There are currently 32 active clinical trials seeking participants for Metabolic Syndrome research studies. The states with the highest number of trials for Metabolic Syndrome participants are California, Ontario, Quebec and Massachusetts.
A Randomized Comparison of Stage-Based Care Versus Risk Factor-Based Care for Prevention of Cardiovascular Events
NCT06112418
Recruiting
TRANSFORM is a prospective, randomized, open blinded endpoint (PROBE), event-driven, pragmatic trial in patients who are at increased risk for atherosclerotic cardiovascular (CV) disease but with no known symptomatic CV disease. The trial tests the hypothesis that a Cleerly Coronary Artery Disease (CAD) Staging System-based care strategy reduces CV events compared with risk factor-based care.
Gender:
ALL
Ages:
55 years and above
Trial Updated:
06/24/2025
Locations: Chandler Clinical Trials, Chandler, Arizona +88 locations
Conditions: Diabetes Mellitus, Type 2, PreDiabetes, Metabolic Syndrome
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Exercise and Time of Day in Type 2 Diabetes
NCT05108987
Recruiting
The overall purpose of the study is to test the effect of Noom on exercise and diet advice in adults with type 2 diabetes. The overarching hypothesis is that the use of Noom may promote better dietary adherence during an exercise program, thereby promoting greater weight loss and cardiometabolic health compared to lifestyle advice only. In particular, the investigators anticipate that changes in metabolic and vascular insulin sensitivity will correlate with glycemic control and blood pressure ch... Read More
Gender:
ALL
Ages:
Between 30 years and 70 years
Trial Updated:
06/11/2025
Locations: New Jersey Institute for Food, Nutrition, and Health, New Brunswick, New Jersey +2 locations
Conditions: Diabetes Mellitus, Type 2, Metabolic Syndrome
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Combined Oral Contraceptive Pill and Resistance Starch
NCT06852365
Recruiting
This study will enroll women with PCOS to study the effects of first line therapy, oral contraceptive pills, and then either 12 weeks of resistant starch or 12 weeks of placebo to explore if resistant starch improves cardiometabolic parameters or impacts gut dysbiosis compared to placebo.
Gender:
FEMALE
Ages:
Between 18 years and 40 years
Trial Updated:
06/11/2025
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Metabolic Syndrome, Polycystic Ovary Syndrome
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The Effect of SGLT2 Inhibition on Adipose Inflammation and Endothelial Function
NCT05972564
Recruiting
Obesity is associated with increased cardiometabolic disease risk due, in part, to heightened chronic inflammation arising from adipose tissue. There are no current targeted therapies to prevent or reverse the chronic inflammation of obesity, and a better understanding of these inflammatory pathways in humans is key to future therapeutic interventions. This trial will determine both the anti-inflammatory potential of the SGLT2 inhibitor empagliflozin, and the contribution of adipose inflammation... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
06/10/2025
Locations: Vanderbilt University Medical Center, Nashville, Tennessee
Conditions: Obesity, Metabolic Syndrome
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Vericiguat in Patients With Metabolic Syndrome and Coronary Vascular Dysfunction
NCT05711719
Recruiting
Coronary vascular dysfunction is one of the "final common pathways" for the impact of multiple cardiovascular risk factors. The investigators will conduct a randomized, double-blind placebo-controlled study in individuals with the metabolic syndrome and baseline coronary vascular dysfunction to evaluate the impact of vericiguat, a stimulator of soluble guanylyl cyclase, on coronary vascular function using non-invasive cardiac magnetic resonance imaging.
Gender:
ALL
Ages:
Between 35 years and 85 years
Trial Updated:
06/09/2025
Locations: Johns Hopkins Hospital, Baltimore, Maryland
Conditions: Metabolic Syndrome, Coronary Microvascular Dysfunction
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Understanding Components of Mind-body Exercise for Physical Activity Engagement in Metabolic Syndrome
NCT05242640
Recruiting
The aim of this study is to assess the feasibility and acceptability (e.g., enrollment, adherence, retention, acceptability of procedures and interventions) of a pilot factorial study design that will help elucidate components of mind-body exercise interventions. The study involves completing a walking program, a mindful attention program, a walking program that includes mindful attention, or no program at all. A "pilot" study is a smaller study that helps researchers to understand whether the s... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
05/20/2025
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Metabolic Syndrome
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Study of the Effect of Innate on the Inflammatory Response to Endotoxin
NCT01143480
Recruiting
Background: - Innate immunity is the process by which white blood cells and other parts of the immune system sense and respond to potential infections by causing an inflammation. Researchers are interested in studying how the body responds to certain environmental factors, and whether the body s response can contribute to chronic illnesses or diseases such as asthma and certain types of cancers. Objectives: - To examine how specific genes and proteins in blood cells respond to environmental e... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
05/02/2025
Locations: NIEHS Clinical Research Unit (CRU), Research Triangle Park, North Carolina
Conditions: Asthma, Atherosclerosis, Metabolic Syndrome, Insulin Resistance, Cancer
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Effects of Exercise and GLP-1 Agonism on Muscle Microvascular Perfusion and Insulin Action in Adults With Metabolic Syndrome
NCT04575844
Recruiting
The primary objective of this study is to examine whether exercise training alone, liraglutide treatment alone or exercise training plus liraglutide treatment increases cardiac and skeletal muscle microvascular blood volume, improves vascular function of the conduit vessels, and enhances insulin's metabolic action in humans with Metabolic Syndrome. Subjects will be randomized to one of the 4 groups: control, exercise training, liraglutide treatment, and exercise + liraglutide. They will be studi... Read More
Gender:
ALL
Ages:
Between 21 years and 60 years
Trial Updated:
04/24/2025
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Metabolic Syndrome
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Animal and Plant Proteins and Glucose Metabolism
NCT03994367
Recruiting
The goal of this proposal is to determine the effect of a high protein diet in which the increase in protein intake is derived from different sources (animal vs plant and protein-rich whole foods vs protein isolates) on: i) liver and muscle insulin sensitivity; ii) the metabolic response to a meal, and iii) 24-h plasma concentration profiles of glucose, glucoregulatory hormones, and protein-derived metabolites purported to cause metabolic dysfunction.
Gender:
ALL
Ages:
Between 21 years and 70 years
Trial Updated:
03/14/2025
Locations: University of Missouri School of Medicine, Columbia, Missouri
Conditions: Metabolic Syndrome, Metabolic Syndrome, Protection Against, Glucose Metabolism Disorders
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Stand Up for Your Health with a Sit-stand Desk
NCT05585190
Recruiting
More than 84 million - or 1 out of every 3 U.S. adults - have prediabetes, a condition that if not treated often leads to type 2 diabetes within five years. Average medical expenditures among diabetics are about 2.3 times higher than expenditures for people without diabetes. Physical inactivity and elevated body mass index (BMI) are major risk factors for the disease. Sedentary behavior is becoming increasingly prevalent with the growth of a 'work from home' culture, most recently driven by the... Read More
Gender:
ALL
Ages:
Between 18 years and 79 years
Trial Updated:
03/11/2025
Locations: Medical College of Wisconsin, Milwaukee, Wisconsin
Conditions: Obesity, Metabolic Syndrome, Pre Diabetes, Sedentary Behavior
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Testing the Adipose Expandability Hypothesis in Vivo During Overfeeding
NCT04583514
Recruiting
Adipose, or fat, tissue is a plastic organ that retains the ability to expand and store excess calories during positive energy balance in humans. The capacity of subcutaneous (subQ) adipose tissue to expand and remodel is an important determinant of obesity-related health complications, and impaired expansion of subQ fat tissue is thought to contribute to the risk of diseases such as the Metabolic Syndrome (MetS) and type 2 diabetes mellitus (T2D). The objectives of the study are to evaluate the... Read More
Gender:
ALL
Ages:
Between 18 years and 42 years
Trial Updated:
02/03/2025
Locations: Pennington Biomedical Research Center, Baton Rouge, Louisiana
Conditions: Overweight and Obesity, Metabolic Syndrome
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The PIVOT Trial: Project on EHR-Integrated Lifestyle Interventions for Adults Aged Fifty and Older
NCT05654142
Recruiting
This is a multisite clinical trial of healthy lifestyle programs for middle-to-older-aged adults (50 -74 years) to improve their weight and, therefore, reduce risk for chronic disease. This study will investigate whether a proven, self-directed video-based lifestyle program can be significantly enhanced with the assistance of a coach via videoconference or phone to help people as they adopt healthy eating and exercise behaviors. Additionally, the study will examine what factors might explain why... Read More
Gender:
ALL
Ages:
Between 50 years and 74 years
Trial Updated:
12/05/2024
Locations: Department of Medicine, Vitoux Program on Aging and Prevention, Chicago, Illinois +2 locations
Conditions: CARDIOMETABOLIC CONDITIONS, Obesity, Pre-diabetes, Metabolic Syndrome, Type2diabetes, Hypertension, Dyslipidemias
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