Physician Group-Mattoon/Charleston, Mattoon, Illinois
Loyola University Medical Center, Maywood, Illinois
HSHS Saint Elizabeth's Hospital, O'Fallon, Illinois
Advocate Children's Hospital-Oak Lawn, Oak Lawn, Illinois
Advocate Children's Hospital-Park Ridge, Park Ridge, Illinois
Saint Jude Midwest Affiliate, Peoria, Illinois
Southern Illinois University School of Medicine, Springfield, Illinois
Springfield Clinic, Springfield, Illinois
Springfield Memorial Hospital, Springfield, Illinois
Carle Cancer Center, Urbana, Illinois
Northwestern Medicine Cancer Center Warrenville, Warrenville, Illinois
Riley Hospital for Children, Indianapolis, Indiana
Reid Health, Richmond, Indiana
UI Health Care Mission Cancer and Blood - Ankeny Clinic, Ankeny, Iowa
UI Health Care Mission Cancer and Blood - West Des Moines Clinic, Clive, Iowa
Blank Children's Hospital, Des Moines, Iowa
Mercy Medical Center - Des Moines, Des Moines, Iowa
UI Health Care Mission Cancer and Blood - Laurel Clinic, Des Moines, Iowa
University of Iowa/Holden Comprehensive Cancer Center, Iowa City, Iowa
Siouxland Regional Cancer Center, Sioux City, Iowa
UI Health Care Mission Cancer and Blood - Waukee Clinic, Waukee, Iowa
Wesley Medical Center, Wichita, Kansas
University of Kentucky/Markey Cancer Center, Lexington, Kentucky
Norton Children's Hospital, Louisville, Kentucky
Children's Hospital New Orleans, New Orleans, Louisiana
Ochsner Medical Center Jefferson, New Orleans, Louisiana
Eastern Maine Medical Center, Bangor, Maine
Maine Children's Cancer Program, Scarborough, Maine
University of Maryland/Greenebaum Cancer Center, Baltimore, Maryland
Greater Baltimore Medical Center, Baltimore, Maryland
Sinai Hospital of Baltimore, Baltimore, Maryland
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland
Walter Reed National Military Medical Center, Bethesda, Maryland
Tufts Medical Center, Boston, Massachusetts
Dana-Farber Cancer Institute, Boston, Massachusetts
C S Mott Children's Hospital, Ann Arbor, Michigan
Children's Hospital of Michigan, Detroit, Michigan
Henry Ford Hospital, Detroit, Michigan
Michigan State University, East Lansing, Michigan
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids, Michigan
Bronson Methodist Hospital, Kalamazoo, Michigan
Corewell Health Lakeland Hospitals - Niles Hospital, Niles, Michigan
Corewell Health Children's, Royal Oak, Michigan
Minnesota Oncology - Burnsville, Burnsville, Minnesota
Mercy Hospital, Coon Rapids, Minnesota
Fairview Southdale Hospital, Edina, Minnesota
Unity Hospital, Fridley, Minnesota
Minnesota Oncology Hematology PA-Maplewood, Maplewood, Minnesota
Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis, Minnesota
Abbott-Northwestern Hospital, Minneapolis, Minnesota
Park Nicollet Clinic - Saint Louis Park, Saint Louis Park, Minnesota
United Hospital, Saint Paul, Minnesota
University of Mississippi Medical Center, Jackson, Mississippi
Saint Luke's Hospital, Chesterfield, Missouri
Siteman Cancer Center at West County Hospital, Creve Coeur, Missouri
Children's Mercy Hospitals and Clinics, Kansas City, Missouri
Washington University School of Medicine, Saint Louis, Missouri
Siteman Cancer Center-South County, Saint Louis, Missouri
Siteman Cancer Center at Christian Hospital, Saint Louis, Missouri
Mercy Hospital Saint Louis, Saint Louis, Missouri
Siteman Cancer Center at Saint Peters Hospital, Saint Peters, Missouri
Children's Hospital and Medical Center of Omaha, Omaha, Nebraska
University of Nebraska Medical Center, Omaha, Nebraska
Alliance for Childhood Diseases/Cure 4 the Kids Foundation, Las Vegas, Nevada
Renown Regional Medical Center, Reno, Nevada
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon, New Hampshire
Memorial Sloan Kettering Basking Ridge, Basking Ridge, New Jersey
Hackensack University Medical Center, Hackensack, New Jersey
Memorial Sloan Kettering Monmouth, Middletown, New Jersey
Memorial Sloan Kettering Bergen, Montvale, New Jersey
Morristown Medical Center, Morristown, New Jersey
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick, New Jersey
Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey
Saint Joseph's Regional Medical Center, Paterson, New Jersey
Presbyterian Hospital, Albuquerque, New Mexico
Albany Medical Center, Albany, New York
Montefiore Medical Center - Moses Campus, Bronx, New York
Roswell Park Cancer Institute, Buffalo, New York
Memorial Sloan Kettering Commack, Commack, New York
Memorial Sloan Kettering Westchester, Harrison, New York
The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park, New York
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York, New York
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York, New York
Memorial Sloan Kettering Cancer Center, New York, New York
NYP/Weill Cornell Medical Center, New York, New York
University of Rochester, Rochester, New York
Stony Brook University Medical Center, Stony Brook, New York
State University of New York Upstate Medical University, Syracuse, New York
Memorial Sloan Kettering Nassau, Uniondale, New York
New York Medical College, Valhalla, New York
Wilmot Cancer Institute at Webster, Webster, New York
Mission Hospital, Asheville, North Carolina
AdventHealth Infusion Center Asheville, Asheville, North Carolina
Carolinas Medical Center/Levine Cancer Institute, Charlotte, North Carolina
Novant Health Presbyterian Medical Center, Charlotte, North Carolina
East Carolina University, Greenville, North Carolina
AdventHealth Hendersonville, Hendersonville, North Carolina
Wake Forest University Health Sciences, Winston-Salem, North Carolina
Sanford Broadway Medical Center, Fargo, North Dakota
Children's Hospital Medical Center of Akron, Akron, Ohio
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Rainbow Babies and Childrens Hospital, Cleveland, Ohio
Cleveland Clinic Foundation, Cleveland, Ohio
Nationwide Children's Hospital, Columbus, Ohio
Dayton Children's Hospital, Dayton, Ohio
Dayton Physician LLC - Englewood, Dayton, Ohio
Greater Dayton Cancer Center, Kettering, Ohio
Kettering Medical Center, Kettering, Ohio
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo, Ohio
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Legacy Emanuel Children's Hospital, Portland, Oregon
Oregon Health and Science University, Portland, Oregon
Lehigh Valley Hospital-Cedar Crest, Allentown, Pennsylvania
Geisinger Medical Center, Danville, Pennsylvania
Penn State Children's Hospital, Hershey, Pennsylvania
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Saint Christopher's Hospital for Children, Philadelphia, Pennsylvania
Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania
Rhode Island Hospital, Providence, Rhode Island
Prisma Health Richland Hospital, Columbia, South Carolina
Saint Francis Hospital, Greenville, South Carolina
BI-LO Charities Children's Cancer Center, Greenville, South Carolina
Saint Francis Cancer Center, Greenville, South Carolina
Prisma Health Cancer Institute - Eastside, Greenville, South Carolina
Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota
East Tennessee Childrens Hospital, Knoxville, Tennessee
Saint Jude Children's Research Hospital, Memphis, Tennessee
The Children's Hospital at TriStar Centennial, Nashville, Tennessee
Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee
Texas Tech University Health Sciences Center-Amarillo, Amarillo, Texas
Dell Children's Medical Center of Central Texas, Austin, Texas
Driscoll Children's Hospital, Corpus Christi, Texas
Medical City Dallas Hospital, Dallas, Texas
UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas
El Paso Children's Hospital, El Paso, Texas
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston, Texas
Houston Methodist Hospital, Houston, Texas
M D Anderson Cancer Center, Houston, Texas
Covenant Children's Hospital, Lubbock, Texas
UMC Cancer Center / UMC Health System, Lubbock, Texas
Children's Hospital of San Antonio, San Antonio, Texas
Methodist Children's Hospital of South Texas, San Antonio, Texas
University of Texas Health Science Center at San Antonio, San Antonio, Texas
Primary Children's Hospital, Salt Lake City, Utah
University of Virginia Cancer Center, Charlottesville, Virginia
Inova Fairfax Hospital, Falls Church, Virginia
Children's Hospital of The King's Daughters, Norfolk, Virginia
VCU Massey Comprehensive Cancer Center, Richmond, Virginia
Carilion Children's, Roanoke, Virginia
Valley Medical Center, Renton, Washington
Seattle Children's Hospital, Seattle, Washington
Providence Sacred Heart Medical Center and Children's Hospital, Spokane, Washington
Mary Bridge Children's Hospital and Health Center, Tacoma, Washington
Madigan Army Medical Center, Tacoma, Washington
West Virginia University Charleston Division, Charleston, West Virginia
University of Wisconsin Carbone Cancer Center - University Hospital, Madison, Wisconsin
Marshfield Medical Center-Marshfield, Marshfield, Wisconsin
John Hunter Children's Hospital, Hunter Regional Mail Centre, New South Wales
The Children's Hospital at Westmead, Westmead, New South Wales
Queensland Children's Hospital, South Brisbane, Queensland
Royal Children's Hospital, Parkville, Victoria
Perth Children's Hospital, Perth, Western Australia
University of Alberta Hospital, Edmonton, Alberta
CancerCare Manitoba, Winnipeg, Manitoba
Janeway Child Health Centre, Saint John's, Newfoundland and Labrador
IWK Health Centre, Halifax, Nova Scotia
McMaster Children's Hospital at Hamilton Health Sciences, Hamilton, Ontario
Children's Hospital, London, Ontario
Children's Hospital of Eastern Ontario, Ottawa, Ontario
Hospital for Sick Children, Toronto, Ontario
The Montreal Children's Hospital of the MUHC, Montreal, Quebec
Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont, Sherbrooke, Quebec
CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL), Quebec, Not set
HIMA San Pablo Oncologic Hospital, Caguas, Not set
Conditions: Primary Mediastinal Large B-Cell Lymphoma
Blinatumomab in Treating Younger Patients With Relapsed B-cell Acute Lymphoblastic Leukemia
Active Not Recruiting
This randomized phase III trial studies how well blinatumomab works compared with standard combination chemotherapy in treating patients with B-cell acute lymphoblastic leukemia that has returned after a period of improvement (relapsed). Immunotherapy with blinatumomab may allow the body's immune system to attack and destroy some types of leukemia cells. It is not yet known whether blinatumomab is more effective than standard combination chemotherapy in treating relapsed B-cell acute lymphoblast... Read More
This randomized phase III trial studies how well blinatumomab works compared with standard combination chemotherapy in treating patients with B-cell acute lymphoblastic leukemia that has returned after a period of improvement (relapsed). Immunotherapy with blinatumomab may allow the body's immune system to attack and destroy some types of leukemia cells. It is not yet known whether blinatumomab is more effective than standard combination chemotherapy in treating relapsed B-cell acute lymphoblastic leukemia. Read Less
Gender:
ALL
Ages:
Between 1 year and 31 years
Trial Updated:
07/25/2025
Locations: Children's Hospital of Alabama, Birmingham, Alabama +185 locations
Children's Hospital of Alabama, Birmingham, Alabama
USA Health Strada Patient Care Center, Mobile, Alabama
Providence Alaska Medical Center, Anchorage, Alaska
Banner Children's at Desert, Mesa, Arizona
Phoenix Childrens Hospital, Phoenix, Arizona
Banner University Medical Center - Tucson, Tucson, Arizona
Arkansas Children's Hospital, Little Rock, Arkansas
Kaiser Permanente Downey Medical Center, Downey, California
City of Hope Comprehensive Cancer Center, Duarte, California
Loma Linda University Medical Center, Loma Linda, California
Miller Children's and Women's Hospital Long Beach, Long Beach, California
Children's Hospital Los Angeles, Los Angeles, California
Cedars Sinai Medical Center, Los Angeles, California
Mattel Children's Hospital UCLA, Los Angeles, California
Valley Children's Hospital, Madera, California
UCSF Benioff Children's Hospital Oakland, Oakland, California
Kaiser Permanente-Oakland, Oakland, California
Children's Hospital of Orange County, Orange, California
Lucile Packard Children's Hospital Stanford University, Palo Alto, California
Sutter Medical Center Sacramento, Sacramento, California
University of California Davis Comprehensive Cancer Center, Sacramento, California
Rady Children's Hospital - San Diego, San Diego, California
UCSF Medical Center-Mission Bay, San Francisco, California
Santa Barbara Cottage Hospital, Santa Barbara, California
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California
Children's Hospital Colorado, Aurora, Colorado
Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center, Denver, Colorado
Connecticut Children's Medical Center, Hartford, Connecticut
Yale University, New Haven, Connecticut
Alfred I duPont Hospital for Children, Wilmington, Delaware
Children's National Medical Center, Washington, District of Columbia
Broward Health Medical Center, Fort Lauderdale, Florida
Golisano Children's Hospital of Southwest Florida, Fort Myers, Florida
University of Florida Health Science Center - Gainesville, Gainesville, Florida
Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood, Florida
Nemours Children's Clinic-Jacksonville, Jacksonville, Florida
Palms West Radiation Therapy, Loxahatchee Groves, Florida
University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida
AdventHealth Orlando, Orlando, Florida
Arnold Palmer Hospital for Children, Orlando, Florida
Nemours Children's Clinic - Pensacola, Pensacola, Florida
Johns Hopkins All Children's Hospital, Saint Petersburg, Florida
Tampa General Hospital, Tampa, Florida
Saint Joseph's Hospital/Children's Hospital-Tampa, Tampa, Florida
Saint Mary's Medical Center, West Palm Beach, Florida
Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta, Georgia
Memorial Health University Medical Center, Savannah, Georgia
Kapiolani Medical Center for Women and Children, Honolulu, Hawaii
Saint Luke's Cancer Institute - Boise, Boise, Idaho
Lurie Children's Hospital-Chicago, Chicago, Illinois
University of Illinois, Chicago, Illinois
University of Chicago Comprehensive Cancer Center, Chicago, Illinois
Loyola University Medical Center, Maywood, Illinois
Advocate Children's Hospital-Oak Lawn, Oak Lawn, Illinois
Advocate Children's Hospital-Park Ridge, Park Ridge, Illinois
Saint Jude Midwest Affiliate, Peoria, Illinois
Southern Illinois University School of Medicine, Springfield, Illinois
Riley Hospital for Children, Indianapolis, Indiana
Ascension Saint Vincent Indianapolis Hospital, Indianapolis, Indiana
University of Kentucky/Markey Cancer Center, Lexington, Kentucky
Norton Children's Hospital, Louisville, Kentucky
Ochsner Medical Center Jefferson, New Orleans, Louisiana
Eastern Maine Medical Center, Bangor, Maine
Maine Children's Cancer Program, Scarborough, Maine
University of Maryland/Greenebaum Cancer Center, Baltimore, Maryland
Sinai Hospital of Baltimore, Baltimore, Maryland
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland
Walter Reed National Military Medical Center, Bethesda, Maryland
Tufts Children's Hospital, Boston, Massachusetts
Baystate Medical Center, Springfield, Massachusetts
UMass Memorial Medical Center - University Campus, Worcester, Massachusetts
C S Mott Children's Hospital, Ann Arbor, Michigan
Wayne State University/Karmanos Cancer Institute, Detroit, Michigan
Henry Ford Health Saint John Hospital, Detroit, Michigan
Michigan State University, East Lansing, Michigan
Hurley Medical Center, Flint, Michigan
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids, Michigan
Corewell Health Children's, Royal Oak, Michigan
Children's Hospitals and Clinics of Minnesota - Minneapolis, Minneapolis, Minnesota
University of Minnesota/Masonic Cancer Center, Minneapolis, Minnesota
Mayo Clinic in Rochester, Rochester, Minnesota
University of Mississippi Medical Center, Jackson, Mississippi
Children's Mercy Hospitals and Clinics, Kansas City, Missouri
Washington University School of Medicine, Saint Louis, Missouri
Mercy Hospital Saint Louis, Saint Louis, Missouri
Children's Hospital and Medical Center of Omaha, Omaha, Nebraska
University of Nebraska Medical Center, Omaha, Nebraska
Sunrise Hospital and Medical Center, Las Vegas, Nevada
Alliance for Childhood Diseases/Cure 4 the Kids Foundation, Las Vegas, Nevada
Summerlin Hospital Medical Center, Las Vegas, Nevada
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon, New Hampshire
Hackensack University Medical Center, Hackensack, New Jersey
Morristown Medical Center, Morristown, New Jersey
Saint Peter's University Hospital, New Brunswick, New Jersey
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick, New Jersey
Newark Beth Israel Medical Center, Newark, New Jersey
Saint Joseph's Regional Medical Center, Paterson, New Jersey
Albany Medical Center, Albany, New York
Montefiore Medical Center - Moses Campus, Bronx, New York
Roswell Park Cancer Institute, Buffalo, New York
NYU Langone Hospital - Long Island, Mineola, New York
The Steven and Alexandra Cohen Children's Medical Center of New York, New Hyde Park, New York
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York, New York
Mount Sinai Hospital, New York, New York
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York, New York
NYP/Weill Cornell Medical Center, New York, New York
University of Rochester, Rochester, New York
Stony Brook University Medical Center, Stony Brook, New York
State University of New York Upstate Medical University, Syracuse, New York
New York Medical College, Valhalla, New York
Mission Hospital, Asheville, North Carolina
UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina
Carolinas Medical Center/Levine Cancer Institute, Charlotte, North Carolina
Novant Health Presbyterian Medical Center, Charlotte, North Carolina
Duke University Medical Center, Durham, North Carolina
East Carolina University, Greenville, North Carolina
Wake Forest University Health Sciences, Winston-Salem, North Carolina
Children's Hospital Medical Center of Akron, Akron, Ohio
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Rainbow Babies and Childrens Hospital, Cleveland, Ohio
Cleveland Clinic Foundation, Cleveland, Ohio
Nationwide Children's Hospital, Columbus, Ohio
Dayton Children's Hospital, Dayton, Ohio
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo, Ohio
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Legacy Emanuel Children's Hospital, Portland, Oregon
Oregon Health and Science University, Portland, Oregon
Lehigh Valley Hospital-Cedar Crest, Allentown, Pennsylvania
Lehigh Valley Hospital - Muhlenberg, Bethlehem, Pennsylvania
Geisinger Medical Center, Danville, Pennsylvania
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Saint Christopher's Hospital for Children, Philadelphia, Pennsylvania
Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania
Rhode Island Hospital, Providence, Rhode Island
Medical University of South Carolina, Charleston, South Carolina
BI-LO Charities Children's Cancer Center, Greenville, South Carolina
Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota
T C Thompson Children's Hospital, Chattanooga, Tennessee
East Tennessee Childrens Hospital, Knoxville, Tennessee
The Children's Hospital at TriStar Centennial, Nashville, Tennessee
Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee
Dell Children's Medical Center of Central Texas, Austin, Texas
Driscoll Children's Hospital, Corpus Christi, Texas
Medical City Dallas Hospital, Dallas, Texas
UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas
El Paso Children's Hospital, El Paso, Texas
Cook Children's Medical Center, Fort Worth, Texas
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston, Texas
Covenant Children's Hospital, Lubbock, Texas
Children's Hospital of San Antonio, San Antonio, Texas
Methodist Children's Hospital of South Texas, San Antonio, Texas
Scott and White Memorial Hospital, Temple, Texas
Primary Children's Hospital, Salt Lake City, Utah
University of Virginia Cancer Center, Charlottesville, Virginia
Inova Fairfax Hospital, Falls Church, Virginia
Children's Hospital of The King's Daughters, Norfolk, Virginia
VCU Massey Comprehensive Cancer Center, Richmond, Virginia
Carilion Children's, Roanoke, Virginia
Seattle Children's Hospital, Seattle, Washington
Providence Sacred Heart Medical Center and Children's Hospital, Spokane, Washington
Madigan Army Medical Center, Tacoma, Washington
West Virginia University Charleston Division, Charleston, West Virginia
West Virginia University Healthcare, Morgantown, West Virginia
Saint Vincent Hospital Cancer Center Green Bay, Green Bay, Wisconsin
Marshfield Medical Center-Marshfield, Marshfield, Wisconsin
Children's Hospital of Wisconsin, Milwaukee, Wisconsin
Princess Margaret Hospital for Children, Perth, Western Australia
Perth Children's Hospital, Perth, Western Australia
British Columbia Children's Hospital, Vancouver, British Columbia
CancerCare Manitoba, Winnipeg, Manitoba
Janeway Child Health Centre, Saint John's, Newfoundland and Labrador
IWK Health Centre, Halifax, Nova Scotia
McMaster Children's Hospital at Hamilton Health Sciences, Hamilton, Ontario
Kingston Health Sciences Centre, Kingston, Ontario
Children's Hospital, London, Ontario
Children's Hospital of Eastern Ontario, Ottawa, Ontario
Hospital for Sick Children, Toronto, Ontario
The Montreal Children's Hospital of the MUHC, Montreal, Quebec
Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec
Saskatoon Cancer Centre, Saskatoon, Saskatchewan
CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL), Quebec, Not set
Starship Children's Hospital, Grafton, Auckland
Christchurch Hospital, Christchurch, Not set
HIMA San Pablo Oncologic Hospital, Caguas, Not set
San Jorge Children's Hospital, San Juan, Not set
University Pediatric Hospital, San Juan, Not set
Conditions: Recurrent B Acute Lymphoblastic Leukemia
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