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Dexamethasone Treatment Options in Canada
A collection of 294 research studies where Dexamethasone is the interventional treatment. These studies are located in the Canada . Dexamethasone is used for conditions such as Multiple Myeloma, Postoperative Pain and Lymphoma.
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Clinical Trial Phase
Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia
Completed
This randomized phase III trial is studying different combination chemotherapy regimens and comparing how well they work in treating patients with newly diagnosed acute lymphoblastic leukemia. Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more cancer cells.
Gender:
ALL
Ages:
Between 1 year and 9 years
Trial Updated:
06/11/2021
Locations: Children's Hospital of Alabama, Birmingham, Alabama +235 locations
Conditions: Acute Lymphoblastic Leukemia, Childhood B Acute Lymphoblastic Leukemia
Dexamethasone Compared With Prednisone During Induction Therapy and Methotrexate With or Without Leucovorin During Maintenance Therapy in Treating Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia
Completed
This randomized phase III trial is studying dexamethasone to see how well it works compared to prednisone during induction therapy. This trial is also studying methotrexate and leucovorin calcium to see how well they work compared to methotrexate alone during maintenance therapy in treating patients with newly diagnosed acute lymphoblastic leukemia (ALL). Drugs used in chemotherapy, such as dexamethasone, prednisone, methotrexate, and leucovorin calcium, work in different ways to stop cancer cel... Read More
Gender:
ALL
Ages:
Between 1 year and 30 years
Trial Updated:
04/02/2021
Locations: Children's Hospital of Alabama, Birmingham, Alabama +233 locations
Conditions: Acute Lymphoblastic Leukemia, Adult B Acute Lymphoblastic Leukemia, Childhood B Acute Lymphoblastic Leukemia
Pegaspargase and Combination Chemotherapy in Treating Younger Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia (Closed to Accrual 4-22-2011)
Completed
This pilot clinical trial studies the side effects of pegaspargase when given together with combination chemotherapy in treating patients with newly diagnosed high-risk acute lymphoblastic leukemia. Pegaspargase may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving more t... Read More
Gender:
ALL
Ages:
Between 1 year and 30 years
Trial Updated:
04/02/2021
Locations: Phoenix Childrens Hospital, Phoenix, Arizona +27 locations
Conditions: Acute Lymphoblastic Leukemia, Adult B Acute Lymphoblastic Leukemia, Childhood B Acute Lymphoblastic Leukemia
Study Comparing Rovalpituzumab Tesirine Versus Topotecan in Subjects With Advanced or Metastatic Small Cell Lung Cancer With High Levels of Delta-like Protein 3 (DLL3) and Who Have First Disease Progression During or Following Front-line Platinum-based Chemotherapy (TAHOE)
Completed
The purpose of this randomized, open-label, 2-arm, phase 3 study is to assess the efficacy, safety and tolerability of rovalpituzumab tesirine versus topotecan in participants with advanced or metastatic SCLC with high levels of DLL3, who have first disease progression during or following front-line platinum-based chemotherapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/19/2021
Locations: Clearview Cancer Institute /ID# 155873, Huntsville, Alabama +194 locations
Conditions: Small Cell Lung Cancer
Perioperative Tonsillectomy Protocol Development
Unknown
Pediatric patients who are undergoing a tonsillectomy at the Children's hospital will be randomly assigned to one of three drug groups: 1) acetaminophen (Tylenol) administered pre-operatively and a low dose of anti-inflammatory drug (dexamethasone) administered intra-operatively; 2) acetaminophen (Tylenol) administered pre-operatively and a high dose of anti-inflammatory drug (dexamethasone) administered intra-operatively; 3) no acetaminophen (Tylenol) administered pre-operatively, low dose anti... Read More
Gender:
ALL
Ages:
Between 3 years and 13 years
Trial Updated:
02/16/2021
Locations: Children's Hospital, London, Ontario
Conditions: Tonsillitis
Hybrid Immunotherapy for Hemophagocytic LymphoHistiocytosis
Completed
Despite good progress during the last decade, hemophagocytic lymphohistiocytosis (HLH) remains difficult to treat. Two different treatment regimens have been used successfully. The first one, a treatment regimen based on two drugs called etoposide and dexamethasone, has been used worldwide. The second regimen, based on two drugs called Anti-thymocyte globulin (ATG) and prednisone, has been used mostly at one hospital in Paris, for over 15 years. With either regimen, about three quarters of treat... Read More
Gender:
ALL
Ages:
18 years and below
Trial Updated:
09/21/2020
Locations: Phoenix Children's Hospital, Phoenix, Arizona +14 locations
Conditions: Hemophagocytic Lymphohistiocytosis
Testing JNJ-42756493 In Combination With Dexamethasone in Multiple Myeloma That Came Back After a Period of Improvement
Terminated
This is a phase 2 study to see how effective investigational drug, JNJ-42756493, is when given in combination with dexamethasone in two groups of patients with multiple myeloma (cancer of the plasma cells, a type of white blood cell present in bone marrow) that has relapsed (has come back after a period of improvement) or refractory (did not respond to standard treatment).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/15/2020
Locations: Princess Margaret Cancer Centre, Toronto, Ontario
Conditions: Multiple Myeloma, Relapsed/Refractory
Dexamethasone Versus Prednisone for Asthma Treatment in the Pediatric Inpatient Population; a Feasibility Study
Terminated
Current corticosteroid regimens for children hospitalized with asthma typically include a 5-day course of prednisone or prednisolone. However, these medications taste poorly and are associated with vomiting and poor compliance. Outpatient evidence suggests that a 2-day course of dexamethasone is as effective as a longer course of prednisone and prednisolone, and better tolerated. Studies in hospitalized patients are lacking.
The investigators' primary objective is to determine the feasibility o... Read More
Gender:
ALL
Ages:
Between 18 months and 17 years
Trial Updated:
09/03/2020
Locations: Children's Hospital of Eastern Ontario, Ottawa, Ontario
Conditions: Asthma
Safety and Efficacy of Blinatumomab in Adults With Newly Diagnosed High-risk Diffuse Large B-Cell Lymphoma
Completed
A phase 2, multicenter, open-label, single arm clinical trial in adults with newly diagnosed aggressive high-risk DLBCL.
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
08/26/2020
Locations: Research Site, Chicago, Illinois +23 locations
Conditions: High-risk Diffuse Large B-Cell Lymphoma
The Effects of Dexamethasone on Low Dose Interscalene Brachial Plexus Block
Completed
A standard interscalene nerve block is performed with long acting local anesthetic (bupivacaine or ropivacaine in concentrations varying from 0.25% to 0.75%). The purpose of this study is to investigate the effect of the addition of perineural dexamethasone (4mg) to a standard ropivacaine solution (0.5%) on analgesic duration of low dose interscalene block compared to ropivacaine alone for interscalene block with systemic dexamethasone.
Ropivacaine is not an intervention as a local anesthetic i... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
07/06/2020
Locations: Sunnybrook Health Sciences Centre, Toronto, Ontario
Conditions: Shoulder Surgery, Nerve Block
Mgt of Chronic Subdural Hematoma Using Dexamethasone
Unknown
Chronic subdural hematoma (cSDH) is a collection of blood and its breakdown products in the subdural compartment. It is a condition frequently seen in any neurosurgical practice. cSDH is believed to arise from tearing of bridging veins as a result of trauma, which may be minor and unapparent to the patient. Management of cSDH is widely varied. A "wait-and-see" or "wait-and-rescan" approach may be acceptable in asymptomatic patients with a relatively small hematoma whilst cSDH with severe neurolo... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/29/2020
Locations: University of Calgary, Calgary, Alberta
Conditions: Chronic Subdural Hematoma
Schedules of Dexamethasone in Patients Incorrectly Taking Dexamethasone Premedication (REaCT-dexamethasone)
Completed
Docetaxel chemotherapy is commonly used in patients with breast cancer. With the widespread use of steroid premedication, the incidence of fluid retention and skin toxicity side effects has been minimal. Premedication with dexamethasone (8mg twice daily) is recommended starting the day before chemotherapy and continuing for three days. Patients may forget to take all or part of their premedication prior to docetaxel administration, and additional doses of steroids are frequently give in place of... Read More
Gender:
ALL
Ages:
19 years and above
Trial Updated:
04/26/2020
Locations: The Ottawa Hospital Cancer Centre, Ottawa, Ontario
Conditions: Cancer
169 - 180 of 294