There are currently 35 active clinical trials seeking participants for Metabolic Syndrome research studies. The states with the highest number of trials for Metabolic Syndrome participants are California, Ontario, Quebec and Massachusetts.
Effects of Ketone Ester Consumption on Exercise Tolerance and Cardiac Function
NCT06078683
Recruiting
This study is being done to evaluate how a ketone ester (KE) beverage affects heart function and health in people with heart failure compared to a placebo beverage (a beverage made with standard food ingredients that do not contain ketone esters).
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
05/30/2024
Locations: The Ross Heart Hospital, Columbus, Ohio
Conditions: Heart Failure With Preserved Ejection Fraction, Type 2 Diabetes, Metabolic Syndrome
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Nutrition Outreach and Understanding: Research In Serving Hearts Through Healthy Eating And Tailored Support
NCT06460272
Recruiting
This study is a human-centered, three-arm, parallel-group, randomized control, implementation trial (n=75) to compare MTM (Medically Tailored Meals) only (14 meals delivered weekly for 10 weeks) vs. MTM + SMA (Shared Medical Appointments; once weekly sessions for 10 weeks) vs. a wait-list control group (MTM-Later) in patients with hypertension, type 2 diabetes, obesity, and/or metabolic syndrome. All intervention components will be culturally congruent (e.g., MTMs will include food that converge... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/19/2024
Locations: Cleveland Clinic, Cleveland, Ohio
Conditions: Hypertension, Type2diabetes, Metabolic Syndrome, Obesity
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Impact of 60 Days Powdered Tart Cherry Supplementation on Metabolic Syndrome
NCT05614947
Recruiting
Metabolic syndrome (MetSyn) is a growing health concern, with up to 25% of the worlds population having the syndrome. MetSyn is a primary risk factor for cardiovascular disease and type II diabetes development, and is independently associated with all-cause mortality, making it an important disease target. The primary treatment for MetSyn is exercise and weight loss, along with medically necessary treatment. Exercise, along with dietary changes such as increased fiber and polyphenol intake can p... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
05/29/2024
Locations: Ohio University Exercise Physiology Lab, Athens, Ohio
Conditions: Metabolic Syndrome
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Understanding Components of Mind-body Exercise for Physical Activity Engagement in Metabolic Syndrome
NCT05242640
Recruiting
The aim of this study is to assess the feasibility and acceptability (e.g., enrollment, adherence, retention, acceptability of procedures and interventions) of a pilot factorial study design that will help elucidate components of mind-body exercise interventions. The study involves completing a walking program, a mindful attention program, a walking program that includes mindful attention, or no program at all. A "pilot" study is a smaller study that helps researchers to understand whether the s... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
05/20/2025
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Metabolic Syndrome
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Ketone Ester Effects on Biomarkers of Brain Metabolism and Cognitive Performance in Cognitively Intact Adults 55 Years Old or Older
NCT04421014
Recruiting
Background: In Alzheimer s disease (AD) the brain cannot use glucose as a fuel. The brain can use ketones as a fuel instead of glucose. Researchers want to test a supplement, Ketone Ester (KE). It may improve brain metabolic function and cognition in normal people and, perhaps, down the road, in patients with AD. Objective: To study the change in brain ketone levels in people after 28 days of taking KE compared with baseline and placebo. Also, to study changes in cognitive performance. Eligi... Read More
Gender:
ALL
Ages:
55 years and above
Trial Updated:
05/16/2025
Locations: National Institute of Aging, Clinical Research Unit, Baltimore, Maryland
Conditions: Metabolic Syndrome, Normal Cognition
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Vericiguat in Patients With Metabolic Syndrome and Coronary Vascular Dysfunction
NCT05711719
Recruiting
Coronary vascular dysfunction is one of the "final common pathways" for the impact of multiple cardiovascular risk factors. The investigators will conduct a randomized, double-blind placebo-controlled study in individuals with the metabolic syndrome and baseline coronary vascular dysfunction to evaluate the impact of vericiguat, a stimulator of soluble guanylyl cyclase, on coronary vascular function using non-invasive cardiac magnetic resonance imaging.
Gender:
ALL
Ages:
Between 35 years and 85 years
Trial Updated:
05/13/2025
Locations: Johns Hopkins Hospital, Baltimore, Maryland
Conditions: Metabolic Syndrome, Coronary Microvascular Dysfunction
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A Randomized Comparison of Stage-Based Care Versus Risk Factor-Based Care for Prevention of Cardiovascular Events
NCT06112418
Recruiting
TRANSFORM is a prospective, randomized, open blinded endpoint (PROBE), event-driven, pragmatic trial in patients who are at increased risk for atherosclerotic cardiovascular (CV) disease but with no known symptomatic CV disease. The trial tests the hypothesis that a Cleerly Coronary Artery Disease (CAD) Staging System-based care strategy reduces CV events compared with risk factor-based care.
Gender:
ALL
Ages:
55 years and above
Trial Updated:
05/12/2025
Locations: Chandler Clinical Trials, Chandler, Arizona +81 locations
Conditions: Diabetes Mellitus, Type 2, PreDiabetes, Metabolic Syndrome
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Study of the Effect of Innate on the Inflammatory Response to Endotoxin
NCT01143480
Recruiting
Background: - Innate immunity is the process by which white blood cells and other parts of the immune system sense and respond to potential infections by causing an inflammation. Researchers are interested in studying how the body responds to certain environmental factors, and whether the body s response can contribute to chronic illnesses or diseases such as asthma and certain types of cancers. Objectives: - To examine how specific genes and proteins in blood cells respond to environmental e... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
05/02/2025
Locations: NIEHS Clinical Research Unit (CRU), Research Triangle Park, North Carolina
Conditions: Asthma, Atherosclerosis, Metabolic Syndrome, Insulin Resistance, Cancer
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Effects of Exercise and GLP-1 Agonism on Muscle Microvascular Perfusion and Insulin Action in Adults With Metabolic Syndrome
NCT04575844
Recruiting
The primary objective of this study is to examine whether exercise training alone, liraglutide treatment alone or exercise training plus liraglutide treatment increases cardiac and skeletal muscle microvascular blood volume, improves vascular function of the conduit vessels, and enhances insulin's metabolic action in humans with Metabolic Syndrome. Subjects will be randomized to one of the 4 groups: control, exercise training, liraglutide treatment, and exercise + liraglutide. They will be studi... Read More
Gender:
ALL
Ages:
Between 21 years and 60 years
Trial Updated:
04/24/2025
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Metabolic Syndrome
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Animal and Plant Proteins and Glucose Metabolism
NCT03994367
Recruiting
The goal of this proposal is to determine the effect of a high protein diet in which the increase in protein intake is derived from different sources (animal vs plant and protein-rich whole foods vs protein isolates) on: i) liver and muscle insulin sensitivity; ii) the metabolic response to a meal, and iii) 24-h plasma concentration profiles of glucose, glucoregulatory hormones, and protein-derived metabolites purported to cause metabolic dysfunction.
Gender:
ALL
Ages:
Between 21 years and 70 years
Trial Updated:
03/14/2025
Locations: University of Missouri School of Medicine, Columbia, Missouri
Conditions: Metabolic Syndrome, Metabolic Syndrome, Protection Against, Glucose Metabolism Disorders
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Stand Up for Your Health with a Sit-stand Desk
NCT05585190
Recruiting
More than 84 million - or 1 out of every 3 U.S. adults - have prediabetes, a condition that if not treated often leads to type 2 diabetes within five years. Average medical expenditures among diabetics are about 2.3 times higher than expenditures for people without diabetes. Physical inactivity and elevated body mass index (BMI) are major risk factors for the disease. Sedentary behavior is becoming increasingly prevalent with the growth of a 'work from home' culture, most recently driven by the... Read More
Gender:
ALL
Ages:
Between 18 years and 79 years
Trial Updated:
03/11/2025
Locations: Medical College of Wisconsin, Milwaukee, Wisconsin
Conditions: Obesity, Metabolic Syndrome, Pre Diabetes, Sedentary Behavior
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Feasibility of the Paso Program for Patients With Metabolic Dysfunction Associated Steatotic Liver Disease
NCT06854185
Recruiting
The purpose of this study is to learn whether the Paso weight loss program is feasible for Mexican and Central American patients with fatty liver disease. In addition, the investigators will also look at whether the program improves weight loss, fatty liver disease, physical activity, diet, and family support among patients.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
03/03/2025
Locations: Harris Health - Smith, Houston, Texas
Conditions: Metabolic Dysfunction Associated Steatotic Liver Disease, Overweight (BMI > 25), Metabolic Syndrome
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