There are currently 26 active clinical trials seeking participants for Generalized Anxiety Disorder research studies. The states with the highest number of trials for Generalized Anxiety Disorder participants are California, Florida, New York and Texas.
Respiratory Training in the Treatment of Transdiagnostic Pathological Anxiety
NCT05427708
Recruiting
Purpose of the Research: The primary aim of the proposed study is to conduct a randomized parallel-group 2-arm clinical trial investigating capnometry-guided respiratory intervention (CGRI) for pathological anxiety. CGRI aims to raise end-tidal CO2 levels thereby lowering hyperventilation-induced respiratory alkalosis and its associated fear-eliciting somatic reactions. Psycho-education about anxiety and its effects (PsyEd) will serve as a credible control comparator.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/18/2025
Locations: University of Texas at Austin, Austin, Texas
Conditions: Anxiety Disorders, Trauma, Generalized Anxiety Disorder, Panic Disorder, Agoraphobia, Illness Anxiety Disorder, Social Anxiety Disorder, Posttraumatic Stress Disorder, Acute Stress Disorder, Adjustment Disorder With Anxious Mood
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A Phase 3 Trial of MM120 for Generalized Anxiety Disorder (Voyage)
NCT06741228
Recruiting
A Phase 3 Double-blind, Placebo-controlled Study (Part A) with an Open-label Extension (Part B) Evaluating MM120 Compared to Placebo in Generalized Anxiety Disorder - Voyage
Gender:
ALL
Ages:
Between 18 years and 74 years
Trial Updated:
08/15/2025
Locations: Lighthouse Psychiatry, Gilbert, Arizona +31 locations
Conditions: Generalized Anxiety Disorder
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A Phase 3 Trial of MM120 for Generalized Anxiety Disorder (Panorama)
NCT06809595
Recruiting
A Phase 3, Double-blind, Placebo-controlled Study (Part A) with an Open-label Extension (Part B) Evaluating MM120 Compared to Placebo in Generalized Anxiety Disorder - Panorama
Gender:
ALL
Ages:
Between 18 years and 74 years
Trial Updated:
08/15/2025
Locations: Preferred Research Partners, Inc., Little Rock, Arkansas +15 locations
Conditions: Generalized Anxiety Disorder
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Adaptation and Feasibility of the Community-Based Anxiety Program Tailored for Autism (CAPTA)
NCT06046170
Recruiting
Anxiety is very common in autistic youth. Recently, an intervention has been created by the investigators to target these symptoms in autistic youth in a community setting. The purpose of this study is to determine the feasibility of implementing this treatment in community care centers.
Gender:
ALL
Ages:
Between 7 years and 17 years
Trial Updated:
07/18/2025
Locations: Johns Hopkins University, Baltimore, Maryland +2 locations
Conditions: Anxiety, Autism Spectrum Disorder, Separation Anxiety, Generalized Anxiety Disorder, Social Anxiety Disorder of Childhood
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Internet-delivered Cognitive-Behavioral Therapy for Adolescents With Autism and Anxiety
NCT06537128
Recruiting
Anxiety is very common in autistic youth. Cognitive behavioral therapy (CBT) is the recommended treatment for both autistic and typically-developing (TD) youth with anxiety, yet most families cannot access CBT due to cost, practicalities of attending in-person treatment sessions, and a shortage of trained providers, especially in rural areas. The goal of this project is to increase access to care for families of autistic adolescents with anxiety through an internet-based treatment model.
Gender:
ALL
Ages:
Between 11 years and 17 years
Trial Updated:
07/18/2025
Locations: Baylor College of Medicine, Houston, Texas
Conditions: Autism Spectrum Disorder, Autism, Anxiety, Anxiety Disorders, Generalized Anxiety Disorder, Social Anxiety Disorder
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CO2 Reactivity as a Biomarker of Non-Response to Exposure-Based Therapy
NCT05467683
Recruiting
Anxiety-, obsessive-compulsive and trauma- and stressor-related disorders reflect a significant public health problem. This study is designed to evaluate the predictive power of a novel biomarker based on a CO2 challenge, thus addressing the central question "can this easy-to-administer assay aid clinicians in deciding whether or not to initiate exposure-based therapy?"
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
06/18/2025
Locations: Boston University, Boston, Massachusetts +1 locations
Conditions: Obsessive-Compulsive Disorder, Post Traumatic Stress Disorder, Generalized Anxiety Disorder, Social Anxiety Disorder, Panic Disorder
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Mindful Self-compassion for Anxiety and Depression: Impact of Delivery Method
NCT07028216
Recruiting
The study will compare the delivery of an 8-week Mindful Self-Compassion training, in-person against video-conference, on anxiety and depression symptom severity in patients with diagnosed anxiety disorders (generalized anxiety disorder, social anxiety disorder, and panic disorder) or major depressive disorder or dysthymia.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
06/11/2025
Locations: Georgetown University Medical Center, Washington, District of Columbia
Conditions: Anxiety Disorders, Generalized Anxiety Disorder, Social Anxiety Disorder, Panic Disorder, Agoraphobia, Major Depressive Disorder, Persistent Depressive Disorder (Dysthymia)
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Mindful Self-Compassion for Anxiety Disorders and Depression
NCT05671419
Recruiting
The study will compare 8-week Mindful Self-Compassion training, compared to a control group that does not receive the intervention, on anxiety and depression symptom severity in patients with diagnosed anxiety disorders (generalized anxiety disorder, social anxiety disorder, and panic disorder) or major depressive disorder.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
06/10/2025
Locations: Georgetown University Medical Center, Washington, District of Columbia
Conditions: Anxiety Disorders, Generalized Anxiety Disorder, Social Anxiety Disorder, Social Phobia, Panic Disorder, Agoraphobia, Major Depressive Disorder
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Neurofeedback Enhanced Cognitive Reappraisal Training - Phase 4
NCT06563310
Recruiting
This study seeks to understand emotion regulation in those with young adults with anxiety using real-time functional magnetic resonance imaging neurofeedback, a tool that allows individuals to control brain activity. The goal of this project is to understand how receiving feedback about one's own brain activity relates to emotion regulation ability. This work will help the study team understand the brain areas involved in emotion regulation and could lay the groundwork to test if psychotherapy o... Read More
Gender:
ALL
Ages:
Between 18 years and 24 years
Trial Updated:
06/05/2025
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: Anxiety, Social Anxiety Disorder, Panic Disorder, Generalized Anxiety Disorder
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Neurofeedback Enhanced Cognitive Reappraisal Training
NCT06132659
Recruiting
This study seeks to understand emotion regulation in those with anxiety using real-time functional magnetic resonance imaging neurofeedback, a tool that allows individuals to control brain activity. The goal of this project is to understand how receiving feedback about one's own brain activity relates to emotion regulation ability. This work will help the study team understand the brain areas involved in emotion regulation and could lay the groundwork to test if psychotherapy outcomes can be enh... Read More
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
05/27/2025
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: Anxiety, Social Anxiety Disorder, Panic Disorder, Generalized Anxiety Disorder
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A Clinical Study That Will Measure How Well SEP-363856 Works and How Safe it is in Adults With Generalized Anxiety Disorder
NCT05729373
Recruiting
A clinical study that will meaure how well SEP-363856 works and how safe it is in adults with Generalized Anixety Disorder. This study will be accepting both male and female subjects between the ages of 18 years and 65 years old. The study will be held in Approximately 50 global study centers and approximately 15 additional centers for a separate Japan population. Participation in the study can be up to approximately 12 weeks.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
04/09/2025
Locations: University of Alabama at Birmingham, Huntsville, Alabama +83 locations
Conditions: Generalized Anxiety Disorder
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Treating Young Adult Generalized Anxiety Disorder with Text-Message Delivered Cognitive Behavioral Therapy
NCT06774573
Recruiting
The purpose of the proposed study is to test the feasibility and efficacy of a "anxiety-focused" text-delivered counseling program to reduce anxiety symptoms among young adults (18-25) with elevated anxiety symptoms. We are primarily interested in whether the intervention will reduce anxiety. We have adapted an effective in-person, manualized cognitive behavioral therapy treatment for anxiety (Muñoz et al, 2000) into an 8-week, text-delivered anxiety treatment, named CBT-txt-Anxiety. We will tes... Read More
Gender:
ALL
Ages:
Between 18 years and 25 years
Trial Updated:
03/24/2025
Locations: University of Tennessee-Knoxville, Knoxville, Tennessee
Conditions: Generalized Anxiety Disorder
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